About The Study: This decision analytic model showed that within the context of a high SARS-CoV-2 probability, monoclonal antibodies pre-exposure prophylaxis (mAbs PrEP) provision was cost-saving when provided to individuals at increased risk of severe COVID-19 if drug prices decrease to $275 and effectiveness is 75% or higher. When newer mAbs PrEP combinations become available, guidance on implementation should be formulated ensuring a fast rollout. Nevertheless, advocacy for mAbs PrEP use and critical discussion on drug prices are necessary to ensuring cost-effectiveness for different epidemic settings.  Authors: Stephanie Popping, M.D., Ph.D., of the University ...

About The Study: Hearing loss was cross-sectionally associated with higher frequency of fatigue after adjustment for demographics, lifestyle factors, and comorbidities in this nationally representative sample of middle-age and older adults. Future studies with fatigue assessments capturing its multidimensionality are needed to understand how hearing loss might contribute to physical and mental fatigue differentially and clarify how hearing loss may be associated with downstream outcomes like physical impairment through fatigue.  Authors: Nicholas ...

According to a recently published research paper by a team of scientists, a groundbreaking approach has been developed to create artificial allosteric sites (where by binding an effector molecule, activity at the distal active site is regulated) in protein complexes. This breakthrough research holds significant promise for a wide range of applications in industrial, biological, medical, and agricultural fields. The team’s work is published in Nature Chemistry on 06 July 2023 at 16:00 (London time)   Protein complexes, such as hemoglobin and molecular motors, ...

A new study by researchers at the University of Cambridge reveals a surprising discovery that could transform the future of electrochemical devices. The findings offer new opportunities for the development of advanced materials and improved performance in fields such as energy storage, brain-like computing, and bioelectronics. Electrochemical devices rely on the movement of charged particles, both ions and electrons, to function properly. However, understanding how these charged particles move together has presented a significant challenge, hindering progress in creating new materials for these devices. In ...

Many Americans can trace some lines of their family tree back to the 1600s. However, African Americans descended from enslaved Africans, who began arriving in North America in 1619, lack ancestral information spanning several centuries. A new USC and Stanford study, recently published in Genetics, provides insight into who occupies these missing branches of family trees — and gives a glimpse of how many branches there are. “Slavery was not that many generations ago, so my family still tells stories about our enslaved ancestors, like who they were and, in my case, how we ended up as light as we are,” said first author Jazlyn Mooney, the Gabilan Assistant Professor of Quantitative ...

Depictions of the Milky Way show a coiling pattern of spiral "arms" filled with stars extending outward from the center. Similar patterns have been observed in the swirling clouds of gas and dust surrounding some young stars – planetary systems in the making. These so-called protoplanetary disks, which are the birthplaces of young planets, are of interest to scientists because they offer glimpses into what the solar system may have looked like in its infancy and into how planets may form in general. Scientists have long thought that spiral arms in these disks ...

HOUSTON – A new study led by researchers at The University of Texas MD Anderson Cancer Center provides a deeper understanding of the evolution of the tumor microenvironment during gastric cancer progression. Highlights of the study, published today in Cancer Cell, include a link between multicellular communities and clinical outcomes as well as a potential new therapeutic target. Gastric adenocarcinoma is one of the most lethal cancers worldwide due to inherent treatment resistance, but the cellular and molecular mechanisms involved in the progression from early pre-cancer to tumor formation and metastasis are not well understood. This research sheds light on how the various ...

SAN FRANCISCO — PLOS today is announcing that it has extended the scope of its “Accessible Data” experiment, which was first launched in March 2022, with support from a Wellcome Trust grant. The experimental “Accessible Data” feature is designed to increase research data sharing and reuse by highlighting links to select repositories with an eye-catching icon on the article page. We are now expanding from the original three repositories to nine, which together host about three quarters of the outputs linked to from PLOS articles. PLOS began its Accessible Data experiment with two overarching goals. First, to increase reuse of datasets linked to PLOS articles ...

Researchers have combined research with real and robotic insects to better understand how they sense forces in their limbs while walking, providing new insights into the biomechanics and neural dynamics of insects and informing new applications for large legged robots. Campaniform sensilla (CS) are force receptors found in the limbs of insects that respond to stress and strain, providing important information for controlling locomotion. Similar force receptors exist in mammals known as Golgi tendon organs, suggesting that understanding the role ...

Obesity risk genes make people feel hungrier and lose control over their eating, but practicing dietary restraint could counteract this. New research by University of Exeter, Exeter Clinical Research Facility, and University of Bristol – funded by the Medical Research Council Doctoral Training Partnership and published in the International Journal of Epidemiology - found that those with higher genetic risk of obesity can reduce the effects that are transmitted via hunger and uncontrolled eating by up to half through dietary restraint. Psychology PhD student, Shahina Begum, from the University of Exeter is lead author and said: “At a time when high ...

Researchers have discovered the most distant active supermassive black hole to date with the James Webb Space Telescope (JWST). The galaxy, CEERS 1019, existed about 570 million years after the big bang, and its black hole is less massive than any other yet identified in the early universe. In addition to the black hole in CEERS 1019, the researchers identified two more black holes that are on the smaller side and existed 1 billion and 1.1 billion years after the big bang. JWST also identified eleven galaxies that existed when the universe was 470 million to 675 million years old. The evidence was provided ...

Viruses in man-made environments cause public health concerns, but they are generally less studied than bacteria. A recent study led by environmental scientists from City University of Hong Kong (CityU) provided the first evidence of frequent interactions between viruses and bacteria in man-made environments. It found that viruses can potentially help host bacteria adapt and survive in nutrient-depleted man-made environments through a unique gene insertion. By understanding these virus–bacteria interactions and identifying the possible spread of antibiotic ...

The American Society for Biochemistry and Molecular Biology sent feedback in June to the National Institutes of Health about its proposed changes to the Ruth L. Kirschstein National Research Service Award fellowship application and review process. The proposed changes indicate that the NIH adopted nearly all of the ASBMB’s earlier recommendations (here and here) to reduce institutional and investigator bias and refocus the evaluation on an applicant’s potential and the impact of the ...

Wastewater monitoring could act as an early warning system to help countries better prepare for future pandemics, according to a new study. An international collaboration involving Murdoch Children’s Research Institute, The Rockefeller Foundation, Mathematica and the United Kingdom’s Health Security Agency has shed light on how different countries monitor wastewater during infectious diseases outbreaks and where improvements could be made. For the study, samples from treatment plants, rivers, wetlands and open drains were reported ...

All cells have their own power plants, called mitochondria. There are often more than 100 mitochondria per cell and each possesses their own genome, which in turn contains genes responsible for energy production. If errors creep into these genes, this can cause problems in the cell and result in diseases. Scientists from the Berlin Institute of Health at Charité (BIH) and the Max Delbrück Center have now discovered that the T cells of the immune system are especially sensitive to genetic disturbances within their mitochondrial power plants. They have published their findings ...

The remarkable level of miniaturization possible in modern electronics has paved the way for realizing healthcare devices previously confined to the realm of science fiction. Wearable sensors are a prominent example of this. As the name suggests, these devices are worn on the body, usually directly on the skin. They can monitor important bodily parameters, including heart rate, blood pressure, and muscle activity. Some wearable sensors can also detect chemicals in bodily fluids. For instance, sweat biosensors ...

How well do children know letters and their corresponding sounds? In Norway, the gender difference on these tasks when children start school is significant. The girls have a clear head start. “We see these differences in all categories – for upper case and lower case letters, for the names of the letters and for their corresponding sounds,” says Hermundur Sigmundsson, a professor at Norwegian University of Science and Technology's (NTNU) Department of Psychology. Girls’ letter-sound knowledge is clearly better than that of boys,’ and girls remain far better readers than boys at age 15. Since reading is key for so many ...

In chemistry, a molecule or ion is said to be chiral if it cannot be superposed on to its mirror image by any combination of rotations, translations, or conformational changes. A chiral molecule or ion exists in two forms, called enantiomers, that are mirror images of each other; they are often distinguished as either ‘right-handed’ or ‘left-handed’ by their absolute configuration. Enantiomers exhibit similar physical and chemical properties, except when interacting with polarized light and reacting with other chiral compounds, ...

New Study Shows Robust Pandemic Preparedness Strongly Linked to Lower COVID-19 Mortality Rates   Preparedness matters: Accounting for age and national capabilities to diagnose COVID-19 deaths reveals that pre-pandemic investments in capacity saved lives—though U.S. remains an outlier.   The vast majority of countries that entered the COVID-19 pandemic with strong capacity to prevent, detect, and respond to disease threats achieved lower pandemic mortality rates than less prepared nations, ...

The 64th Supplement to the American Ornithological Society’s (AOS) Check-list of North American Birds, published today in Ornithology, includes numerous updates to the classification of North American bird species.  A few highlights from this year’s supplement, detailed below, include a species lump for the Western Flycatcher, species status for the goshawk of North America, and species splits in several Caribbean birds leading to five additional species.  The Check-list, published since 1886, is updated annually by the AOS’s North American Classification Committee (NACC), the official authority on the names and classification of the ...

There are more than 2 million people incarcerated in the United States. In 2019, more than 608,000 individuals were released from prison. It is estimated that up to 55 percent of people released from prison will be re-incarcerated within five years. The cause of high recidivism or re-offense rates in the U.S. is multi-dimensional. Moreover, the relationship between employment and crime is complex. To combat an unstable work history and lack of interpersonal skills, some communities have implemented transitional employment programs, ...

Ongoing research by Prof. Lewis Halsey and his team at the University of Roehampton, UK has identified that an upper critical temperature (UCT) exists for humans and is likely to be between 40°C and 50°C. Further research is now underway to explain this rise in metabolic energy costs at high temperatures. Prof. Halsey and his team have found that resting metabolic rate, a measure of how much energy the human body consumes to keep ticking over, can be higher when people are exposed to hot and humid conditions. ...

Labile expression of sex was frequently reported by empirical observation in a variety of Populus species, but the underlying genetic mechanism remains largely unknown.  This article has been published on Horticulture Research with title: The proposed role of MSL-lncRNAs in causing sex lability of female poplars. In this study, we carried out a systematic study on a maleness promoting gene, MSL, detected in Populus deltoides genome. Our results showed that both strands of MSL contained multiple cis-activating elements, which generated long non-coding RNAs (lncRNAs) ...

A new study, published in PeerJ Life and Environment, conducted by Dr. Martina Lazzaroni (University of Veterinary Medicine, Vienna), Dr Joana Schar (University of Vienna) and colleagues, has shed light on the cognitive abilities of village dogs in understanding human communication. The research, which aimed to explore the impact of the domestication process on dogs' behavior and cognition, has yielded fascinating results, highlighting the importance of studying free-ranging dogs as representatives of the broader dog population.  Previous studies examining dogs' cognitive skills in understanding ...

HOUSTON – (July 6, 2023) – Songtao Chen, an assistant professor of electrical and computer engineering at Rice University, has won a prestigious National Science Foundation CAREER Award to advance the development of quantum networks by leveraging imperfections ⎯ known as point defects ⎯ in silicon material. The grants are awarded each year to a selective cohort of about 500 early career faculty across all disciplines engaged in pathbreaking research and committed to growing their field through outreach and education. Chen ...