Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of UC San Francisco scientists, in collaboration with others. Methylation is a process by which DNA is chemically modified at specific sites, resulting in changes in the expression of certain genes. Methylation of particular sets of genes, called "DNA methylation clocks," typically change in predictable ways as people ...

During the early phase of the pandemic, approximately 40% of the COVID-19 literature was shared as preprints - freely available manuscripts that are shared prior to peer-review. In a new study publishing in the open access journal PLOS Biology, researchers led by Dr Jonathon Coates (Queen Mary University of London), Dr Nicholas Fraser (Leibniz Information Centre for Economics, Germany) and Dr Liam Brierley (University of Liverpool) explore the crucial role of preprint servers in hosting COVID-19 related science and how these preprints have been used to disseminate knowledge of COVID-19, leading to cultural shifts in journalistic and policy practices. There has been a rapid and incredible scientific response to the COVID-19 pandemic, with research ...

Innovation and advances in technology have facilitated agricultural activity in recent years, as traditional irrigation techniques have been supplanted by pressure-basedones, improving water efficiency but increasing energy dependence. This drives up the Agriculture sector's energy costs, some of the highest in the European Union. With the aim of increasing the energy efficiency of irrigation, researchers at the Hydraulics and Irrigation Group with the María de Maeztu Unit of Excellence,at the Department of Agronomy of the University of Cordoba (DAUCO), Juan Antonio Rodríguez Díaz and Jorge García Morillo, have field-tested a low-cost technology that takes advantage of the excess pressure on the grid to generate energy. This ...

It is difficult to imagine our daily life without lithium-ion batteries. They dominate the small format battery market for portable electronic devices, and are also commonly used in electric vehicles. At the same time, lithium-ion batteries have a number of serious issues, including: a potential fire hazard and performance loss at cold temperatures; as well as a considerable environmental impact of spent battery disposal. According to the leader of the team of researchers, Professor in the Department of Electrochemistry at St Petersburg University END ...

Ambient air pollution is a global public health crisis, causing more than 4.9 million premature deaths per year around the world. In Africa, it has surpassed AIDS as the leading cause of premature death. According to one study, air pollution--specifically, fine particulate matter (PM2.5)--may cause at least as many as 780,000 premature deaths annually in Africa and worsen a significant number of diseases, including asthma, lung cancer, and chronic obstructive pulmonary disease. Kinshasa, capital of the Democratic Republic of the Congo, and Brazzaville, capital of the Republic of Congo, are both large metropolises. However, neither Kinshasa (population 14. 3 million) nor Brazzaville (population 2.4 million) have had comprehensive air quality monitoring programs. ...

Scientists at UCL have used artificial intelligence (AI) to identify three new multiple sclerosis (MS) subtypes. Researchers say the groundbreaking findings will help identify those people more likely to have disease progression and help target treatments more effectively. MS affects over 2.8 million people globally and 130,000 in the UK, and is classified into four* 'courses' (groups), which are defined as either relapsing or progressive. Patients are categorised by a mixture of clinical observations, assisted by MRI brain images, and patients' symptoms. These observations guide the timing and choice of treatment. For this study, published in Nature Communications, researchers wanted to find out if there were any - as yet unidentified - patterns ...

HOUSTON - (April 6, 2021) - Runoff from Houston's 2016 Tax Day flood and 2017's Hurricane Harvey flood carried human waste onto coral reefs more than 100 miles offshore in the Flower Garden Banks National Marine Sanctuary, according to a Rice University study. "We were pretty shocked," said marine biologist Adrienne Correa, co-author of the study in Frontiers in Marine Science. "One thing we always thought the Flower Garden Banks were safe from was terrestrial runoff and nutrient pollution. It's a jolt to realize that in these extreme events, it's not just the salt marsh or the seagrass that we need to worry about. Offshore ecosystems can be affected too." The Flower Garden Banks sit atop several salt domes near the edge ...

Mitochondria, known as the powerhouses within human cells, generate the energy needed for cell survival. However, as a byproduct of this process, mitochondria also produce reactive oxygen species (ROS). At high enough concentrations, ROS cause oxidative damage and can even kill cells. An overabundance of ROS has been connected to various health issues, including cancers, neurological disorders, and heart disease. An enzyme called manganese superoxide dismutase, or MnSOD, uses a mechanism involving electron and proton transfers to lower ROS levels in mitochondria, thus preventing oxidative damage and maintaining cell health. More than a quarter of known enzymes also rely on electron and proton transfers to facilitate cellular activities ...

Boron nitride is a technologically interesting material because it is very compatible with other two-dimensional crystalline structures. It therefore opens up pathways to artificial heterostructures or electronic devices built on them with fundamentally new properties. About a year ago, a team from the Institute of Physics at Julius-Maximilians-Universität (JMU) Wuerzburg in Bavaria, Germany, succeeded in creating spin defects, also known as qubits, in a layered crystal of boron nitride and identifying them experimentally. Recently, the team led by Professor ...

Misinformation about COVID-19 is spreading from the United States into Canada, undermining efforts to mitigate the pandemic. A study led by McGill University shows that Canadians who use social media are more likely to consume this misinformation, embrace false beliefs about COVID-19, and subsequently spread them. Many Canadians believe conspiracy theories, poorly-sourced medical advice, and information trivializing the virus--even though news outlets and political leaders in the country have generally focused on providing reliable scientific information. How then, is misinformation spreading so rapidly? "A lot of Canadians are struggling to understand COVID-19 denialism and anti-vaccination attitudes among their loved ones," says ...

New York, NY--April 6, 2021--The digital revolution is built on a foundation of invisible 1s and 0s called bits. As decades pass, and more and more of the world's information and knowledge morph into streams of 1s and 0s, the notion that computers prefer to "speak" in binary numbers is rarely questioned. According to new research from Columbia Engineering, this could be about to change. A new study from Mechanical Engineering Professor Hod Lipson and his PhD student Boyuan Chen proves that artificial intelligence systems might actually reach higher levels of performance if they are programmed with sound files of human language rather than with numerical data labels. The researchers discovered that in a side-by-side comparison, a neural network whose "training labels" consisted ...

CHAMPAIGN, Ill. -- Exposure to phthalates, a class of chemicals widely used in packaging and consumer products, is known to interfere with normal hormone function and development in human and animal studies. Now researchers have found evidence linking pregnant women's exposure to phthalates to altered cognitive outcomes in their infants. Most of the findings involved slower information processing among infants with higher phthalate exposure levels, with males more likely to be affected depending on the chemical involved and the order of information presented to the infants. Reported in the journal Neurotoxicology, the study ...

The global movement of goods and people, in its modern form, has many unwanted side effects. One of these is that animal and plant species travel around the world with it. Often they fail to establish themselves in the ecosystems of the destination areas. Sometimes, however, due to a lack of effective management, they multiply to such an extent in the new environment that they become a threat to the entire ecosystem and economy. Thousands of alien species are currently documented worldwide. A quarter of them are in highly vulnerable, aquatic habitats. So far, research has mainly focused on the ecological consequences of these invasions. In a first global data analysis, 20 scientists from 13 countries led by GEOMAR Helmholtz Centre for Ocean Research Kiel have now compiled the economic ...

Researchers from Columbia University and Georgetown University published a new paper in the Journal of Marketing that examines how consumers can adopt a sustainable consumption lifestyle by purchasing durable high-end and luxury products. The study, forthcoming in the Journal of Marketing, is titled "Buy Less, Buy Luxury: Understanding and Overcoming Product Durability Neglect for Sustainable Consumption" and is authored by Jennifer Sun, Silvia Bellezza, and Neeru Paharia. What do luxury products and sustainable goods have in common? Luxury goods possess a unique, sustainable trait that gives them a longer lifespan than lower-end products. Sustainable consumption is on the rise with all consumers. However, younger millennial ...

BOSTON - A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals by the U.S. Food and Drug Administration anticipated later this year. Unfortunately, cancer cells often develop additional mutations that make them resistant to such targeted drugs, resulting in disease relapse. Now researchers led by a team at Massachusetts General Hospital (MGH) have identified the first resistance mechanisms that may occur to these drugs and identified strategies to overcome them. The findings are published in END ...

With over 70% of respondents to a AAA annual survey on autonomous driving reporting they would fear being in a fully self-driving car, makers like Tesla may be back to the drawing board before rolling out fully autonomous self-driving systems. But new research from Northwestern University shows us we may be better off putting fruit flies behind the wheel instead of robots. Drosophila have been subjects of science as long as humans have been running experiments in labs. But given their size, it's easy to wonder what can be learned by observing them. Research published today in the journal Nature Communications demonstrates that fruit flies use decision-making, learning and memory to perform simple functions like escaping heat. And researchers are using ...

LAWRENCE -- An international trade law expert at the University of Kansas argues in a pair of new articles that human rights and trade are now inextricably linked, as evidenced by U.S. and international reactions to actions in China, and asserts that approach is an appropriate use of trade. Raj BhalaAfter the United States, then Canada and the Netherlands, declared the Chinese Communist Party's actions against Uyghur Muslims as genocide, the nations followed with various trade sanctions. Likewise, countries have adopted trade measures in response to China's violation of its one-country, two-systems agreement with Hong Kong. ...

Researchers at the University of Konstanz and Max Planck Institute for Animal Behavior in Germany have found that birds are able to change their culture to become more efficient. Populations of great tits were able to switch from one behavior to a better alternative when their group members were slowly replaced with new birds. Published today as open access in the journal Current Biology, this research reveals immigration as a powerful driver of cultural change in animal groups that could help them to adapt to rapidly changing environments. In animals, "culture" is considered to be any behavior that is learned from others, shared by members of the ...

Ann Arbor, April 6, 2021 - New data from the Centers for Disease Control and Prevention (CDC) show that one in four adults with HIV in the United States has experienced intimate partner violence (IPV), which disproportionately affects women and LGBT populations. Further, people with HIV who experienced IPV in the past 12 months were more likely to engage in behaviors associated with elevated HIV transmission risk, were less likely to be engaged in routine HIV care and more likely to seek emergency care services and have poor HIV clinical outcomes. The findings are reported in the American Journal of Preventive Medicine, published by Elsevier. Lead Investigator Ansley B. Lemons-Lyn, MPH, and colleagues from the CDC's National Center for HIV/AIDS, Viral Hepatitis, ...

At a cost of $38 billion a year, an estimated 5.3 million people are living with a permanent disability related to traumatic brain injury in the United States today, according to the Centers for Disease Control and Prevention. The physical, mental and financial toll of a TBI can be enormous, but new research from the University of Georgia provides promise. In a new study, researchers at UGA's Regenerative Biosciences Center have demonstrated the long-term benefits of a hydrogel, which they call "brain glue," for the treatment of traumatic brain injury. The new study provides evidence that not only does the gel protect against loss of brain tissue after ...

Bethesda, MD (April 6, 2021) -- Obesity is a global pandemic, affecting about 40% of adults in the United States. There is an enormous unmet need for an effective weight-loss solution. After a detailed review of available literature, the American Gastroenterological Association (AGA) has released new clinical guidelines recommending the use of intragastric balloons (IGB) for patients with obesity who have not been able to lose weight with traditional weight-loss strategies. This treatment is most successful with accompanying therapy, such as lifestyle modifications and pharmacological agents, ...

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife. A more reliable indicator of an individual's response to glucocorticoid drugs could be used to develop a clinically applicable test that could help tailor treatments and potentially minimise side-effects. Glucocorticoids, such as cortisol, are a type of hormone with key roles in the body's response to stress. Glucocorticoid ...

Researchers from Skoltech and their collaborators have designed, synthesized and evaluated new compounds that can serve as catholytes and anolytes for organic redox flow batteries, bringing this promising technology closer to large-scale implementation. The two papers were published in the END ...

A new U.S. Geological Survey study provides an updated, statewide estimate of high levels of naturally occurring arsenic and uranium in private well water across Connecticut. This research builds on a USGS report published in 2017, with the new study including additional groundwater samples and focusing on previously underrepresented areas. The research, undertaken in cooperation with the Connecticut Department of Public Health, projects that approximately 3.9% of private wells across Connecticut contain water with arsenic at concentrations higher than the U.S. Environmental Protection Agency's maximum contaminant level for ...

Sea urchins receive a lot of attention in California. Red urchins support a thriving fishery, while their purple cousins are often blamed for mowing down kelp forests to create urchin barrens. Yet for all the notice we pay them, we know surprisingly little about the microbiomes that support these spiny species. Researchers at UC Santa Barbara led by geneticist Paige Miller sought to uncover the diversity within the guts of these important kelp forest inhabitants. Their results reveal significant differences between the microbiota of the two species, as well as between individuals living ...