Nanoparticles used in drug delivery systems, bioimaging, and regenerative medicine migrate from tissues to lymphatic vessels after entering the body, so it is necessary to clarify the interaction between nanoparticles and lymphatic vessels. Although technology to observe the flow of nanoparticles through lymphatic vessels in vivo has been developed, there has been no method to evaluate the flow of nanoparticles in a more detailed and quantitative manner ex vivo. Thus, research was conducted to develop an ex vivo lymphatic vessel lumen perfusion system to determine how nanoparticles move in lymphatic vessels and how they affect the physiological movement of lymphatic vessels. Nanoparticles introduced into the ...

A research team led by Prof. QIAN Peiyuan, Head and Chair Professor from the Hong Kong University of Science and Technology (HKUST)'s Department of Ocean Science and David von Hansemann Professor of Science, has published their cutting-edge findings of symbiotic mechanisms of a deep-sea vent snail (Gigantopelta aegis) in the scientific journal Nature Communications. They discovered that Gigantopelta snail houses both sulfur-oxidizing bacteria and methane-oxidizing bacteria inside its esophageal gland cells (part of digestive system) as endosymbionts. By decoding the ...

A new study looking at how COVID-19 affects people with asthma provides reassurance that having the condition doesn't increase the risk of severe illness or death from the virus. George Institute for Global Health researchers in Australia analysed data from 57 studies with an overall sample size of 587,280. Almost 350,000 people in the pool had been infected with COVID-19 from Asia, Europe, and North and South America and found they had similar proportions of asthma to the general population. The results, published in the peer-reviewed END ...

Researchers at the University of Illinois Chicago have discovered a way to convert the methane in natural gas into liquid methanol at room temperature. This discovery, reported in the journal Proceedings of the National Academy of Sciences, could potentially provide a cleaner energy source for many of our everyday activities. When burned, natural gas -- the fuel used to heat homes, cook food and generate electricity -- produces carbon dioxide, a powerful greenhouse gas. According to the U.S. Energy Information Administration, the U.S. consumed approximately 31 trillion cubic feet of natural gas in 2019, contributing roughly 1.6 gigatons of carbon dioxide to the atmosphere. A better way to use natural gas would be to convert it to methanol, a liquid fuel that burns more ...

University of Queensland scientists have developed an ultraviolet 'television' display designed to help researchers better understand how animals see the world. Until now, standard monitors on devices like televisions or computer screens have been used to display visual stimuli in animal vision studies, but none have been able to test ultraviolet vision - the ability to see wavelengths of light shorter than 400 nanometres. Dr Samuel Powell, from the Queensland Brain Institute's Marshall lab, said this new technology will help unveil the secrets of sight in all sorts of animals, such as fish, birds and insects. "Human TVs generally use three colours - red, green and blue - to create images, but our newly-developed ...

Mitochondria are organelles that act as the powerhouses in our body. They use oxygen which we inhale and food we eat to produce energy that supports our life. This molecular activity is performed by bioenergetic nano-factories incorporated in specialized mitochondrial membranes. The nano-factories consist of proteins cooperatively transporting ions and electrons to generate chemical energy. Those have to be constantly maintained, replaced and duplicated during cell division. To address this, mitochondria have their own bioenergy protein-making machine called the mitoribosome. Given its key role, a deregulation of the mitoribosome can lead to medical disorders such as deafness and diseases including cancer development. The first fundamental understanding of how mitoribosomes ...

A POSTECH-KAIST joint research team has successfully developed a technique to reach near-unity efficiency of SHEL by using an artificially-designed metasurface. Professor Junsuk Rho of POSTECH's departments of mechanical engineering and chemical engineering, and Ph.D. candidate Minkyung Kim and Dr. Dasol Lee of Department of Mechanical Engineering in collaboration with Professor Bumki Min and Hyukjoon Cho of the Department of Mechanical Engineering at KAIST have together proposed a technique to enhance the SHEL with near 100% efficiency using an anisotropic metasurface. For this, the joint research team designed a metasurface that transmits most ...

Photo and map Robotic laboratories on the bottom of Lake Erie have revealed that the muddy sediments there release nearly as much of the nutrient phosphorus into the surrounding waters as enters the lake's central basin each year from rivers and their tributaries. Excessive phosphorus, largely from agricultural sources, contributes to the annual summer cyanobacteria bloom that plagues Lake Erie's western basin and the central basin's annual "dead zone," an oxygen-starved region that blankets several thousand square miles of lake bottom and that reduces habitat for fish and other organisms. The release of phosphorus from Lake Erie sediments during periods of low oxygen--a phenomenon known as self-fertilization or internal loading--has been acknowledged since the 1970s. ...

We are most familiar with the four conventional phases of matter: solid, liquid, gas, and plasma. Changes between two phases, known as phase transitions, are marked by abrupt changes in material properties such as density. In recent decades a wide body of physics research has been devoted to discovering new unconventional phases of matter, which typically emerge at ultra-low temperatures or in specially-structured materials. Exotic "topological" phases exhibit properties that can only change in a quantized (step-wise) manner, making them intrinsically robust against impurities and defects. In addition to topological ...

Despite our great progress in understanding various cellular mechanisms over the last decades, many of them remain unclear. Such is the case for exosomes, small vesicles released by cells that contain genetic materials called "RNA" and various proteins. The roles of exosomes are believed to be very varied and important, both for normal bodily functions and also in the spreading of diseases like cancer. However, exosomes are so small that studying them is challenging and calls for costly and time-consuming techniques, such as electron microscopy (EM). To tackle this issue, a team of undergraduate students from ...

Scientists have achieved a breakthrough in predicting the behaviour of neurons in large networks operating at the mysterious edge of chaos. New research from the University of Sussex and Kyoto University outlines a new method capable of analysing the masses of data generated by thousands of individual neurons. The new framework outperforms previous models in predicting and assessing network properties by more accurately estimating a system's fluctuations with greater sensitivity to parameter changes. As new technologies allow recording of thousands of neurons from living animals, there is a pressing demand for mathematical tools to study the non-equilibrium, complex dynamics of the high-dimensional ...

Cancer researcher Rita Fior uses zebrafish to study human cancer. Though this may seem like an unlikely match, her work shows great promise with forthcoming applications in personalised medicine. The basic principle of Fior's approach relies on transplanting human cancer cells into dozens of zebrafish larvae. The fish then serve as "living test tubes" where various treatments, such as different chemotherapy drugs, can be tested to reveal which works best. The assay is rapid, producing an answer within four short days. Some years ago, when Fior was developing this assay, she noticed something curious. "The majority of human ...

University of Warwick scientists model movements of nearly 300 protein structures in Covid-19 Scientists can use the simulations to identify potential targets to test with existing drugs, and even check effectiveness with future Covid variants Simulation of virus spike protein, part of the virus's 'corona', shows promising mechanism that could potentially be blocked Researchers have publicly released data on all protein structures to aid efforts to find potential drug targets: https://warwick.ac.uk/flex-covid19-data Researchers have detailed a mechanism in the ...

Genetic mutations which occur naturally during the earliest stages of an embryo's development can cause the severe birth defect spina bifida, finds a new experimental study in mice led by UCL scientists. The research, published in Nature Communications, explains for the first time how a 'mosaic mutation' - a mutation which is not inherited from either parent (either via sperm or egg cell) but occurs randomly during cell divisions in the developing embryo - causes spina bifida. Specifically the scientists, based at UCL Great Ormond Street Institute of Child Health, found that when a mutation in the gene Vangl2 (which contains information needed to create spinal cord tissue) was present in 16% of developing spinal cord cells of mouse embryos, this ...

The Biden administration is revising the social cost of carbon (SCC), a decade-old cost-benefit metric used to inform climate policy by placing a monetary value on the impact of climate change. In a newly published analysis in the journal Nature, a team of researchers lists a series of measures the administration should consider in recalculating the SCC. "President Biden signed a Day One executive order to create an interim SCC within a month and setting up a process to produce a final, updated SCC within a year," explains Gernot Wagner, a climate economist at New York University's Department of Environmental Studies and NYU's Robert F. Wagner Graduate School of Public Service and the paper's lead author. "Our work outlines how the ...

Scientific strides in HIV treatment and prevention have reduced transmissions and HIV-related deaths significantly in the United States in the past two decades. However, despite coordinated national efforts to implement HIV services, the epidemic persists, especially in the South. It also disproportionately impacts marginalized groups, such as Black/African-American and Latinx communities, women, people who use drugs, men who have sex with men, and other sexual and gender minorities. Following the release of the HIV National Strategic Plan and marking two years since the launch of the Ending the HIV Epidemic: ...

People who are racial, sexual, and gender minorities continue to be affected by HIV at significantly higher rates than white people, a disparity also reflected in the COVID-19 pandemic. The US HIV epidemic has shifted from coastal, urban settings to the South and rural areas. Despite its role as the largest funder for HIV research and global AIDS programs worldwide, the USA has higher rates of new HIV infections and a more severe HIV epidemic than any other G-7 nation. Series authors call for a unified effort to curb the HIV epidemic in the USA, including universal health ...

Researchers from California Polytechnic State University and University of Oregon published a new paper in the Journal of Marketing that examines the potential benefits for firms and consumers of pick-your-price (PYP) over pay-what-you-want (PWYW) and fixed pricing strategies. The study, forthcoming in the Journal of Marketing, is titled "The Control-Effort Trade-Off in Participative Pricing: How Easing Pricing Decisions Enhances Purchase Outcomes" and is authored by Cindy Wang, Joshua Beck, and Hong Yuan. Over the past few decades, marketers have experimented with pricing strategies ...

The imposition of various local and national restrictions in England during the summer and autumn of 2020 gradually reduced contacts between people, but these changes were smaller and more varied than during the lockdown in March, according to a study published in the open access journal BMC Medicine. A team of researchers at London School of Hygiene & Tropical Medicine (LSHTM), UK combined data from the English participants of the UK CoMix survey and information on local and national restrictions from Gov.uk collected between August 31st and December 7th 2020. CoMix is an online survey asking individuals to record details of their direct contacts in the day prior to the survey. The authors used the data to compare the number of contacts in different settings, such ...

Boys who regularly play video games at age 11 are less likely to develop depressive symptoms three years later, finds a new study led by a UCL researcher. The study, published in Psychological Medicine, also found that girls who spend more time on social media appear to develop more depressive symptoms. Taken together, the findings demonstrate how different types of screen time can positively or negatively influence young people's mental health, and may also impact boys and girls differently. Lead author, PhD student Aaron Kandola (UCL Psychiatry) said: "Screens allow us to engage in a wide range of activities. Guidelines and recommendations about screen time should be based on our understanding of how these different ...

Peer-reviewed | Observational | People Study based on 26.5 million Medicare records finds significant racial and ethnic disparities in uptake of seasonal flu vaccine in people living in the USA aged 65 years and older during the 2015-2016 flu season. Inequities persist among those who were vaccinated, with racial and ethnic minority groups 26-32% less likely to receive the High Dose Vaccine, which is more effective in older people, compared with white older adults. Authors note that while these results are from the 2015-2016 flu season, the findings ...

UPTON, NY--Scientists have demonstrated that modifying the topmost layer of atoms on the surface of electrodes can have a remarkable impact on the activity of solar water splitting. As they reported in Nature Energy on Feb. 18, bismuth vanadate electrodes with more bismuth on the surface (relative to vanadium) generate higher amounts of electrical current when they absorb energy from sunlight. This photocurrent drives the chemical reactions that split water into oxygen and hydrogen. The hydrogen can be stored for later use as a clean fuel. Producing only water when it recombines with oxygen to generate electricity in fuel cells, hydrogen could help us achieve a clean ...

Several treatments for cancer have been devised by science, but unfortunately none of them are completely efficient or foolproof. Novel treatments with minimum side effects are one of the main aims of the ongoing cancer research. All research so far points to several therapy modes, of which immunotherapy, which prepares the body's own immune system to fight cancer, is a promising option. Bispecific antibodies (BsAbs) are synthetically made proteins that emerged as a promising second-generation immunotherapy. They engage with immune cells and enable them to target cancer in a specific manner. Conventional use of T cells for this therapy has caused adverse effects in some cases. Moreover, they are ineffective against cold tumors, which are invisible to T cells of the immune system. ...

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18. This latest discovery could improve development of future stem cell therapies to generate "skin on a dish" to transplant into burn victims and patients with skin-blistering disorders. Polycomb complexes are groups of proteins that maintain the gene-expression patterns during early development by regulating the structure of DNA and proteins in cells. They play a critical role in the repression of gene expression, or the switching-off of individual genes to help control responses ...

Acres of asphalt parking lots, unshaded roads, dense apartment complexes and neighborhoods with few parks have taken their toll on the poor. As climate change accelerates, low-income districts in the Southwestern United States are 4 to 7 degrees hotter in Fahrenheit -- on average -- than wealthy neighborhoods in the same metro regions, University of California, Davis, researchers have found in a new analysis. This study provides the most detailed mapping yet of how summer temperatures in 20 urban centers in California, Nevada, Utah, Arizona, Colorado, New Mexico and Texas affected different neighborhoods between 2018 and 2020. The researchers found even greater heat disparities in California than in other states. The largest disparities showed up in the Riverside and San Bernardino ...