Newly published papers further elucidate the mechanisms underlying pridopidine's neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidine's therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, ...

COLUMBUS, Ohio - A comprehensive analysis of 437 studies from around the world provides the best evidence to date that narcissism is an important risk factor for both aggression and violence, researchers said. The link between narcissism and aggression was found for all dimensions of narcissism and for a variety of types of aggression. Results were similar regardless of gender, age, whether they were college students, or country of residence. And, to have an impact, narcissism doesn't have to be at levels so high as to be pathological. Findings showed ...

Two articles published online today by Alzheimer's & Dementia: Translational Research & Clinical Interventions, a journal of the Alzheimer's Association, show substantial changes in the focus and funding of clinical trials for Alzheimer's disease therapies. The newly published articles throw a greater spotlight on a decision -- now before the U.S. Food and Drug Administration (FDA) -- that would potentially bring a new drug therapy to Alzheimer's patients for the first time in nearly 20 years. Researchers analyzed clinicaltrials.gov, the U.S. National Library of Medicine's database, and five years of annual Alzheimer's pipeline reviews published by UNLV School of Integrated Health Sciences research professor Jeffrey L. Cummings ...

Researchers at the Vienna BioCenter designed a testing protocol for SARS-CoV-2 that can process tens of thousands of samples in less than 48 hours. The method, called SARSeq, is published in the journal Nature Communications and could be adapted to many more pathogens. The COVID-19 pandemic has lasted more than a year and continues to impact our lives tremendously. Although some countries have launched speedy vaccination campaigns, many still await large-scale immunization schemes and effective antiviral therapies - before that happens, the world urgently needs to regain a semblance ...

While we sleep, the brain produces particular activation patterns. When two of these patterns - slow oscillations and sleep spindles - gear into each other, previous experiences are reactivated. The stronger the reactivation, the clearer will be our recall of past events, a new study reveals. Scientists have long known that slow oscillations (SOs) and sleep spindles - sudden half-second to two-second bursts of oscillatory brain activity - play an important role in the formation and retention of new memories. But experts in the UK and Germany have discovered that the precise combination of SOs and sleep spindles is vital for opening windows during which ...

As devices continue to be built on an increasingly small scale, scientists are looking toward developing ways to engineer materials at the atomic level. In a breakthrough that will contribute to this, published in Nature Communications, researchers from the RIKEN Cluster for Pioneering Research and RIKEN Center for Advanced Photonics, along with collaborators, have developed a way to use a "dry transfer technique"--a technique that uses no solvent--to position optical quality carbon nanotubes in a precise way. Carbon nanotubes are a promising type of materials with potential uses in applications such as light-emitting diodes, ...

HOUSTON - (May 25, 2021) - Sometimes things are a little out of whack, and it turns out to be exactly what you need. That was the case when orthoferrite crystals turned up at a Rice University laboratory slightly misaligned. Those crystals inadvertently became the basis of a discovery that should resonate with researchers studying spintronics-based quantum technology. Rice physicist Junichiro Kono, alumnus Takuma Makihara and their collaborators found an orthoferrite material, in this case yttrium iron oxide, placed in a high magnetic field showed uniquely tunable, ultrastrong interactions between magnons in the crystal. Orthoferrites ...

PULLMAN, Wash. - Before the huge potential of tiny nanocarriers for highly targeted drug delivery and environmental clean-up can be realized, scientists first need to be able to see them. Currently researchers have to rely on attaching fluorescent dyes or heavy metals to label parts of organic nanocarrier structures for investigation, often changing them in the process. A new technique using chemically-sensitive "soft" X-rays offers a simpler, non-disruptive way of gaining insight into this nano-world. In a study published by Nature Communications, a research team demonstrates the capability of the X-ray method on a smart drug delivery nanoparticle and a polysoap nanostructure intended to capture crude oil spilled in the ocean. "We have developed a ...

Ancient Judeans commonly ate non-kosher fish surrounding the time that such food was prohibited in the Bible, suggests a study published in the peer-reviewed journal Tel Aviv. This finding sheds new light on the origin of Old Testament dietary laws that are still observed by many Jews today. Among these rules is a ban on eating any species of fish which lacks scales or fins. The study reports an analysis of ancient fish bones from 30 archaeological sites in Israel and Sinai which date to the more than 2,000-year span from the Late Bronze Age (1550-1130 ...

Emergency department visits for common conditions such as appendicitis, miscarriage, gallbladder attacks and ectopic pregnancy decreased markedly at the start of the COVID-19 pandemic, but patient outcomes were not worse, found research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.202821. "These findings are reassuring, as patients who required emergency care in the first wave of the pandemic continued to present to the emergency department, received similar care and had similar outcomes to patients presenting in the prepandemic period," writes Dr. David Gomez, a trauma surgeon at St. Michael's Hospital, Unity ...

Summary: A new study published by the open access publisher Frontiers shows the usefulness of opportunistically collected specimens, such as stranded carcasses, to study elusive species. The researchers used stable isotope analysis of skin, muscle, and bone tissue of Sowerby's beaked whales to study their spatial ecology. They found that the species exhibits both short- and long-term habitat fidelity. The results are published in Frontiers in Conservation Science and show the importance of such studies for marine wildlife conservation. A mysterious whale species Beaked whales, a species of toothed whales, make up more than 25% of extant cetaceans (dolphins, porpoises, and whales), but are elusive and notoriously difficult to study. They live in deep waters and stay away ...

In a study funded by National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC) researchers examined whether depression, either before or during pregnancy, affects the mother-infant relationship. The research was published today (Tuesday 25 May) in BJPsych Open. Researchers looked at the quality of mother-infant interactions eight weeks and 12 months after birth in three groups of women; healthy women, women with clinically-significant depression in pregnancy, and women with a lifetime history of depression but healthy pregnancies. The study used a sample of 131 women: 51 healthy mothers with no current or past depression, 52 mothers with depression referred to the South London and Maudsley ...

A team of UBC Okanagan researchers is looking at strategies that could help the homeless during a pandemic. John Graham, director of UBC Okanagan's School of Social Work, says while many populations have been targeted with guidelines to keep them safe, homeless people have been mostly overlooked. While this research project began a few years ago, Graham says his team quickly turned their attention to the impact of COVID-19. His team looked at peer-reviewed publications, dating back to 1984, that examined how homeless populations were impacted by other highly contagious or communicable illnesses such as tuberculous, H1NI and Severe Acute Respiratory Syndrome ...

Researchers from University of Sydney, University of Florida, and Rutgers University published a new paper in the Journal of Marketing that examines the role of serendipity in customer satisfaction and how marketers can provide it. The study, forthcoming in the Journal of Marketing, is titled "Serendipity: Chance Encounters in the Marketplace Enhance Consumer Satisfaction" and is authored by Aekyoung Kim, Felipe Affonso, Juliano Laran, and Kristina Durante. Netflix knows you are tired of choice. The streaming service recently introduced what might be the perfect hack: a shuffle button that eliminates choice and plays a randomly selected program for the consumer. Under COVID-19 restrictions, the newly homebound were happy to have so many programming ...

BINGHAMTON, N.Y. - A team of evolutionary biologists including faculty at Binghamton University, State University of New York have shown that some Anolis lizards, or anoles, have adapted to rebreathe exhaled air underwater using a bubble clinging to their snouts. Semi-aquatic anoles live along neotropical streams and frequently dive for refuge, remaining underwater for up to 16 minutes. Lindsey Swierk, assistant research professor of biological sciences at Binghamton University, documented this behavior in a Costa Rican anole species in 2019. She had been shocked to see an anole submerge itself for such long periods and used a GoPro underwater to document the behavior. "It's easy to imagine the advantage that these small, slow anoles gain by hiding from their predators ...

A new study from the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) at King's College London has established that Intermittent Fasting (IF) is an effective means of improving long term memory retention and generating new adult hippocampal neurons in mice, in what the researchers hope has the potential to slow the advance of cognitive decline in older people. The study, published today in Molecular Biology, found that a calorie restricted diet via every other day fasting was an effective means of promoting Klotho gene expression in mice. Klotho, which is often referred to as the "longevity gene" has now been shown in this study to play ...

A study of healthcare workers shows they were three times more likely to become infected during the COVID-19 pandemic compared to the general population. Around one in five of workers who were infected were asymptomatic and unaware they had COVID-19. The study published in ERJ Open Research [1] also shows that it was not only frontline staff who faced the higher risk, suggesting that there was transmission between staff and within the wider community. However, health care workers who had been infected were very unlikely to contract COVID-19 a second time in the following six months. The research was led by Professor James Chalmers, a consultant respiratory physician from the University of Dundee, UK. He said: "We have always believed that front line health workers face a high risk ...

Rubisco is arguably the most abundant--and most important--protein on Earth. This enzyme drives photosynthesis, the process that plants use to convert sunlight into energy to fuel crop growth and yield. Rubisco's role is to capture and fix carbon dioxide (CO2) into sugar that fuels the plant's activities. However, as much as Rubisco benefits plant growth, it also can operate at a notoriously slow pace that creates a hindrance to photosynthetic efficiency.  About 20 percent of the time Rubisco fixes oxygen (O2) molecules instead of CO2, costing the plant energy that could have been utilized ...

According to researchers at the University of Illinois Chicago, the antibiotics used to treat common bacterial infections, like pneumonia and sinusitis, may also be used to treat human diseases, like cancer. Theoretically, at least. As outlined in a new Nature Communications study, the UIC College of Pharmacy team has shown in laboratory experiments that eukaryotic ribosomes can be modified to respond to antibiotics in the same way that prokaryotic ribosomes do. Fungi, plants, and animals -- like humans -- are eukaryotes; they are made up of cells that have a clearly defined nucleus. Bacteria, on the other hand, are prokaryotes. They are made up of cells, which do not have a nucleus and have a different structure, size and properties. The ribosomes of eukaryotic and procaryotic cells, ...

New York, NY--May 24, 2021--Whenever you buy something on Amazon, your customer data is automatically updated and stored on thousands of virtual machines in the cloud. For businesses like Amazon, ensuring the safety and security of the data of its millions of customers is essential. This is true for large and small organizations alike. But up to now, there has been no way to guarantee that a software system is secure from bugs, hackers, and vulnerabilities. Columbia Engineering researchers may have solved this security issue. They have developed SeKVM, the ...

MISSOULA, Mont., May 24, 2021 -- Scientists from the Rocky Mountain Research Station collaborated to explore how research and management can confront increasing uncertainty due to climate change, invasive species, and land use conversion. Wildland management and policy have long depended on the idea that ecosystems are fundamentally static, and periodic events like droughts are just temporary detours from a larger, stable equilibrium. However, ecosystems are currently changing at unprecedented rates. For example, bark beetle infestations, droughts, and severe wildfires have killed large numbers of trees across the western ...

A new research, carried out by the D'Or Institute for Research and Education (IDOR) and the Federal University of ABC (UFABC), has shown for the first time that storytelling is capable of providing physiological and emotional benefits to children in Intensive Care Units (ICUs). The study was published in the Proceedings of the National Academy of Sciences, the official scientific journal of the National Academy of Sciences of the U.S. The study was led by Guilherme Brockington, PhD, from UFABC, and Jorge Moll, MD, PhD, from IDOR. "During storytelling, something happens that we call 'narrative ...

Researchers from Skoltech and their colleagues from Russia and the US have shown that the two components of the bacterial CRISPR-Cas immunity system, one that destroys foreign genetic elements such as viruses and another that creates "memories" of foreign genetic elements by storing fragments of their DNA in a special location of bacterial genome, are physically linked. This link helps bacteria to efficiently update their immune memory when infected by mutant viruses that learned to evade the CRISPR-Cas defense. The paper was published in the journal Proceedings of the National Academy of Sciences. CRISPR-Cas, a defense mechanism that provides bacteria with resistance to their viruses (bacteriophages), destroys DNA from ...

LOS ANGELES (May 24, 2021) -- Today, The Lundquist Institute announced that Wei Yan, MD, PhD, and his research group have solved a longstanding mystery and scientific debate about the mechanism underlying the gamete and embryo transport within the Fallopian tube. Using a mouse model where the animals lacked motile cilia in the oviduct, Dr. Yan's group demonstrated that motile cilia in the very distal end of the Fallopian tube, called infundibulum, are essential for oocyte pickup. Disruptions of the ciliary structure and/or beating patterns lead to failure in oocyte pickup and consequently, a loss of female fertility. Interestingly, motile cilia in other parts of the oviduct can facilitate sperm ...

Hearing loss is a disability that affects approximately 5% of the world's population. Clinically determining the exact site of the lesion is critical for choosing a proper treatment for hearing loss. For example, the subjects with damage in sound conduction or mild outer hair cell damage would benefit from hearing aids, while those with significant damage to outer or inner hair cells would benefit from the cochlear implant. On the other hand, the subjects with impairments in more central structures such as the cochlear nerve, brainstem, or brain do not benefit from either hearing aids or cochlear implants. However, the role of impairments in cochlear glial cells in hearing loss is not as well known. While it is known that connexin channels in cochlear glial ...