Every day space telescopes provide spectacular images of the solar activity. However, their instruments are blind to its main driver: the magnetic field in the outer layers of the solar atmosphere, where the explosive events that occasionally affect the Earth occur. The extraordinary observations of the polarization of the Sun's ultraviolet light achieved by the CLASP2 mission have made it possible to map the magnetic field throughout the entire solar atmosphere, from the photosphere until the base of the extremely hot corona. This investigation, published today in the journal Science Advances, has been carried out by the international team responsible for this suborbital experiment, which includes several scientists of the POLMAG group of the Instituto de Astrofísica de Canarias ...

Disorders of the cells' energy supply can cause a number of serious diseases, but also seem to be connected to ageing. More research is needed on mitochondrial function to find future treatments. A new study involving researchers at Karolinska Institutet shows how an important molecule inside the mitochondria affects their function in mice and fruit flies. The study, which is published in Science Advances, adds valuable knowledge on formerly relatively unexplored protein modifications. In each cell of the body is an organ called the mitochondrion, which converts nutrients in our food to energy. Mitochondria are an essential part of the ...

A combination of robust vaccination programmes and strict physical distancing rules could avoid recurring peaks of COVID-19 without the need to rely on stay-at-home restrictions, according to a new study by epidemiologists and demographers from WorldPop at the University of Southampton, in collaboration with The Chinese University of Hong Kong. This research used anonymised mobile phone geolocation data with epidemiological and coronavirus case data from China to model the potential impact of vaccination and physical distancing on virus transmission. They predicted the effect of different combinations of interventions on low, medium and high density cities in the country. The ...

A new study published in The British Medical Journal by researchers including SFU health sciences professor Scott Lear found consuming a high number of refined grains, such as croissants and white bread, is associated with a higher risk of major cardiovascular disease, stroke and death. The Prospective Urban Rural Epidemiology (PURE) study has been examining diets from diverse populations in low-, middle- and high-income countries around the world. Over 16 years of analysis of 137,130 participants in 21 countries, including Canada, the researchers found the intake of refined grains and added sugars have greatly increased over the years. Grains were categorized into three groups: refined grains, whole ...

Scientists have discovered the first evidence of protein folding driven by liquid-liquid phase separation, a phenomenon in which fluids form into microscopic droplets and separate inside cells -- like drops of oil in water. In a study published in the journal Chemical Science, researchers at the University of Notre Dame found that elevated concentrations of proteins within the droplets triggered a folding event, increasing the potential for protein aggregation -- or misfolding -- which has been linked to neurological diseases including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). "These particular proteins are intrinsically disordered -- they have no well-defined ...

In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. Findings of the multi-center study, which analyzed the whole genomes of more than 1,700 affected individuals with Crohn's disease and ulcerative colitis and more than 1,600 controls, were published on February 17 in the American Journal of Human Genetics. As ...

In a new Review, P.J. Klasse and colleagues present an extensive overview of the immunogenicity profiles of several leading SARS-CoV-2 vaccine candidates, including several developed under the auspices of the U.S. Government's "Operation Warp Speed" program, as well as leading candidates from China and Russia. Since the paper was submitted, two of these vaccines - from Pfizer/BioNTech and Moderna - have been authorized for use by the FDA. The authors review data from evaluations in non-human primates as well as human clinical trials, summarizing what is known about antibody and T cell immunogenicity for roughly a dozen leading candidates. Noting the variability in ...

Even in the world of the smallest particles with their own special rules, things cannot proceed infinitely fast. Physicists at the University of Bonn have now shown what the speed limit is for complex quantum operations. The study also involved scientists from MIT, the universities of Hamburg, Cologne and Padua, and the Jülich Research Center. The results are important for the realization of quantum computers, among other things. They are published in the prestigious journal Physical Review X, and covered by the Physics Magazine of the American Physical Society. Suppose ...

Exploratory analyses including 17,178 participants find that higher vaccine efficacy is obtained with a longer interval between the first and second standard dose (81% for 3-month interval vs 55% for up to 6-week interval). In addition, a single dose of vaccine is highly efficacious in the first 3 months (76% efficacy from 22 days after vaccination onwards). The study also includes updated estimates of overall vaccine efficacy against symptomatic disease for two standard doses, which confirm that the vaccine is effective. There were no hospitalisations or deaths among those receiving ...

The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease. Research led by Baylor College of Medicine reveals in the Journal of Clinical Investigation that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance to standard therapy. Importantly, inhibiting MAPK4 simultaneously inactivated both AR and AKT and stopped cancer growth in animal models. The findings open the possibility that targeting MAPK4 in human prostate cancer might provide a novel therapeutic strategy for this ...

The results, recently published in the journal Communications Biology, have important applications in the field of coevolutionary biology The physical movement of species determines their potential scope to leave their primary ecosystem behind in the quest for new niches in which to survive or reproduce--a decisive factor for the processes that determine their genomic characteristics. Researchers from the University of Granada (UGR) and the University of Illinois (UI) have, for the first time, analysed the relationship between this potential for movement in different species of parasites--their dispersal capacity--and their levels of genetic introgression. Introgression--the gradual movement of genes from one species into the gene pool of another--affects the proportion of regions of ...

A new study, in which the Andalusian Earth Sciences Institute (IACT) (CSIC-UGR) participated, has described for the first time a key stage in the beginning of the great glaciations and indicates that it can happen to our planet in the future. The findings were recently published in the scientific journal Nature The study claims to have found a new connection that could explain the beginning of the ice ages on Earth Antarctic iceberg melt could hold the key to the activation of a series of mechanisms that cause the Earth to suffer prolonged periods of global ...

The mating process is one of the most important mechanisms for maintaining genetic variation in natural populations. The emergence of sexual reproduction turned out to be the most important evolutionary innovation that facilitated the evolution of eukaryotes. Paramecium is a well-known genus of ciliated protists with a complex system of 'sexes', or mating types. Paramecium reproduces asexually, by binary fission, which is not related to the mating process. During conjugation, Paramecium of compatible mating types exchange haploid nuclei, equivalent to gametes. The nuclei of each organism ...

LOUISVILLE, Ky. - The SARS-CoV-2 pandemic has caused tremendous upheaval, leading to more than 2.3 million deaths worldwide and 465,000 in the United States. Understanding the impact of seasonal temperature changes on transmission of the virus is an important factor in reducing the virus's spread in the years to come. SARS-CoV-2 belongs to a large family of human coronaviruses, most of which are characterized by increased transmission in cooler, less humid months and decreased transmission in warmer, more humid months. With this understanding, researchers at the University of Louisville's Christina ...

HSE University researchers Yuri Markov and Natalia Tyurina discovered that when people visually estimate the size of objects, they are also able to consider their distance from the observer, even if there are many such objects. The observers rely not only on the objects' retinal representation, but also on the surrounding context. The paper was published in the journal Acta Psychologica. Multiple studies in visual 'ensemble statistics' have proven that humans are able to visually estimate the statistical characteristics of multiple objects in a fast and rather ...

ROCHESTER, Minn. ? Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). The findings were published today in a study in the American Journal of Human Genetics. "There are 4,565 different VUS in the BRCA2 gene listed in the National Institutes for Health (NIH) Clinical Variant Database," says Fergus Couch, Ph.D., a breast cancer researcher at ...

A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators. Studies of humans who live longer than 100 years have shown that many share an unusual version of a gene called Forkhead box protein O3 (FOXO3). That discovery led Dr. Jihye Paik, associate professor of pathology and laboratory medicine at Weill Cornell Medicine, and her colleagues to investigate how this gene contributes to brain health during aging. In 2018, Dr. Paik and her team showed that mice who lack the FOXO3 gene ...

How much personal information can our phone apps gather through location tracking? To answer this question, two researchers - Mirco Musolesi (University of Bologna, Italy) and Benjamin Baron (University College London, UK) - carried out a field study using an app specifically developed for this research. Through the app employed in the study - published in Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies - researchers were able to identify which kind of personal information the app extracted and its privacy sensitivity according to users. "Users are largely unaware of the privacy implications ...

The University of Leeds has coordinated a study with 170 experts from 35 countries, including E.T.S. Agronomic Engineering lecturer Luis Perez Urrestarazu. The study conclusions have just been published in the journal Nature Ecology & Evolution. The researchers highlighted opportunities to improve the way green spaces are monitored and maintained and helping people to interact with and appreciate the natural world around them. Similarly, as autonomous vehicles become more widely used in cities, pollution and traffic congestion are set to fall. But they also warn that advances in robotics and automation could be harmful to the environment. They may, for example generate new sources of waste and pollution, with potentially substantial negative implications for urban nature. Cities may ...

Social identity is a factor linked to wellbeing and community participation. Various studies have demonstrated the link existing between ethnic identity and empowerment and that the interaction between both of them leads to a rise in the indices of wellbeing and community participation. However, the nature of these relationships may be determined by the fact that the individual perceives his or her own group as a minority one and/or one that is subject to discrimination. In fact, these relations emerge mostly in groups that find themselves in a minority situation and/or one of discrimination, but not in groups that are more hegemonic or in the majority. To further ...

Parent education programs and interventions that begin shortly after the birth of a child have shown to significantly impact parenting behaviors that support social and academic engagement for children growing up in poverty, according to a study led by pediatricians and psychologists across the country, including NYU Grossman School of Medicine, NYU Steinhardt, and the University of Pittsburgh. The study, published today in the journal Pediatrics, examines the Smart Beginnings Project, a first-of-its-kind comprehensive approach to the promotion of school readiness in low-income families. This model addresses one of the most important causes of inequity - that many children from ...

Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. This new analysis of 3D images and quantitative data "will help to appreciate from within how the tumor is built in its full dimensionality, and to identify where different cell types are located", explains George Paul Cribaro, first author of the study. "It provides more complete information than the usual 2D analyses performed for ...

Prion diseases are a group of rapidly progressive, fatal and infectious neurodegenerative disorders affecting both humans and animals: Bovine Spongiform Encephalopathy (BSE) or 'mad cow' disease is one of the most famous since in 1996 scientists found that the agent responsible for the disease in cows, is the same agent responsible for the so-called variant Creutzfeldt-Jakob Disease (vCJD), a disease affecting humans. A new study carried out by SISSA - Scuola Internazionale Superiore di Studi Avanzati in collaboration with other institutions including Genos Glycoscience ...

DURHAM, N.H.-- A new report from the University of New Hampshire's Crimes against Children Research Center (CCRC), using data collected by the U.S. Department of Health and Human Services, showed a marked increase in the share of child maltreatment cases resulting in fatalities as well as a decline in cases of physical abuse and neglect in 2019. The report, which highlights 2019 statistics from the National Child Abuse and Neglect Data System (NCANDS), showed that fatalities rose 4%. The statistics gathered from child protection agencies in each state indicated that the uptick in child maltreatment fatalities was broadly distributed, with 25 states reporting an increase of 10% or more. This increase in fatalities continues an already upward trend ...

The first global-scale assessment of the role ecosystems play in providing sanitation finds that nature provides at least 18% of sanitation services in 48 cities worldwide, according to researchers in the United Kingdom and India. The study, published February 19 in the journal One Earth, estimates that more than 2 million cubic meters of the cities' human waste is processed each year without engineered infrastructure. This includes pit latrine waste that gradually filters through the soil--a natural process that cleans it before it reaches groundwater. "Nature can, and does, take the role of sanitation infrastructure," said Alison Parker, a Senior Lecturer in International Water and Sanitation at Cranfield University in the United ...