Throughout her career, Arizona State University Edson College of Nursing and Health Innovation Associate Professor Kelly Davis has worked to translate her research into action. An expert in alcohol-involved sexual assault, Davis’ studies have been cited in U.S. legislation and have earned her a MERIT Award and now the prestigious Fulbright Scholar Award. The program will take her to the United Kingdom beginning in early 2024 to collaborate with colleagues at the University ...

The Okinawa Institute of Science and Technology (OIST), in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression. The technology, which was described in the Journal of the American Chemical Society on March 30, 2023, worked in mammalian cell cultures and in mice. The ability to precisely control whether a gene is turned on or off is expected to lead to more efficient production of compounds that are made using animal cells, and make gene therapy, cell therapy, and regenerative medicine safer. For genes to be expressed, cells make many RNA copies of a section ...

It has been a longstanding assumption that birth mode and associated exposure of newborns to their mothers’ vaginal microbiome during delivery greatly affects the development of babies’ gut microbiome. To test the scientific validity of this assumption, a team of Canadian researchers has now published a study in Frontiers in Cellular and Infection Microbiology in which they examined the effect of maternal vaginal microbiome composition on the development of infants’ stool microbiome at 10 days and three months after birth. “We show that ...

The Gairdner Foundation is pleased to announce the 2023 Canada Gairdner Award laureates, recognizing some of the world’s most significant biomedical and global health research and discoveries.  “Congratulations to all the 2023 Canada Gairdner Award recipients! The ground-breaking work of this year’s laureates has resulted in innovative, globally accessible tools to fight diseases and improve our well-being. The work of two Canadian researchers – Dr. Christopher Mushquash and Dr. Gelareh Zadeh especially ...

Researchers use tiny diamonds to create intracellular sensors Optically trapped nanodiamonds could be used to measure temperature, magnetic fields and other properties inside living cells VANCOUVER -- Researchers have developed a new way to study the intricate dynamics within living cells by using optically trapped nanodiamond particles as intracellular sensors. Using custom built optical tweezers, the research team trapped the particles within the cell at low power while the cell was alive. The work represents an important advancement in quantum sensing, which takes advantage of quantum mechanics to analyze changes at the atomic level.  The researchers used optical tweezers ...

Arlington, Va., March 30, 2023 – Findings from an analysis of more than 66,000 abdominal hysterectomies performed in New York hospitals reveal key risk factors for surgical site infections (SSIs) following these procedures, including open surgery, obesity, diabetes, gynecological cancer, and age under 45. Published today in the American Journal of Infection Control (AJIC), the data can help inform surgical and clinical decisions to reduce post-operative infections. “Improved understanding of patient-related, clinical, and surgical factors ...

“Children who are in regular contact with mobile phone screens, tablets or computers are more irritable and have worse attention, memory and concentration than those who do not use them.”  Parents should strictly ration or not allow screen time for children aged under six, according to a leading neuropsychologist in a new book.   Dr Álvaro Bilbao, Ph.D., uses current and established research to highlight how the risk of psychological and behavioral issues increases the ...

By Emily Greenhalgh WOODS HOLE, MASS. -- Cape Cod’s salt marshes are as iconic as they are important. These beautiful, low-lying wetlands are some of the most biologically productive ecosystems on Earth. They play an outsized role in nitrogen cycling, act as carbon sinks, protect coastal development from storm surge, and provide critical habitats and nurseries for many fish, shellfish, and coastal birds. And, according to new research from the Marine Biological Laboratory (MBL), more than 90 percent of ...

Insilico Medicine (“Insilico”) is featured in the new BBC StoryWorks-produced film series Nature’s Building Blocks made in conjunction with the Biotechnology Innovation Organization (BIO). Through 29 short films, the series showcases science innovations and cutting-edge technological advances that are poised to dramatically improve human life.  Insilico, a generative artificial intelligence (AI)-driven drug discovery company, is featured in a segment focused on democratizing and accelerating ...

Scientists often look to the past for clues about how Earth’s landscapes might shift under a changing climate, and for insight into the migrations of human communities through time. A new study offers both by providing, for the first time, a reconstruction of prehistoric temperatures for some of the first known North American settlements. The study, published in Quaternary Science Reviews, uses new techniques to examine the past climate of Alaska’s Tanana Valley. With a temperature record that reaches back 14,000 years, researchers now have ...

CHAMPAIGN, Ill. — An ancient biological enzyme known as nickel-iron hydrogenase may play a key role in producing hydrogen for a renewables-based energy economy, researchers said. Careful study of the enzyme has led chemists from the University of Illinois Urbana-Champaign to design a synthetic molecule that mimics the hydrogen gas-producing chemical reaction performed by the enzyme. The researchers reported their findings in the journal Nature Communications. Currently, industrial hydrogen is usually produced by separating hydrogen gas molecules from oxygen atoms in water using a process called ...

NEW ORLEANS, LOUISIANA— Ochsner Health, Louisiana’s largest nonprofit, academic, multi-specialty, healthcare delivery system, has received the 2023 Gallup Exceptional Workplace Award (GEWA). This award recognizes the most engaged workplace cultures in the world. After another year of unpredictability in the workplace, Gallup found that Ochsner Health continued to put their employees’ engagement at the center of their business strategy, embedding engagement into their very culture. “Our employees are the reason for the culture of positive engagement at Ochsner Health. From physicians and providers to clinical ...

LA JOLLA, CALIF. Mar 29, 2023 - Sanford Burnham Prebys researchers have identified a group of proteins that could be the secret to cellular reprogramming, an emerging approach in regenerative medicine in which scientists transform cells to repair damaged or injured body tissues. The researchers were able to reprogram damaged heart cells to repair heart injuries in mice following a heart attack. The findings, which appear in the journal Nature Communications, could one day transform the way we treat a variety of diseases, including cardiovascular disease, Parkinson’s ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, MARCH 29, 2023   MINNEAPOLIS – Both cluster headache and migraine have strong links to the circadian system, the internal clock that regulates body processes, according to a meta-analysis published in the March 29, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The meta-analysis included all available studies on cluster headache and migraine that included circadian features. This included information on the timing of headaches during ...

Deep brain stimulation (DBS) is a promising therapy for treatment-resistant obsessive-compulsive disorder (OCD). A first-of-its-kind collaborative study led by researchers at Texas Children’s Hospital, Baylor College of Medicine, and Brigham & Women’s Hospital has found that mapping neural connections in the brains of OCD patients offers key insights that explain the observed improvements in their clinical outcomes after DBS. The study was published in Biological Psychiatry. Neuropsychiatric disorders such as obsessive-compulsive ...

PORTLAND, Oregon -- New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment. The natural immune response to invading pathogens normally involves making protective proteins called antibodies. A study published today in Science Translational Medicine suggests that a single monoclonal antibody infusion can strengthen the body’s fight against yellow fever. In the study, the yellow fever virus was undetectable in all animals that received monoclonal antibody infusions after being exposed to the virus. “Two ...

Evermed and the American College of Cardiology (ACC) have announced the launch of ACC Anywhere, a new content hub that provides cardiologists around the world with on-demand access to the latest clinical knowledge. The hub contains original content from five conferences including ACC’s 2022 and 2023 Annual Scientific Session, with additional conferences to be added in the future. Evermed was selected to collaborate with ACC due to its advanced AI-powered recommender engine and its ability to effectively deliver medical education content 365 days per year. In addition, Evermed’s technology will help drive yearlong engagement to ensure that users are able ...

A recent study from Texas Children’s Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD) with the identification of the first recurrently affected residue identified in the protein kinase domain of PAK1 protein. The study, published in the American Journal of Medical Genetics: Part A, found potential correlations between how and which organ ...

“In the present study, we found that downregulation of angulin-1/LSR induced malignancy via upregulation of EGF-dependent CLDN-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma.”  BUFFALO, NY- March 29, 2023 – A new research paper was published in Oncotarget's Volume 14 on March 24, 2023, entitled, “Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.” Abnormal expression of bicellular tight junction claudins, including ...

Nearly one in five American adults has diabetes. But that doesn’t mean the common condition is simple to treat or manage. Diabetes and its complications are the No. 1 cause of kidney failure, adult blindness, and lower-limb amputations. It’s also the seventh-leading cause of death in the U.S. As with so many chronic conditions, diabetes also disproportionately affects the most vulnerable in our communities, further exacerbating existing health disparities. In a new supplemental issue of the ...

(03/29/2023) — Resistance to Paxlovid is already evident among viral SARS-CoV-2 variants currently circulating globally, indicating that this stand-alone drug known as a protease inhibitor could soon become less effective in treating COVID-19 infections. This conclusion was presented in a study published today online in the peer-reviewed journal Science Advances. This study — conducted by the Midwest Antiviral Drug Discovery (AViDD) Center — shows that drug-resistant variants have appeared multiple times independently in different parts of the world, with regional clusters providing evidence for person-to-person transmission. In ...

“[...] there has been limited research to date on the effect of cellular ‘ageing’, termed senescence, on amyloidosis.” BUFFALO, NY- March 29, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, “Senescence and extracellular vesicles: novel partners in vascular amyloidosis.” In their editorial, researchers Meredith Whitehead, Marco Antonazzi and Catherine M. Shanahan from King’s College London discussed amyloidosis—a ...

A new analysis shows that, compared to similarly high-income European countries, the US continues to have substantially higher death rates at all but the oldest ages, resulting in more “excess deaths,” and this gap widened during the Covid-19 pandemic. Patrick Heuveline, of the University of California, Los Angeles (UCLA), presents these findings in the open-access journal PLOS ONE on March 29, 2023. Calculating excess death rates can be useful for comparing mortality between different countries or sub-populations, as well as before and after the onset of a health crisis. Prior research has documented a substantial widening of ...

Ancient 2m-long amphibians swam like crocodiles long before true crocodiles existed, according to a study published March 29, 2023 in the open-access journal PLOS ONE by David P. Groenewald of the University of the Witwatersrand, South Africa and colleagues. During the Late Permian Period, just over 250 million years ago, South Africa was home to rhinesuchid temnospondyls, large predatory amphibians with bodies similar to crocodiles or big salamanders. These extinct animals are known mainly from skeletal remains, but in this study, researchers ...

Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283089 Article Title: The impact of BMI on psychological health in oldest old individuals–Are there differences between women and men? Author Countries: Germany Funding: This study was funded by the @ktivPLUS study (German Federal Ministry of Education and Research, grant number 01GY2108) awarded to M. Löbner. Publication was funded by the Open Access Publishing Fund of Leipzig University, which is supported by the German Research ...