A new software tool allows researchers to quickly query datasets generated from single-cell sequencing. Users can identify which cell types any combination of genes are active in. Published in Nature Methods on 1st March, the open-access 'scfind' software enables swift analysis of multiple datasets containing millions of cells by a wide range of users, on a standard computer. Processing times for such datasets are just a few seconds, saving time and computing costs. The tool, developed by researchers at the Wellcome Sanger Institute, can be used much like a search engine, as users can input free text as well as gene names. Techniques to sequence the genetic material from an individual cell have advanced ...

Information is encoded in data. This is true for most aspects of modern everyday life, but it is also true in most branches of contemporary physics, and extracting useful and meaningful information from very large data sets is a key mission for many physicists. In statistical mechanics, large data sets are daily business. A classic example is the partition function, a complex mathematical object that describes physical systems at equilibrium. This mathematical object can be seen as made up by many points, each describing a degree of freedom of a physical system, that is, the minimum number of data that can describe all of its properties. An ...

CAMBRIDGE, MA -- Boron, a metalloid element that sits next to carbon in the periodic table, has many traits that make it potentially useful as a drug component. Nonetheless, only five FDA-approved drugs contain boron, largely because molecules that contain boron are unstable in the presence of molecular oxygen. MIT chemists have now designed a boron-containing chemical group that is 10,000 times more stable than its predecessors. This could make it possible to incorporate boron into drugs and potentially improve the drugs' ability to bind their targets, the researchers say. "It's an entity ...

Judging by its massive, bone-crushing teeth, gigantic skull and powerful jaw, there is no doubt that the Anteosaurus, a premammalian reptile that roamed the African continent 265 to 260 million years ago - during a period known as the middle Permian - was a ferocious carnivore. However, while it was previously thought that this beast of a creature - that grew to about the size of an adult hippo or rhino, and featuring a thick crocodilian tail - was too heavy and sluggish to be an effective hunter, a new study has shown that the Anteosaurus would have been able to outrun, track down and kill its prey effectively. Despite its name and fierce appearance, ...

When the Eyjafjallajökull volcano in Iceland erupted in April 2010, air traffic was interrupted for six days and then disrupted until May. Until then, models from the nine Volcanic Ash Advisory Centres (VAACs) around the world, which aimed at predicting when the ash cloud interfered with aircraft routes, were based on the tracking of the clouds in the atmosphere. In the wake of this economic disaster for airlines, ash concentration thresholds were introduced in Europe which are used by the airline industry when making decisions on flight restrictions. However, a team of researchers, ...

The planet Mars has no global magnetic field, although scientists believe it did have one at some point in the past. Previous studies suggest that when Mars' global magnetic field was present, it was approximately the same strength as Earth's current field. Surprisingly, instruments from past Mars missions, both orbiters and landers, have spotted patches on the planet's surface that are strongly magnetized--a property that could not have been produced by a magnetic field similar to Earth's, assuming the rocks on both planets are similar. Ahmed AlHantoobi, an intern working with Northern Arizona University planetary scientists, assistant professor Christopher Edwards and postdoctoral ...

PITTSBURGH, March 3, 2021 - Women who experience an accelerated accumulation of abdominal fat during menopause are at greater risk of heart disease, even if their weight stays steady, according to a University of Pittsburgh Graduate School of Public Health-led analysis published today in the journal Menopause. The study--based on a quarter century of data collected on hundreds of women--suggests that measuring waist circumference during preventive health care appointments for midlife women could be an early indicator of heart disease risk beyond the widely used body mass index (BMI)--which is a calculation of weight vs. height. "We need to shift gears on how we think about heart disease risk in women, particularly as they approach and go through menopause," said senior ...

A review of nearly 28,000 emergency department records shows less than 2% of patients diagnosed with COVID-19 suffered an ischemic stroke but those who did had an increased risk of requiring long-term care after hospital discharge. Those are the findings from a study conducted by researchers from the University of Missouri School of Medicine and MU Health Care. The researchers teamed up with the MU Institute for Data Science and Informatics and the Tiger Institute for Health Innovation to review data from 54 health care facilities. They found 103 patients (1.3%) developed ischemic stroke among 8,163 patients with COVID-19. ...

PHILADELPHIA (March 3, 2021) - According to a new study published in Medical Care, improving hospital nurse staffing as proposed in pending legislation in New York state would likely save lives. The cost of improving nurse staffing would be offset by savings achieved by reducing hospital readmissions and length of hospital stays. Researchers at the Center for Health Outcomes and Policy Research (CHOPR) at the University of Pennsylvania School of Nursing, conducted independent research in early 2020 on whether pending nurse staffing legislation in New York state is in the public's interest. The study of 116 hospitals and 418,000 Medicare patients documented large differences in patient-to-nurse ratios by hospital from an average of 4.3 patients for each nurse to as many ...

SALT LAKE CITY - Utah researchers report significant new insights into the development of blood cancers. In work published today in Blood Cancer Discovery, a journal of the American Association for Cancer Research, scientists describe an analysis of published data from more than 7,000 patients diagnosed with leukemia and other blood disorders. Their findings provide new clues about mutations that may initiate cancer development and those that may help cancer to progress. The researchers sought to identify mutation hotspots, or frequent changes ...

BEER-SHEVA, ISRAEL...March 3, 2021 - Ben-Gurion University of the Negev Researchers (BGU) have found for the first time that cigarette smoke toxicity impacts the protective biofilm in the lungs, particularly concerning when paired with COVID-19 respiratory issues. Though many health factors are known about smoking, little is known about the overall toxicity potential of its ingredients. Researchers developed a new smoke testing system called a bacterial panel with genetically modified bioluminescent bacteria to measure both filtered and unfiltered cigarette smoke's complex molecular mixture. According to the new study published in the journal Talanta, the researchers found that cigarette smoke affects communication between bacteria, which can affect microorganisms ...

HAMILTON, ON, March 3, 2021 -- Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded. The human genome has evolved to favour the inheritance of very different characteristics in males and females, which in turn makes men more vulnerable to a host of physical and mental health conditions, say the researchers responsible for a new paper published in the Journal of Molecular Evolution. Their analysis shows that while there are certain conditions that occur only in women (cervical cancer and ovarian cancer, for example), or much more frequently in women (such as multiple sclerosis), men are more prone to medical conditions overall and, as a result, on average die sooner than ...

A variant of SARS-CoV-2 that emerged in southeast England in November 2020 is more transmissible than pre-existing variants, a new modeling study finds. Further analyses suggest the variant - VOC 202012/01 - will lead to large resurgences of COVID-19 cases. "Without stringent control measures, including limited closure of educational institutions and a greatly accelerated vaccine roll-out, COVID-19 hospitalizations and deaths across England in 2021 will exceed those in 2020," the study's authors say. After emerging in November 2020, evidence began to emerge ...

Researchers of the Center for Photonics and Two-Dimensional Materials at MIPT, together with their colleagues from Spain, Great Britain, Sweden, and Singapore, including co-creator of the world's first 2D material and Nobel laureate Konstantin Novoselov, have measured giant optical anisotropy in layered molybdenum disulfide crystals for the first time. The scientists suggest that such transition metal dichalcogenide crystals will replace silicon in photonics. Birefringence with a giant difference in refractive indices, characteristic of these substances, will make it possible to develop faster yet tiny optical devices. The work is published in the ...

In a potential boost for quantum computing and communication, a European research collaboration reported a new method of controlling and manipulating single photons without generating heat. The solution makes it possible to integrate optical switches and single-photon detectors in a single chip. Publishing in Nature Communications, the team reported to have developed an optical switch that is reconfigured with microscopic mechanical movement rather than heat, making the switch compatible with heat-sensitive single-photon detectors. Optical switches in use today work by locally heating light guides inside a semiconductor chip. "This approach does not work for quantum optics," says co-author Samuel Gyger, a PhD student at KTH Royal Institute of Technology ...

Just as James Cameron's Terminator-800 was able to discriminate between "clothes, boots, and a motorcycle", machine-learning could identify different areas of interest on 2D materials. The simple, automated optical identification of fundamentally different physical areas on these materials (eg, areas displaying doping, strain, and electronic disorder) could significantly accelerate the science of atomically-thin materials. Atomically-thin (or 2D) layers of matter are a new, emerging class of materials that will serve as the basis for next-generation energy-efficient computing, optoelectronics and future smart-phones. "Without any supervision, machine-learning algorithms ...

While consumers look out for the Dolphin Safe mark on seafood purchases, a major research stocktake of Australian-New Zealand waters gives new guidelines to managers of dolphin fisheries. The extensive new genomic study of almost 500 common dolphins (Delphinus delphis), spanning multiple spatial areas of more than 1500 sq km from the southern and east coast of Australia to Tasmania and New Zealand, calls for greater collaboration between the two countries' conservation and fisheries plans. Just published in Frontiers in Marine Science, the study of DNA diversity of several dolphin populations in Australia and NZ suggests connectivity between ...

Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those affected by heart disease, respiratory disease and type 2 diabetes - all of which increase with age - are at greatest risk of severe disease and even death, making the care home population especially vulnerable. Care homes are known to be high-risk settings for infectious diseases, owing to a combination of the underlying vulnerability of residents who are often frail and elderly, the shared living environment with multiple ...

As odd as it sounds, many scientists have attempted to place extremely small diamonds inside living cells. Why? Because nanodiamonds are consistently bright and can give us unique knowledge about the inner life of cells over a long time. Now physics researchers at Lund University in Sweden have succeeded in injecting a large number of nanodiamonds directly to the cell interior. Diamonds are not only sought after for their beauty, but also for their uniquely luminescent properties, at least among scientists. Unlike other fluorescent materials, they do not bleach. "We actually think of them as a dye. In addition, they are biocompatible", says Elke Hebisch, researcher at solid state physics at Lund University. Together ...

European Union law rules that Member States must provide fair and appropriate compensation for victims of sexual offences. In some countries, few victims receive any financial compensation, or often the amount received is very low. According to figures from the Spanish Government's Ministry of Finance, obtained by professor of Criminal Law at the UOC, Josep M. Tamarit, between 1998 and 2018 in Spain some 1,356 applications for public compensation were made, of which 272 were favourably settled. "During these two decades, only 20% of the compensation ...

A team of scientists has, for the first time, identified landfalls of tropical cyclones (TCs) in Japan for the period from 1877 to 2019; this knowledge will help prepare for future TC disasters. In recent years strong TCs have been making landfalls in Japan, such as Typhoon Jebi in 2018, which severely hit the Kinki region, and Typhoon Hagibis in 2019, which severely hit eastern Japan. While Japan has suffered from a number of TC impacts throughout its history, meteorological data for these events has been sparse. The team, including Specially Appointed Associate Professor Hisayuki Kubota of the Faculty of ...

While the digitization process offers an extensive list of opportunities, it also presents a number of challenges for higher education institutions, a primary one of which is learner authentication in online education. More and more higher education establishments are making use of digital learning environments (DLE), and electronic assessment systems are now an increasingly important element in the digital age, both for academic institutions and for students, including those with special educational needs and disabilities (SEND). David Bañeres is a researcher with the IN3 SOM Research Lab group and professor at the Faculty ...

Climate experts have revealed that rising temperatures will intensify future rainfall extremes at a much greater rate than average rainfall, with largest increases to short thunderstorms. New research by Newcastle University has shown that warming temperatures in some regions of the UK are the main drivers of increases in extreme short-duration rainfall intensities, which tend to occur in summer and cause dangerous flash flooding. These intensities are increasing at significantly higher rates than for winter storms. A study, led by Professor Hayley Fowler, of Newcastle University's School of Engineering, highlights the urgent need for climate change adaptation measures as heavier short-term rainfall increases ...

As is sensed in our daily life, jiaozi frozen in domestic refrigerator tastes less delicious than an instant frozen one sold in the supermarket. The formation of the ice crystal is to blame. In scientific researches ranging from aerospace to biology and medicine, the formation, growth and elimination of the ice crystal are of significant importance. By far, slow freezing and vitrification are generally adopted for cryopreservation. The former method, assembling freezing jiaozi with domestic refrigerator, is accompanied by mass formation of ice crystal which inevitably does irreversible damage to the cell. Vitrification effectively avoids former problems but requires either extremely rapid freezing rate which is too hard to achieve or high ...

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal Angewandte Chemie. In order for the SARS-CoV-2 coronavirus to replicate, it relies on the main protease as a key enzyme. The virus ...