How the brain deals with trauma is complex, and it's intuitive to say that we, as humans, get over trauma differently depending on if it happened a long time ago or if it was recent. But what scientific evidence do we have about the way the brain deals with short-term versus long-term traumatic memories? EPFL scientists have identified the specific regions in the brains of mice responsible for reprograming traumatic experiences towards safety, and the brain regions are indeed different and depend on whether the trauma happened recently or a long time ago. They found that they could facilitate the extinction of long-lasting traumatic memories by enhancing the activity of a primitive region of the brain called the nucleus reuniens. The results are published today in Nature ...

Montréal, May 20, 2021--Researchers at the University of Montreal Hospital Research Centre (CRCHUM) and Yale University have succeeded in reducing the size of the HIV reservoir in humanized mice by using a "molecular can opener" and a combination of antibodies found in the blood of infected individuals. In their study published in Cell Host & Microbe, the team of scientists, in collaboration with their colleagues at the University of Pennsylvania and Harvard Medical School, show that they were also able to significantly delay the return of the virus after stopping antiretroviral therapy in this animal model. Humanized mice are generated from immunodeficient mice that don't have their own ...

Realizing the potential of self-driving cars hinges on technology that can quickly sense and react to obstacles and other vehicles in real time. Engineers from The University of Texas at Austin and the University of Virginia created a new first-of-its-kind light detecting device that can more accurately amplify weak signals bouncing off of faraway objects than current technology allows, giving autonomous vehicles a fuller picture of what's happening on the road. The new device is more sensitive than other light detectors in that it also eliminates inconsistency, or noise, associated with the detection process. Such noise can cause systems to miss signals and put autonomous vehicle passengers at risk. "Autonomous ...

Scientists from Queen Mary University of London and Rothamsted Research have used radar technology to track male honeybees, called drones, and reveal the secrets of their mating behaviours. The study suggests that male bees swarm together in specific aerial locations to find and attempt to mate with queens. The researchers found that drones also move between different congregation areas during a single flight. Drones have one main purpose in life, to mate with queens in mid-air. Beekeepers and some scientists have long believed that drones gather in huge numbers of up to 10,000 in locations known as 'drone congregation areas'. Previous research has used pheromone lures to attract drones, raising concerns ...

What The Study Did: These preliminary findings using U.S. Centers for Disease Control and Prevention Vaccine Adverse Events Reporting System data in the early phase of societal COVID-19 vaccination using two messenger RNA vaccines suggest that no association exists between inoculation with a SARS-CoV-2 messenger RNA vaccine and incident sudden hearing loss. Authors: Eric J. Formeister, M.D., M.S., of the Johns Hopkins University School of Medicine in Baltimore, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoto.2021.0869) Editor's Note: Please see the article for additional information, ...

What The Study Did: Researchers assessed associations between prenatal, early postnatal or current exposure to secondhand smoke and symptoms of attention-deficit/hyperactivity disorder (ADHD) among school-age children in China. Authors: Li-Wen Hu, M.D., Ph.D., and Guang-Hui Dong, M.D., Ph.D., of Sun Yat-sen University in Guangzhou, China, are the corresponding authors. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10931) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions ...

BOSTON - Screening for colorectal cancer - the second most common cause of cancer-related death in the United States - can save lives by detecting both pre-cancerous lesions that can be removed during the screening procedure, and colorectal cancer in its early stages, when it is highly curable. Screening is most commonly performed with endoscopy: visualization of the entire colon and rectum using a long flexible optical tube (colonoscopy), or of the lower part of the colon and rectum with a shorter flexible tube (sigmoidoscopy). This week, the United States Preventive Services Task Force (USPSTF) lowered the recommended beginning age for screening from 50 to 45 for persons without a family history of colorectal ...

The discovery of a new species of ancient turtle is shedding light on hard-to-track reptile migrations about 100 million years ago. Pleurochayah appalachius, a bothremydid turtle adapted for coastal life, is described in a new paper published by a multi-institution research group in the journal Scientific Reports. P. appalachius was discovered at the Arlington Archosaur Site (AAS) of Texas, which preserves the remnants of an ancient Late Cretaceous river delta that once existed in the Dallas-Fort Worth area and is also known for discoveries of fossil crocodyliformes and dinosaurs. P. appalachius belonged to an extinct lineage of pleurodiran (side-necked) ...

For many engineers and scientists, nature is the world's greatest muse. They seek to better understand natural processes that have evolved over millions of years, mimic them in ways that can benefit society and sometimes even improve on them. An international, interdisciplinary team of researchers that includes engineers from The University of Austin has found a way to replicate a natural process that moves water between cells, with a goal of improving how we filter out salt and other elements and molecules to create clean water while consuming less energy. In a new paper published today in Nature Nanotechnology, researchers created a molecule-sized water transport channel that can carry water between cells while excluding protons ...

Self-organizing heart organoids developed at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - are also effective injury- and in vitro congenital disease models. These "cardioids" may revolutionize research into cardiovascular disorders and malformations of the heart. The results are published in the journal Cell. About 18 million people die each year from cardiovascular diseases, making them the leading cause of fatalities globally. Moreover, the most prevalent birth defects in children pertain to the heart. Currently, a major bottleneck in understanding human heart malformations and developing regenerative therapies are missing human physiological models of the heart. The research group of Sasha Mendjan established cardioids ...

NEW YORK, NY (May 20, 2021)--The immune nature of kidney cancer stands out when compared to other cancers: More immune cells infiltrate kidney cancers than most other solid tumors, and kidney cancer is one of the most responsive malignancies to today's immunotherapy regimens. But despite treatment, many patients with clear cell renal carcinoma--the most common type of kidney cancer--eventually relapse and develop incurable metastatic disease. A new study shows that the presence of a rare and previously unknown type of immune cell in kidney tumors can predict which patients are likely to have cancer recur after surgery. These cells could even ...

We observe water vapor condensing into liquid droplets on a daily basis, be it as dew drops on leaves or as droplets on the lid of a cooking pot. Since the work of Dutch physicist J.D. van der Waals in the 19th century, condensation has been understood to result from attractive forces between the molecules of a fluid. Now, an international team of researchers has discovered a new mechanism of condensation: Even if they don't attract each other, self-propelled particles can condense by turning toward dense regions, where they accumulate. The study was published in Nature Physics. "It's like if cars steered toward crowded areas and made the crowd even bigger," explained Steve Granick, director of the IBS Center for Soft and Living ...

Antiretroviral therapy, the common approach in the treatment of HIV, halts replication of the virus and has saved the lives of millions of people. However, for patients the drug cocktail becomes a lifetime necessity because they continue to harbor latent HIV in a small number of immune system cells. In the absence of treatment, HIV can again replicate and rebound into full blown AIDs. A new study, however, suggests that addition of a single small molecule can rip away the cloak that shields those cells containing HIV and make them susceptible the patient's own antibodies that otherwise are not normally of much use against HIV. For the study, a team of researchers ...

HOUSTON - Researchers at The University of Texas MD Anderson Cancer Center have developed a first-of-its-kind artificial intelligence (AI)-based tool that can accurately identify rare groups of biologically important cells from single-cell datasets, which often contain gene or protein expression data from thousands of cells. The research was published today in Nature Computational Science. This computational tool, called SCMER (Single-Cell Manifold presERving feature selection), can help researchers sort through the noise of complex datasets to study cells that would likely not be identifiable otherwise. SCMER may be used broadly for many applications in oncology and beyond, explained senior author Ken Chen, Ph.D., associate professor of Bioinformatics ...

A national study from researchers at Michigan Medicine found that nearly 3% of insured U.S. adults under 65 take medications that weaken their immune systems. The findings, published in JAMA Network Open, are based on data from over 3 million patients with private insurance. They focus on patients' use of immunosuppressive drugs, including chemotherapy medications and steroids such as prednisone. The analysis reveals nearly 90,000 people met the study criteria for drug-induced immunosuppression that may elevate risk for severe COVID-19 symptoms and hospitalization ...

Young children who practice visual working memory and reasoning tasks improve their math skills more than children who focus on spatial rotation exercises, according to a large study by researchers at Karolinska Institutet in Sweden. The findings support the notion that training spatial cognition can enhance academic performance and that when it comes to math, the type of training matters. The study is published in the journal Nature Human Behaviour. "In this large, randomized study we found that when it comes to enhancing mathematical learning in young children, the type of cognitive training performed plays a significant role," says corresponding author Torkel Klingberg, professor in the Department of Neuroscience, Karolinska Institutet. "It is an important finding because it provides ...

A particular type of dendritic cell is responsible for the tissue damage that occurs in non-alcoholic steatohepatits (NASH) in mice and humans. The dendritic cells cause aggressive, proinflammatory behavior in T cells, as now discovered by researchers from the German Cancer Research Center (DKFZ) in collaboration with colleagues from Israeli research institutes. Blocking these dendritic cells alleviates symptoms in mice. This type of approach might also prevent the development of serious liver damage in NASH patients. Obesity is extremely widespread in the Western world, and 90 percent of those affected show signs of fatty degeneration of the liver. If they maintain an unhealthy lifestyle ...

Solar geoengineering -- putting aerosols into the atmosphere to reflect sunlight and reduce global warming -- is not a fix-all for climate change but it could be one of several tools to manage climate risks. A growing body of research has explored the ability of solar geoengineering to reduce physical climate changes. But much less is known about how solar geoengineering could affect the ecosystem and, particularly, agriculture. Now, research from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) finds that solar geoengineering may be surprisingly effective in alleviating some of the worst impacts of ...

CHAPEL HILL, NC - American politics can be stressful and confrontational, which can lead to anger. The combination of intense stress and negative emotions can trigger potentially fatal cardiovascular events in people who are susceptible to these health issues. But the direct link between a stressful political election and an increase in cardiac events hadn't been established, until now. A new study in the Journal of the American Heart Association is the first to show that exposure to a stressful political election is strongly associated with an increase in potentially life-threatening cardiac events. "This retrospective ...

A team led by a social work researcher at The University of Toledo has published the first empirical evidence that emotional support animals can provide quantifiable benefits to individuals with serious mental illness who are experiencing depression, anxiety and loneliness. The research brings credence to the many anecdotal reports of emotional support animals having positive impacts on chronic mental health issues. "This is the first peer-reviewed, published scientific evidence that emotional support animals may benefit people's mental health," said Dr. Janet Hoy-Gerlach, a professor of social work and the lead investigator on the project. "My hope is that our pilot study catalyzes additional research in this area with more rigorous ...

FRANKFURT. As first pointed out by the German astronomer Karl Schwarzschild, black holes bend space-time to an extreme degree due to their extraordinary concentration of mass, and heat up the matter in their vicinity so that it begins to glow. New Zealand physicist Roy Kerr showed rotation can change the black hole's size and the geometry of its surroundings. The "edge" of a black hole is known as the event horizon, the boundary around the concentration of mass beyond which light and matter cannot escape and which makes the black hole "black". Black holes, theory predicts, can be described by a handful ...

When scientists hunt for life, they often look for biosignatures, chemicals or phenomena that indicate the existence of present or past life. Yet it isn't necessarily the case that the signs of life on Earth are signs of life in other planetary environments. How do we find life in systems that do not resemble ours? In groundbreaking new work, a team* led by Santa Fe Institute Professor Chris Kempes has developed a new ecological biosignature that could help scientists detect life in vastly different environments. Their work appears as part of a special issue of theBulletin ...

The chemical bisphenol F (found in plastics) can induce changes in a gene that is vital for neurological development. This discovery was made by researchers at the universities of Uppsala and Karlstad, Sweden. The mechanism could explain why exposure to this chemical during the fetal stage may be connected with a lower IQ at seven years of age - an association previously seen by the same research group. The study is published in the scientific journal Environment International. "We've previously shown that bisphenol F (BPF for short) may be connected with children's cognitive development. However, with this study, we can now begin to understand which biological mechanisms may explain such a link, which is unique for an epidemiological study." ...

A new study provides public health planning authorities with a method of calculating the number of COVID-19 isolation beds they would need for people experiencing homelessness based on level of infection in the city. The research holds promise for controlling spread of the virus - or future infectious diseases - in a population that is highly vulnerable and less likely than many others to access health care services. The report, developed to support public health decision-making in Austin, Texas, was recently published by PLOS ONE. The paper's first author is an undergraduate student at The University of Texas at Austin, Tanvi Ingle, who harnessed ...

In April 2017, a landslide in Mocoa, Colombia, ripped through a local town, killing more than 300 people. Nicolás Pérez-Consuegra grew up about 570 miles north in Santander, Colombia, and was shocked as he watched the devastation on television. At that time, he was an undergraduate intern at the Smithsonian Tropical Research Institute in Panama. As a budding geologist raised hiking the tropical mountains of Colombia, he wondered, what causes greater erosion in some areas of the mountains than in others? And, is it tectonic forces - where Earth's tectonic plates slide against one another leading to the formation of steep mountains - or high precipitation rates, that play a more important role in causing erosion within that region? To answer those questions would require a geological ...