Malignant melanoma is a relatively aggressive type of skin cancer. When detected early, it is usually treatable by surgical resection only, but metastases develop often spreading to distant areas. Currently, tumor thickness and the presence of ulceration are some of the known prognostic factors used as indicators of malignant melanoma. Therefore, the discovery of valuable markers to assess the malignant potential of melanoma more accurately may be necessary to develop appropriate treatments. Cross talk between cancer cells and surrounding stromal cells is ...

For the first time, researchers have developed a form of the omega-3 fatty acid docosahexaenoic acid (DHA) that is capable of crossing into the eye’s retina to ward off visual declines related to Alzheimer’s disease, diabetes and other disorders.   The DHA found in fish oil capsules and other supplements is typically in a form called triacylglycerol (TAG) DHA. Although TAG-DHA has benefits in other parts of the body, it does not reach the eyes because it cannot travel from the bloodstream into the retina. For the study, ...

The lower prevalence of ‘risky’ sex—with multiple or new partners without using condoms—which occurred during the early stages of the COVID-19 pandemic, was still evident a year after Britain’s first lockdown, reveal the results of a major national survey, published online in the journal Sexually Transmitted Infections. While there were fewer reported unplanned pregnancies and abortions than indicated by a comparable survey a decade earlier, there were significantly higher prevailing levels of sexual dissatisfaction and worries ...

People with atopic (allergic) diseases like asthma or eczema may be at heightened risk of the painful and often disabling joint condition, osteoarthritis, finds research published online in the Annals of the Rheumatic Diseases. Drugs used to dampen down the physiological prompts for allergic reactions in the body may help lessen this risk, suggest the researchers. Osteoarthritis is the most common form of arthritis. But despite the high prevalence, substantial costs, and debilitating impact of the disease, there is as yet no effective ...

Engaging communities in developing a real-time early warning system could help to reduce the often-devastating impact of flooding on people and property – particularly in mountainous regions where extreme water events are a ‘wicked’ problem, a new study reveals Flash floods are becoming more frequent and damaging to the lives and property of vulnerable people, but researchers believe that using a SMART approach to engage with those living in such areas will help to better signal impending risk from flooding. Scientists believe that combining meteorological data with information on how people live and work in such regions, will help disaster risk ...

For the first time, researchers have identified specific regions of the brain that are damaged by high blood pressure and may contribute to a decline in mental processes and the development of dementia.   High blood pressure is known to be involved in causing dementia and damage to brain function. The study, which is published in the European Heart Journal [1] today (Tuesday), shows how this happens. It gathered information from a combination of magnetic resonance imaging (MRI) of brains, genetic analyses and observational data from thousands of patients to look at the effect of high blood pressure on cognitive function. The researchers then checked their findings ...

Growing concerns over the potential health effects of exposure to phthalates, a component of many plastics and also known as a plasticizer, have led to a search for safer alternatives. In a new study conducted in cell cultures, researchers found that the chemical acetyl tributyl citrate (ATBC) might not be the best replacement because it appears to interfere with the growth and maintenance of neurons.   “In the past, industries have promptly shifted away from the usage of toxic chemicals only to produce an equally toxic chemical, so this is something we are actively trying to avoid repeating,” said Kyle Sease, a graduate student at Central Washington ...

A new study found that people who are currently suffering or face a high risk of post-traumatic stress disorder show particular patterns in four biomarkers measurable with a simple blood test. The findings suggest these biomarkers could be used to predict a person’s likelihood of developing PTSD, diagnose the disorder or monitor the response to treatment.   PTSD can occur after experiencing or witnessing a traumatic event. It is currently diagnosed based on symptoms such as flashbacks, difficulty sleeping or concentrating, ...

M1 and M2 are activated macrophages that protect our immune system and maintain homeostasis. Interestingly, they are characterized by distinct and opposing phenotypes. M1 macrophages are known for their bactericidal and tumoricidal properties by secreting pro-inflammatory cytokines, while M2 macrophages facilitate immunosuppressive responses and help cancer progression. As such, reprogramming macrophages from M2 to M1 phenotype has been regarded as a significant interest in the view of potential cancer ...

People reveal more personal information when you ask them the same questions a second time – according to new research from the University of East Anglia. A new study published today reveals how simple repetition can make people over-disclose, and potentially put themselves at risk of identity theft and cyber crime. The research team say that understanding why people disclose personal data could help inform measures to address the problem. From subscribing to online newspapers to completing customer surveys, our personal data is being mined continuously; the world’s most valuable resource is no longer oil, but data. But for consumers who provide their personal ...

In February of this year, Graphene Flagship associated member Graphenest and manufacturing company Hubron International entered a new strategic partnership. Their shared aim is to explore the development and commercialization of graphene-based polymer masterbatch and compounds with unprecedented electromagnetic interference (EMI) shielding performance for electronic enclosures manufacturing. This new product line will start with a graphene-based thermoplastic suitable to be implemented as a remarkable EMI shielding solution in medium-high and high frequencies (for 5G and beyond). The agreement brings together Graphenest’s knowledge around graphene ...

A new drug combination for men with advanced prostate cancer has shown sustained increase in survival rates. The results from the clinical trial of ENZAMET, co-chaired by Professor Christopher Sweeney, Director of the South Australian immunoGENomics Cancer Institute (SAiGENCI) that operates within the University of Adelaide, have been published today in The Lancet Oncology. For people with metastatic hormone-sensitive prostate cancer, the addition of an androgen receptor blocker with enzalutamide ...

AUGUSTA, Ga. (March 28, 2023) – Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report. That newly found strategy used by tumors that have spread — and are consequently more deadly — may help explain why sometimes promising immunotherapies designed to help the immune system kill cancer don’t, says Kebin Liu, PhD, cancer immunologist in the Department of Biochemistry and Molecular Biology at the Medical College of Georgia. It also may mean an additional therapeutic maneuver is needed to stop some tumors, which ...

FOR IMMEDIATE RELEASE March 27, 2023 Contact: Jillian McKoy, jpmckoy@bu.edu Michael Saunders, msaunder@bu.edu ## Growing evidence suggests that e-cigarettes may serve as a less harmful alternative to smoking traditional cigarettes, but socioeconomic and racial inequities in cigarette and e-cigarette use are preventing certain populations from reaping these potential health benefits, according to a new study led by Boston University School of Public Health (BUSPH) and the Keck School of Medicine of the University of Southern California (Keck School of Medicine of USC). Published in the American Journal of Preventive ...

Berkeley — When University of California, Berkeley, entomologist Kipling Will first heard that former Gov. Jerry Brown was hosting field scientists on his Colusa County ranch, he jumped at the chance to hunt for beetles on the property. “I reached out and said, ‘Hey, I want to sample your beetles,’” Will said. “And [Brown] was quite game to let me come up there.” Will, a professor of environmental science, policy and management, has travelled to all corners of California ...

Reston, VA—A new article in The Journal of Nuclear Medicine explores the potential for using ChatGPT, an artificial intelligence chatbot, in the field of nuclear medicine and molecular imaging. In the article, Irène Buvat, PhD, and Wolfgang Weber, MD, PhD, report on discussions they held with ChatGPT regarding several nuclear medicine and molecular imaging topics and provide their commentary on the pros and cons of using the chatbot. Developed by OpenAI, ChatGPT is a natural language processing chatbot that can intelligently respond to questions. ...

“Ultimately, while both chronological and biological age appear to be important determinants of vaccine-preventable outcomes in older adults, the underlying context and mechanisms of their effects remain unclear.” BUFFALO, NY- March 27, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, “Parsing chronological and biological age effects on vaccine responses.” Researchers ...

A University of Massachusetts Amherst nutrition scientist who has spent his career studying breast milk has demonstrated how beneficial microbes in the gut of infants use nitrogen from human milk to support pediatric nutrition and development. “The molecules in breast milk not only feed the baby but also feed the baby’s microbiome,” says David Sela, associate professor of food science and director of the Fergus M. Clydesdale Center for Foods for Health and Wellness. “This ...

How often do you glance at your neighborhood app, like Nextdoor or others, and learn about some crime in your area? Surely, it was not the intention of the app developers, but every time you hear of a crime nearby you might think that crime in your area is rampant. A new study by a University of Houston psychologist indicates that is exactly how the mind works – those helpful and popular neighborhood apps are actually increasing perceptions of crime rates that may not be as high as you think.  “Neighborhood ...

Cannabis use disorder is defined by the Diagnostic and Statistical Manual of Mental Disorders as a problematic pattern leading to clinically significant impairment or distress, with symptoms that may include increased tolerance, withdrawal symptoms, strong desire to use marijuana and spending large amounts of time using cannabis.   Tammy Chung, director of the Center for Population Behavioral Health at Rutgers Institute for Health, Health Care Policy and Aging Research, along with colleagues Marc Steinberg of Rutgers Robert Wood Johnson Medical School and Mary Barna Bridgeman of the Rutgers ...

WASHINGTON (March 27, 2023) – Today, the Society for Cardiovascular Angiography & Interventions (SCAI) and the Heart Rhythm Society (HRS) released an updated expert consensus statement on transcatheter left atrial appendage closure (LAAC). SCAI and HRS prioritized the development of an updated consensus statement to provide recommendations on contemporary, evidence-based best practices for transcatheter LAAC focusing on endovascular devices. Left atrial appendage closure is a minimally invasive procedure that is used to reduce the risk of stroke associated with atrial fibrillation. ...

A new species of ancient beaver that was rediscovered by researchers in The University of Texas at Austin’s fossil collections has been named after Buc-ee’s, a Texas-based chain of popular travel centers known for its cartoon beaver mascot. The beaver is called Anchitheriomys buceei, or “A. buceei” for short. Steve May, a research associate at the UT Jackson School of Geosciences, said that the beaver’s Texas connection and a chance encounter with a Buc-ee’s billboard are what inspired the name. May is the lead author of the paper that describes A. buceei, along with another, much smaller, species of fossil beaver. Published ...

HOUSTON – (March 27, 2023) – Rice University bioscientist and synthetic biologist James Chappell has won a National Science Foundation CAREER Award to develop RNA programming methods to improve human health and the environment. “Synthetic biology has progressed a lot in the past decade, and we’ve gotten really good at genetically programming microbes in confined laboratory environments where conditions are ideal,” said Chappell, an assistant professor both of biosciences and of bioengineering. “But, of course, most microbes on the planet don't live in pure cultures where the temperature is always 37 degrees ...

Scientists seeking a way to eliminate an adverse reaction to treatments for acute lymphocytic leukemia, a common childhood cancer, have found what they believe to be an early warning indicator. Mouse studies conducted by Rutgers researchers as part of a larger scientific team are pointing to vitamin A levels as a signal that a patient may or may not be vulnerable to a dangerous toxicity. Summarizing their findings in Science Translational Medicine, the scientists found that, in patients being treated for acute lymphocytic leukemia with the chemotherapy drug asparaginase, there is an ...

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health. In the study, researchers used a new quantitative method to show that HIV in specific myeloid cells—short-lived monocytes and longer-lived monocyte-derived macrophages—can be reactivated and infect new cells. The findings, published in Nature Microbiology, suggest that ...