Human actions are threatening the resilience and stability of Earth's biosphere - the wafer-thin veil around Earth where life thrives. This has profound implications for the development of civilizations, say an international group of researchers in a report published for the first Nobel Prize Summit, a digital gathering to be held in April to discuss the state of the planet in the wake of the COVID-19 pandemic. "Humanity is now the dominant force of change on planet Earth," according to the analysis published in Ambio, a journal of the Royal Swedish Academy of Sciences. "The risks we are taking are astounding," says co-author Johan Rockström, director of the Potsdam Institute for Climate Impact Research and co-author of the analysis. "We are at the dawn of what must be a transformative ...

Study taken throughout the pandemic shows those who feel government should be less controlling believe COVID-19 poses less risk, which in turn was associated with the adoption of fewer protective behaviours "A fearful population is not necessarily desirable... people may be underestimating or overestimating the actual risk at different times." People's politics and values are exerting a bigger influence on how much of a threat they feel from COVID-19 compared to objective indicators such as the number of confirmed cases. That's the finding of a new University of Cambridge survey which measured how attitudes to the coronavirus have varied over the course of 10 months of the pandemic for more ...

Hearing loss and other auditory problems are strongly associated with Covid-19 according to a systematic review of research evidence led by University of Manchester and NIHR Manchester Biomedical Research Centre (BRC) scientists. Professor Kevin Munro and PhD researcher Ibrahim Almufarrij found 56 studies that identified an association between COVID-19 and auditory and vestibular problems. They pooled data from 24 of the studies to estimate that the prevalence of hearing loss was 7.6%, tinnitus was 14.8% and vertigo was 7.2%. They publish their findings in the International Journal of Audiology. However, the team - who followed up their review carried out a year ago - ...

Scientists from the University of Leeds's Nutritional Epidemiology Group used data from 500,000 people, discovering that consuming a 25g serving of processed meat a day, the equivalent to one rasher of bacon, is associated with a 44% increased risk of developing the disease. But their findings also show eating some unprocessed red meat, such as beef, pork or veal, could be protective, as people who consumed 50g a day were 19% less likely to develop dementia.? The researchers were exploring a potential link between consumption of meat and the development of dementia, a health condition that affects 5%-8% of over 60s worldwide. Their results, titled Meat consumption and risk of incident dementia: cohort study of 493888 UK Biobank participants, are published today in the American ...

WASHINGTON--One in five adults with type 1 diabetes who require in-hospital treatment of the life-threatening condition diabetic ketoacidosis has an unplanned repeat hospital visit within a month and is twice as likely to die during the second hospitalization, a new study finds. The results, which will be presented at ENDO 2021, the Endocrine Society's annual meeting, also identified several factors that increased the readmission risk for these patients. Diabetic ketoacidosis, which can occur from insufficient insulin medicine or from an infection, is a dangerous accumulation of acid in the blood due to ...

WASHINGTON--A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society's annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes. "These study results demonstrate that BIF has promise as a once-weekly basal insulin and could be an advancement in insulin therapy," ...

WASHINGTON--Some patients with moderate to severe COVID-19 disease seem to experience inflammation of the thyroid gland that is different from thyroid inflammation caused by other viruses, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. One-third of the study participants still had signs of thyroid inflammation after three months, even though their thyroid function had normalized. The study is following patients to determine whether this inflammation will trigger permanent thyroid dysfunction. In spring 2020, 15 percent of the COVID-19 patients hospitalized in acute medicine units ...

WASHINGTON--People with obesity who are hospitalized with COVID-19 have a significantly higher rate of ICU admissions and longer duration of ICU stay compared to people with a normal body mass index (BMI), according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "The association between obesity and a more severe clinical course of COVID-19 highlights the vulnerability of this population during the current pandemic and the need for public health efforts to prevent and treat obesity, in the current pandemic and beyond," said lead researcher Yu Mi Kang, M.D., Ph.D., of Yale New Haven ...

WASHINGTON--Children with poorly controlled type 1 diabetes have a 10 times higher risk of COVID-19-related complications and death compared to those with well-controlled diabetes, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "This study shows keeping diabetic children's blood sugar under control is more important than ever during the pandemic," said lead author Manish Raisingani, M.D., of the University of Arkansas for Medical Sciences and Arkansas Children's in Little Rock, Ark. "The findings will help children with type 1 diabetes and their families make better choices about the safety of attending school in person and engaging ...

WASHINGTON--Commonly used medications for type 2 diabetes and obesity called glucagon like peptide-1 receptor agonists (GLP-1 RAs), are not associated with an increased risk of breast cancer, despite previous studies that suggested a possible link, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "GLP-1RAs can be used as adjunct to diet and exercise in subjects with type 2 diabetes and those without type 2 diabetes and excess weight, without an increased risk of breast cancer or noncancerous masses in the breast," said lead researcher Giovana Fagundes Piccoli, M.D., of the Universidade Federal do Rio Grande do Sul in Brazil. GLP-1 RAs have been shown to be effective in treating obesity and type 2 diabetes ...

WASHINGTON--New genetic research suggests men can develop characteristics of polycystic ovary syndrome (PCOS)--a common metabolic and reproductive disorder that affects women. The study was presented virtually at ENDO 2021, the Endocrine Society's annual meeting. PCOS is a common disorder characterized by irregular menstrual periods, disruption of normal metabolism and elevated testosterone levels. PCOS affects up to 10% of all women of reproductive age. The disorder can lead to obesity, diabetes and cardiovascular disease, which are often life-long conditions. Men who have genetic risk factors ...

WASHINGTON--Addressing sleep symptoms during menopause may reduce susceptibility to weight gain, according to a small study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "Our findings suggest that not only estrogen withdrawal but also sleep disturbances during menopause may contribute to changes in a woman's body that could predispose midlife women to weight gain," said lead researcher Leilah Grant, Ph.D., of Brigham and Women's Hospital in Boston, Mass. "Helping women sleep better during menopause may therefore reduce the chances ...

WASHINGTON--Endogenous Cushing's syndrome, a rare hormonal disorder, is associated with a threefold increase in death, primarily due to cardiovascular disease and infection, according to a study whose results will be presented at ENDO 2021, the Endocrine Society's annual meeting. The research, according to the study authors, is the largest systematic review and meta-analysis to date of studies of endogenous (meaning "inside your body") Cushing's syndrome. Whereas Cushing's syndrome most often results from external factors--taking cortisol-like medications such as prednisone--the endogenous type occurs when the body overproduces the hormone cortisol, affecting multiple bodily ...

WASHINGTON--Two-thirds of patients with chronic endocrine health problems who need close monitoring say they would like to continue with telemedicine follow-up visits after the COVID-19 pandemic ends, according to a survey that will be presented virtually at ENDO 2021, the Endocrine Society's annual meeting. Three-quarters of providers also said they want to continue with telehealth after the pandemic. "Endocrinology clinics have significant number of patients who need long-term close follow-up for medication adjustments, symptom checks and counseling," said lead researcher Maryam Nemati, M.D., of San Joaquin General Hospital in French Camp, Calif. "Our ...

WASHINGTON--Treatment of hypothyroidism, which results from an underactive thyroid gland, should be individualized and consideration should be given to alternatives to the first-line therapy, including desiccated thyroid extract and combination therapy to replace the body's two main thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Results of their new randomized clinical study are being presented at ENDO 2021, the Endocrine Society's annual meeting. Combination therapy has been shown to be equally as effective as the standard treatment with levothyroxine alone, researchers say. "There are now proven good treatment options for the more than one in 10 patients with hypothyroidism who continue to experience symptoms of fatigue, mental fogginess, weight ...

WASHINGTON--An industry-supported study of an oral testosterone replacement therapy (TRT), testosterone undecanoate (TU, brand name Jatenzo) finds it is an effective, long-term treatment for men with low testosterone levels, with no evidence of liver toxicity. The findings are being presented virtually at ENDO 2021, the Endocrine Society's annual meeting. TST is currently available in multiple modes of administration, including implantable pellets, transdermal gels and intramuscular injections. "For many men with low testosterone levels, an oral option is preferred to avoid issues associated with other ...

WASHINGTON--Among women who develop diabetes during pregnancy, night owls have a higher risk of complications for mother and baby than early birds do, according to a study whose results will be presented at ENDO 2021, the Endocrine Society's annual meeting. Compared with other pregnant women with gestational diabetes, those with a preference for evening activity had three times higher the chance of having preeclampsia, which is pregnancy-induced high blood pressure, and four times the rate of their newborns being treated in a neonatal intensive care unit, the study investigators reported. These findings suggest a ...

WASHINGTON--Children with achondroplasia, the most common form of disproportionate short stature, grow taller with trends in improved body proportions after two years of daily vosoritide treatment, a new study analysis finds. Results of the industry-sponsored study will be presented at ENDO 2021, the Endocrine Society's annual meeting. "This is the first robust evidence of a precision therapy for achondroplasia," said the lead investigator, Ravi Savarirayan, M.D., Ph.D., a professor at Murdoch Children's Research Institute at Royal Children's Hospital in Parkville, Australia. Achondroplasia is a genetic bone growth ...

WASHINGTON--A study in mice finds treatment with a molecule called MCB-613 repairs heart tissue after a severe heart attack, preventing damage that can lead to heart failure. The findings are being presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "This is a remarkable discovery that may lead to effective and safe treatments to prevent the progression to heart failure after a heart attack," said lead researcher Lisa K. Mullany, Ph.D., of Baylor College of Medicine in Houston. Heart failure after a heart attack is the leading cause of death in humans, and currently there are no definitive therapies other than heart transplantation. Researchers had previously found that MCB-613 stimulates proteins called steroid receptor coactivators ...

WASHINGTON--Children with adrenal insufficiency--a condition in which the adrenal gland does not function properly--are at more than 10 times higher risk for COVID-19 complications and death compared with children with normal adrenal glands, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. Adrenal insufficiency is a disorder that occurs when the adrenal glands, located just above the kidneys, don't make enough of the hormone cortisol. The primary form of adrenal insufficiency is also called Addison's disease. Known as the "stress ...

WASHINGTON--Blood glucose levels improved among children and teens with type 1 diabetes during the first 12 weeks of COVID-19 lockdown in the United Kingdom, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "The findings demonstrate the difficulties faced by patients and families managing type 1 diabetes around school pressures, meals away from home, social life and peer pressure," said lead researcher Neil Lawrence, M.B.Ch.B., of Sheffield Children's Hospital NHS Foundation Trust in Sheffield, United Kingdom. "Children and families found it easier to manage this disease when they were ...

WASHINGTON--The chemicals present in white button mushrooms may slow the progression of prostate cancer, according to a mouse study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "Androgens, a type of male sex hormone, promote the growth of prostate cancer cells by binding to and activating the androgen receptor, a protein that is expressed in prostate cells," said lead researcher Xiaoqiang Wang, M.D., Ph.D., M.B. (A.S.C.P.), of the Beckman Research Institute of City of Hope, a comprehensive cancer center in Duarte, Calif. "White button mushrooms appear to suppress the activity of the androgen receptor." City of Hope's Shiuan ...

WASHINGTON--Women with obesity and polycystic ovarian syndrome (PCOS) are at increased risk of developing type 2 diabetes, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. Normal-weight women with PCOS are not at increased risk, the researchers found. Women with PCOS had a more than three-fold increased risk of developing type 2 diabetes during their lifetime, the study found. This risk was evident only in women who met the criteria for overweight or obesity, but not in lean women. "We strongly suggest weight management in women with obesity and PCOS in an attempt to reduce this major risk of ...

WASHINGTON--Only 3% of patients at high risk for primary aldosteronism (PA), a common disorder that causes high blood pressure and can lead to heart and kidney complications, are screened for the condition, according to a study that will be presented virtually at ENDO 2021, the Endocrine Society's annual meeting. "The results of our study indicate that initiatives to encourage PA screening are crucial for preventing cardiovascular and kidney disease in many patients with hypertension," said lead researcher Seda Grigoryan, M.D., of Michigan State University in Lansing, Mich. PA is the most common form of secondary hypertension--high blood pressure caused by another disease. END ...

WASHINGTON--A lifestyle intervention targeting women with obesity and infertility is more effective in increasing the pregnancy rate compared with fertility treatments, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. The lifestyle intervention, called the Fit-For-Fertility (FFF) program, is a cost-effective alternative to the usual standard of care for women with obesity seeking fertility treatments, according to lead researcher Matea Belan, Ph.D., of the University of Sherbrooke and the Research Center of the Centre Hospitalier Universitaire de Sherbrooke (RC-CHUS) in Quebec, Canada. "Our study shows that the FFF program can significantly improve the pregnancy rate, especially the spontaneous pregnancy ...