Impact Journals (Oncotarget's publisher) is proud to participate at the American Association for Cancer Research (AACR) Annual Meeting 2023, which convenes April 14-19 in Orlando, Florida. BUFFALO, NY-April 4, 2023 – Impact Journals will be participating as an exhibitor at the American Association for Cancer Research (AACR) Annual Meeting 2023 from April 14-19 at the Orange County Convention Center in Orlando, Florida. This year, the AACR meeting theme is: “Advancing ...

Cambridge, Mass. - Researchers at the Forsyth Institute have discovered an important mechanism that may have profound implications for how we prevent colorectal cancer. Oddly enough, their discovery began in the mouth.  Colorectal cancer is the second most deadly cancer, killing over 52,000 people a year. Increasing evidence indicates Fusobacterium nucleatum, an opportunistic oral pathogen is one of the factors causing colorectal cancer. Fusobacteria are often found in healthy mouths, living in balance ...

Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability.   University of Maryland School of Medicine (UMSOM) researchers wanted to better understand what happens in the brain during injury, so they conducted a study in mice to determine how different types of brain cells in mice react to severe trauma. In a new study published in the January issue of Autophagy, they found that after traumatic brain injury, the brain’s immune system cells’ internal recycling ...

Animals, like humans, appear to be troubled by a Linda problem. The famous “Linda problem” was designed by psychologists to illustrate how people fall prey to what is known as the conjunction fallacy: the incorrect reasoning that if two events sometimes occur in conjunction, they are more likely to occur together than either event is to occur alone.  Now, for the first time, UCLA psychology researchers have shown that this type of logical error isn’t the sole province of humans ...

“Cortactin (also known as EMS1 or CTTN) is expressed broadly in a variety of cancers [...]”  BUFFALO, NY- April 4, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on March 21, 2023, entitled, “Impact of cortactin in cancer progression on Wnt5a/ROR1 signaling pathway.” In this editorial, researchers Kamrul Hasan and Thomas J. Kipps from the University of California discuss cortactin—an intracellular cytoskeletal protein that can undergo tyrosine phosphorylation upon external stimulation and promote polymerization and the assembly of the actin filament that is required for cell migration. Upon stimulation, cortactin ...

Male beetles face a trade-off between competing with other males for mating opportunities and repairing damage to their sperm DNA, according to a study publishing April 4th in the open access journal PLOS Biology by Mareike Koppik from Uppsala University, Sweden, and colleagues. Mutations in sperm and egg DNA can reduce the survival and fitness of offspring, so animals use a variety of repair and maintenance mechanisms in their reproductive cells. However, previous research has shown that sperm DNA has more mutations than egg DNA in a variety of ...

The prevalence of multimorbidity, the co-occurrence of two or more chronic conditions, varies depending on exactly how it is defined. And the healthcare costs associated with many disease combinations cost more together than the sum of each individual disease. Those are the conclusions of two new studies, publishing April 4th in the open access journal PLOS Medicine, that broadly analyze the concept and costs of multimorbidity. Multimorbidity is increasing in prevalence due to improved survival from chronic diseases and population aging, and now poses major challenges to healthcare systems worldwide. ...

SCI Canada Awards 2023 dinner, seminar and presentations to take place on 18 April in Toronto  Seminar theme is ‘Unlocking the potential of science talent enabling impact on Canada’s economic growth’ Award winners include the first indigenous community members Dr Paul Smith, Perimeter Institute for Theoretical Physics, will receive the 2023 Canada Medal A panel representing the best of Canadian science and industry will discuss its role in boosting economic growth at a special awards event on 18 April in Toronto.  Winners of the 2023 SCI Canada Awards include ...

CAMBRIDGE, MA -- Materials known as metal-organic frameworks (MOFs) have a rigid, cage-like structure that lends itself to a variety of applications, from gas storage to drug delivery. By changing the building blocks that go into the materials, or the way they are arranged, researchers can design MOFs suited to different uses. However, not all possible MOF structures are stable enough to be deployed for applications such as catalyzing reactions or storing gases. To help researchers figure out which MOF structures might work best for a given application, MIT researchers have developed a computational approach that allows ...

Sexual selection provides an answer to the existence of lavishly ornate signals in animals, but not to the question of why such signals are attractive, why do females prefer the extravagant plumage of peacocks? As part of an international team, researchers at Eötvös Loránd University (ELTE) have shown that the reason is not the presumed wasteful cost of ornaments, as honest signals need not have to be costly at all as long as cheaters would have to pay to fake them. Researchers have developed a general formula to calculate honest equilibrium in any model, independent of the cost ...

RIVERSIDE, Calif. -- A University of California, Riverside, study has identified the biological underpinnings of a reproductive disorder caused by the mutation of a gene. This gene mutation also causes Fragile X Syndrome, a leading genetic cause of intellectual impairment and autism. The researchers found mutations of the Fragile X messenger ribonucleoprotein 1 gene, or FMR1, contribute to premature ovarian failure, or POF, due to changes in neurons that regulate reproduction in the brain and ovaries. The mutation has been associated with early infertility, due ...

PHILADELPHIA — Chronic kidney disease (CKD) is a strong cardiovascular risk factor and is often accompanied by hypertension and diabetes. Despite the disease’s prevalence—10 percent of individuals across the globe suffer from CKD—there are limited tools for measuring cardiac risk for CKD patients, until now. A new proteomic risk model for cardiovascular disease was found to be more accurate than current methods of measuring cardiac risk, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The study published today in the European Heart Journal. The Penn researchers developed ...

How Little-Known Brain Cells Tamp Down Overexcited Neurons During Acute Stress A brimming inbox on Monday morning sets your head spinning. You take a moment to breathe and your mind clears enough to survey the emails one by one. This calming effect occurs thanks to a newly discovered brain circuit involving a lesser-known type of brain cell, the astrocyte. According to new research from UC San Francisco, astrocytes tune into and moderate the chatter between overactive neurons. This new brain circuit, described March 30, 2023 in Nature Neuroscience, plays a role in modulating attention and perception, and may hold a key to treating attention disorders like ...

Worcester, Mass. – April 4, 2023 – WPI Researcher Kristen Billiar has been awarded $429,456 from the National Institutes of Health to investigate how stretching and blood flow can inhibit or encourage cardiovascular cells to populate and grow in tissue-engineered heart valves. The three-year project focuses on experimental valves that are not yet used in humans, and the work will expand understanding about how mechanical forces propel cells in the body. “Existing heart valves have drawbacks, ...

Articles Disclosing Conflicts of Interest to Potential Research Participants: Good for Nothing? Inmaculada de Melo-Martín The growing commercialization of science has raised concerns about financial conflicts of interest. Evidence suggests that such conflicts threaten the integrity of research and the well-being of research participants. Trying to minimize these negative effects, federal agencies, academic institutions, and publishers have developed conflict-of-interest policies. Among such policies, recommendations or requirements to disclose financial COIs to potential research participants ...

The American Association for the Advancement of Science (AAAS) has recognized physicist and humanitarian Sekazi Mtingwa for his invaluable work in the field of intrabeam scattering and particle accelerator research as well as his tireless efforts to promote accessibility, diversity, and equity in STEM. Mtingwa’s career and achievements exemplified the theme of this year’s meeting? “Science for Humanity.” Mtingwa has worked for many years in close collaboration with the U.S. Department of Energy’s Brookhaven National Laboratory and other science organizations around the world. According ...

In criminal justice, public belief in redeemability reduces punitiveness and increases support for policy measures like rehabilitation, expungement, and housing and employment opportunities. In a new study, researchers examined the effects of racial attitudes on redeemability—the belief that offenders can change and go on to lead law-abiding lives. Belief in redeemability was high for offenders in general as well as for Black offenders, but White nationalism reduced White people’s beliefs in the redeemability of Black offenders. The study was conducted by Leah C. Butler, incoming assistant professor of criminal justice at the University ...

New research in the field of plant sciences has made significant advances towards understanding the underlying reasons behind why certain crops are better at generating more yield than others.    The study, published in the journal Science Advances, paves the way for how smart plants could be engineered in the future to improve their productivity and yield.   The research - conducted at the Department of Plant Sciences, University of Cambridge, and led by Dr Pallavi Singh, currently at the University of Essex’s School of Life Sciences - focused on photosynthesis, which is one of the most complicated and important processes that plants use to turn light, ...

Strength training practiced with moderate to vigorous intensity two or three times a week is an effective way to mitigate arterial hypertension (high blood pressure), according to a Brazilian study described in an article published in the journal Scientific Reports. The mechanisms behind the lowering of blood pressure by aerobic exercise are well studied, but little research has been done on the effects of strength exercise on hypertension along similar lines to this review conducted by researchers at São Paulo State University (UNESP). Led by Giovana Rampazzo Teixeira, a professor in UNESP’s ...

The University of Chicago Medicine Comprehensive Cancer Center has been named the newest member institution of the National Comprehensive Cancer Network (NCCN), the not-for-profit alliance of leading cancer centers announced today. With the addition, there are now 33 academic centers across the United States contributing multidisciplinary subject matter experts to 61 different panels determining the latest evidence-based expert consensus recommendations for risk assessment, prevention, evaluation and ...

DARIEN, IL – The Count on Sleep partnership, a collaboration between several professional and patient-focused organizations, has released a national indicator report for obstructive sleep apnea through a grant awarded to the American Academy of Sleep Medicine by the Centers for Disease Control and Prevention’s National Center for Chronic Disease Prevention and Health Promotion. The report provides an in-depth analysis of the symptoms, risk factors, prevalence, and burden of obstructive sleep apnea and serves as a resource for both the public and the health care communities on the importance of diagnosis and long-term treatment. “Through ...

An innovative app from Ann & Robert H. Lurie Children’s Hospital of Chicago aims to increase earlier recognition of abuse in babies and children under 4 years of age who have bruises, with the hope of decreasing the incidence of severe injury and death from child abuse in this age group. The hospital launched the app in April, which coincides with National Child Abuse Prevention month. Bruising caused by physical abuse is the most common injury to be overlooked or misdiagnosed as accidental before an abuse-related fatality or ...

Memphis, Tennessee, April 4, 2023 – St. Jude Children’s Research Hospital has named Greg Armstrong, M.D., MSCE, the new chair of the Department of Epidemiology and Cancer Control, the department that has established the institution as a world leader in the study of childhood cancer survivorship.    A physician-scientist, Armstrong is the principal investigator of the Childhood Cancer Survivor Study (CCSS), a multi-institutional cohort and multidisciplinary ...

About The Study: This study demonstrated that same-sex lesbian couples undergoing assisted reproductive technology (ART) had more favorable or similar birth outcomes to heterosexual couples who conceived naturally or underwent ART to conceive, suggesting that infertility-related factors rather than reproductive treatments contribute to higher rates of adverse birth outcomes in ART pregnancies.  Authors: Alice Goisis, Ph.D., of University College London, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2023.1345) Editor’s ...

About The Study: Prenatal telehealth visits increased substantially during the early phase of the COVID-19 pandemic. The highest percentage of pregnancies with telehealth was observed in April 2020. Deliveries in November 2020 had the highest telehealth visit rates during the 40-week pregnancy. Authors: Hari Eswaran, Ph.D., of the University of Arkansas for Medical Sciences in Little Rock, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi: 10.1001/jamanetworkopen.2023.6630) Editor’s Note: Please see the article for additional ...