Research from the University of Adelaide has found that some species of fish will have higher reproductive capacity because of larger sex organs, under the more acidic oceans of the future. Published in PLOS Biology, the researchers say that far from the negative effects expected under the elevated CO2 levels in our oceans predicted for the end of the century, these fish capitalise on changes to the underwater ecosystems to produce more sperm and eggs. They also look after them better, enhancing the chances of reproductive success. "The warming oceans absorb about one-third of the additional CO2 being released into the atmosphere from carbon emissions, causing the oceans to acidify," says lead author Professor Ivan Nagelkerken from the University's Environment ...

Dendritic cells are a vital component of the innate immune system, which constitutes the body's first line of defense against infectious agents and tumor cells. Their job is to activate the T-cell arm of the adaptive immune system, which confers specific and long-lasting protection against bacterial and viral infections. Dendritic cells engulf and degrade proteins that signal the presence of invasive pathogens. The resulting fragments (antigens) are displayed on their surfaces. T cells bearing the appropriate receptors are then activated to seek out and eliminate the pathogen. Newborns and young children ...

Packing a lunchbox with fruit, sandwiches, and snacks is common practice for most Australian families. But what if there was another way? Flinders University researchers investigating the pros and cons of school-provided lunches say uniform delivery of lunchtime food at school could be a solution to better childhood nutrition and learning in Australia. Flinders Caring Futures Institute deputy director Professor Rebecca Golley says universal school-provided lunch models - a common practice in other countries such as the UK - would involve all children in the ...

Scientists have for the first time established a sensory neuron model able to mass-reproduce two key sensory neuron types involved in pain sensation, enabling the easy generation of large numbers of the cells to fast-track chronic pain research. In research applications usually sensory neurons need to be isolated from animals. They represent a wide variety of different cell types, making it difficult to collect and isolate large quantities of pain sensing neurons. Using a new technique, researchers at Flinders University have found a way to reproduce millions of the cells, providing ample resources for the simultaneous testing of thousands of samples or potential drug libraries. "Our ...

Education, professional skills and experience are the essential criteria for filling a position - or at least that is the expectation. The reality often looks different, as numerous studies have shown. When deciding whether to hire a candidate or not, gender, origin or ethnicity sometimes also play an important role; factors that say little about a candidate's suitability for a job. This type of discrimination violates the principle of equal opportunities. For those affected, this may have long-term disadvantages, such as longer unemployment or lower wages. This is why it is crucial to understand who is discriminated against, and why. The study conducted by Dominik Hangartner (Public Policy Group), Daniel Kopp and Michael Siegenthaler (both KOF Swiss Economic Institute) ...

Autophagy is a fundamental cellular process by which cells capture and degrade their own dysfunctional or superfluous components for degradation and recycling. Recent research has revealed that phase separated droplets have a range of important functions in cells. An international collaboration between German, Norwegian, and Japanese researchers has unravelled the mechanisms underpinning both how these droplets are captured through autophagy, as well as how droplets can serve as a platform from which structures facilitating cytosolic autophagy arise. Two worlds meet Autophagy[1], a critical intracellular ...

Just like us, many insects need a decent night's sleep to function properly, but this might not be possible if they have been exposed to neonicotinoid insecticides, the most common form of insecticide used worldwide, suggests research by academics at the University of Bristol. Two studies by scientists at Bristol's Schools of Physiology, Pharmacology and Neuroscience and Biological Sciences have shown these insecticides affect the amount of sleep taken by both bumblebees and fruit flies, which may help us understand why insect pollinators are vanishing from the wild. Dr Kiah Tasman, Teaching Associate in the School of Physiology, ...

Just over 200,000 Americans suffer from systemic lupus erythematosus, or SLE, a condition in which the body's immune system mistakenly attacks its own healthy tissues, especially joints and skin, a new study shows. Led by a researcher at NYU Grossman School of the Medicine, the study provides the first national estimate of how widespread the autoimmune disease is since the U.S. Centers for Disease Control and Prevention (CDC) set up a half dozen state registries to track the illness more than a decade ago. SLE affects mostly women, can be fatal, and often involves debilitating flare-ups of fatigue and pain that keep nearly ...

PHILADELPHIA--Patients with inactive cancer and not currently undergoing treatments also face a significantly higher risk of severe illness from COVID-19, a new study from Penn Medicine published online today in JNCI Cancer Spectrum shows. Past reports have established an increased risk of severe disease and death for sick or hospitalized cancer patients with COVID-19 compared to patients without cancer, but less is known about patients in the general population. The findings underscore the importance of COVID-19 mitigation, like social distancing and mask wearing, and vaccinations for all patients, not just those recently diagnosed or with active disease. "Patients who have cancer need to be careful ...

New research has shown that people are more likely to follow Covid-19 restrictions based on what their friends do, rather than their own principles. Research led by the University of Nottingham carried out in partnership with experts in collective behaviour from British, French, German and American universities shows how social influence affects people's adherance to government restrictions. The researchers found that the best predictor of people's compliance to the rules was how much their close circle complied with the rules, which had an even stronger effect than people's own approval of the rules. The research published in British Journal of Psychology highlights a blindspot in policy responses ...

The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries. The analysis, which is published in END ...

Where people die can affect the quality of their deaths and the end-of-life care that they receive. A study published in the END ...

Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the END ...

Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on *PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pains. *Prostate-Specific Antigen (PSA): a prostate-specific antigen (a cancer factor) used as an index for the screening of prostate cancer. The Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique ...

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers. According to the World Health Organisation, antibiotic resistance is one of the greatest threats to global health, food safety and development. It already causes over 33,000 deaths a year in Europe alone. Completely ...

Since 1997 (Reno vs. American Civil Liberties Union), the Supreme Court has used the metaphor of the free market of ideas to define the Internet, thus addressing the regulation of the net as a matter of freedom of speech. In law, metaphors have a constitutive value and, once established, affect the debate and the decisions of the Courts for a long time. In the paper 'Judicial Frames and Fundamental Right in Cyberspace', published in the American Journal of Comparative Law, Oreste Pollicino (Bocconi University) and Alessandro Morelli (Università Magna Graecia, Catanzaro) apply to judicial reasoning reflections on metaphors and go so far as to criticize, on the one hand, the US Supreme Court's orientations on (non-)regulation of the Internet and, on the other, to invoke changes ...

In the first systematic large-scale evaluation of the UK National Early Warning Risk Score (NEWS) 2 as a scoring system for predicting severe COVID-19 outcomes in patients, researchers at King's College London have found poor-to-moderate accuracy for identifying patients at risk of being transferred to intensive care units (ICUs) or dying after 14 days of hospitalisation. Accuracy of predictions in short term (three days) showed moderate success. For people who are hospitalised with severe COVID-19, it is vital to quickly identify which patients may deteriorate and require transfer to an intensive care unit (ICU) for organ support or may die. NEWS2 is an ...

Researchers from the University of Cambridge have discovered a fossil of the earliest starfish-like animal, which helps us understand the origins of the nimble-armed creature. The prototype starfish, which has features in common with both sea lilies and modern-day starfish, is a missing link for scientists trying to piece together its early evolutionary history. The exceptionally preserved fossil, named Cantabrigiaster fezouataensis, was discovered in Morroco's Anti-Atlas mountain range. Its intricate design - with feathery arms akin to a lacework - has been frozen in time for roughly 480 million years. The new species is unusual because it doesn't have many of the key features of its contemporary relatives, lacking roughly 60% of ...

Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm. Back pain and knee osteoarthritis affect millions of people globally and are leading causes of disability. When first-line pain medications such as paracetamol and ibuprofen fail to improve symptoms, many people are prescribed antidepressants for their pain. Most clinical practice guidelines recommend antidepressants for long term (chronic) back pain and hip and knee osteoarthritis, yet evidence supporting their use is uncertain. Published today in the BMJ the ...

Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by The BMJ today. The findings, based on moderate certainty evidence, show that for people with back pain the effects were too small to be worthwhile, but for osteoarthritis a small beneficial effect cannot be ruled out. Most clinical practice guidelines recommend antidepressants for long term (chronic) back pain and hip and knee osteoarthritis, yet evidence supporting their use is uncertain. To address this knowledge gap, researchers led by Giovanni Ferreira at the ...

Adding the arthritis drug tocilizumab to standard care for patients in hospital with severe or critical covid-19 is no better than standard care alone in improving clinical outcomes at 15 days, finds a new trial published by The BMJ today. There was an increased number of deaths at 15 days in patients receiving tocilizumab, resulting in the trial being stopped early. Today's results contradict earlier observational studies suggesting a benefit of tocilizumab. However, observational effects are limited by a high risk that they may be due to other unknown (confounding) factors - and some studies have not yet been peer ...

MINNEAPOLIS - A new study has found a brain pressure disorder called idiopathic intracranial hypertension is on the rise, and the increase corresponds with rising obesity rates. The study is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that for women, socioeconomic factors like income, education and housing may play a role in their risk. Idiopathic intracranial hypertension is when the pressure in the fluid surrounding the brain rises. It can mimic the symptoms of a ...

MINNEAPOLIS - A new study shows that intense immunosuppression followed by a hematopoietic stem cell transplant may prevent disability associated with multiple sclerosis (MS) from getting worse in 71% of people with relapsing-remitting MS for up to 10 years after the treatment. The research is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that in some people their disability improved over 10 years after treatment. Additionally, more than half of the people with the secondary progressive form of MS experienced no worsening of their symptoms 10 years after a transplant. While most people with MS are first diagnosed with relapsing-remitting MS, marked by symptom ...

The new tech elite share distinct views setting them apart from other segments of the world's elite more generally, according to a study published January 20, 2020 in the open-access journal PLOS ONE by Hilke Brockmann from Jacobs University Bremen, Germany, and colleagues. The global economic landscape over the last half-century is marked by a shift to a high-tech economy, dominated by the "Big Nine" (Amazon, Apple, Facebook, Google, IBM, Microsoft, Alibaba, Baidu, Huawei, and Tencent), computer hardware and software manufacturers, and most recently, app companies. In this study, Brockmann and colleagues investigate the worldviews of the 100 richest people in the tech world (as defined by Forbes). Though the authors initially approached all 100 of their subjects for a face-to-face ...

In the Early Bronze Age of Europe, ancient people used bronze objects as an early form of money, even going so far as to standardize the shape and weight of their currency, according to a study published January 20, 2020 in the open-access journal PLOS ONE by Maikel H. G. Kuijpers and C?t?lin N. Popa of Leiden University, Netherlands. Money is an important feature of modern human society. One key feature of money is standardization, but this can be difficult to identify in the archaeological record since ancient people had inexact forms of measurement compared with today. In this study, the authors assessed possible money from the Early Bronze Age of Central Europe, comparing the objects based on their perceived - if not ...