A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine in March 2021. Based on their analyses, the researchers are calling for prioritizing clinical trials of drugs targeting the proteins IFNAR2 and ACE2. The goal is to identify existing drugs, either FDA-approved or in clinical development for other conditions, that can be repurposed for the early management of COVID-19. Doing so, they say, will help keep people with the virus from being hospitalized. IFNAR2 is the target ...

PHILADELPHIA - Psychosocial stress - typically resulting from difficulty coping with challenging environments - may work synergistically to put women at significantly higher risk of developing coronary heart disease, according to a study by researchers at Drexel University's Dornsife School of Public Health, recently published in the Journal of the American Heart Association. The study specifically suggests that the effects of job strain and social strain -- the negative aspect of social relationships -- on women is a powerful one-two punch. Together they are associated with a 21% higher risk of developing coronary heart disease. Job strain ...

There are millions of people who face the loss of their eyesight from degenerative eye diseases. The genetic disorder retinitis pigmentosa alone affects 1 in 4,000 people worldwide. Today, there is technology available to offer partial eyesight to people with that syndrome. The Argus II, the world's first retinal prosthesis, reproduces some functions of a part of the eye essential to vision, to allow users to perceive movement and shapes. While the field of retinal prostheses is still in its infancy, for hundreds of users around the globe, the "bionic eye" enriches the way they interact with the world on a daily basis. For instance, seeing outlines of objects enables them to move around unfamiliar environments with increased safety. That is ...

A new biosealant therapy may help to stabilize injuries that cause cartilage to break down, paving the way for a future fix or - even better - begin working right away with new cells to enhance healing, according to a new animal-based study by researchers at the Perelman School of Medicine at the University of Pennsylvania. Their research was published in Advanced Healthcare Materials. "Our research shows that using our hyaluronic acid hydrogel system at least temporarily stops cartilage degeneration that commonly occurs after injury and causes pain in joints," said the study's senior author, Robert Mauck, PhD, a professor of Orthopaedic Surgery and the director of Penn Medicine's McKay Orthopaedic Research Laboratory. "In addition to pausing cartilage breakdown, we think that applying ...

Experts have uncovered a new molecular reason why faecal transplants are highly effective in treating infections such as C. difficile (a nasty bacteria that can infect the bowel), which could lead to more targeted treatments for this and other similar diseases. The study, published today in Gastroenterology, was led by experts from the University of Nottingham and Nottingham Trent University. Clostridium difficile, also known as C. difficile or C. diff, is a bacterium that can infect the bowel and cause diarrhoea. The infection most commonly affects people who have recently been treated with antibiotics. It can spread easily to others. A stool transplant - or to give it its full title "a faecal ...

New York, NY (April 9, 2021) - Sets of genes associated with resistance to immunotherapy in patients with metastatic urothelial cancer of the bladder have been identified and validated by researchers at Mount Sinai. In a study published in Clinical Cancer Research, the team uncovered gene signatures representing adaptive immunity and pro-tumorigenic inflammation that were responsible for sensitivity or resistance to immune checkpoint inhibitors, drugs that help the body's immune system recognize and attack cancerous cells. "These findings enabled us to identify potential biomarkers in patients who are less likely to respond favorably to immune checkpoint inhibitors, as well as new combination therapeutic approaches that might overcome such resistance ...

Nine out of ten Danes say that they will accept the COVID-19 vaccine when offered. This is the same level as before the AstraZeneca vaccine was paused. This is shown by a questionnaire-based survey collected by Søren Dinesen Østergaard and co-authors. He is professor at the Department of Clinical Medicine at Aarhus University and affiliated with the Department of Affective Disorders at Aarhus University Hospital, Psychiatry. "In February 2021, we asked a sample of Danes whether they were willing to be vaccinated against the coronavirus, and 89 per cent replied that they would. This picture was unchanged when the same people were asked again after the pausing of the AstraZeneca vaccine," says Søren Dinesen Østergaard. ...

Throughout the last ice age, the climate changed repeatedly and rapidly during so-called Dansgaard-Oeschger events, where Greenland temperatures rose between 5 and 16 degrees Celsius in decades. When certain parts of the climate system changed, other parts of the climate system followed like a series of dominos toppling in succession. This is the conclusion from an analysis of ice-core data by a group of researchers that included postdoc Emilie Capron and associate professor Sune Olander Rasmussen from the Section for the Physics of Ice, Climate and Earth at the Niels Bohr ...

Tsukuba, Japan - Plants in the bean family (legumes) form nodules on their roots to take up nitrogen. Legumes will stop nodule production when nitrogen is plentiful (Figure 1), but precisely how nitrate presence controls nodule formation in these plants has been a mystery. Now, researchers from Japan have found that interactions between proteins and nitrate can induce and repress genes, controlling nodulation with potential applications in sustainable agriculture. In a study published in April in The Plant Cell, a research team from the University of Tsukuba has shown that the different DNA-binding properties between proteins that establish nodule development determine if genes involved in symbiosis that govern nodulation turn on or off and that ...

Two studies led by the Mental Health Unit of the Virgen del Rocio University Hospital and involving researchers from the US conclude that antipsychotic drugs could have a protective effect against SARS-CoV-2. For this reason, patients treated with these drugs have a lower risk of becoming infected or suffer a milder form of the disease if they do become infected. Thus, a first descriptive epidemiological study of a sample of 698 patients treated with antipsychotics at the Seville hospital revealed that antipsychotic drugs could provide protection against both infection and the tendency to clinical severity of Covid-19 infection. "These are very interesting findings that reflect a clinical reality where we see few patients ...

Since the beginning of the coronavirus pandemic, scientists and physicians worldwide undertook enormous efforts to understand the disease caused by the virus. In their latest collaborative study, researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and physicians from the University of Freiburg Medical Center unveil a novel feature of COVID-19 immunity, which could have implications for future therapies. The study points to the involvement of Interleukin 33, an important danger signal, when immune cells encounter Sars-CoV-2 for a ...

An international group of scientists led by the RIKEN Cluster for Pioneering Research have studied the chemical composition of 50 protoplanetary-disk forming regions in the Perseus Molecular Cloud, and found that despite being in the same cloud, the amounts of complex organic molecules they contain are quite different. Interestingly, the chemically rich young disks have similar compositions of organic molecules. These findings raise an important question: do solar-like systems share a common chemistry at birth? It was once believed that complex organic molecules were rare in the universe, and that this rarity ...

Imperial Brands scientists have utilised Toxys' ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke. Imperial scientists are the first to publish results using the ToxTracker system for the assessment of vape e-liquids and aerosols, and it forms part of the company's continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. The assays help assess how product samples may impact cellular functioning across six reporter cell lines, picking up the tell-tale molecular signs of potential harm in the ...

Glass is ubiquitous, from high-tech products in the fields of optics, telecommunications, chemistry and medicine to everyday objects such as bottles and windows. However, shaping glass is mainly based on processes such as melting, grinding or etching. These processes are decades old, technologically demanding, energy-intensive and severely limited in terms of the shapes that can be realized. For the first time, a team led by Prof. Dr. Bastian E. Rapp from the Laboratory of Process Technology at the Department of Microsystems Engineering at the University of Freiburg, in collaboration with the Freiburg-based start-up Glassomer, has developed a process that makes it possible to form glass easily, quickly and in almost any shape using injection ...

The unpopular guests are already here. Hazel-, alder- and elm tree pollen sweep in over us during the early spring months, with birch pollen following in May. Then grass follows in June-July before mugwort pollen closes the season in late summer. All leading to more and more people suffering. Over fifty years, the proportion of young Danes who sneeze, rub itchy eyes or suffer a blocked nose because of pollen has grown from 7-8 per cent in the 1970s to 24 per cent today. And for asthma, the proportion has risen from 4 to 12 per cent during the same period. ...

Diet and the gut microbiome With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract. There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species. The gut microbiome thus plays a major role in determining how nutrition affects our health. "So far, however, the metabolic capabilities of many of these microorganisms in the microbiome are still unknown. That means we don't know what substances they feed on and how they process them," explains ...

Researchers at Lund University in Sweden have discovered that bird blood produces more heat in winter, when it is colder, than in autumn. The study is published in The FASEB Journal. The secret lies in the energy factories of cells, the mitochondria. Mammals have no mitochondria in their red blood cells, but birds do, and according to the research team from Lund and Glasgow this means that the blood can function as a central heating system when it is cold. "In winter, the mitochondria seem to prioritize producing more heat instead of more energy. The blood becomes a type of radiator that they can turn up when it gets colder", says Andreas Nord, researcher in evolutionary ecology at Lund University who led the study. Until ...

Ferroelectric materials are used in many devices, including memories, capacitors, actuators and sensors. These devices are commonly used in both consumer and industrial instruments, such as computers, medical ultrasound equipment and underwater sonars. Over time, ferroelectric materials are subjected to repeated mechanical and electrical loading, leading to a progressive decrease in their functionality, ultimately resulting in failure. This process is referred to as 'ferroelectric fatigue'. It is a main cause of the failure of a range of electronic devices, with discarded electronics a leading contributor to e-waste. Globally, tens of millions of tonnes of failed electronic devices go to landfill every year. Using advanced ...

During the acute phase of the COVID-19 pandemic, emergency department doctors, nurses and other frontline staff experienced unprecedented levels of stress and emotional exhaustion that included nightmares or insomnia, according to a UC San Francisco-led study of emergency departments across the country. The study, among the first to assess mental health effects of the pandemic at a geographically diverse sample of emergency rooms, found that nearly one-fifth of the ER staff were at elevated risk for post-traumatic stress disorder (PTSD). The study also reported that regular testing for COVID-19 helped to reduce stress among emergency personnel, particularly for those with previous positive antibody ...

COLUMBUS, Ohio - In some men, having traditional masculine characteristics such as competitiveness and adventurousness was linked to being better fathers to infants, a new study found. But the men in this study - highly educated and from dual-earner couples - combined those stereotypically masculine traits with the belief that they should be nurturing, highly involved fathers. The researchers were surprised that traits often seen as old-fashioned male stereotypes were linked to more positive parenting behaviors, said study lead author Sarah Schoppe-Sullivan, professor of psychology at The Ohio State University. It ...

An international research team led by Monash University has uncovered a new technique that could speed up recovery from bone replacements by altering the shape and nucleus of individual stem cells. The research collaboration involving Monash University, the Melbourne Centre for Nanofabrication, CSIRO, the Max Planck Institute for Medical Research and the Swiss Federal Institute of Technology in Lausanne, developed micropillar arrays using UV nanoimprint lithography that essentially 'trick' the cells to become bone. Nanoimprint lithography allows for the creation of microscale patterns with low cost, high ...

The concentration of the radioactive element radon is known to change in the ground before and after earthquakes. Previous studies have shown elevated radon levels in the atmosphere before the mainshock of a large inland earthquake due to foreshock activity and slow slip. But now, researchers from Tohoku University have revealed an anomaly in this phenomenon. Through the analysis of data before and after the 2018 Northern Osaka Earthquake, they discovered that the atmospheric radon concentration decreased. The results of their research were published online in Scientific Reports on April 2, 2021. "For the first time, we found a decrease in the atmospheric radon associated with seismic quiescence before the mainshock of ...

A team from the Department of Agronomy at the UCO has demonstrated, through field tests carried out during 8 agricultural seasons, that foliar feeding with fertilizer increases the concentration of zinc in wheat more than if it is applied to the soil Micronutrient deficiencies pose health problems for a third of the world's population. Worldwide, zinc deficits are more problematic in the rural areas of developing countries, where diets are largely limited to vegetable products grown in soils suffering from low nutrient availability. Biofortification, the process of bolstering the nutritional value of crops by increasing ...

Researchers at the Obesity Research Unit of the University of Helsinki have found that obesity clearly reduces mitochondrial gene expression in fat tissue, or adipose tissue. Mitochondria are important cellular powerplants which process all of our energy intake. If the pathways associated with breaking down nutrients are lazy, the changes can often have health-related consequences. A total of 49 pairs of identical twins discordant for body weight participated in the study conducted at the University of Helsinki: their body composition and metabolism were studied in detail, and biopsies from adipose and muscle tissue were collected. Multiple techniques for ...

WASHINGTON, April 9, 2021 -- For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Today, researchers will describe the discovery of a small molecule with the potential to address the root cause of sickle cell disease by boosting levels of fetal hemoglobin, a healthy form that adults normally do not make. The drug could be formulated into a convenient daily tablet. The researchers will present their results today at the spring meeting of the American Chemical Society (ACS). ACS Spring 2021 is being held online April 5-30. Live sessions will be hosted April 5-16, and on-demand and networking content will continue through ...