Thousands of our daily activities, from making coffee to taking a walk to saying hello to a neighbor, are made possible through an ancient collection of brain structures tucked away near the center of the cranium. The cluster of neurons known as the basal ganglia is a central hub for regulating a vast array of routine motor and behavior functions. But when signaling in the basal ganglia is weakened or broken, debilitating movement and psychiatric disorders can emerge, including Parkinson's disease, Tourette's syndrome, attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive ...

Alzheimer's disease treatments that slow progression of the disease could significantly reduce the financial burden to U.S. state budgets, according to a new USC study. The study outlines how states -- which have been hit particularly hard by the COVID-19 pandemic -- would see relief: Medicare would cover the costs of treating the disease, while Medicaid expenditures would be reduced due to fewer patients entering nursing homes. Assuming a 40% relative reduction of Alzheimer's disease progression rates with treatment, researchers projected two decades of savings beginning in 2021, using a simulation model of state Medicaid programs. They forecast annual savings for Medicaid programs of $7.4 billion in 2030; by 2040, the annual savings would be more than $22 billion. All ...

March 10, 2021 - Hackensack, NJ - Convalescent plasma, the use of survivors' antibodies transfused into sick COVID-19 patients is safe and significantly improves clinical outcomes when using high levels of antibodies, according to a new publication by scientists at Hackensack Meridian Health, New Jersey's largest and most comprehensive health network. The treatment was safe, transferred the survivors' antibodies, and did not prevent the recipients from making their own antibodies, according to the results published recently in the journal JCI Insights. "We have developed this technique and methodology to save the lives of patients," said Michele Donato, ...

Public trust in the federal Centers for Disease Control and Prevention has fallen during the coronavirus pandemic, with the decline bringing overall population-level trust in the agency to the same lower level of trust long held by Black Americans about the agency, according to a new RAND Corporation study. Surveys done among a representative group of Americans in May and October of 2020 show about a 10% decline in trust of the CDC over that period. In contrast, the same research found that public trust in the U.S. Postal Service and the Federal Emergency Management Agency increased significantly over the period, despite those agencies facing their own challenges. "The Biden administration will have an uphill ...

New research suggests anxiety among men transitioning into parenthood is significantly higher than reported by the global World Health Organization (WHO) regional prevalence rates. In a new study published in The Journal of Psychosomatic Obstetrics & Gynecology, researchers from the Colorado School of Public Health on the University of Colorado Anschutz Medical Campus studied the prevalence of anxiety among fathers during the perinatal period, which includes pregnancy through the first year of postpartum. "The transition to parenthood is a major life event that's often accompanied with new challenges related to financial, relationship, and work-life balance concerns. Despite those changes happening for both men and women, not much is known about the prevalence of anxiety ...

The diffraction limit, also known as Abbe diffraction limit in optics, poses a great challenge in many systems that involve wave dynamics, such as imaging, astronomy, and photolithography. For example, the best optical microscope only possesses resolution around 200 nm, but the physical size of the photolithography process with an excimer laser is around tens of nanometers. Meanwhile, physical sizes in current research and applications in biology and the semiconductor industry have scaled down to several nanometers, which is far beyond the ability of optical waves. According ...

A new publication from the Dauphin Island Sea Lab's Marine Mammal Research Program (DISL) examines how bridge-building and in-water construction activities may affect manatees and other large aquatic species. The article, which was recently published in END ...

ORLANDO, April 5, 2021 - A new study from the University of Central Florida suggests that masks and a good ventilation system are more important than social distancing for reducing the airborne spread of COVID-19 in classrooms. The research, published recently in the journal Physics of Fluids, comes at a critical time when schools and universities are considering returning to more in-person classes in the fall. "The research is important as it provides guidance on how we are understanding safety in indoor environments," says Michael Kinzel, an assistant professor in UCF's Department of Mechanical and Aerospace Engineering and study co-author. "The study finds that aerosol transmission routes do not display ...

DURHAM, N.C. - A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation. The finding, which appears April 2 in Gastroenterology, indicates that the keratinocyte cells of the skin surface are acting as what lead researcher Wolfgang Liedtke, MD PhD, calls 'pre-neurons.' "The skin cells themselves are sensory under certain conditions, specifically the outermost layer of cells, the keratinocytes," said Liedtke, who is a professor of neurology ...

Despite the continued development and commercialization of various wearable electronic devices, such as smart bands, progress with these devices has been curbed by one major limitation, as they regularly need to be recharged. However, a new technology developed by a South Korean research team has become a hot topic, as it shows significant potential to overcome this limitation for wearable electronic devices. The Korea Institute of Science and Technology (KIST), or KIST, announced that a research team led by Director Jin-Sang Kim of the Jeonbuk Institute of Advanced Composite ...

A new study at Tel Aviv University reveals a possible defense mechanism developed by fireflies for protection against bats that might prey on them. According to the study, fireflies produce strong ultrasonic sounds - soundwaves that the human ear, and more importantly the fireflies themselves, cannot detect. The researchers hypothesize that these sounds are meant for the ears of bats, keeping them away from the poisonous fireflies, and thereby serving as a kind of 'musical armor'. The study was led by Prof. Yossi Yovel, Head of the Sagol School of Neuroscience, and a member of the School of Mechanical Engineering and the School of Zoology at the George S. Wise Faculty of Life Sciences. It was conducted in collaboration with the Vietnam Academy of Science and Technology (VAST). ...

Could the next Hollywood blockbuster be written by a computer? Scientists from the University of Granada (UGR) and the University of Cádiz (UCA) have designed the world's first computer system based on artificial intelligence techniques that can help film scriptwriters create storylines with the best chance of box-office success. The researchers focused their analysis on the "tropes" of existing films--that is, the commonplace, predictable, and even necessary clichés that repeatedly feature in film plots, based on rhetorical figures. These storytelling devices and conventions enable directors to readily convey scenarios that ...

A lot of people think regret must be a good thing because it helps you not repeat a mistake, right? But that turns out not to be the case. Not even when it comes to casual sex, according to new research from the Norwegian University of Science and Technology's (NTNU) Department of Psychology. "For the most part, people continue with the same sexual behaviour and the same level of regret," says Professor Leif Edward Ottesen Kennair. So, we repeat what we thought was a mistake, and we regret it just as much the next time around. Professor Kennair and colleagues professor Mons Bendixen and postdoctoral ...

Scientists from Russia and Germany studied the molecular composition of carbonaceous chondrites - the insoluble organic matter of the Murchison and Allende meteorites - in an attempt to identify their origin. Ultra-high resolution mass spectrometry revealed a wide diversity of chemical compositions and unexpected similarities between meteorites from different groups. The research was published in the Scientific Reports. Carbonaceous chondrites contain nearly the entire spectrum of organic molecules encountered on Earth, including nucleic acids which might have played a pivotal role in the origin of life. Since the majority of modern meteorites are of nearly the same age ...

WHO Ingrid Katz, MD, MHS, Associate Physician, Department of Medicine, Brigham and Women's Hospital; lead author of a new Perspective piece published in the New England Journal of Medicine. WHAT While the U.S. has begun to vaccinate millions of Americans each day, COVID-19 vaccine supplies around the world remain scarce. Experts estimate that 80 percent of people in low-resource countries will not receive a vaccine in 2021. At the time of the paper's writing, the global vaccination rate was 6.7 million doses per day -- a rate at which it would take 4.6 years to achieve global herd immunity. In a new Perspective piece in the New England Journal of Medicine, Katz and colleagues highlight the need ...

A recent study of more than 2,000 companies finds that corporations feeling the pinch of financial constraints can benefit significantly from taking a more aggressive stance in their tax planning strategies. One takeaway of the finding is that tax authorities should look closely at the activities of companies facing financial constraints to make sure their tax activities don't become too aggressive. Financial constraints aren't unusual and occur when a company can't afford to fund a project that would increase its value. Sometimes the constraints are caused by an external event - like a pandemic - that leaves companies with less income than they were anticipating. ...

Manufacturing - Mighty Mo Oak Ridge National Laboratory scientists proved molybdenum titanium carbide, a refractory metal alloy that can withstand extreme temperature environments, can also be crack free and dense when produced with electron beam powder bed fusion. Their finding indicates the material's viability in additive manufacturing. Molybdenum, or Mo, as well as associated alloys, are difficult to process through traditional manufacturing because of their high melting temperature, reactivity with oxygen and brittleness. To address these shortcomings, the team formed a Mo metal matrix composite by mixing molybdenum and titanium carbide powders and used an electron beam to melt the ...

Piping plover breeding groups in the Northern Great Plains are notably connected through movements between habitats and show lower reproductive rates than previously thought, END ...

A comprehensive assessment of 12 different strategies for reducing beef production emissions worldwide found that industry can reduce greenhouse gas (GHG) emissions by as much as 50% in certain regions, with the most potential in the United States and Brazil. The study, " END ...

In 2018, Kang-Kuen Ni and her lab earned the cover of Science with an impressive feat: They took two individual atoms, a sodium and a cesium, and forged them into a single dipolar molecule, sodium cesium. Sodium and cesium normally ignore each other in the wild; but in the Ni lab's carefully calibrated vacuum chamber, she and her team captured each atom using lasers and then forced them to react, a capability that gifted scientists with a new method to study one of the most basic and ubiquitous processes on Earth: the formation of a chemical bond. With Ni's invention, scientists could not only discover more about our chemical underpinnings, they could start creating ...

Syracuse, N.Y. - Emergency medical service (EMS) workers face triple the risk for significant mental health problems such as depression and posttraumatic stress disorder compared to the general population, according to a recently published study by researchers from Syracuse University. The study also showed that daily mental health symptoms for EMS workers can be reduced through recovery activities such as exercising, socializing with other people, and finding meaning in the day's challenges. The study, " END ...

Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report. Also seemingly paradoxically, patients with high expression of this "21-gene cell death signature" the researchers have identified, have indicators that their immune system is attacking the cancer, like higher levels of cytotoxic T cells, which typically kill cancer. But they also have high levels of molecules that can suppress those T cells, helping transform them into dysfunctional, "exhausted" T cells, they report in the journal Cancers. This novel genomic signature can be used both to better predict how a patient with ...

In 2020, the International Agency for Research on Cancer of the World Health Organization stated that breast cancer accounts for most cancer morbidities and mortalities in women worldwide. This alarming statistic not only necessitates newer methods for the early diagnosis of breast cancer, but also brings to light the importance of risk prediction of the occurrence and development of this disease. Ultrasound is an effective and noninvasive diagnostic procedure that truly saves lives; however, it is sometimes difficult for ultrasonologists to distinguish between malignant tumors and other ...

X-Ray Experiments, Machine Learning Could Trim Years Off Battery R&D By Glenn Roberts Jr. An X-ray instrument at Berkeley Lab contributed to a battery study that used an innovative approach to machine learning to speed up the learning curve about a process that shortens the life of fast-charging lithium batteries. Researchers used Berkeley Lab's Advanced Light Source, a synchrotron that produces light ranging from the infrared to X-rays for dozens of simultaneous experiments, to perform a chemical imaging technique known as scanning transmission ...

Parkinson's disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease's progression has been largely tied to the loss of motor functions, non-motor symptoms, including the loss of cognitive abilities, often emerge early in the disease. Much less understood is the role that specific neural circuits play in these distinct motor and non-motor functions. A new study led by neurobiologists at the University of California San Diego and their colleagues found that specific, identifiable neural pathways are charged with particular functions during stages of the disease. ...