The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of ...

The cover for issue 1 of Oncotarget features Figure 2, "Results in clinical trials," published in "Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer" by Blagoev, et al. which reported that most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered. There is evidence that metastases are formed by phenotypically plastic cancer cells with stem-cell-like properties. Currently, the population structure and growth dynamics ...

The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor. Another validation set, which comprised 58 HCC with radical resection, was analyzed to investigate the relationships between tumor phenotype and TBX15 mRNA expression. TBX15 mRNA levels in tumor tissues were significantly lower compared ...

Aging-US Issue 1 Volume 13 features "PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging" which reported that despite a growing proportion of aged individuals at risk for developing cancer in the brain, the prognosis for these conditions remains abnormally poor due to limited knowledge of underlying mechanisms and minimal treatment options. While cancer metabolism in other organs is commonly associated with upregulated glycolysis and hyperactivation of PIK3/AKT/mTOR pathways, the unique bioenergetic demands of the central nervous system ...

Aging-US published "Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment" which reported that here, the authors investigated nicotinamide mononucleotide, a precursor of nicotinamide adenine dinucleotide, in a retinal detachment induced photoreceptor degeneration. NMN administration after RD resulted in a significant reduction of TUNEL photoreceptors, CD11b macrophages, and GFAP labeled glial activation; a normalization of protein carbonyl content, and a preservation of the outer nuclear layer thickness. NMN administration significantly increased NAD levels, SIRT1 protein expression, and heme oxygenase-1 expression. Delayed NMN administration still exerted protective effects after RD. This ...

A nuclear war could trigger an unprecedented El Niño-like warming episode in the equatorial Pacific Ocean, slashing algal populations by 40 percent and likely lowering the fish catch, according to a Rutgers-led study. The research, published in the journal END ...

DALLAS, Jan. 25, 2021 -- Psychological health can positively or negatively impact a person's health and risk factors for heart disease and stroke, according to "Psychological Health, Well-Being, and the Mind-Heart-Body Connection," a new American Heart Association Scientific Statement, published today in the Association's flagship journal Circulation. The statement evaluates the relationship between psychological health and heart health, summarizing ways to help improve psychological health for people with and at risk for heart disease. "A person's mind, heart and body are all interconnected and interdependent in what can be termed 'the mind-heart-body-connection,'" said Glenn N. Levine, M.D., FAHA, master clinician and professor of medicine at ...

DALLAS, Jan. 25, 2021 -- The continued global burden of stroke and how it disproportionately affects women are highlighted in new science published online today in the February issue of Stroke, a journal of the American Stroke Association, a division of the American Heart Association. Stroke editors selected nine manuscripts focused on stroke disparities in women in this collaboration with Go Red for Women®, the Association's global movement to end heart disease and stroke in women. "Stroke continues to be a leading cause of death and disability worldwide, with women being more adversely affected by the global burden of stroke," said Stroke Editor-In-Chief Ralph L. Sacco, M.D., M.S., FAHA, ...

Scientists have identified a key nutrient source used by algae living on melting ice surfaces linked to rising sea levels. The Greenland ice sheet - the second largest ice body in the world after the Antarctic ice sheet - covers almost 80% of the surface of Greenland. Over the last 25 years, surface melting and water runoff from the ice sheet has increased by about 40%. The international research team, led by the University of Leeds, analysed samples from the southwestern margin on Greenland's 1.7 million km² ice sheet over two years. They discovered that phosphorus containing minerals may be driving ever-larger algal blooms on the Greenland Ice Sheet. As the algal blooms grow they darken the ice surface, decreasing albedo - ...

EAST LANSING, Mich. - An international team of researchers led by Michigan State University's Morteza Mahmoudi has developed a new method to better understand how nanomedicines -- emerging diagnostics and therapies that are very small yet very intricate -- interact with patients' biomolecules. Medicines based on nanoscopic particles have the promise to be more effective than current therapies while reducing side effects. But subtle complexities have confined most of these particles to research labs and out of clinical use, said Mahmoudi, an assistant professor in the Department of Radiology and the Precision Health Program. "There's been a considerable investment of taxpayer money in cancer nanomedicine research, but that research hasn't successfully translated ...

Even before public announcements of the first cases of COVID-19 in Europe were made, at the end of January 2020, signals that something strange was happening were already circulating on social media. A new study of researchers at IMT School for Advanced Studies Lucca, published in END ...

The rate at which ice is disappearing across the planet is speeding up, according to new research. And the findings also reveal that the Earth lost 28 trillion tonnes of ice between 1994 and 2017 - equivalent to a sheet of ice 100 metres thick covering the whole of the UK. The figures have been published today (Monday, 25 January) by a research team which is the first to carry out a survey of global ice loss using satellite data. The team, led by the University of Leeds, found that the rate of ice loss from the Earth has increased markedly within the past three decades, from 0.8 trillion tons per year in the 1990s to 1.3 trillion tons per year by 2017. Ice melt across the globe ...

Female childhood cancer survivors face a lower likelihood of becoming pregnant than women in the general population, but once pregnant, they are not more likely to undergo an abortion. The findings come from a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Cancer survivors might be reluctant to start a family due to concerns for their children's health as well as the potential recurrence of their own cancer. This could lead to a greater likelihood of induced abortions in female survivors who become pregnant. To examine whether pregnancies of childhood cancer survivors are more likely to end with ...

AUGUSTA, Ga. (January 25, 2021) - Immediately after a traumatic brain injury and as long as one year later, there are increased levels of immune cells called ILCs in the brain promoting inflammation, which can worsen brain damage, scientists report. They also report for the first time that the cell energy sensor AMPK is a brake that can stop what becomes a chronic state of destructive inflammation driven by these ILCs, or innate lymphoid cells. "We think ILCs are kind of a master regulator of all that inflammation happening within the brain," says Dr. Krishnan Dhandapani, neuroscientist in the Department of Neurosurgery at the Medical College of Georgia at Augusta University. "It's like the ...

These results were published in the prestigious journal ChemSusChem and thanks to the remarkable reviews, the paper was ranked among the top five percent publications in the field, thus earning a Very Important Paper (VIP) status. Furthermore, the editorial board featured this study on its cover. Plastic pollution has become one of the most complex environmental issues, especially in the context of increasing production and demand for plastic materials. While innovations in polymer chemistry have radically changed our lives in the mid-20th century, the outstanding properties of plastics such as durability, chemical stability, strength and many other pose a serious problem ...

PULLMAN, Wash. - Man's best friend might actually belong to a woman. In a cross-cultural analysis, Washington State University researchers found several factors may have played a role in building the mutually beneficial relationship between humans and dogs, including temperature, hunting and surprisingly - gender. "We found that dogs' relationships with women might have had a greater impact on the dog-human bond than relationships with men," said Jaime Chambers, a WSU anthropology Ph.D. student and first author on the paper published in the Journal of Ethnobiology. "Humans were more likely to regard dogs as a type of person if the dogs had a special ...

Arctic sea ice is rapidly diminishing due to global warming, and scientists have found that sea ice dynamics have a big impact on circulation and precipitation patterns in Arctic Alaska, which lies at a climatological crossroads between the Arctic and North Pacific Oceans. Recent studies--most of which focus on current trends in the region and on what will happen in the future--have shown that circulation patterns in the Arctic and North Pacific Oceans influence one another. Doctoral candidate Ellie Broadman of Northern Arizona University's School of Earth and Sustainability wanted to learn about this relationship on a longer timescale, so she developed and led a ...

A group of scientists is calling on governments to consider the continued use of strict control measures as the only way to reduce the evolution and spread of new COVID-19 variants. The experts in evolution, virology, infectious disease and genomics - at the University of East Anglia (UEA), Earlham Institute and University of Minnesota - warn that while governments are negotiating a "precarious balance" between saving the economy and preventing COVID-19 fatalities, stronger action now is the best way to mitigate against more serious outcomes from such virulent strains later. While COVID-19 vaccine deployment is now underway, a threat to vaccine effectiveness comes from other emerging strains, both existing - such as the UK, South Africa and Brazil variants ...

New estimates reveal extent of the health burden of armed conflict--affecting at least 630 million women and children worldwide in 2017, and contributing to more than 10 million deaths among children under 5 years of age over 20 years. Changing nature of war is a growing threat to humanitarian access and the provision of essential health services for women and children, but responses in countries like Syria, Pakistan, and Colombia may provide context-specific innovative ways forward. Armed conflicts are becoming increasingly complex and protracted and a growing threat to humanitarian access and the delivery of essential health services, affecting at least 630 million women and ...

Dramatic changes were seen in the delivery of radiotherapy treatments for cancer during the first wave of the coronavirus pandemic in England. Much shorter radiotherapy courses were delivered, treatments were delayed where it was safe to do so and some increases were seen in order to compensate for reduced surgical capacity. Experts believe the changes reflect an impressive adaption of services by the NHS, and that the overall impact on cancer outcomes is likely to be modest. The new research, led by the University of Leeds, with Public Health England and the Royal College of Radiologists, reveals that there was a decrease in radiotherapy treatment courses of 19.9% in April, 6.2% in May, and 11.6% in June 2020, compared with the same months the previous year. These decreases equated ...

GALVESTON, Texas - The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'. The study has been published in Science Advances. It has long been suspected that pre-term labor is triggered by inflammation caused by a sick fetus. A new study by scientists at UTMB has proved the hypothesis by studying several important assumptions about the relationship between the health of a mother and her unborn child. According to Dr. Ramkumar Menon, ...

PROVIDENCE, R.I. [Brown University] -- Metallurgists have all kinds of ways to make a chunk of metal harder. They can bend it, twist it, run it between two rollers or pound it with a hammer. These methods work by breaking up the metal's grain structure -- the microscopic crystalline domains that form a bulk piece of metal. Smaller grains make for harder metals. Now, a group of Brown University researchers has found a way to customize metallic grain structures from the bottom up. In a paper published in the journal Chem, the researchers show a method for smashing individual metal nanoclusters together to form solid macro-scale hunks of solid metal. Mechanical testing of the metals manufactured ...

The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the most abundant type of RNA within cells, when resources are scarce and the bacteria Escherichia coli needs to slow its growth. Researchers used cryo-electron microscopy (cryo-EM) to capture the structures of the RNA polymerase while in complex with DNA and showed how its activity is changed in response to poor-growth conditions. A paper describing the research led by Penn State scientists appears January 22, 2020 in the journal Nature Communications. "RNA polymerase is an enzyme that produces a variety of RNAs using information encoded in DNA," said Katsuhiko Murakami, professor of biochemistry and molecular biology at Penn State and the leader of the research ...

In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1267, Hai Zou and Shengqing Li from the Institute of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China consider ECMO/CRRT combined support in the treatment of critically ill SARS-CoV-2 pneumonia patients. The authors of this article explored the experience with, and complications of, extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) for treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. The survival rate of patients with cardiopulmonary failure treated with ECMO/CRRT in whom conventional ...

In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1263, Yao Dong, Jun-E Liu and Ling Song from the Capital Medical University, Beijing, China consider risk factors for intraoperative pressure injury in aortic surgery. Intraoperative pressure injuries are some of the most significant health problems in clinical practice. Patients undergoing aortic surgery are at high risk of developing an intraoperative pressure injury, with an incidence much higher than that associated with other types of cardiac surgery. In this article the authors identify risk factors associated with an increased risk of intraoperative pressure injury in patients undergoing aortic ...