Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that cellular senescence of cancer-associated fibroblasts (CAFs) play an important role in the peritoneal dissemination of gastric cancer foci (cells different from surrounding cells). This understanding should enable the development of new treatments for cancer dissemination in the peritoneum by targeting cancer cells at focal sites and CAFs in patients with gastric cancer. Peritoneal dissemination ...

Plant species with short generation times are more sensitive to climate change than those with long generation times. This is one of the findings of a synthesis study by researchers from the German Centre for Integrative Biodiversity Research (iDiv), the Martin Luther University Halle-Wittenberg (MLU) and the Helmholtz-Centre for Environmental Research (UFZ). The international team comprehensively compiled worldwide available data, mostly from Europe and North America, to address the question of how plant populations react to climate change. The study, published in Nature Communications, shows that plant characteristics such as generation ...

Consumption of ultra-processed foods and drink could increase the risk of developing colorectal cancer. This was the conclusion of a large study undertaken by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, based on questionnaires about food behaviours completed by around 8,000 people in Spain. The study, the first of its kind in the country, also analysed the relationship between ultra-processed food and drink products and two other cancers; while no association was observed with prostate cancer, in the case of breast cancer a higher risk was observed in the sub-group of former and current smokers who reported a ...

More extroverted people suffered mood declines while more introverted people saw mood improvements during the early COVID-19 pandemic, in survey of students at a U.S. university. INFORMATION: Publicly available article: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248895 Article Title: "Personality trait predictors of adjustment during the COVID pandemic among college students" Funding: This work was supported by a grant to Dr. Jim Hudziak from the Conrad Hilton Foundation (https://www.hiltonfoundation.org/). The funders had no role in study design, data collection and analysis, decision ...

The question of the origin of the language is one of the most important and at the same time one of the most difficult to solve. It was formulated in antiquity and has inspired religion and philosophy ever since, in some periods, above all the Enlightenment, becoming the axis of reflection on other fundamental issues, such as human nature. In the last few decades, research in this field has intensified, drawing on evolutionism and having an interdisciplinary character, involving linguists, psychologists, primatologists and neuroscientists. The study of language evolution is currently considered one of the most ...

The Covid-19 Crisis is deepening the divide between energy transition frontrunners and laggards. In a new publication, researchers from the Institute for Advanced Sustainability Studies (IASS) in Potsdam present an overview of the global impact of the coronavirus pandemic on the energy sector. Their findings show that low- and middle-income countries need more support in their efforts to ditch fossil fuels. The crisis will heighten existing imbalances in an uneven energy transition landscape. Despite the crisis, frontrunners in the global energy transition will continue to expand their renewable energy capacities, while laggards will fall further behind. In Europe, the Green Deal ...

A new study of mortality among young adults born prematurely includes 6.3 million adults under the age of 50 in Norway, Sweden, Finland and Denmark. Among this group, 5.4 per cent were born before term, according to Professor Kari Risnes at the Norwegian University of Science and Technology's (NTNU) Department of Clinical and Molecular Medicine and St. Olavs Hospital. Researchers used national birth registers and compared them with the cause of death registers that all Scandinavian countries have. "We already know that preemies have increased mortality in childhood and early adulthood. Now we've confirmed the risk of death from chronic diseases such as heart disease, ...

An international group of researchers led by the University of Adelaide has conducted a comprehensive genetic analysis and found no evidence of interbreeding between modern humans and the ancient humans known from fossil records in Island Southeast Asia. They did find further DNA evidence of our mysterious ancient cousins, the Denisovans, which could mean there are major discoveries to come in the region. In the study published in Nature Ecology and Evolution, the researchers examined the genomes of more than 400 modern humans to investigate the interbreeding events between ancient humans and modern ...

TALLAHASSEE, Fla. -- Scientists peering into the beating heart have solved a decades-old, fundamental mystery about how the heart works. The revelation could herald the development of new treatments for heart diseases -- the leading cause of death worldwide. Researchers from Eastern Virginia Medical School, Florida State University and the University of Virginia have observed a tiny muscle filament during a crucial stage in a beating heart for the first time. The research was published in Proceedings of the National Academy of Sciences. The heart is a unique muscle which contracts and relaxes about once every second ...

PROVIDENCE, R.I. [Brown University] -- The COVID-19 pandemic has had devastating effects in U.S. nursing homes and long-term care facilities, resulting in an estimated 1.2 million infections and 147,000 deaths as of early 2021. Yet even as mortality rates in the general population have decreased over time, little evidence has been uncovered to determine whether nursing home residences have experienced similar reductions. Now, new data collected and analyzed by researchers at Brown University shows that mortality rates among nursing home residents with COVID-19 declined from March to November 2020, and that the deadliest ...

An international group of scientists from India and Russia has created edible food films for packaging fruits, vegetables, poultry, meat, and seafood. Films consist of natural ingredients, they are safe for health and the environment. In addition, films are water-soluble and dissolve by almost 90% in 24 hours. Description of the research and results of experiments are published in the Journal of Food Engineering. "We have created three types of food films based on the well-known naturally occurring seaweed biopolymer sodium alginate," said Rammohan Aluru, senior researcher Organic synthesis laboratory at Ural Federal University and co-author of the paper. "Its molecules have film-forming ...

Recently, a published study in Science Advances assessed the contribution of pollinators to international market flows and showed that biodiversity conservation is essential to sustain global consumption patterns. This study results from the work of an interdisciplinary team that integrated researchers across the fields of economics, ecology, environmental sciences and social sciences. Given the growing global demand for crops, sustainability in agriculture is one of the main challenges for human society. Together with the excessive use of chemical inputs, the loss of natural habitat associated with cropland expansion is one of the main drivers ...

Philadelphia, March 23, 2021 - Researchers from Children's Hospital of Philadelphia (CHOP) have discovered that a widely used nutritional supplement may significantly reduce the risk of fatal strokes caused by a rare genetic disorder. Additionally, the findings suggest that the supplement could be used to both block precipitation of and break up the formation of amyloid plaque deposits, a common feature found in serious forms of dementia. The findings were published online today by the journal Nature Communications. The findings centered around a genetic disorder known as hereditary cystatin C amyloid angiopathy (HCCAA). HCCAA is part ...

Evolution of auroral substorms revealed by physicists at University of Warwick using the same methods that link people through social media 'If you like this magnetometer, you might like this one too:' historical data from magnetometers used to match them with 'like-minded friends' during 41 substorms Shows that a single coherent electrical current, that accompanies the Northern Lights during substorms, covers most of the Earth's night-side at high latitudes Will help to validate models used to predict auroral substorms, which can disrupt electronics and power distribution systems Space weather often manifests as substorms, where a beautiful auroral display such as the Northern Lights is accompanied ...

A pioneering study, published in Scientific Reports, found that the Parkinon's gene PINK1 is important for the generation of dopamine-producing neurons throughout life, and is not just responsible for the premature death of these neurons The international research, led by University of Sheffield's Neuroscience Institute, used two model systems to examine how neurons are produced throughout our lifetime Parkinson's disease is a relentlessly progressive neurodegenerative disorder that affects around 145,000 people in the UK A gene defect linked to Parkinson's disease may not only cause the early death of neurons, ...

Hennigsdorf/Berlin, Germany, March 23, 2021 - Diagnostics company SphingoTec GmbH ("SphingoTec") announced today the first published data (1) on the biomarker DPP3 that can predict the evolution of organ function and survival in septic patients. Measured on top of routinely used standard parameters, such as Lactate and Procalcitonin, DPP3 is an early indicator of short-term outcomes and patient severity. Sepsis is a medical emergency caused by a dysregulated host response to an infection, with mortality rates increasing rapidly for each hour that appropriate treatment is delayed (2). The rapid evolution of sepsis into its severe form, septic shock, raises the need for more precise and faster testing to support better clinical decision-making. DPP3 is an ...

Researchers from the Department of Orthopedics of Tongji Hospital at Tongji University in Shanghai have successfully used a nanobiomaterial called layered double hydroxide (LDH) to inhibit the inflammatory environment surrounding spinal cord injuries in mice, accelerating regeneration of neurons and reconstruction of the neural circuit in the spine. The researchers were also able to identify the underlying genetic mechanism by which LDH works. This understanding should allow further modification of the therapy which, in combination with other elements, could finally produce a comprehensive, clinically applicable system for spinal cord injury relief in humans. The ...

Researchers at the University of Toronto have found that food industry interactions with government heavily outnumbered non-industry interactions on Bill S-228, also known as the Child Health Protection Act, which died in the Senate of Canada in 2019. The researchers looked at more than 3,800 interactions, which included meetings, correspondence and lobbying, in the three years before the bill failed. They found that over 80 per cent were by industry, compared to public health or not-for-profit organizations. They also found that industry accounted for over 80 per cent of interactions with the highest-ranking government offices, including elected parliamentarians and their staff and unelected ...

BINGHAMTON, NY -- When it comes to local government, does the gender of a mayor or county executive matter in sustainability policymaking? Yes, but only in certain ways, according to new research from Binghamton University, State University of New York. Kristina Lambright, associate professor of public administration, and George Homsy, associate professor of public administration and director of the environmental studies program, explored the correlation between female leadership and local government adoption of sustainability policies in "Beyond community characteristics: a leader's gender and local government adoption of energy conservation practices and redistributive programmes," published recently ...

Researchers at Chalmers University of Technology, Gothenburg, Sweden, have developed a novel type of thermometer that can simply and quickly measure temperatures during quantum calculations with extremely high accuracy. The breakthrough provides a benchmarking tool for quantum computing of great value - and opens up for experiments in the exciting field of quantum thermodynamics. A key component in quantum computers are coaxial cables and waveguides - structures which guide waveforms, and act as the vital connection between the quantum processor, and the classical electronics which control it. Microwave pulses travel along the waveguides to the quantum processor, and are cooled ...

Incorporating Black churches and clergy in COVID-19 vaccination education and distribution has been found to be an effective model in helping to increase vaccination delivery to historically at-risk populations in San Bernardino County, a study says. Focused education efforts and an on-site mobile clinic in Black church parking lots resulted in the vaccinations of 417 people, 84% of whom were Black. The study also found an increase in Black attendance of mass vaccination clinics to 3.6% of total patients, up from 3%, in the week post-initiative. Researchers at Loma Linda University School of Pharmacy published their findings on March 10 in The Lancet Global Health, ...

Almost 90 percent of infectious travelers could be detected with rapid SARS-CoV-2 tests at the airport, and most imported infections could be prevented with a combination of pre-travel testing and a five-day post-travel quarantine that would only lift with a negative test result, according to a computer simulation by UC San Francisco researchers. The study offers much-needed data to airlines and states that have struggled through a year of the pandemic with little guidance on how to enable safe travel. The issue is becoming more pressing as states ...

Root-knot nematodes (RKNs, Meloidogyne spp.) infect a broad range of plants, including several agriculturally important species such as cotton, soybean and corn, as well as various vegetables and ornamentals. These parasites cause roots to develop galls that result in severe plant damage and, ultimately, important crop losses. Growers currently use synthetic nematicides to manage RKNs; however, these compounds are detrimental to the microbial diversity of soil and harmful for the environment. Thus, it is necessary to develop alternative sustainable control methods. "We have been seeking natural compounds that activate plant defense ...

A team of scientists at the University of Massachusetts Amherst have developed the thinnest and most sensitive flow sensor, which could have significant implications for medical research and applications, according to new research published recently in Nature Communications. The research was led by Jinglei Ping, assistant professor of mechanical and industrial engineering, along with a trio of mechanical engineering Ph.D. students: Xiaoyu Zhang, who fabricated the sensor and made the measurement, Eric Chia and Xiao Fan. The findings pave the way for future research on all-electronic, in-vivo flow monitoring in investigating ...

A cast of so-called 'nurse cells' surrounds and supports the growing fruit fly egg during development, supplying the egg -- or 'oocyte' -- with all the nutrients and molecules it needs to thrive. Long viewed as passive in this process, the Drosophila egg actually plays an active role not only in its own growth, but also in the growth of the surrounding nurse cells, Princeton University researchers report on March 21 in Developmental Cell. "Here we show an example of bidirectional communication -- a dialogue -- between different cells. The egg is taking an active hand in controlling its own feeding ...