Buck Institute professor Pankaj Kapahi thinks the eye is a window to aging.  His lab, in collaboration with Google Health and Zuckerberg San Francisco General Hospital, has shown how imaging of the fundus, the blood vessel-rich tissue in the retina, can be used to track human aging, in a way that is noninvasive, less expensive and more accurate than other aging clocks that are currently available.   Publishing in eLife, researchers also did a genome-wide association study (GWAS) to establish the genetic basis for such a clock, which they call eyeAge.   “This type of imaging could be really ...

CAMBRIDGE, MA -- Despite the many advantages of concrete as a modern construction material, including its high strength, low cost, and ease of manufacture, its production currently accounts for approximately 8 percent of global carbon dioxide emissions. Recent discoveries by a team at MIT have revealed that introducing new materials into existing concrete manufacturing processes could significantly reduce this carbon footprint, without altering concrete’s bulk mechanical properties. The findings are published today in the ...

Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease. The absorption of intestinal cholesterol is primarily mediated by Niemann-Pick C1-like 1 (NPC1L1) protein, which is responsible for about 70% cholesterol absorption. NPC1L1-deficient mice are resistant to diet-induced hypercholesterolemia, which provides a compelling strategy for intervention the related diseases through inhibiting NPC1L1 expression or activity. NPC1L1 protein is expressed in the brush border membrane of small intestine. The protein is extensively N-glycosylated ...

Today, the Biden-Harris Administration announced Darleane C. Hoffman and Gabor A. Somorjai as recipients of the Enrico Fermi Presidential Award, one of the oldest and most prestigious science and technology honors bestowed by the U.S. government.   “Dr. Hoffman and Dr. Somorjai’s work to open the frontiers of radiochemistry and surface chemistry helped change what was possible, and advanced efforts to tackle some of the world’s greatest challenges,” said Assistant to the President and Director of the White House Office of Science and Technology Policy Arati Prabhakar. “They are world-class ...

Key findings: There are no vaccines or therapies available for lymphocytic choriomeningitis virus (LCMV) infection. This pathogen spreads easily and is extremely common in people worldwide. Infection with LCMV can cause birth defects in developing fetuses, and severe illness and even death in the immuncompromised. New findings from La Jolla Institute for Immunology (LJI) scientists show how an engineered antibody can target LCMV and neutralize the virus. They found this antibody has the potential to both prevent infection and treat an already established infection. With this better understanding of LCMV's weak spots, scientists can move forward ...

The COVID-19 pandemic posed an immense challenge on the health care industry in 2020 and 2021. While hospitals were inundated with COVID-19 cases, other illnesses such as respiratory syncytial virus (RSV) saw a decrease in hospital visits, particularly in the fourth quarter of 2020 and the first quarter of 2021. A Texas A&M University School of Public Health study recently published in the journal Frontiers found that while there were an unusually low number of hospitalizations in 2020, there was an unusual peak in the third quarter of 2021, when hospital admissions for RSV were approximately twice ...

A cold sparkling water. Waves crashing on the beach. The crackle of a bonfire. Steam from a kettle. These are not only the makings of a relaxing weekend, but also sources of aerosols in our environment. Though some of these sources of aerosols aren’t much of a concern, aerosols originating from industrial sources, such as wastewater treatment plants, and even natural sources, such as sea spray and dust, have the capacity to make more of an impact on the environment and even public health.   An aerosol ...

A new supplemental issue to The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences features papers resulting from a gathering of experts that emphasized racial/ethnic and contextual factors in the study of Alzheimer’s disease and related dementias (ADRD) care using a team science approach. According to this journal issue, titled “ADRD Care in Context,” recent estimates indicate that 6.5 million people in the U.S. live with ADRD, and more than 11 million Americans care for people with these conditions, providing 16 billion hours (valued at $271 billion) of unpaid assistance annually. Further, older adults from minoritized ...

Cambridge, Mass. – On October 9, 2022, an intense pulse of gamma-ray radiation swept through our solar system, overwhelming gamma-ray detectors on numerous orbiting satellites, and sending astronomers on a chase to study the event using the most powerful telescopes in the world.  The new source, dubbed GRB 221009A for its discovery date, turned out to be the brightest gamma-ray burst (GRB) ever recorded.  In a new study that appears today in the Astrophysical Journal Letters, observations of GRB 221009A spanning from radio ...

At 2AM of March 29, 2023 (Beijing Time), the Institute of High Energy Physics (IHEP) of the Chinese Academy of Sciences (CAS), together with some 40 research institutions worldwide, released their latest discoveries on the brightest Gamma-Ray Burst (dubbed as GRB 221009A) ever detected by human. With the unique observations made by two Chinese space telescopes, namely Insight-HXMT and GECAM-C, scientists were able to accurately measure how bright and how much energy released by this burst, which is the key to understand this historical event. For ...

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases. The molecule targets a lesser-studied enzyme in COVID-19 research, PLpro, that helps the coronavirus multiply and hampers the host body’s immune response. The molecule, called a covalent inhibitor, forms a strong chemical bond with its intended protein target and thus increases its effectiveness as an antiviral treatment. “We’re ...

GRAND RAPIDS, Mich. (March 28, 2023) — A team led by Van Andel Institute and Max Planck Institute of Immunobiology and Epigenetics scientists has identified two distinct subtypes of insulin-producing beta cells, or ß cells, each with crucial characteristics that may be leveraged to better understand and treat Type 1 and Type 2 diabetes.   ß cells are critical guardians of the body’s metabolic balance. They are the only cells capable of producing insulin, which regulates blood sugar levels by designating dietary sugar for immediate use ...

LAWRENCE — When the Kinks’ Ray Davies penned the tune “Last of the Steam-Powered Trains,” the vanishing locomotives stood as nostalgic symbols of a simpler English life. But for a paleontologist at the University of Kansas, the replacement of steam-powered trains with diesel and electric engines, as well as cars and trucks, might be a model of how some species in the fossil record died out. Bruce Lieberman, professor of ecology & evolutionary biology and senior curator of invertebrate paleontology at the KU Biodiversity Institute & Natural History Museum, sought to use steam-engine history to test the merits of “competitive exclusion,” ...

“[...] mutations in G-proteins have been associated in the progress of several cancers [...]”  BUFFALO, NY- March 28, 2023 – A new research paper was published in Oncotarget's Volume 14 on March 24, 2023, entitled, “Polyisoprenylated cysteinyl amide inhibitors deplete singly polyisoprenylated monomeric G-proteins in lung and breast cancer cell lines.” Finding effective therapies against cancers driven by mutant and/or overexpressed hyperactive G-proteins remains an area of active research. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational ...

Reston, VA—A newly published literature review sheds light on how nuclear medicine brain imaging can help evaluate the biological changes that cause chemotherapy-related cognitive impairment (CRCI), commonly known as chemo-brain. Armed with this information, patients can understand better the changes in their cognitive status during and after treatment. This summary of findings was published ahead-of-print by The Journal of Nuclear Medicine. CRCI describes a clinical condition characterized by memory and concentration impairment, difficulties with information processing ...

IIASA researchers collaborated with the FAIRR Initiative – a collaborative investor network – on the development of a new IPCC-aligned climate risk analysis tool for investors. Analyses done using the new tool, show that climate-related cost increases could significantly affect the bottom lines of the largest listed livestock companies unless new strategies are urgently adopted. The FAIRR Initiative today launched an enhanced iteration of its Coller FAIRR Climate Risk Tool providing investors with company-level data on how climate risks may impact costs and ...

The study surveyed school nurses working across the UK about their current working practices and experiences of working during the pandemic.  Dr Sarah Bekaert RN, Senior Lecturer in Child Health at Oxford Brookes University, said: “This research has highlighted the vital role school nurses play in the identification and prevention of issues that are likely to negatively impact young people as they navigate their teenage years, and then transition into adulthood. “Our findings call for advocacy by policymakers and professional organisations ...

Understanding What Prevents Shared Decision Making From Wider Implementation With Black Patients To understand the perspectives of Black patients on shared decision making (SDM) during medical appointments, researchers and clinicians investigated the preferences, needs and challenges around SDM as experienced by Black individuals. The team also offers possible adaptations and modifications for SDM models, practice and research within Black communities. The study team recruited 32 Black patients – 18 men and 17 women – with type ...

The transformative changes brought by deep learning and artificial intelligence are accompanied by immense costs. For example, OpenAI’s ChatGPT algorithm costs at least $100,000 every day to operate. This could be reduced with accelerators, or computer hardware designed to efficiently perform the specific operations of deep learning. However, such a device is only viable if it can be integrated with mainstream silicon-based computing hardware on the material level. This was preventing the implementation of one highly promising deep learning ...

SAN FRANCISCO – The Public Library of Science (PLOS) is pleased to announce that PLOS Global Public Health and PLOS Digital Health are now fully indexed in PubMed Central (PMC), expanding our reach and furthering our mission of ensuring research content is accessible and discoverable as widely as possible. Both journals have an explicit mandate to promote equity in research that can tackle the most urgent priorities for the field, such as access to healthcare, or addressing bias in AI and developing machine learning tools for underserved communities. PLOS is proud to feature ...

American Geophysical Union Press Release 23-12 28 March 2023 For Immediate Release This press release is available online at: https://news.agu.org/press-release/some-coastal-salt-marshes-are-keeping-up-with-sea-level-rise-for-now Some coastal salt marshes are keeping up with sea level rise — for now Salt marshes on the U.S. East Coast have accumulated soil more quickly over the past century, and some appear to be keeping pace with rising waters. But that won’t last forever. AGU press contact: Rebecca Dzombak, +1 (202) ...

Free-range organic chicken or factory farming? Scientists at the German Cancer Research Center (DKFZ) have developed a new detection method that can reveal such differences in husbandry. The so-called epigenetic method is based on the analysis of the characteristic patterns of chemical markers on the genome of the animals. Was the salmon for dinner with friends really caught wild or did it come from aquaculture? What to make of the alleged "biolabel quality“ of the shrimp for the seafood salad? And was the chicken for the Sunday roast really allowed to spend its life in the open air? Food analysis laboratories can only answer ...

Abscisic acid (ABA) is a plant hormone with essential functions in plant physiology. It is involved in developmental and growth processes and the adaptive stress response. Thus, the plant adaptation to stress situations caused by water deficit can be favored by activating this phytohormone pathway. In this project, the teams led by Pedro Luis Rodríguez at the IBMCP in Valencia and Armando Albert at the IQRF in Madrid developed a genetic-chemical method to activate this route in an inducible way and without penalizing plant growth. Based ...

Rates of prescriptions for naloxone to people at high risk for opioid overdose, as well as co-prescribing with opioids, has increased in emergency departments throughout the United States over the past decade, providing insight on the positive impact of federal policies and regulations, according to a Rutgers study.    Federal opioid prescribing guidelines in 2016 made it easier for doctors to prescribe naloxone to patients at high risk for opioid overdose. When used properly, naloxone is highly effective at reversing or reducing the life-threatening adverse effects of ...

While the outpatient management of stroke survivors through telehealth is prone to multiple barriers, it offers many advantages for addressing health equity in stroke survivors, according to a review from UTHealth Houston. The review – written by Anjail Sharrief, MD, MPH, first author and associate professor of neurology with McGovern Medical School at UTHealth Houston – was published recently in Stroke. Telehealth has seen rapid expansion into chronic care management over the past several years because of the COVID-19 pandemic, Sharrief said. However, there is limited ...