“In summary, our goal was to identify additional therapeutic targets for KRAS-driven PDAC.” BUFFALO, NY- March 24, 2023 – A new research paper was published in Genes & Cancer on March 10, 2023, entitled, “VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer.” Researchers have recently shown that proteins involved in the DNA damage response (DDR) are critical for KRAS-mutant pancreatic ductal ...

Putting less sugar in sodas and reducing the package size of sodas sold in supermarkets may help reduce our collective sugar intake and thus lower the associated health risks. Good news for consumers, but how does it affect manufacturers? Research conducted in the US has shown that marketing diet or sugar-free varieties does not lead to an increase in the overall turnover of soda manufacturers. This is because consumers tend to switch from sugary to sugar-free versions of the same brand. However, reducing the package size of soda does have a positive effect on the sales ...

A group of scientists from the University of Seville, in collaboration with experts from the University of the Basque Country, has led the first detailed study of the evolution of the discontinuity of Venus’s clouds, a gigantic atmosphere wave with the appearance of a “tsunami” that is propagated in the planet’s deepest clouds and which, it is believed, may be playing a very significant role in the acceleration of Venus’s fast-moving atmosphere. The observations were carried out non-stop for more than 100 days. “This observational ...

BOSTON – New research from Boston Medical Center found that substance use disorders do not increase the likelihood of dying from COVID-19. Published in Substance Abuse: Research and Treatment, the study showed that the increased risk for severe COVID-19 in people with SUD that has been seen may be the result of co-occurring medical conditions. Multiple large cohort studies from early in the pandemic have shown higher rates of hospitalization, intubation, and death from COVID-19 in those with SUD, while other studies found no ...

Embargoed for release: Friday, March 24, 2023, 12:00 PM ET Key points: The Environmental Protection Agency is currently considering new limits on PM2.5 air pollution. Implementing stronger limits would protect the health of all Americans, and in particular could reduce mortality rates among communities that are most threatened by air pollution—including Black and low-income Americans—by up to 7%.  Structural racism and poverty combine to change PM2.5 susceptibility, but structural racism may be more impactful when determining susceptibility. Stronger air quality policies may also drive innovative ways to reduce the emission of heat-trapping gasses and could save ...

When someone smiles at us, we tend to smile back. On the other hand, if we spend time with someone who is mad or stressed, we end up absorbing these negative emotions. This tendency to align with the emotions of others is called emotional contagion. This basic form of empathy has been programmed in our brain for thousands of years and it is not difficult to get why. When there is a threat, this phenomenon allows fear to spread quickly, increasing the chances of survival. Besides, by mimicking emotions, we establish social bonds with others. But this behavior is not exclusive to humans. New data from the Instituto Gulbenkian de Ciência (IGC) confirm that the ...

Fungicide application, while helpful in controlling plant diseases, has complicated limitations that may cost growers both peace of mind and quantity of yield. Plant pathogens which would otherwise be killed off by fungicides can evolve to avenge their dead siblings, developing resistance that renders the standard dose of fungicide application ineffective. To delay fungicide resistance, growers commonly use mixtures of fungicides to treat yield-limiting fungal diseases—based on extensive research outlining how to construct these mixtures. However, this research does not completely translate to the common, real-world scenario where one fungicide ...

Your circadian rhythm doesn’t just govern your sleeping schedule; it can also impact cancer development, diagnosis, and treatment. In a review paper publishing in the journal Trends in Cell Biology on March 24, researchers discuss the role of circadian rhythms in tumor progression and spread and describe how we could better time when patients are tested for cancer and when they receive therapies to improve diagnostic accuracy and improve treatment success. “The circadian rhythm governs most of the cellular functions implicated in cancer progression, ...

Newly developed mRNA vaccines against Zika virus and HIV-1 produced strong antibody responses that transferred from pregnant rabbits to their offspring, researchers report March 24th in the journal Molecular Therapy. As noted by the authors, the results support further development of their vaccine platform, LIONTM/repRNA, for maternal and neonatal settings to protect against mother-to-child transmission of pathogens in animals and humans. The recent success of mRNA vaccines in response to the COVID-19 pandemic is a catalyst for the development of mRNA vaccines targeting other infectious diseases. The U.S. Food and Drug Administration has authorized mRNA vaccines for children ...

A novel statewide incentive program intended to improve “warm hand-offs” from Pennsylvania emergency departments to opioid use disorder treatment programs is associated with a 50% improvement in the initiation of medication-assisted treatment in Medicaid-enrolled patients, according to new research from University of Pittsburgh, Howard University, Johns Hopkins University, University of Pennsylvania and Vital Strategies scientists. The finding, published today in JAMA Health Forum, points to a potential policy ...

About The Study: Marriage and children were associated with a greater earnings penalty for female physicians, primarily due to fewer hours worked relative to men, in this study of 95,000 U.S. physicians. Addressing the barriers that lead to women working fewer hours could contribute to a reduction in the male-female earnings gap while helping to expand the effective physician workforce.  Authors: Lucy Skinner, M.P.H., of the Geisel School of Medicine at Dartmouth in Hanover, New Hampshire, is the corresponding author. To access the embargoed study: Visit ...

About The Study: In this study using data from 3,037 community-dwelling Medicare beneficiaries, food insecurity was prevalent and associated with a decline in executive function. Interventions and policies aiming to increase healthy food access or reduce food insecurity should be assessed for their impact on older adults’ cognitive outcome.  Authors: Boeun Kim, Ph.D., M.P.H., R.N., of Johns Hopkins University in Baltimore, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.4674) Editor’s ...

Lower electricity costs for consumers and more reliable clean energy could be some of the benefits of a new study by the University of Adelaide researchers who have examined how predictable solar or wind energy generation is and the impact of it on profits in the electricity market. PhD candidate Sahand Karimi-Arpanahi and Dr Ali Pourmousavi Kani, Senior Lecturer from the University’s School of Electrical and Mechanical Engineering, have looked at different ways of achieving more predictable renewable energy with the ...

Higher alcohols (C2+ alcohols), which are important raw materials, have been used as the intermediates of valued products. They are also widely applied in various fields of fuel, food, fine chemicals, pharmaceuticals and energy. With the gradual depletion of petroleum resources, the direct synthesis of higher alcohols from syngas has become a sustainable and potential process because of its wide source of raw materials and high atomic utilization. However, the low yield of higher alcohols restricted industrial application. Recently, a research team led by Prof. SUN Jian and Prof. GE Qingjie from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has ...

Researchers from Tokyo Medical and Dental University (TMDU) demonstrate how a polymeric nanoparticle gene delivery system can promote bone formation Tokyo, Japan - Does a “magic bullet” exist in regenerative medicine? Researchers have long wished to design a cutting-edge gene therapy that regenerates tissues damaged by disease or trauma. That wish may come true now that a research team has developed a polymeric gene delivery therapy that promotes new bone formation after traumatic inflammation. In a study published this month in the International Journal of Molecular Sciences, researchers from ...

Pesticide use must be reduced. The EU has set a target to reduce pesticide use by 50% by 2030. Therefore, a strong focus on integrated weed management must be maintained in the coming years. When it comes to weeds, the focus has mainly been on improving the efficacy of pesticides, replacing or complementing them with mechanical treatments in the field.  In the last five years, the Horizon 2020 project IWMPraise – Integrated Weed Management: PRActical Implementation and Solutions for Europe has conducted a large number of trials on ...

LMU chemists use high-precision quantum chemistry to study key elements of super-efficient energy transfer in an important element of photosynthesis. Photosynthesis is the motor of all life on Earth. Complex processes are required for the sunlight-powered conversion of carbon dioxide and water to energy-rich sugar and oxygen. These processes are driven by two protein complexes, photosystems I and II. In photosystem I, sunlight is used with an efficiency of almost 100%. Here a complex network of 288 chlorophylls plays the decisive role. A team led by LMU chemist Regina de Vivie-Riedle has ...

Blind people are better at sensing their own heartbeats than sighted, shows a study by researchers at Karolinska Institutet in Sweden and Jagiellonian University in Poland. The study indicates that blindness leads to a heightened ability in feeling signals from the inner body. The findings are published in the Journal of Experimental Psychology: General. Thirty-six blind and as many sighted individuals were asked to count their own heartbeats without checking their pulse or touching their body. At the same time, the ...

An IIASA study shows that maternal education, and particularly secondary education, plays a significant role in reducing deaths in newborns and children under five years of age in both rural and urban areas of India. Sustainable Development Goal (SDG) 3.2.1. aims to end preventable deaths of newborns and under-five children by 2030. Although significant progress has been made worldwide in this regard with global under-five deaths falling from 12.5 million in 1990 to 5 million in 2020, it is still ...

Researchers at the Indian Institute of Science (IISc) are working on designing antennas that can empower 6G technology, which is instrumental in realising efficient V2X (Vehicle to Everything) communications. In a recent study, the team, led by Debdeep Sarkar, Assistant Professor at the Department of Electrical Communication Engineering, shows how self-interference in full-duplex communication antennas can be reduced, and consequently the movement of signals across the communication network can be faster and more bandwidth-efficient. Such full-duplex ...

A parasite which has devasting impacts on agriculture and human health is the first pathogen to have its proteins located and mapped within its cells – providing clues to their function and helping to identify potential drug targets. African trypanosomes are parasites transmitted by tsetse flies that cause sleeping sickness in humans (presenting as fever, anaemia and, in serious cases, death) and a similar disease celled nagana in cattle. These parasites have made large areas of Africa unsuitable for ...

Graphene is the strongest of all materials. On top of that, it is exceptionally good at conducting heat and electrical currents, making it one of the most special and versatile materials we know. For all these reasons, the discovery of graphene was awarded the Nobel Prize in Physics in 2010. Yet, many properties of the material and its cousins are still poorly understood – for the simple reason that the atoms they are made up of are very difficult to observe. A team of researchers from the University of Amsterdam and New York University have now ...

A new high resolution model of the CA1 region of the human hippocampus has been developed by the Institute of Biophysics of the Italian National Research Council (CNR-IBF) and University of Modena e Reggio Emilia (UNIMORE), part of the Human Brain Project. The single-cell resolution model, which replicates the structure and architecture of the area, along with the position and relative connectivity of the neurons, was developed from a full-scale dataset of high resolution images. The dataset is available in the BigBrain Atlas and it will be soon available on EBRAINS. According to the study, published in the journal ...

Moderate and severe ovarian hyperstimulation syndrome (OHSS) developed in 1.14% of Chinese women of reproductive age between 2013 and 2017. Moreover, women under 35 years of age receiving assisted reproductive technology (ART) should be monitored for OHSS more closely compared with other age groups. These findings were concluded from the first report on the incidence of moderate and severe OHSS in China recently published in Health Data Science, a Science Partner Journal. OHSS constitutes the most severe iatrogenic ...

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes for a specific protein involved in the transportation of calcium and manganese ions from the cell cytoplasm and into a sac-like organelle called the Golgi apparatus. Scientists at Tohoku University, together with colleagues in Japan, have uncovered some aspects of this protein's structure that could help researchers understand how it works. The findings, published ...