CHAPEL HILL, NC - UNC School of Medicine scientists led a collaboration of researchers to demonstrate a potentially powerful new strategy for treating cystic fibrosis (CF) and potentially a wide range of other diseases. It involves small, nucleic acid molecules called oligonucleotides that can correct some of the gene defects that underlie CF but are not addressed by existing modulator therapies. The researchers used a new delivery method that overcomes traditional obstacles of getting oligonucleotides into lung cells. As the scientists reported in the journal Nucleic Acids Research, they demonstrated the striking effectiveness of their approach in cells derived from a CF patient and in mice. "With our oligonucleotide delivery platform, we were able to restore the activity of ...

Stuttgart/Boulder - It is not the first time that spiders have served as biological models in the research field of soft robotics. The hydraulic actuation mechanisms they apply to move their limbs when weaving their web or hunting for prey give them powers many roboticists and engineers have drawn inspiration from. A team of researchers at the Max Planck Institute for Intelligent Systems in Germany and at the University of Boulder in Colorado in the US has now found a new way to exploit the principles of spiders' joints to drive articulated robots without any bulky components and connectors, which weigh down the robot and reduce portability and speed. Their slender and lightweight simple ...

Magnetic-spin interactions that allow spin-manipulation by electrical control allow potential applications in energy-efficient spintronic devices. An antisymmetric exchange known as Dzyaloshinskii-Moriya interactions (DMI) is vital to form various chiral spin textures, such as skyrmions, and permits their potential application in energy-efficient spintronic devices. Published this week, a Chinese-Australia collaboration has for the first time illustrated that DMI can be induced in a layered material tantalum-sulfide (TaS2) by intercalating iron atoms, and can further be tuned by gate-induced proton intercalation. REALIZING AND TUNING DMI IN VAN-DER-WAALS MATERIAL TaS2 Searching ...

WASHINGTON --Just a small number of cells found in tumors can enable and recruit other types of cells nearby, allowing the cancer to spread to other parts of the body, report END ...

It sounds like a plot from a Quentin Tarantino movie -- something sets off natural killers and sends them on a killing spree. But instead of characters in a movie, these natural killers are part of the human immune system and their targets are breast cancer tumor cells. The triggers are fusion proteins developed by Clemson University researchers that link the two together. "The idea is to use this bifunctional protein to bridge the natural killer cells and breast cancer tumor cells," said Yanzhang (Charlie) Wei, a professor in the College of Science's Department of Biological Sciences. "If the two cells are brought close enough together through this receptor ligand connection, the natural killer cells can release what I call killing machinery to have the tumor cells killed." It's ...

A group of researchers from the University of Jyvaskyla and Stanford University were part of an expedition to French Guiana to study tropical frogs in the Amazon. Various amphibian species of this region use ephemeral pools of water as their nurseries, and display unique preferences for specific physical and chemical characteristics. Despite species-specific preferences, researchers were surprised to find tadpoles of the dyeing poison frog surviving in an incredible range of both chemical (pH 3-8) and vertical (0-20 m in height) deposition sites. This research was published in the journal Ecology and Evolution in June 2021. Neotropical frogs are special because, unlike species in temperate regions, many tropical frogs ...

Postdoctoral Researcher Outi Keinänen from the University of Helsinki developed a method to radiolabel plastic particles in order to observe their biodistribution on the basis of radioactivity with the help of positron emission tomography (PET). As a radiochemist, Keinänen has in her previous radiopharmaceutical studies utilised PET imaging combined with computed tomography (CT), which produces a very accurate image of the anatomical location of the radioactivity signal. In the recently completed study, radiolabelled plastic particles were fed to mice, and their elimination from the body was followed with PET-CT scans. This was the first time that ...

Research published today in the Journal of General Virology has identified missed cases of SARS-CoV-2 by retrospective testing of throat swabs. Researchers at the University of Nottingham screened 1,660 routine diagnostic specimens which had been collected at a Nottingham hospital between 2 January and 11 March 2020 and tested for SARS-CoV-2 by PCR. At this stage of the pandemic, there was very little COVID-19 testing available in hospitals, and to qualify patients had to meet a strict criterion, including recent travel to certain countries in Asia or contact with a known positive case. Three previously unidentified cases of SARS-CoV-2 infection were identified by the retrospective screening, including one from a 75-year-old ...

The phenomenon of quantum nonlocality defies our everyday intuition. It shows the strong correlations between several quantum particles some of which change their state instantaneously when the others are measured, regardless of the distance between them. While this phenomenon has been confirmed for slow moving particles, it has been debated whether nonlocality is preserved when particles move very fast at velocities close to the speed of light, and even more so when those velocities are quantum mechanically indefinite. Now, researchers from the University of Vienna, the Austrian Academy of Sciences and the Perimeter Institute report in the latest issue of Physical Review Letters that ...

Tokyo, Japan - Colloids--mixtures of particles made from one substance, dispersed in another substance--crop up in numerous areas of everyday life, including cosmetics, food and dyes, and form important systems within our bodies. Understanding the behavior of colloids therefore has wide-ranging implications, yet investigating the rotation of spherical particles has been challenging. Now, an international team including researchers from The University of Tokyo Institute of Industrial Science has created particles with an off-center core or "eye" that can be tracked ...

Getting energy and nutrients from the environment - that is, eating - is such an important function that it has been regulated through sophisticated mechanisms over hundreds of millions of years. Some of these mechanisms are only now beginning to be unravelled. A group at the Spanish National Cancer Research Centre (CNIO) has found one of their key components - a switch that controls the ability of organisms to adapt to low cellular nutrient levels. The protein involved is RagA, which is part of the mTOR molecular pathway, whose importance in metabolic activity regulation has been known for decades now. CNIO researchers have found that if RagA is continuously activated, cells do not know that there are no sufficient nutrients and so ...

The encryption algorithm GEA-1 was implemented in mobile phones in the 1990s to encrypt data connections. Since then, it has been kept secret. Now, a research team from Ruhr-Universität Bochum (RUB), together with colleagues from France and Norway, has analysed the algorithm and has come to the following conclusion: GEA-1 is so easy to break that it must be a deliberately weak encryption that was built in as a backdoor. Although the vulnerability is still present in many modern mobile phones, it no longer poses any significant threat to users, according to the researchers. Backdoors not useful according to researchers "Even though intelligence services and ministers of the interior understandably want such backdoors ...

ENVIRONMENT Diesel-polluted soil from now defunct military outposts in Greenland can be remediated using naturally occurring soil bacteria according to an extensive five-year experiment in Mestersvig, East Greenland, to which the University of Copenhagen has contributed. Mothballed military outposts and stacks of rusting oil drums aren't an unusual sight in Greenland. Indeed, there are about 30 abandoned military installations in Greenland where diesel, once used to keep generators and other machinery running, may have seeped into the ground. This is the case with Station 9117 Mestersvig, an abandoned military airfield ...

These findings were published in the journal Cellular and Molecular Life Sciences on 8 June 2021. Huge splicing diversity in the brain The human genome was sequenced around 20 years ago. Since then, the sequence information encoding our proteins is known - at least in principle. However, this information is not continuously stored in the individual genes, but is divided into smaller coding sections. These coding sections, also known as exons, are assembled in a process called splicing. Depending on the gene, different exon combinations are possible, which is why they are referred to as different or ...

With increasing vaccination rates and decreasing numbers of infections, the population's feeling of safety is also rising. As the results of the 37th edition of the BfR-Corona-Monitor, a regular survey conducted by the German Federal Institute for Risk Assessment (BfR), show, the majority of the population in Germany thinks it can control its risk of an infection well. "62 percent are confident that they can protect themselves from an infection with the coronavirus," says BfR-President Professor Dr. Dr. Andreas Hensel. "We see that the feeling of safety has increased considerably. ...

Chinese researchers have recently discovered links between reduction in microbial stability and soil carbon loss in the active layer of degraded alpine permafrost on the Qinghai-Tibet Plateau (QTP). The researchers, headed by Prof. CHEN Shengyun from the Northwest Institute of Eco-Environment and Resources (NIEER) of the Chinese Academy of Sciences (CAS), and XUE Kai from University of Chinese Academy of Sciences, conducted a combined in-depth analysis of soil microbial communities and their co-occurrence networks in the active permafrost layer along an extensive gradient of permafrost degradation. The QTP encompasses the largest extent of high-altitude mountain ...

Greater Helsinki -- Transitioning to low-carbon energy production is the biggest climate challenge to overcome. Many countries are already looking to adopt clean heating solutions more widely, with the International Energy Agency projecting that by 2045 nearly half of global heating will be done with heat pumps. To ensure speedy uptake, governments are likely to offer subsidies to ensure these energy-efficient options actually make their way into homes and offices. A new study from Aalto University assesses the impact of heat pumps on energy consumption as well as how ...

Research published in the journal ACS Materials and Interfaces has provided new understanding of how false-negative results in Lateral Flow Tests occur and provides opportunity for simple improvements to be made. Lateral Flow Devices were introduced late in 2020 on a global scale to help detect novel coronavirus infection in individuals, with test results produced rapidly in half an hour or less. However, their potential has been somewhat hindered by inadequate sensitivity, with a high number of false-negative results. Using X-ray fluorescence imaging from Diamond Light Source, researchers from King's College London ...

Researchers from the University of Kent's School of Psychology have found that when people are presented with the idea of a Covid-19 "immunity passport", they show less willingness to follow social distancing and face covering guidelines. However, this willingness seems to return when people read more cautious information about Covid-19 immunity. PhD students Ricky Green and Mikey Biddlestone and Professor Karen Douglas asked participants from the UK and USA to imagine they had either recovered from Covid-19 or were currently infected. Participants asked to imagine ...

Several different causes of ageing have been discovered, but the question remains whether there are common underlying mechanisms that determine ageing and lifespan. Researchers from the Max Planck Institute for Biology of Ageing and the CECAD Cluster of Excellence in Ageing research at the University Cologne have now come across folate metabolism in their search for such basic mechanisms. Its regulation underlies many known ageing signalling pathways and leads to longevity. This may provide a new possibility to broadly improve human health during ageing. In recent decades, ...

In an international study published by the journal Environment International, the University of Surrey led an international team of air pollution experts in monitoring pollution hotspots in 10 global cities: Dhaka (Bangladesh); São Paulo (Brazil); Guangzhou (China); Medellín (Colombia); Cairo (Egypt); Addis Ababa (Ethiopia); Chennai (India); Sulaymaniyah (Iraq); Blantyre (Malawi); and Dar-es-Salaam (Tanzania). Surrey's Global Centre for Clean Air Research (GCARE) set out to investigate whether the amount of fine air pollution particles (PM2.5) drivers inhaled is connected to the duration drivers spend in pollution hotspots and socio-economic indicators such ...

2 June 2021, Singapore - The human fetal immune system begins to develop early during gestation, however, factors responsible for fetal immune-priming remain elusive. Using multiple complementary approaches, Dr Florent Ginhoux from A*STAR's Singapore Immunology Network (SIgN), Professor Jerry Chan from KK Women's and Children's Hospital (KKH), Professor Salvatore Albani from the SingHealth Duke-NUS Translational Immunology Institute, with collaborators from Cambridge University explored potential exposure to microbial agents in-utero. The team identified live microbes across fetal organs that stimulate activation of fetal T-cells during the second trimester of gestation. Study published in scientific journal, Cell, on 24 June 2021. The team profiled microbes ...

Do you like the thick brush strokes and soft color palettes of an impressionist painting such as those by Claude Monet? Or do you prefer the bold colors and abstract shapes of a Rothko? Individual art tastes have a certain mystique to them, but now a new Caltech study shows that a simple computer program can accurately predict which paintings a person will like. The new study, appearing in the journal Nature Human Behaviour, utilized Amazon's crowdsourcing platform Mechanical Turk to enlist more than 1,500 volunteers to rate paintings in the genres of impressionism, cubism, abstract, and color field. The volunteers' answers were fed into a computer program and then, after this training period, the computer ...

Chatbots hold promise for dementia patient or caregiver support, but are still in their infancy, finds a paper published in the Journal of Medical Internet Research. None of the interactive digital apps tested by medical researchers and a computer scientist performed well on all testing criteria, and all the apps contained linguistic biases and usability challenges. The authors conclude that until developers produce evidence-based chatbots that have undergone end user evaluation it will be hard to evaluate their potential to adequately educate and support dementia patients and their caregivers. "Dementia care is complex and no two cases of dementia are alike. Chatbots have the potential of providing ...

Ozone is a pollutant at ground level, but very high in the atmosphere's "ozone layer," it absorbs damaging ultraviolet radiation. Past studies have examined ozone levels in the Southern Hemisphere, but little is known about levels of the molecule in Antarctica over long periods. Now, researchers reporting in ACS' Environmental Science & Technology have analyzed more than 25 years of Antarctic data, finding that concentrations near the ground arose from both natural and human-related sources. Ozone gas has a sharp or acrid scent that sometimes accompanies smog or summer storms. It forms when sunlight ...