HOUSTON ? A high rate of genetic mutations within a tumor, known as high tumor mutation burden (TMB), was only useful for predicting clinical responses to immune checkpoint inhibitors in a subset of cancer types, according to a new study led by researchers from The University of Texas MD Anderson Cancer Center. The findings, published today in Annals of Oncology, suggest that TMB status may not be reliably used as a universal biomarker for predicting immunotherapy response. While TMB status was capable of successfully predicting response to checkpoint blockade in certain cancers, such as melanoma, lung and bladder cancer, there was no association with improved outcomes in others, including breast, prostate and brain ...

A large study of people in 28 countries found men aged 50 and over had a 60% greater risk of death than women, partly explained by heavier rates of smoking and heart disease in men, although the gap varied across countries, according to new research in CMAJ (Canadian Medical Association Journal) . "Many studies have examined the potential impact of social, behavioural and biological factors on sex differences in mortality, but few have been able to investigate potential variation across countries," writes Dr. Yu-Tzu Wu, Institute of Psychiatry, Psychology and Neuroscience, King's College London, and Population Health Sciences Institute, Newcastle University, United Kingdom, with coauthors. "Different cultural traditions, historical contexts, ...

ANN ARBOR, Mich. - For teens, pandemic restrictions may have meant months of virtual school, less time with friends and canceling activities like sports, band concerts and prom. And for young people who rely heavily on social connections for emotional support, these adjustments may have taken a heavy toll on mental health, a new national poll suggests. Forty-six percent of parents say their teen has shown signs of a new or worsening mental health condition since the start of the pandemic in March 2020, according to the C.S. Mott Children's Hospital National Poll on Children's Health at Michigan Medicine. Parents of teen girls were more likely to say their child had a ...

PULLMAN, Wash. - People who talk with their doctors are more likely to get vaccinated during a pandemic, according to a study of evidence collected during the "swine flu," the last pandemic to hit the U.S. before COVID-19. Researchers from Washington State University and University of Wisconsin-Madison surveyed patients about the vaccine for the H1N1 virus, also known as the swine flu, which was declared a pandemic by the World Health Organization in 2009. They found that doctor-patient communication helped build trust in physicians, which led to more positive attitudes toward the H1N1 vaccine--and it was more than just talk; it correlated to people actually getting vaccinated. ...

(COLUMBUS, Ohio) - High-powered magnets are small, shiny magnets made from powerful rare earth metals. Since they started showing up in children's toys in the early 2000s and then later in desk sets in 2009, high-powered magnets have caused thousands of injuries and are considered to be among the most dangerous ingestion hazards in children. When more than one is swallowed, these high-powered magnets attract to each other across tissue, cutting off blood supply to the bowel and causing obstructions, tissue necrosis, sepsis and even death. The U.S. Consumer Product Safety Commission (CPSC) found them dangerous enough that in 2012 they halted the sale of high-powered magnet sets and instituted a recall followed by a federal rule that ...

A fear of poor SATs results is driving headteachers to separate pupils by ability despite the impact on children's self-esteem and confidence, according to a study by researchers from UCL published in the peer-reviewed British Journal of Sociology of Education. The findings, based on a survey of nearly 300 principals of primary schools in England, provide new evidence of a high-stakes culture around testing where some pupils are prioritised above others and physically segregated from them. More than a third (35%) of headteachers said SATs were the reason for grouping children into different ability sets for English, and just under half (47%) for maths, according to the results which also ...

In the world of neurodevelopment, one thing is clear: the earlier the intervention the better. Infancy is a critical time in brain development, and neuroscientists are increasingly identifying factors that can negatively impact cognition and ones that can improve cognition early in life. At the annual meeting of the Cognitive Neuroscience Society (CNS), researchers from the University of Minnesota are presenting new work on two early interventions: one on the potential use of engineered gut microbes for antibiotic-exposed infants and another on a choline supplement to treat infants exposed prenatally to alcohol. "These talks underscore how patient-based neuroscience can advance ...

Men experiencing vital exhaustion are more likely to have a heart attack, according to research presented today at ESC Acute CardioVascular Care 2021, an online scientific congress of the European Society of Cardiology (ESC).1 The risk of a myocardial infarction linked with exhaustion was particularly pronounced in never married, divorced and widowed men. "Vital exhaustion refers to excessive fatigue, feelings of demoralisation and increased irritability," said study author Dr. Dmitriy Panov of the Institute of Cytology and Genetics, Novosibirsk, Russian Federation. "It is thought to be a response to intractable problems in people's lives, particularly when they are unable to adapt to prolonged ...

Tokyo, Japan - Scientists from Tokyo Metropolitan University have developed a new method for making ordered arrays of nanoholes in metallic oxide thin films using a range of transition metals. The team used a template to pre-pattern metallic surfaces with an ordered array of dimples before applying electrochemistry to selectively grow an oxide layer with holes. The process makes a wider selection of ordered transition metal nanohole arrays available for new catalysis, filtration, and sensing applications. A key challenge of nanotechnology is getting control over the structure of materials at the nanoscale. In the search for materials that are porous at this length scale, the field of electrochemistry offers a particularly elegant ...

MRI scanning can more precisely define and detect head, neck, thoracic, abdominal and spinal malformations in unborn babies, finds a large multidisciplinary study led by King's College London with Evelina London Children's Hospital, Great Ormond Street Hospital and UCL. In the study, published today in Lancet Child and Adolescent Health, the team of researchers and clinicians demonstrate the ways that MRI scanning can show malformations in great detail, including their effect on surrounding structures. Importantly, they note that MRI is a very safe procedure for pregnant women and their babies. They say the work is invaluable both to clinicians caring for babies before they are born and for teams planning care of the baby after delivery. Recent research has concentrated ...

The Affordable Care Act (ACA) dramatically increased children's preventive healthcare while reducing out-of-pocket costs, according to a new Boston University School of Public Health (BUSPH) study. Published in JAMA Network Open, the study found that checkups with out-of-pocket costs dropped from 54.2% of visits in 2010 (the year the ACA passed) to 14.5% in 2018. "This is a great feather in the cap of the ACA, even though there is still some work to do," says study lead author Dr. Paul Shafer, assistant professor of health law, policy & management at BUSPH. "We found ...

MIAMI--A new study lead by scientists at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science demonstrates that under realistic environmental conditions oil drifting in the ocean after the DWH oil spill photooxidized into persistent compounds within hours to days, instead over long periods of time as was thought during the 2010 Deepwater Horizon oil spill. This is the first model results to support the new paradigm of photooxidation that emerged from laboratory research. After an oil spill, oil droplets on the ocean surface ...

Cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, a type of "active hibernation" that enables them to weather the stress induced by aggressive treatments aimed at destroying them, according to a new study by scientists at Weill Cornell Medicine. These findings have implications for developing new drug combinations that could block senescence and make chemotherapy more effective. In a study published Jan. 26 in Cancer Discovery, a journal of the American Association for Cancer Research, the investigators reported that this biologic process could help explain why cancers so often recur after treatment. The research was done in both organoids and mouse models ...

A study of the relationship between temperature and yields of various rice varieties, based on 50 years of weather and rice-yield data from farms in the Philippines, suggests that warming temperatures negatively affect rice yields. Recent varieties of rice, bred for environmental stresses like heat, showed better yields than both traditional rice varieties and modern varieties of rice that were not specifically bred to withstand warmer temperatures. But the study found that warming adversely affected crop yields even for those varieties best suited to the heat. Overall, the advantage of varieties bred to withstand increased heat was too small to be statistically significant. One of ...

Intake of a high-fat diet leads to an increased risk for obesity, type 2 diabetes, cardiovascular diseases and fatty liver. A study in mice from Karolinska Institutet in Sweden shows that it is possible to eliminate the deleterious effects of a high-fat diet by lowering the levels of apolipoprotein CIII (apoCIII), a key regulator of lipid metabolism. The study is published in the journal Science Advances. Increased levels of the protein apoCIII are related to cardiovascular diseases, insulin resistance and type 2 diabetes. Researchers at the Rolf Luft Research ...

New research led by the University of Cambridge has found rare evidence - preserved in the chemistry of ancient rocks from Greenland - which tells of a time when Earth was almost entirely molten. The study, published in the journal Science Advances, yields information on a important period in our planet's formation, when a deep sea of incandescent magma stretched across Earth's surface and extended hundreds of kilometres into its interior. It is the gradual cooling and crystallisation of this 'magma ocean' that set the chemistry of Earth's interior - a defining stage in the assembly of our planet's structure and the formation of our early atmosphere. Scientists know that catastrophic impacts during the formation of the Earth and Moon would have generated ...

As the driver of global atmospheric and ocean circulation, the tropics play a central role in understanding past and future climate change. Both global climate simulations and worldwide ocean temperature reconstructions indicate that the cooling in the tropics during the last cold period, which began about 115,000 years ago, was much weaker than in the temperate zone and the polar regions. The extent to which this general statement also applies to the tropical high mountains of Eastern Africa and elsewhere is, however, doubted on the basis of palaeoclimatic, geological and ecological studies at high elevations. A research team led by Alexander Groos, Heinz Veit (both from the Institute of Geography) and Naki Akçar (Institute of Geological Sciences) at the University ...

How much did SARS-CoV-2 need to change in order to adapt to its new human host? In a research article published in the open access journal PLOS Biology Oscar MacLean, Spyros Lytras at the University of Glasgow, and colleagues, show that since December 2019 and for the first 11 months of the SARS-CoV-2 pandemic there has been very little 'important' genetic change observed in the hundreds of thousands of sequenced virus genomes. The study is a collaboration between researchers in the UK, US and Belgium. The lead authors Prof David L Robertson (at the MRC-University of Glasgow Centre for Virus Research, Scotland) ...

Informing how COVID-19 response plans may incorporate digital contact tracing, a model of COVID-19 spread within a simulated French population found that if about 20% of the population adopted a contact tracing app on their smartphones, an outbreak could be reduced by about 35%. If more than 30% of the population adopted the app, the epidemic could be suppressed to manageable levels. Jesús Moreno López and colleagues note that the effectiveness of digital contact tracing would depend on a given population's level of immunity to the virus; the intervention alone would be unable to suppress a COVID-19 epidemic where transmission - and especially asymptomatic transmission - remains high. While many countries have implemented ...

DURHAM, N.C. -- If you binged on high-calorie snacks and then spent the winter crashed on the couch in a months-long food coma, you'd likely wake up worse for wear. Unless you happen to be a fat-tailed dwarf lemur. This squirrel-sized primate lives in the forests of Madagascar, where it spends up to seven months each year mostly motionless and chilling, using the minimum energy necessary to withstand the winter. While zonked, it lives off of fat stored in its tail. Animals that hibernate in the wild rarely do so in zoos and sanctuaries, with their climate controls and ...

Decades of feminist gains in the workforce have been undermined by the COVID-19 pandemic, which has upended public education across the United States, a critical infrastructure of care that parents -- especially mothers -- depend on to work, according to new research from Washington University in St. Louis. The research, published in Gender & Society, draws on new data from the Elementary School Operating Status (ESOS) database to show that the gender gap between mothers and fathers in the labor force has grown significantly since the onset of the pandemic in states where schools primarily offered remote instruction. And if these circumstances continue, it could deliver ...

Sound sleep plays a critical role in healing traumatic brain injury, a new study of military veterans suggests. The study, published in the Journal of Neurotrauma, used a new technique involving magnetic resonance imaging developed at Oregon Health & Science University. Researchers used MRI to evaluate the enlargement of perivascular spaces that surround blood vessels in the brain. Enlargement of these spaces occurs in aging and is associated with the development of dementia. Among veterans in the study, those who slept poorly had more evidence of these enlarged spaces and more post-concussive symptoms. "This has huge implications for the armed forces as well as civilians," said lead author Juan Piantino, M.D., MCR, assistant professor of pediatrics (neurology) in the ...

Astronomers have painted their best picture yet of an RV Tauri variable, a rare type of stellar binary where two stars - one approaching the end of its life - orbit within a sprawling disk of dust. Their 130-year dataset spans the widest range of light yet collected for one of these systems, from radio to X-rays. "There are only about 300 known RV Tauri variables in the Milky Way galaxy," said Laura Vega, a recent doctoral recipient at Vanderbilt University in Nashville, Tennessee. "We focused our study on the second brightest, named U Monocerotis, which is now the first of these systems from which X-rays have been detected." A paper describing the findings, led by Vega, was published in The Astrophysical Journal. The system, called U ...

Water is perhaps Earth's most critical natural resource. Given increasing demand and increasingly stretched water resources, scientists are pursuing more innovative ways to use and reuse existing water, as well as to design new materials to improve water purification methods. Synthetically created semi-permeable polymer membranes used for contaminant solute removal can provide a level of advanced treatment and improve the energy efficiency of treating water; however, existing knowledge gaps are limiting transformative advances in membrane technology. One basic problem is ...

BOSTON -- SARS-CoV-2, the virus that causes COVID-19, has mutated throughout the pandemic. New variants of the virus have arisen throughout the world, including variants that might possess increased ability to spread or evade the immune system. Such variants have been identified in California, Denmark, the U.K., South Africa and Brazil/Japan. Understanding how well the COVID-19 vaccines work against these variants is vital in the efforts to stop the global pandemic, and is the subject of new research from the Ragon Institute of MGH, MIT and Harvard and Massachusetts General Hospital. In a study recently published in Cell, Ragon Core Member Alejandro Balazs, PhD, found that the neutralizing antibodies induced by the ...