What The Study Did: Researchers compared rates of psychotropic drug prescriptions during adolescence and young adulthood between individuals born preterm and at term. Authors: Christine S. Bachmann, M.D., of the Norwegian University of Science and Technology in Trondheim, Norway, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.1420) Editor's Note: Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, ...

(Philadelphia, PA) - About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed. Now, in new work, scientists at the Lewis Katz School of Medicine (LKSOM) at Temple University identify a path to a promising novel therapeutic strategy, taking aim at a molecule in the heart known as G protein-coupled receptor kinase 5 (GRK5). In a study published online in the journal Cardiovascular Research, the scientists show in mice that reducing GRK5 levels can significantly improve survival ...

Scientists have long theorized that supermassive black holes can wander through space--but catching them in the act has proven difficult. Now, researchers at the Center for Astrophysics | Harvard & Smithsonian have identified the clearest case to date of a supermassive black hole in motion. Their results are published today in the Astrophysical Journal. "We don't expect the majority of supermassive black holes to be moving; they're usually content to just sit around," says Dominic Pesce, an astronomer at the Center for Astrophysics who led the study. "They're just so heavy that it's tough to get them going. Consider how much more ...

Since the pandemic hit, researchers have been uncovering ways COVID-19 impacts other parts of the body, besides the lungs. Now, for the first time, a visual correlation has been found between the severity of the disease in the lungs using CT scans and the severity of effects on patient's brains, using MRI scans. This research is published in the American Journal of Neuroradiology. It will be presented at the 59th annual meeting of the American Society of Neuroradiology (ASNR) and has also been selected as a semifinalist for that organization's Cornelius Dyke Award. The results show that by looking at lung CT scans of patients diagnosed with COVID-19, physicians may be able to predict just how badly they'll experience other ...

ITHACA, N.Y. - A new Penn State and Cornell study describes an effort to produce the most comprehensive and high-resolution map yet of chromosome architecture and gene regulation in yeast, a major step toward improving understanding of development, evolution and environmental responses in higher organisms. Specifically, the study mapped precise binding sites of more than 400 different chromosomal proteins in the yeast genome, most of which regulate the expression of genes. Yeast cells provide a simple model system with 6,000 genes, most of which are found in other organisms, including humans, making them excellent candidates for studying fundamental genetics and complex biological pathways. The paper, "A High-Resolution Protein Architecture of the Budding Yeast ...

Around three times as many males are diagnosed with autism than females. This suggests that biological sex factors may play a role in the development and presentation of autism. Studies on the neurobiology (brain biology) of males and females with autism have begun to examine brain networks but results have been mixed. This is largely due to the limited availability of data from autistic females. In response, researchers from END ...

Humans rely on nature extensively for everything from food production to coastal protection, but those contributions might be more threatened than previously thought, according to new findings from the University of Colorado Boulder. This research, out today in Nature Communications, looked at three different coastal food webs that include those services provided to humans, or ecosystem services, and found that even if the services themselves aren't directly threatened, they can become threatened when other species around them go extinct--often called secondary ...

More than one million operations are performed in Switzerland every year. A surgeon's skill has a direct impact on the outcome of the operation. Training and experience, as well as momentary fatigue and other influencing factors all play a role. At present, skill is tested by experts, either directly during an operation or by evaluating video footage. This approach is very costly and only a limited number of experts are available. Moreover, the assessment may vary and is not always fully reproducible. For some time, attempts have been made to automate and objectify the assessment of surgeons' skills. Proof of feasibility The key result of the study is the proof of the fundamental feasibility of an ...

Colloidal suspensions of microscopic particles show complex and interesting collective behaviors. In particular, the collective dynamics of colloids is fundamental and ubiquitous for materials assembly, robotic motion, microfluidic control, and in several biological scenarios. The collective dynamics of confined colloids can be completely different from that of free colloids: for instance, confined colloids can self-organize into vortex structures, coherent motion, or different phase behaviors. On one hand, due to the complexity of colloidal suspensions, how to finely tune the ...

As the world continues to grapple with the COVID-19 pandemic, an international team of researchers have published a review of the best techniques to collect airborne aerosols containing viruses. In the review, which was published by the Science of the Total Environment journal, a team led by the University of Surrey concluded that the most effective way to collect and detect airborne pathogens, particularly viruses, was to use cyclone sampling techniques. For example, the sampler draws the air through the cyclone separator. It then uses centrifugal forces to collect the particles on a sterile cone containing the liquid collection vessel, such as DMEM (Dulbecco's minimal essential ...

Photovoltaics decisively contributes to sustainable energy supply. The efficiency of solar cells in directly converting light energy into electrical energy depends on the material used. Metal-halide perovskites are considered very promising materials for solar cells of the next generation. With these semiconductors named after their special crystal structure, a considerable increase in efficiency was achieved in the past years. Meanwhile, perovskite solar cells have reached an efficiency of up to 25.5 percent, which is quite close to that of silicon ...

Proteins are the key component in all modern forms of life. Haemoglobin, for example, transports the oxygen in our blood; photosynthesis proteins in the leaves of plants convert sunlight into energy; and fungal enzymes help us to brew beer and bake bread. Researchers have long been examining the question of how proteins mutate or come into existence in the course of millennia. That completely new proteins - and, with them, new properties - can emerge practically out of nothing, was inconceivable for decades, in line with what the Greek philosopher Parmenides said: "Nothing can emerge from nothing" (ex nihilo nihil fit). Working with colleagues from the USA and ...

The Cabeza de los Gatos waste rock pile, left from mining activities in the town of Tharsis (Huelva), underwent a rehabilitation process consisting of remodelling the slope of the pile, applying liming materials and then a layer of soil. Finally, trees and shrubs typical of the area were planted and a hydroseeding with a mixture of shrub and herbaceous seeds was applied. Twelve years later, a study led by researchers from IRNAS-CSIC, in collaboration with Sabina Rossini Oliva, a researcher from the University of Seville and the Environment and Water Agency of Andalusia (AMAYA), has proven the effectiveness of this sort of rehabilitation. "The results obtained show that the steps taken were successful. Now, ...

People with high levels of emotional intelligence are less likely to be susceptible to 'fake news', according to research at the University of Strathclyde. The study invited participants to read a series of news items on social media and to ascertain whether they were real or fictitious, briefly describing the reasons for their answers. They were also asked to complete a test to determine their levels of emotional intelligence (EQ or emotional quotient) and were asked a number of questions when considering the veracity of each news item. Researchers found that those who identified the types of news correctly were most likely to score highly in the EQ tests. There was a similar correlation between correct identification and educational attainment. The ...

In asthma, the airways become hyperresponsive. Researchers from Uppsala University have found a new mechanism that contributes to, and explains, airway hyperresponsiveness. The results are published in the scientific journal Allergy. Some 10 per cent of Sweden's population suffer from asthma. In asthmatics, the airways are hyperresponsive (overreactive) to various types of stimuli, such as cold air, physical exertion and chemicals. The airways become constricted, making breathing difficult. To diagnose asthma, a "methacholine test" is commonly used to determine whether a person is showing signs of airway hyperresponsiveness. Methacholine binds to what are known as muscarinic receptors in the smooth muscle cells lining the inside ...

The researchers say this is a big step in tackling smouldering peat fires, which are the largest fires on Earth. They ignite very easily, are notoriously difficult to put out, and release up to 100 times more carbon into the atmosphere than flaming fires, contributing to climate change. The fires, known as 'zombie fires' for their ability to hide and smoulder underground and then reanimate as new flames days or weeks after the wildfire had been extinguished, are prevalent in regions like Southeast Asia, North America, and Siberia. They are driven by the burning of soils rich in organic content like peat, which is a large natural reservoir of carbon. Worldwide, peat fires account for millions of tonnes of carbon released into the atmosphere each year. Firefighters currently use millions ...

A new model of aging takes into account not only genetics and environmental exposures but also the tiny changes that randomly arise at the cellular level. University Professor Caleb Finch introduced the "Tripartite Phenotype of Aging" as a new conceptual model that addresses why lifespan varies so much, even among human identical twins who share the same genes. Only about 10 to 35 percent of longevity can be traced to genes inherited from our parents, Finch mentioned. Finch authored the paper introducing the model with one of his former graduate students, Amin Haghani, who received his PhD in the Biology of Aging from the USC ...

Researchers at Lund University in Sweden can now show that a new examination method identifies high-risk plaques in the blood vessels surrounding the heart, that cannot be seen solely with traditional angiograms. This type of plaque, rich in fat, could potentially cause recurring heart attacks in patients with heart disease. The study is published in the The Lancet. "We have been working on this study for ten years. This creates a unique opportunity to treat plaques before they cause a heart attack", says David Erlinge, professor of cardiology at Lund University and Consultant in ...

During 1995-2015, fullerene derivatives had been the dominating electron acceptors in organic solar cells (OSCs) owing to their performance superior to other acceptors. However, the drawbacks of fullerenes, such as weak visible absorption, limited tunability of electronic properties and morphological instability, restrict further development of OSCs toward higher efficiencies and practical applications. Therefore, the development of new acceptors beyond fullerenes is urgent in the field of OSCs. Professor Zhan Xiaowei from the College of Engineering at Peking University is one of the pioneers engaging in development of nonfullerene acceptors in the world. ...

University of Otago researchers have discovered one of the reasons why more than 50 per cent of people with type 2 diabetes die from heart disease. And perhaps more significantly, they have found how to treat it. Associate Professor Rajesh Katare, of the Department of Physiology, says it has been known that stem cells in the heart of diabetic patients are impaired. While stem cell therapy has proved effective in treating heart disease, it is not the case in diabetic hearts. It has not been known why; until now. It comes down to tiny molecules called microRNA which control gene expression. "Based on the results of laboratory testing, ...

New bioarchaeological research shows malaria has threatened human communities for more than 7000 years, earlier than when the onset of farming was thought to have sparked its devastating arrival. Lead author Dr Melandri Vlok from the Department of Anatomy, University of Otago, says this ground-breaking research, published today in Scientific Reports, changes the entire understanding of the relationship humans have had with malaria, still one of the deadliest diseases in the world. "Until now we've believed malaria became a global threat to humans when we turned to farming, but our research shows in at least Southeast Asia this disease was a threat to human groups well before that. "This research providing a new cornerstone of malaria's evolution with humans is a great achievement ...

When people think of sea level rise, they usually think of coastal erosion. However, recent computer modeling studies indicate that coastal wastewater infrastructure, which includes sewer lines and cesspools, is likely to flood with groundwater as sea-level rises. A new study, published by University of Hawai'i (UH) at Mānoa earth scientists, is the first to provide direct evidence that tidally-driven groundwater inundation of wastewater infrastructure is occurring today in urban Honolulu, Hawai'i. The study shows that higher ocean water levels ...

Light-emitting diodes (LEDs) have revolutionized the displays industry. LEDs use electric current to produce visible light without the excess heat found in traditional light bulbs, a glow called electroluminescence. This breakthrough led to the eye-popping, high-definition viewing experience we've come to expect from our screens. Now, a group of physicists and chemists have developed a new type of LED that utilizes spintronics without needing a magnetic field, magnetic materials or cryogenic temperatures; a "quantum leap" that could take displays to the next level. "The companies that make LEDs or TV and computer displays don't want to deal with magnetic fields and magnetic materials. It's heavy ...

TOKYO - Toshiba Corporation (TOKYO: 6502), the industry leader in solutions for large-scale optimization problems, today announced a scale-out technology that minimizes hardware limitations, an evolution of its optimization computer, the Simulation Bifurcation Machine (SBM), that supports continued increases in computing speed and scale. Toshiba expects the new SBM to be a game changer for real-world problems that require large-scale, high-speed and low-latency, such as simultaneous financial transactions involving large numbers of stock, and complex control of multiple robots. The research results were published in Nature Electronics*1 on March 1. Speed and scale are keys to success in industrial sectors ...

Waste cooking oil, sulfur and wool offcuts have been put to good use by green chemists at Flinders University to produce a sustainable new kind of housing insulation material. The latest environmentally friendly building product from experts at the Flinders Chalker Lab and colleagues at Deakin and Liverpool University, has been described in a new paper published in Chemistry Europe ahead of Global Recycling Day (18 March 2021) The insulating composite was made from the sustainable building blocks of wool fires, sulfur, and canola oil to produce a promising new model for next-generation insulation - not only capitalising on wool's natural low flammability but also to make significant energy savings for property owners and tenants. The new composite is one of several exciting ...