According to researchers at the University of Illinois Chicago, the antibiotics used to treat common bacterial infections, like pneumonia and sinusitis, may also be used to treat human diseases, like cancer. Theoretically, at least. As outlined in a new Nature Communications study, the UIC College of Pharmacy team has shown in laboratory experiments that eukaryotic ribosomes can be modified to respond to antibiotics in the same way that prokaryotic ribosomes do. Fungi, plants, and animals -- like humans -- are eukaryotes; they are made up of cells that have a clearly defined nucleus. Bacteria, on the other hand, are prokaryotes. They are made up of cells, which do not have a nucleus and have a different structure, size and properties. The ribosomes of eukaryotic and procaryotic cells, ...

New York, NY--May 24, 2021--Whenever you buy something on Amazon, your customer data is automatically updated and stored on thousands of virtual machines in the cloud. For businesses like Amazon, ensuring the safety and security of the data of its millions of customers is essential. This is true for large and small organizations alike. But up to now, there has been no way to guarantee that a software system is secure from bugs, hackers, and vulnerabilities. Columbia Engineering researchers may have solved this security issue. They have developed SeKVM, the ...

MISSOULA, Mont., May 24, 2021 -- Scientists from the Rocky Mountain Research Station collaborated to explore how research and management can confront increasing uncertainty due to climate change, invasive species, and land use conversion. Wildland management and policy have long depended on the idea that ecosystems are fundamentally static, and periodic events like droughts are just temporary detours from a larger, stable equilibrium. However, ecosystems are currently changing at unprecedented rates. For example, bark beetle infestations, droughts, and severe wildfires have killed large numbers of trees across the western ...

A new research, carried out by the D'Or Institute for Research and Education (IDOR) and the Federal University of ABC (UFABC), has shown for the first time that storytelling is capable of providing physiological and emotional benefits to children in Intensive Care Units (ICUs). The study was published in the Proceedings of the National Academy of Sciences, the official scientific journal of the National Academy of Sciences of the U.S. The study was led by Guilherme Brockington, PhD, from UFABC, and Jorge Moll, MD, PhD, from IDOR. "During storytelling, something happens that we call 'narrative ...

Researchers from Skoltech and their colleagues from Russia and the US have shown that the two components of the bacterial CRISPR-Cas immunity system, one that destroys foreign genetic elements such as viruses and another that creates "memories" of foreign genetic elements by storing fragments of their DNA in a special location of bacterial genome, are physically linked. This link helps bacteria to efficiently update their immune memory when infected by mutant viruses that learned to evade the CRISPR-Cas defense. The paper was published in the journal Proceedings of the National Academy of Sciences. CRISPR-Cas, a defense mechanism that provides bacteria with resistance to their viruses (bacteriophages), destroys DNA from ...

LOS ANGELES (May 24, 2021) -- Today, The Lundquist Institute announced that Wei Yan, MD, PhD, and his research group have solved a longstanding mystery and scientific debate about the mechanism underlying the gamete and embryo transport within the Fallopian tube. Using a mouse model where the animals lacked motile cilia in the oviduct, Dr. Yan's group demonstrated that motile cilia in the very distal end of the Fallopian tube, called infundibulum, are essential for oocyte pickup. Disruptions of the ciliary structure and/or beating patterns lead to failure in oocyte pickup and consequently, a loss of female fertility. Interestingly, motile cilia in other parts of the oviduct can facilitate sperm ...

Hearing loss is a disability that affects approximately 5% of the world's population. Clinically determining the exact site of the lesion is critical for choosing a proper treatment for hearing loss. For example, the subjects with damage in sound conduction or mild outer hair cell damage would benefit from hearing aids, while those with significant damage to outer or inner hair cells would benefit from the cochlear implant. On the other hand, the subjects with impairments in more central structures such as the cochlear nerve, brainstem, or brain do not benefit from either hearing aids or cochlear implants. However, the role of impairments in cochlear glial cells in hearing loss is not as well known. While it is known that connexin channels in cochlear glial ...

Scientists at UC San Diego, San Diego State University and colleagues find that extreme heat and elevated ozone levels, often jointly present during California summers, affect certain ZIP codes more than others. Those areas across the state most adversely affected tend to be poorer areas with greater numbers of unemployed people and more car traffic. The science team based this finding on data about the elevated numbers of people sent to the hospital for pulmonary distress and respiratory infections in lower-income ZIP codes. The study identified hotspots throughout ...

In 2018, the Camp Fire ripped through the town of Paradise, California at an unprecedented rate. Officials had prepared an evacuation plan that required 3 hours to get residents to safety. The fire, bigger and faster than ever before, spread to the community in only 90 minutes. As climate change intensifies, wildfires in the West are behaving in ways that were unimaginable in the past--and the common disaster response approaches are woefully unprepared for this new reality. In a recent study, a team of researchers led by the University of Utah proposed a framework for simulating dire scenarios, which the authors define as scenarios where there is less time to ...

Mosquitoes are one of humanity's greatest nemeses, estimated to spread infections to nearly 700 million people per year and cause more than one million deaths. UC Santa Barbara Distinguished Professor Craig Montell has made a breakthrough in one technique for controlling populations of Aedes aegypti, a mosquito that transmits dengue, yellow fever, Zika and other viruses. The study, published in the Proceedings of the National Academy of Sciences, documents the first use of CRISPER/Cas9 gene editing to target a specific gene tied to fertility in male mosquitoes. The researchers were then able to discern how this mutation can suppress ...

A study conducted by researchers at the U.S. Department of Energy's (DOE) Argonne National Laboratory reveals that the use of corn ethanol is reducing the carbon footprint and diminishing greenhouse gases. The study, recently published in Biofuels, Bioproducts and Biorefining, analyzes corn ethanol production in the United States from 2005 to 2019, when production more than quadrupled. Scientists assessed corn ethanol's greenhouse gas (GHG) emission intensity (sometimes known as carbon intensity, or CI) during that period and found a 23% reduction in CI. According ...

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer. According to the American Cancer Society, the estimated risk of developing oral cancer in the U.S. is 1 in 60 for men and 1 in 140 for women. Cancer therapies face multiple challenges, including off-target side effects and low efficacy. ...

MAY 24, 2021, NEW YORK - A Ludwig Cancer Research study has discovered how to revive a powerful but functionally inert subset of anti-cancer immune cells that are often found within tumors for cancer therapy. Led by Ludwig Lausanne's Ping-Chih Ho and Li Tang of the École Polytechnique Fédérale de Lausanne, the study describes how an immune factor known as interleukin-10 orchestrates the functional revival of "terminally exhausted" tumor-infiltrating T lymphocytes (TILs), which have so far proved impervious to stimulation by immunotherapies. It also demonstrates that the factor, when applied in combination with cell therapies, can eliminate tumors in mouse models of melanoma and colon cancer. The findings are reported in the current issue of Nature ...

MIAMI - Scientists from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science analyzed ground movements measured by Interferometric Synthetic Aperture Radar (InSAR) satellite data and GPS stations to precisely model where magma intruded and how magma influx changed over time, as well as where faults under the flanks moved without generating significant earthquakes. The GPS network is operated by the U.S. Geological Survey's Hawaii Volcano Observatory. "An earthquake of magnitude-6 or greater would relieve the stress imparted by the influx of magma along ...

BOSTON - Cardiovascular disease (CVD) is the leading cause of death in the United States. Public health advocates frequently site Americans' high-sodium diet as one factor in the nation's cardiac health. While sodium has been definitively linked to high-blood pressure -- a key risk factor for CVD -- few rigorously controlled studies make the direct causal link between high sodium intake and cardiovascular damage, heart attack, or stroke. In a new analysis, researchers from Beth Israel Deaconess Medical Center (BIDMC) examined three cardiovascular biomarkers, which are measurable indicators ...

California state school nutrition policies and federal policies for school meals have mixed impacts on childhood obesity in children of Pacific Islander (PI), Filipino (FI) and American Indian/Alaska native (AIAN) origins, according to a new study published this week in the open access journal PLOS Medicine by Mika Matsuzaki of Johns Hopkins Bloomberg School of Public Health, USA, and colleagues. Children of PI, FI and AIAN origin are some of the most understudied subgroups experiencing high rates of overweight/obesity. California has enacted policies on foods and beverages available in schools through a series of standards ...

People don't gain or lose weight because they live near a fast-food restaurant or supermarket, according to a new study led by the University of Washington. And, living in a more "walkable", dense neighborhood likely only has a small impact on weight. These "built-environment" amenities have been seen in past research as essential contributors to losing weight or tending toward obesity. The idea appears obvious: If you live next to a fast-food restaurant, you'll eat there more and thus gain weight. Or, if you have a supermarket nearby, you'll shop there, eat healthier and thus lose weight. Live in a neighborhood that makes walking and biking easier and you'll get out, exercise more and burn more calories. ...

Researchers at the Karolinska Institutet, University of Oxford and University of Copenhagen have shown that elevated levels of lipids known as ceramides can be associated with a ten-fold higher risk of death from cardiovascular disease. Treatment with liraglutide could keep the ceramide levels in check, compared with placebo. The results have been published in the Journal of the American College of Cardiology. Approximately 16 percent of the Swedish population suffers from obesity (BMI over 30), which is one of the greatest risk factors for cardiovascular diseases such as myocardial infarction and stroke. The World Health ...

Has your heart ever started to race at the thought of an upcoming deadline for work? Or has the sight of an unknown object in a dark room made you jump? Well, you can probably thank your amygdala for that. The small almond-shaped brain structure is central to how we perceive and process fear. As we start to learn to associate fear with cues in our environment, neuronal connections within the amygdala are dynamically altered in a process called synaptic plasticity. Although this physiological mechanism is important for facilitating fear learning, it has mostly been studied in the context of excitatory neurons within the amygdala. Far less is known about the role inhibitory cells ...

CHICAGO, May 24, 2021--More than a year after COVID-19 appeared in the U.S., dentists continue to have a lower infection rate than other front-line health professionals, such as nurses and physicians, according to a study published online ahead of the June print issue in the Journal of the American Dental Association. The study, "COVID19 among Dentists in the U.S. and Associated Infection Control: a six-month longitudinal study," is based on data collected June 9 - Nov. 13, 2020. According to the study, based on the number of dentists with confirmed or probable COVID-19 infections over more than six months, the cumulative infection rate for U.S. dentists is 2.6%. The monthly incidence ...

Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer's disease in the future. The findings are published in Nature Medicine. Approximately 20-30% of patients with Alzheimer's disease are wrongly diagnosed within specialist healthcare, and diagnostic work-up is even more difficult in primary care. Accuracy can be significantly improved by measuring the proteins tau and beta-amyloid via a spinal fluid sample, or PET scan. However, those methods are expensive and only available at a relatively few specialized memory clinics worldwide. Early and accurate ...

Ecology, the field of biology devoted to the study of organisms and their natural environments, needs to account for the historical legacy of colonialism that has shaped people and the natural world, researchers argued in a new perspective in the journal Nature Ecology & Evolution. To make ecology more inclusive of the world's diverse people and cultures living in diverse ecosystems, researchers from University of Cape Town, North West University in South Africa and North Carolina State University proposed five strategies to untangle the impacts of colonialism on research and thinking in the field today. "There are significant biases in our understanding ...

The neural representation of a familiar face strengthens faster when you see someone in person, according to a new study published in JNeurosci. The brain loves faces -- there's even an interconnected network of brain areas dedicated to face-processing. Despite all the research on how the brain sees faces, little is known about how the neural representation of a face changes as it becomes familiar. To track how familiarity brain signals change, Ambrus et al. measured participants' brain activity with EEG before and after getting to know different ...

A strange phenomenon happens with modern blue whales, humpback whales and gray whales: they have teeth in the womb but are born toothless. Replacing the teeth is baleen, a series of plates composed of thin, hair- and fingernail-like structures growing from the roof of their mouths that act as a sieve for filter feeding small fish and tiny shrimp-like krill. The disappearing embryonic teeth are testament to an evolutionary history from ancient whales that had teeth and consumed larger prey. Modern baleen whales on the other hand use their fringed baleen to strain their miniscule prey from water, hence the term filter feeding. A new study that utilized high-resolution computed tomography (CT) to ...

East Hanover, NJ. May 24, 2021. A recent qualitative study of rehabilitation professionals caring for people with spatial neglect enabled researchers to identify interventions to improve rehabilitation outcomes. Experts reported that implementation of spatial neglect care depends on interventions involving family support and training, promotion of interdisciplinary collaboration, development of interprofessional vocabulary, and continuous treatment and follow-up assessment through care transitions. The article, "Barriers and Facilitators to Rehabilitation Care of Individuals with Spatial ...