Endometrial cancer, which makes up about 90% of uterine cancers, will be diagnosed in more than 65,000 people in the United States this year. It is the fourth most common cancer in women and is one of the few cancers that is increasing in incidence and mortality. Unfortunately, very few treatments have been developed specifically for endometrial cancer. Now, new research published March 27, 2023, in The New England Journal of Medicine finds adding the immunotherapy drug pembrolizumab (Keytruda®) to standard chemotherapy greatly improves patient outcomes in both patients whose tumors have a genetic alteration leading ...

The American Society for Biochemistry and Molecular Biology submitted testimony to the U.S. House Appropriations Committee March 22 outlining its recommended budgets for major scientific funding agencies. Notably, the society requested a significant 10% increase in the budget for the National Institute of General Medical Sciences, which is part of the National Institutes of Health. “The ASBMB has a longstanding history of advocating for NIGMS and its researchers, and the majority of our members are funded by and rely on NIGMS to advance their research,” Sarina Neote, public affairs director of the ASBMB, said. “The ...

WHAT: Scientists have identified an autoinflammatory disease caused by mutations in the LYN gene, an important regulator of immune responses in health and disease. Named Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI), the identification sheds light on how genes linked to certain illnesses can potentially be targets for treatment by repurposing existing drugs. The research, published in Nature Communications, was led by Adriana A. de Jesus, M.D. Ph.D., and Raphaela Goldbach-Mansky, M.D., M.H.S. of the Translational ...

The Korea Institute of Civil Engineering and Building Technology (KICT, President Kim Byung-suk) developed a smart sensor that detects signs of ground or structure collapses and a real-time remote monitoring system.   The development of the sensor and system began with a search for a method of instant sensing of the collapse of slopes or buildings caused by ground movement for immediate response. This led to the development of a smart sensor that turns on a LED warning light upon detecting ground movement. The ...

Replacement per- and polyfluoroalkyl substances (PFAS) heralded as safe for use in food packaging break down into toxic PFAS that leak into our food and environment, suggests a study published today in Environmental Science & Technology Letters. Due to the known exposure risks of using smaller PFAS molecules like PFOA and PFOS in food-contact materials, many companies have pivoted to using larger polymeric PFAS to make their wrappers, bowls, and other fast-food packaging water- and grease-repellant. ...

Gaithersburg, MD—March 28, 2023 – Cartesian Therapeutics, a fully integrated biopharmaceutical company pioneering RNA cell therapy for autoimmune diseases and cancer, today announced the appointment of five internationally recognized experts in autoimmune diseases.  Cartesian’s appointments include distinguished physicians and scientists as leaders in clinical trials and medicine. “Cartesian is proud to have these prestigious, multidisciplinary advisors committed to treating other autoimmune diseases,” said Miloš Miljković, M.D., Chief Medical Officer at Cartesian Therapeutics. “Their perspectives will provide the utmost value ...

Researchers at the University of Toronto, Indiana University and University of Notre Dame have detected levels of toxic PFAS chemicals—short for per- and polyfluoroalkyl substances—for the first time in Canadian fast-food packaging, specifically water-and-grease repellent paper alternatives to plastic.  Published today in Environmental Science and Technology Letters, the findings suggest that food packaging exposes people directly to PFAS, which have been linked to serious health effects such as increased cancer risk and immune system damage, by contaminating the food they eat. Further, once discarded packaging enters waste streams, PFAS enter the environment, where these ...

HOUSTON – (March 28, 2023) – The road to a net-zero future must be paved with greener concrete, and Rice University scientists know how to make it. The production of cement, an ingredient in concrete, accounts for roughly 8% of the world’s annual carbon dioxide emissions, making it a significant target of greenhouse gas emissions reduction goals. Toward those efforts, the Rice lab of chemist James Tour used flash Joule heating to remove toxic heavy metals from fly ash, a powdery ...

CHAMPAIGN, Ill. — As new environmental regulations are rolling out to mitigate the industry-retired long-chain chemicals known as PFAS in drinking water, there are concerns regarding a new breed of “forever chemicals” called short-chain PFAS. Research from the University of Illinois Urbana-Champaign is helping shift the focus to include mitigation of the chemicals – which researchers say are just as persistent as, more mobile and harder to remove from the environment than their long-chain counterparts. A ...

SAN FRANCISCO, CA (March 28, 2023) — In a paper published today in the journal Environmental Research Letters, an international research team composed of scientists affiliated with more than a dozen institutions, including the California Academy of Sciences, propose a first-of-its-kind framework for governments around the world to evaluate their preparedness for—and guide future policies to address—ocean acidification, among the most dire threats to marine ecosystems.   “Ocean acidification is one of climate change’s silent killers,” says Rebecca Albright, PhD, Academy Curator of Invertebrate Zoology and ...

In North America’s hottest, driest desert, climate change is causing the decline of plants once thought nearly immortal and replacing them with shorter shrubs that can take advantage of sporadic rainfall and warmer temperatures.   Many studies have documented how a hotter, drier world is causing a redistribution of plants in temperate mountain regions. A new UC Riverside study documents the unexpected ways plants in part of the Sonoran Desert are doing the same.  “The plants ...

INDIANAPOLIS, March 28, 2023 — Colorful particles of plastic drift along under the surface of most waterways, from headwater streams to the Arctic Ocean. These barely visible microplastics — less than 5 mm wide — are potentially harmful to aquatic animals and plants, as well as humans. So, researchers are devising ways to remove them and to stop them at their source. Today, a team reports a two-stage device made with steel tubes and pulsing sound waves that removes most of the plastic particles from real water samples. The researchers will present ...

INDIANAPOLIS, March 28, 2023 — The ancient art of origami is well known for transforming sheets of paper and other foldable materials into complex 3D shapes. But now, chemical engineers have extended the centuries-old practice to produce intricate shapes made of glass or other hard materials. Their thoroughly modern method, which can be combined with 3D printing, could have applications ranging from sculpture to catalysis and beyond. The researchers will present their results today at the spring meeting of the American Chemical Society (ACS). ACS Spring 2023 is a hybrid meeting being held virtually and in-person ...

INDIANAPOLIS, March 28, 2023 — There’s been a recent push in the U.S. to make naloxone — a fast-acting opioid antidote — available without a prescription. This medication has saved lives, but it’s less effective against powerful synthetic opioids, such as fentanyl. In an interesting twist, researchers are now looking to cannabidiol (CBD), a component of marijuana, as a possible alternative to the popular antidote. Today, a team reports compounds based on CBD that reduce fentanyl binding and boost the effects of naloxone. The researchers will present their results at the spring meeting of the American Chemical Society (ACS). ...

INDIANAPOLIS, March 28, 2023 — Have a cough, sore throat and congestion? Any number of respiratory viruses could be responsible. Conventional tests can identify certain likely culprits by relying on chemical reactions, but some researchers want to swap chemistry for electrical changes sensed by nanomaterials. Today, scientists report using a single-atom-thick nanomaterial to build a device that can simultaneously detect the presence of the viruses that cause COVID-19 and the flu — at much lower levels and much more quickly than conventional tests for either. The researchers will present their results at the spring meeting ...

Research Highlights: Weight loss was associated with decreased risk factors for cardiovascular disease and Type 2 diabetes for at least five years — even if some weight was regained, according to a review of research on behavioral weight loss programs. People who lost weight through an intensive behavioral weight loss program had lower systolic blood pressure levels, total cholesterol-to-good cholesterol ratio and HbA1c levels (a diabetes marker), when compared to people who did not participate in a program or participated in a lower-intensity behavioral program. Embargoed ...

New research led by the University of Oxford has revealed that the most endangered turtle and crocodile species are those that are most unique. Their loss could have widespread impacts on the ecosystems they live in, since they carry out critical processes important for many other species. Turtles and crocodiles are two of the world's most endangered animal groups, with approximately half of species globally threatened (International Union for Conservation of Nature, IUCN). Greater understanding on which species are most threatened and why is urgently needed to inform conservation efforts to save them. In a new study led by researchers at the Department of Biology, ...

Every year, millions of birds crash into windows in cities along their migratory path. For decades, scientists and volunteers have risen at dawn in spring and fall to collect the fallen birds, rehabilitating the injured and documenting the dead. The bodies of the birds killed in these collisions are a treasure trove of scientific information, especially when compared year after year. A new study in the journal Molecular Ecology makes use of these specimens to help understand the relationship between birds and the microbes living in their guts—which appears ...

Understanding of and trust in science and scientists are dangerously low, and initial studies suggest that a general lack of interest in science is even more of a problem than skepticism in Austria. A key partner in alleviating this mistrust, clearing up misunderstandings, and building up enthusiasm for science must be the media in general and science journalists in particular. However, these journalists need access to the information as well as the resources to work independently and give full flight to their curiosity and creativity. To work towards these goals and promote excellent science journalism, ISTA initiated a program to host journalists for two-to-four-month ...

Malignant melanoma is a relatively aggressive type of skin cancer. When detected early, it is usually treatable by surgical resection only, but metastases develop often spreading to distant areas. Currently, tumor thickness and the presence of ulceration are some of the known prognostic factors used as indicators of malignant melanoma. Therefore, the discovery of valuable markers to assess the malignant potential of melanoma more accurately may be necessary to develop appropriate treatments. Cross talk between cancer cells and surrounding stromal cells is ...

For the first time, researchers have developed a form of the omega-3 fatty acid docosahexaenoic acid (DHA) that is capable of crossing into the eye’s retina to ward off visual declines related to Alzheimer’s disease, diabetes and other disorders.   The DHA found in fish oil capsules and other supplements is typically in a form called triacylglycerol (TAG) DHA. Although TAG-DHA has benefits in other parts of the body, it does not reach the eyes because it cannot travel from the bloodstream into the retina. For the study, ...

The lower prevalence of ‘risky’ sex—with multiple or new partners without using condoms—which occurred during the early stages of the COVID-19 pandemic, was still evident a year after Britain’s first lockdown, reveal the results of a major national survey, published online in the journal Sexually Transmitted Infections. While there were fewer reported unplanned pregnancies and abortions than indicated by a comparable survey a decade earlier, there were significantly higher prevailing levels of sexual dissatisfaction and worries ...

People with atopic (allergic) diseases like asthma or eczema may be at heightened risk of the painful and often disabling joint condition, osteoarthritis, finds research published online in the Annals of the Rheumatic Diseases. Drugs used to dampen down the physiological prompts for allergic reactions in the body may help lessen this risk, suggest the researchers. Osteoarthritis is the most common form of arthritis. But despite the high prevalence, substantial costs, and debilitating impact of the disease, there is as yet no effective ...

Engaging communities in developing a real-time early warning system could help to reduce the often-devastating impact of flooding on people and property – particularly in mountainous regions where extreme water events are a ‘wicked’ problem, a new study reveals Flash floods are becoming more frequent and damaging to the lives and property of vulnerable people, but researchers believe that using a SMART approach to engage with those living in such areas will help to better signal impending risk from flooding. Scientists believe that combining meteorological data with information on how people live and work in such regions, will help disaster risk ...

For the first time, researchers have identified specific regions of the brain that are damaged by high blood pressure and may contribute to a decline in mental processes and the development of dementia.   High blood pressure is known to be involved in causing dementia and damage to brain function. The study, which is published in the European Heart Journal [1] today (Tuesday), shows how this happens. It gathered information from a combination of magnetic resonance imaging (MRI) of brains, genetic analyses and observational data from thousands of patients to look at the effect of high blood pressure on cognitive function. The researchers then checked their findings ...