A new discovery in Ewing sarcoma, an aggressive and often fatal childhood cancer, has uncovered the potential to prevent cancer cells from spreading beyond their primary tumour site. The breakthrough provides new insight into what triggers the process that allows cancer cells to survive while traveling through the body in the bloodstream. Researchers with the University of British Columbia and BC Cancer have learned that Ewing sarcoma cells--and likely other types of cancer cells--are able to develop a shield that protects them from the harsh environment of the bloodstream and other locations as they search for a new place to settle, or metastasize. The study has just been published in Cancer Discovery. "You ...

TROY, N.Y. -- As more dissolved organic matter enters lakes across the northeast United States, darkening the lakes in a phenomena called "browning," new research shows that these waters may be growing less productive and able to sustain less life. In a study published today in Limnology and Oceanography Letters, scientists found that, rather than enriching lakes with nutrients as had previously been assumed, water more heavily laden with dissolved organic matter blocks sunlight and limits plant growth. "A key question regarding lake browning is what impact it will have on aquatic food webs, including algal growth and fisheries," said Kevin Rose, co-author ...

The brain is often likened to a computer: its hardware - neurons organized in complex circuits, its software - a plethora of codes that govern the neurons' behavior. But sometimes the brain performs exceptionally well even when its hardware seems inadequate for the task. For example, it's been puzzling how we and other mammals manage to navigate large-scale environments even though the brain's spatial perception circuits are seemingly suited to representing much smaller areas. A team of researchers from the Weizmann Institute of Science, led by Prof. Nachum Ulanovsky of the Neurobiology Department, tackled this riddle by thinking outside the experimental box. By combining an unusual research model - fruit bats - with an unusual setting - a 200 meters-long bat-tunnel - they were ...

The genetic material of most organisms is carried by DNA, a complex organic molecule. DNA is very long -- for humans, the molecule is estimated to be about 2 m in length. In cells, DNA occurs in a densely packed form, with strands of the molecule coiled up in a complicated but efficient space-filling way. A key role in DNA's compactification is played by histones, structural-support proteins around which a part of a DNA molecule can wrap. The DNA-histone wrapping process is reversible -- the two molecules can unwrap and rewrap -- but little is known about the mechanisms at play. Now, by applying high-speed atomic-force microscopy (HS-AFM), Richard ...

By ensuring ethnic diversity in a largescale genetic study, an international team of researchers, including a University of Massachusetts Amherst genetic epidemiologist, has identified more regions of the genome linked to type 2 diabetes-related traits. The findings, published May 31 in Nature Genetics, broaden the understanding of the biological basis of type 2 diabetes and demonstrate that expanding research into different ancestries yields better results. Ultimately the goal is to improve patient care worldwide by identifying genetic targets to treat the chronic metabolic disorder. Type 2 diabetes affects and sometimes debilitates more than 460 million adults worldwide, according to the International Diabetes Federation. About 1.5 million deaths were directly ...

The quality of a sewn garment is dependent on the quality of its seams that are the basic structural element. The factors affecting seam quality in garments include sewing thread type and stitch density. Making the right choice of these helps in getting quality seams in garments. However, the choice of suitable sewing threads and stitch densities for particular fabrics can only be determined through testing. Dr. Patience Danquah Monnie, from the University of Cape Coast, Ghana, with fellow researchers, conducted research aimed to determine sewing thread brand and stitch density suitable for seams for a selected fabric (79% polyester and 21% cotton) for public basic school uniforms in Ghana. For the research, a 2×3 factorial ...

Nitrates are critical for the growth of plants, so plants have evolved sophisticated mechanisms to ensure sufficient nitrate uptake from their environments. In a new study published in Nature Plants, researchers at Nagoya University, Japan, have identified a plant enzyme that is key to activating a nitrate uptake mechanism in response to nitrogen starvation. This finding explains how plants meet their needs in challenging environments, opening doors to improving agriculture in such environments. When nitrate levels are plentiful in a plant's environment, a plant can achieve adequate nitrate uptake levels by relying ...

Oxygen (O2) is an essential gas not only for us and most other lifeforms, but also for many industrial processes, biomedicine, and environmental monitoring applications. Given the importance of O2 and other gases, many researchers have focused on developing and improving gas-sensing technologies. At the frontier of this evolving field lie modern nanogap gas sensors--devices usually comprised of a sensing material and two conducting electrodes that are separated by a minuscule gap in the order of nanometers (nm), or thousand millionths of a meter. When molecules of specific gases get inside this gap, they electronically interact with the sensing layer and the electrodes, altering measurable ...

The Yakushima sika deer (yakushika: Cervus nippon yakushimae), a subspecies of the Japanese sika deer (Cervus nippon), evolved without natural predators on the island of Yakushima, in Kagoshima Prefecture, Japan. It inhabits the forests on the island which were declared a World Heritage Site in 1993. Within the site, the yakushika has not been hunted in the past 50 years; however, since 2014, their population has been decreasing. This phenomenon is especially curious, as Japanese researchers believed that sika deer populations in Japan would not decrease without human intervention. A group of three scientists, including Hokkaido ...

Led by the University of Sydney's Charles Perkins Centre, the study looked at medical data from nearly half a million people and found having overweight or obesity considerably amplified the harmful effects of alcohol on liver disease and mortality. "People in the overweight or obese range who drank were found to be at greater risk of liver diseases compared with participants within a healthy weight range who consumed alcohol at the same level," said senior author and research program director Professor Emmanuel Stamatakis from the Charles Perkins Centre and the Faculty of Medicine and Health. "Even for people who drank within alcohol guidelines, participants classified as obese were at over 50 percent greater risk of liver disease." The researchers ...

Mussels survive by sticking to rocks in the fierce waves or tides underwater. Materials mimicking this underwater adhesion are widely used for skin or bone adhesion, for modifying the surface of a scaffold, or even in drug or cell delivery systems. However, these materials have not entirely imitated the capabilities of mussels. A joint research team from POSTECH and Kangwon National University (KNU) - led by Professor Hyung Joon Cha and Ph.D. candidate Mincheol Shin of the Department of Chemical Engineering at POSTECH with Professor Young Mee Jeong and Dr. Yeonju Park of the Department ...

Nearly two billion people live in a region where tropical cyclones (TC) are an annual threat. TCs are deadly and can cause billions of dollars in economic losses worldwide. During peak season in the Northern Hemisphere, typically July through October, about two TCs develop or are ongoing every day. However, this and overall TC frequency vary substantially year-to-year. To quantify this variability, scientists developed a metric called the tropical storm day (TSD). TSD is a collective measure of how frequently tropical cyclones develop, storm track, and cyclone lifespan, which reflects overall activity. Despite this advancement, researchers have not often studied tropical cyclone variability on a global scale. Now, ...

In a paper published in NANO, researchers from Guizhou Meiling Power Sources Co., Ltd., China have reviewed the recent progress in biopolymer-based electrolyte. The biopolymer materials with unique characteristics including water solubility, film-forming capability and adhesive property played a key role in the design of zero pollution lithium battery. The biopolymers mentioned in this review were polysaccharide, protein, natural rubber and other polymers. For polysaccharide, cellulose with good wettability, low cost and good mechanical properties can enhance the mechanical strength of membranes and improve interfacial stability between electrolyte and electrode. However, the porosity control of cellulose-based membranes was ...

Habitat change, for example through urbanisation, is one of the most important causes of biodiversity decline. By 2050, settlements and cities across the globe are predicted to increase by two to three million square kilometres - about half the size of Greenland. Natural and semi-natural habitats will thus gradually be replaced by urban habitats. How wildlife can adapt to such fundamental changes has mostly been studied for a few species groups, such as mammals and birds. "In order to make predictions about the development of biodiversity as a whole and to combat current phenomena such as insect declines, robust knowledge is also needed for other species groups," ...

To realize tritium self-sustaining cycle through tritium breeding blanket has been one of the core technologies of future fusion reactor. Therefore the design and function of blanket must be validated by neutronic experiment under D-T neutron environment. But due to the scarcity of DT neutron source, and highly radioactivity during neutronic experiments, it is very difficult to validate the nuclear response of the blanket, the data of tritium production rate mainly rely on Monte Carlo simulation. Recently, a research group led by ZHU Qingjun from Institute of Plasma Physics, ...

As anyone who has ever procrastinated knows, remembering that you need to do something and acting on that knowledge are two different things. To understand how learning changes nerve cells and leads to different behaviors, researchers studied the much simpler nervous system of worms. "In this study, we can now translate neuronal activity to behavioral response," said Project Researcher Hirofumi Sato, a neuroscientist at the University of Tokyo and first author of the research paper recently published in Cell Reports. The discovery was made possible using technology that researchers describe as a "robot microscope," first developed in 2019 by researchers at Tohoku University in Miyagi Prefecture, northeastern Japan. The technique involves genetically modifying the worms ...

A team of scientists from the Max Planck Institute for Marine Microbiology, the Max Planck Institute for Meteorology and the GEOMAR - Helmholtz Centre for Ocean Research Kiel have been studying biogeochemical processes in the oxygen minimum zone of the eastern South Pacific off Peru, one of the largest low oxygen regions of the world ocean. The researchers focused on so-called marine snow particles of different sizes, which are composed of algal debris and other organic material, aiming to understand how these particles affect the nitrogen cycle in the oxygen minimum zone. Thereby, they solved ...

Women carrying human papillomavirus (HPV) run an elevated risk of preterm birth, a University of Gothenburg study shows. A connection can thus be seen between the virus itself and the risk for preterm birth that previously has been observed in pregnant women who have undergone treatment for abnormal cell changes due to HPV. A Swedish study now published in the high-ranking journal PLOS Medicine comprises data on more than a million births. Accordingly, the researchers have compared very large groups. They emphasize that the findings do not support any assessment of risk ...

In a study that will be published in Nature Communications on May 28, 2021, a research team led by Dr. Yuan Liu from Georgia State University reports that intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells to eliminate various syngeneic cancers under radiotherapy. As a major component of the suppressive tumor microenvironment, tumor-associated macrophages (TAMs) are generally regarded as facilitators of tumor progression. It has been shown that depleting TAMs can enhance the response of tumors to radiotherapy (RT). However, Yuan's ...

The average IQ of adults born very preterm or very low birth weight was compared to those who were term born in the 1970s to 1990s in 8 longitudinal cohorts from 7 countries around the world The IQ was significantly lower for very pre-term and very low birth weight adults in comparison to those term born, researchers from the University of Warwick have found Action needs to be taken to ensure support is available for those born very preterm or very low birth weight The average IQ of adults who were born very preterm (VP) or at a very low birth weight (VLBW) has been compared to adults born full term by researchers from the Department of Psychology at the University of Warwick. Researchers have found VP/VLBW children may require special ...

A new extensive genetic resource of rat-infecting malaria parasites may help advance the development of malaria prevention and treatment strategies. This trove of genome and phenome information has been published1 by a team of KAUST researchers, along with colleagues in Japan, and the datasets have been made publicly available for malaria researchers. Rodent malaria parasites are closely related to human parasites but are easier to study because they can be grown in laboratory mice. "Investigations on rodent malaria parasites have played a key role in revealing many aspects of fascinating biology across ...

It is time for the management and conservation of the Antarctic to begin focusing on responsibility, rather than rights, through an Indigenous Māori framework, a University of Otago academic argues. In an article published in Nature Ecology & Evolution, Associate Professor Priscilla Wehi, of the Centre for Sustainability, says now is the time to be thinking of these potential changes. "New Zealand is currently re-setting its priorities for future Antarctic research, and there may be review of the current international environmental conventions as we approach the 50-year anniversary of the protocols in 2048. "We argue that Indigenous Māori frameworks offer powerful ways of thinking about how we protect the Antarctic, by focusing on ...

Invasive species, beware: Your days of hiding may be ending. Biologists led by the University of Iowa discovered the presence of the invasive New Zealand mud snail by detecting their DNA in waters they were inhabiting incognito. The researchers employed a technique called environmental DNA (eDNA) to reveal the snails' existence, showing the method can be used to detect and control new, unknown incursions by the snail and other invasive species. "eDNA has been used successfully with other aquatic organisms, but this is the first time it's been applied to detect a new invasive population of these snails, which are a destructive invasive species in fresh waters around the world," says Maurine Neiman, associate professor in the Department ...

How old is your brain compared to your chronological age? A new measure of brain health developed by researchers at Rush University Medical Center may offer a novel approach to identifying individuals at risk of memory and thinking problems, according to research results published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association on June 1. Dubbed the "cognitive clock" by the researchers, the tool is a measure of brain health based on cognitive performance. It may be used in the future to predict the likelihood of memory and thinking problems that develop ...

Rare disease experts detail the first results of an unprecedented collaboration to diagnose people living with unsolved cases of rare diseases across Europe. The findings are published today in a series of six papers in the European Journal of Human Genetics. In the main publication, an international consortium, known as Solve-RD, explains how the periodic reanalysis of genomic and phenotypic information from people living with a rare disease can boost the chance of diagnosis when combined with data sharing across European borders on a massive scale. Using this new approach, a preliminary reanalysis of data from 8,393 individuals resulted in 255 new diagnoses, some with atypical manifestations of known diseases. A complementary study ...