Comorbidities such as heart disease, respiratory disease, renal disease and cancer lead to an increased risk of death from Covid-19 according to new research from the University of East Anglia (UEA) and the Norfolk and Norwich University Hospital (NNUH). At the start of the pandemic, there was concern that specific medications for high blood pressure could be linked with worse outcomes for Covid-19 patients. Previous research from the UEA team showed this wasn't the case and that medications for high blood pressure could, in fact, improve Covid-19 survival rates and reduce the severity of infection. New findings, published today in the Journal of the American Medical Association (JAMA) Network Open, additionally show that it is comorbidities such as heart disease, respiratory ...

Mount Sinai researchers have identified genetic and cellular mechanisms of Crohn's disease, providing new insights for future treatments that could offer a tailored approach to patients with the chronic inflammatory disease, according to a study published in END ...

CAMBRIDGE, MA -- When someone is sick, it's natural to want to stay as far from them as possible. It turns out this is also true for mice, according to an MIT study that also identified the brain circuit responsible for this distancing behavior. In a study that explores how otherwise powerful instincts can be overridden in some situations, researchers from MIT's Picower Institute for Learning and Memory found that when male mice encountered a female mouse showing signs of illness, the males interacted very little with the females and made no attempts to mate with them as they normally would. The researchers also showed that this behavior is controlled by a circuit in the amygdala, which detects distinctive odors from sick animals and triggers a warning signal ...

NEW YORK, NY (March 31, 2021)--A shift in the definition of high blood pressure may help identify more women who are at risk of developing life-threatening complications during pregnancy and delivery, suggests a new study from Columbia University Vagelos College of Physicians and Surgeons. Under the stricter definition, more than 50,000 additional women each year in the United States could become eligible for treatment with aspirin in pregnancy, which lowers the risk of developing preeclampsia, a sudden increase in blood pressure that can lead to stroke, seizures, hemorrhage, and death. The ...

What The Study Did: This study sought to assess dermatologists' perceptions of and experiences with teledermatology in the context of the COVID-19 pandemic and new regulatory changes including parity in reimbursements between video and in-person visits. Authors: Jules B. Lipoff, M.D., of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamadermatol.2020.0195) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, ...

What The Study Did: Researchers compared mortality and severe adverse events in this systematic review and meta-analysis of 52 studies that evaluated clinical outcomes among nearly 102,000 patients with COVID-19 who did and didn't receive angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs). Authors: Vassilios S. Vassiliou, M.B.B.S., Ph.D., of the University of East Anglia in Norwich, United Kingdom is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.3694) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, ...

What The Study Did: This study identified risk factors for SARS-CoV-2 incidence, hospitalization and death among nursing home residents in the United States. Authors: James S. Goodwin, M.D., of the University of Texas Medical Branch in Galveston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.6315) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media ...

What The Study Did: This study documented how perception of risk of infection and severe complications from COVID-19 were associated with underlying reported health. Authors: Robert F. Schoeni, Ph..D., of the University of Michigan in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.3984) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

What The Study Did: In this decision analytical modelling study, researchers investigated the association of school reopening or closure with new and cumulative COVID-19 case numbers compared with other community-based interventions. Authors: David Naimark, M.D., M.Sc., of the Sunnybrook Health Sciences Centre in Toronto, Canada, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.3793) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict ...

CAMBRIDGE, MA -- Thousands of different bacterial species live within the human gut. Most are beneficial, while others can be harmful. A new study from an MIT-led team has revealed that these bacterial populations can remake themselves within the lifetime of their host, by passing genes back and forth. The researchers also showed that this kind of gene transfer occurs more frequently in the microbiomes of people living in industrialized societies, possibly in response to their specific diets and lifestyles. "One unexpected consequence of humans living ...

For middle-aged women, exercise has many health benefits, but it may not help maintain cognitive function over the long term, according to a new UCLA Health study. The study observed a diverse group of roughly 1,700 women over a 21-year period starting when the women's average age was 45. In the study, women's cognitive ability was tested in three key areas: cognitive processing speed (how fast the mind works); verbal memory (the ability to recall a story that they heard); and working memory (the ability to manipulate information). The study was published in JAMA Network Open, and is one of the first ...

LA JOLLA, CA--What's the difference between a giggle and a belly laugh? Or a yelp and an all-out scream? In many species, including humans, the volume and duration of a verbal sound conveys as much information as the noise itself. A group of scientists, led by Scripps Research, has discovered a node in the brains of male mice that modulates the sounds they make in social situations. This discovery, published in Nature, could help identify similar locations in the human brain, and potentially lead to a better understanding of social disorders such as autism or depression. "Identifying this node gives us signatures of what to look for when human behavior goes awry," says Lisa Stowers, PhD, a neuroscientist and professor at Scripps Research who led the study. ...

Harvard University researchers have identified the biological mechanism of how chronic stress impairs hair follicle stem cells, confirming long-standing observations that stress might lead to hair loss. In a mouse study published in the journal Nature, the researchers found that a major stress hormone causes hair follicle stem cells to stay in an extended resting phase, without regenerating the hair follicle and hair. The researchers identified the specific cell type and molecule responsible for relaying the stress signal to the stem cells, and showed that this pathway can be potentially targeted to restore hair growth. "My lab is interested in understanding how stress affects ...

Swansea University physicists, as leading members of the ALPHA collaboration at CERN, have demonstrated laser cooling of antihydrogen atoms for the first time. The groundbreaking achievement produces colder antimatter than ever before and enables an entirely new class of experiments, helping scientists learn more about antimatter in future. In a paper published today in Nature, the collaboration reports that the temperature of antihydrogen atoms trapped inside a magnetic bottle is reduced when the atoms scatter light from an ultraviolet laser beam, slowing the atoms down and reducing the space they occupy in the bottle -- both vital aspects of future more detailed ...

Scientists have developed vaccines for COVID-19 with record speed. The first two vaccines widely distributed in the U.S. are mRNA-based and require ultracold storage (-70 C for one and -20 C for the other). Now, researchers reporting in ACS Omega have developed a tamper-proof temperature indicator that can alert health care workers when a vial of vaccine reaches an unsafe temperature for a certain period, which could help ensure distribution of effective mRNA vaccines. The two COVID mRNA vaccines contain instructions for building harmless pieces of the SARS-CoV-2 spike protein. Once the vaccine is injected into the body, human cells use the mRNA instructions to make the spike protein, which they temporarily ...

Increased consumption of flavanols - a group of molecules occurring naturally in fruit and vegetables - could protect people from mental stress-induced cardiovascular events such as stroke, heart disease and thrombosis, according to new research. Researchers have discovered that blood vessels were able to function better during mental stress when people were given a cocoa drink containing high levels of flavanols than when drinking a non-flavanol enriched drink. A thin membrane of cells lining the heart and blood vessels, when functioning efficiently the endothelium helps ...

LAWRENCE -- New research from the University of Kansas END ...

Meat and fish fraud are global problems, costing consumers billions of dollars every year. On top of that, mislabeling products can cause problems for people with allergies, religious or cultural restrictions. Current methods to detect this fraud, while accurate, are slower than inspectors would like. Now, researchers reporting in ACS' Journal of Agricultural and Food Chemistry have optimized their handheld MasSpec Pen to identify common types of meat and fish within 15 seconds. News stories of food fraud, such as beef being replaced with horse ...

SAN ANTONIO (March 31, 2021) -- Insomnia and obstructive sleep apnea have increased dramatically among active-duty military members over a 14-year period, 2005 through 2019. Insomnia increased 45-fold and sleep apnea went up more than 30-fold, according to a study led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio). The study found that the most likely military member to be diagnosed with either sleep disorder was married, male, white, a higher-ranking enlisted Army service member and age 40 or older. The researchers compared medical codes that represent diagnosis of sleep apnea or insomnia in active-duty Army, Navy, Marine Corps and Air Force personnel. No medical ...

Risks of SARS-CoV-2 coronavirus infection for long-stay nursing home residents were mainly dependent on factors in their nursing homes and surrounding communities, according to a large study led by a researcher at the Johns Hopkins Bloomberg School of Public Health. By contrast, the study found that the risks of being hospitalized with, and of dying from, COVID-19, depended more on patient-specific characteristics such as age and body mass index--although the mix of factors linked to hospitalization was distinct from the mix of factors linked to mortality. The study, which appears online March 31 in JAMA Network Open, detailed COVID-19 risk factors among more than 480,000 long-stay nursing home residents in the ...

Roughly five years ago, Institute Head Prof. Dr. William (Bill) Martin and his team introduced the last universal common ancestor of all living organisms and named it "LUCA". It lived approximately 3.8 billion years ago in hot deep sea hydrothermal vents. Now the evolutionary biologists in Duesseldorf have described a further ancient cell named "LBCA" ("Last Bacterial Common Ancestor"). It is the ancestor of today's largest domain of all living organisms: Bacteria. In Communications Biology, they report on their new research approaches which led to the successful prediction ...

Every day, people are exposed to microplastics from food, water, beverages and air. But it's unclear just how many of these particles accumulate in the human body, and whether they pose health risks. Now, researchers reporting in ACS' Environmental Science & Technology have developed a lifetime microplastic exposure model that accounts for variable levels from different sources and in different populations. The new model indicates a lower average mass of microplastic accumulation than previous estimates. Microplastics, which are tiny pieces of plastic ranging in size from 1 μm to 5 mm (about the ...

In Brazil, researchers are puzzling over socioeconomic and environmental indicators that do not add up. They are concerned with what they call the São Paulo Macrometropolitan Area, a mega-region comprising five metropolitan areas in the state of São Paulo with a total of 180 municipalities, some of which provide ecosystem services while others receive them. The problem is that the former, which provide the others with water, food and power generation inputs, suffer from steep inequities in terms of defective human development and lack of social inclusion. "Urban centers have always been ...

Glass, rubber and plastics all belong to a class of matter called amorphous solids. And in spite of how common they are in our everyday lives, amorphous solids have long posed a challenge to scientists. Since the 1910s, scientists have been able to map in 3D the atomic structures of crystals, the other major class of solids, which has led to myriad advances in physics, chemistry, biology, materials science, geology, nanoscience, drug discovery and more. But because amorphous solids aren't assembled in rigid, repetitive atomic structures like crystals are, they have defied researchers' ability to determine their atomic structure with the same level of precision. Until now, that is. ...

Sugar practically screams from the shelves of your grocery store, especially those products marketed to kids. Children are the highest consumers of added sugar, even as high-sugar diets have been linked to health effects like obesity and heart disease and even impaired memory function. However, less is known about how high sugar consumption during childhood affects the development of the brain, specifically a region known to be critically important for learning and memory called the hippocampus. New research led by a University of Georgia faculty member in collaboration with a University ...