Announcing a new article publication for BIO Integration journal. In this review article the authors Yingxue Deng, Rui Huang, Songyin Huang and Menghua Xiong from South China University of Technology, Guangzhou, Guangdong, P. R. China and Sun Yat-sen University, Guangzhou, Guangdong, P. R. China discuss how nanoparticles enable efficient delivery of antimicrobial peptides for the treatment of deep infections. Antimicrobial peptides (AMPs) are rarely directly used to treat deep infections due to their systemic toxicity and low bioavailability. The authors summarize recent progress that researchers employed nanoparticles based delivery systems to deliver AMPs for the treatment of deep infections. Nanoparticles-based delivery systems offer a strategy ...

(Boston)-- Uncontrolled diabetes increases maternal and fetal risks during pregnancy. As a result, the American Diabetes Association (ADA) recommends that family planning should be discussed and effective contraception should be available to the more than three percent of (more than one million) reproductive-age women in the United States with diabetes. Yet a new study has found that women with diabetes are less likely to use contraception after their diabetes diagnosis. "Efforts are needed to ensure that women with diabetes receive the counseling and clinical services needed to carefully plan their pregnancies," said corresponding author Mara Murray Horwitz, MD, assistant ...

When the COVID-19 pandemic forced medical students out of classrooms and clinical rotations this time last year, the state of Georgia's only public medical school had to quickly rethink its traditional curriculum. Faculty and staff at the Medical College of Georgia at Augusta University were able to quickly adapt and provide an online platform for learning about the pandemic and initiating student-led service projects to aid frontline workers and help educate the public, MCG faculty and students write in a review article in the journal Medical Science Educator. The University System of Georgia suspended in-classroom learning ...

Prior infection with COVID-19 protects most people against reinfection, with 0.65% of patients returning a positive PCR test twice during Denmark's first and second waves, compared with 3.27% of people who tested positive after initially being negative. People over the age of 65 are at greater risk of catching COVID-19 again, with only 47% protection against repeat infection compared with 80% for younger people. Protection against reinfection remained stable for more than six months. The findings underline that measures to protect the elderly - including social distancing and vaccinations are essential even if people have already been diagnosed with COVID-19. The analysis focused on the original COVID-19 strain and made no assessment ...

When it comes to adapting to new situations, goats are a step ahead. Compared to sheep, they can more quickly adapt to changing environmental conditions. These are the findings of a new study by researchers at Martin Luther University Halle-Wittenberg (MLU) and the Leibniz Institute for Farm Animal Biology (FBN) which were published in Royal Society Open Science. The study investigated how well the animals were able to navigate around obstacles to reach food. Sheep and goats have many things in common: They are closely related genetically, roughly the same size, have similar social structures, and have both been domesticated by humans over approximately the same amount of time. They do, however, differ greatly when it comes to their foraging strategies. "While sheep ...

As their name suggests, by-the-wind sailor jellyfish know how to catch a breeze. Using a stiff, translucent sail propped an inch above the surface of the ocean, these teacup-sized organisms skim along the water dangling a fringe of delicate purple tentacles just below the surface to capture zooplankton and larval fish as they travel. At the mercy of the wind, these jellies can wash ashore and strand -- sometimes numbering in the trillions -- on beaches around the world, including up and down the U.S. West Coast. And while these mass stranding events are hard to miss, very little actually is known about how or why they happen. Now, thanks to 20 years of observations from thousands of citizen scientists, ...

When it comes to the use of driverless vehicles, an individual's support for their adoption hinges on how safe they are, rather than their economic impact or privacy concerns stemming from the data they might collect, a Nanyang Technological University, Singapore (NTU Singapore) study of 1,006 Singaporeans has found.   The NTU Singapore study led by the Wee Kim Wee School of Communication and Information exposed its participants to positive and negative blog posts about driverless vehicles and their safety, their impact on jobs and the economy, ...

The collaborative work is published online in the journal Communications Biology on March 8th, 2021. The power of photosynthesis Photosynthesis represents the only biological process, which converts the energy of sunlight into chemically stored energy. On molecular level, the photosynthetic key enzymes called photosystems are responsible for this conversion process. Photosystem I (PSI), one of the two photosystems, is a large membrane protein complex that can be present in different forms - as monomers, dimers, trimers or even tetramers. New isolation technique helps revealing ...

An international team of scholars studied how the COVID-19 pandemic has impacted Europeans' stress levels and their trust in their national governments and the healthcare systems. They found that respondents were most stressed by the state of the national economy, and only after that, by the risk of catching COVID-19 and possibly being hospitalized. The results of the study were published in Royal Society Open Science. The authors of the study represent over 50 universities. Among them is Dmitrii Dubrov, Junior Research Fellow at the HSE Center for Sociocultural Research, who developed and organized the global survey, COVIDiSTRESS. The researchers studied the psychological ...

An international study led by the University Complutense of Madrid (UCM) proposed new computational image processing methods that improve the analysis and three-dimensional reconstruction of biological macromolecules. Currently, determining the composition (i.e., the sequence of amino acids) of macromolecules such as proteins is relatively simple; however, determining the shape in which they are ordered in a three-dimensional structure is not. The new methodology, published in Nature Communications, improves the visualization of the 3D reconstructions obtained through cryogenic electron microscopy, as well as their quality. "This study helps us broaden our understanding of proteins ...

Every year 600-900 million tons of carbon flow through rivers to the ocean either as particles or in dissolved form. Researchers have known for a long time that this does not represent the total amount of carbon that gets transported from the land to the ocean. But the remaining contributors mostly from coastal ecosystems, such as carbon-rich mangrove forests, and from groundwater discharge into the ocean have been notoriously difficult to measure. A new study published in the journal Global Biogeochemical Cycles and spearheaded by Dr. Eun Young Kwon, project leader at the IBS Center for Climate Physics South Korea provides new estimates of this elusive component of the global carbon cycle. The study makes use of the existence of two stable carbon isotopes, 12C and 13C, with the latter ...

Statisticians have calculated the probability of ships of different Polar Ship Categories becoming beset in ice along the Northern Sea Route. Their data will help assess the risks of maritime traffic in the Arctic. The results of the new study, published recently in the Cold Regions Science and Technology journal, will support safer maritime transport planning and the prevention of oil spills. The results will also benefit authorities that regulate maritime traffic by providing a foundation for statutes and legislation. A comprehensive approach to computing helps shipping companies plan transport routes. Tankers more common on the Northern Sea Route The Northern Sea Route is attracting more tankers and cargo ships travelling from Russia and ...

Powerful and squat stegosaurs are now one of the most recognisable dinosaurs: they are easily identified by the spines on the tail and the bony plates on the back - osteoderms. The representatives of this group lived about 165-125 million years ago, during the Jurassic and early Cretaceous periods. They were five to seven metres long and had a disproportionately small head. Their teeth were therefore quite small - about a centimetre in height and about the same in width. Palaeontologists from St Petersburg University worked together with colleagues from: the Zoological Institute of the Russian Academy of Sciences; the ...

The ocean covers about 70% of the Earth's surface area and is the largest reservoir of energy. Researchers have been exploring the approach for harnessing ocean energy to solve the world energy crisis and pollution problems caused by thermal power generation. The nanogenerator, including piezoelectric, triboelectric, and pyroelectric nanogenerators, is one of the key technologies for mechanical energy conversion. The triboelectric nanogenerator (TENG) makes use of the triboelectric effect and electrostatic induction to harvest mechanical energy based on contact or sliding electrification. However, conventional TENG device is often based on solid/solid contact, and it is hard to ensure the contact intimacy of the two tribo-materials. In the meanwhile, the material surfaces will wear or become ...

Research from the University of Kent's School of Biosciences has revealed that a molecule produced by the human immune system can severely diminish the potency of certain antibiotics. This may explain why antibiotics effective in laboratory settings can be less effective at clearing infections in humans. The research findings, which have been published in the journal Archives of Microbiology, reveal that nitric oxide, a molecule produced by our immune systems, can render aminoglycoside antibiotics ineffective when used against E. coli strains isolated from ...

Geopolitical boundaries can have a profound effect on the protection of threatened species. A case in point is the native cycads of the United States. A recent review paper written by researchers at the Western Pacific Tropical Research Center at the University of Guam highlights extinction risks of cycad species that occur in U.S. controlled lands and the profound effect geopolitical boundaries has had on the protection of these threatened species. The paper appears in the December 2020 issue of the MDPI journal Diversity. Cycads are the most threatened plant order worldwide. This is due to a combination of factors including habitat loss, poaching predation by invasive species, and lack of appropriate ...

Shipping provides the very foundation for world trade, by moving an estimated 11 billion tonnes of goods a year from where they are produced to where they will be used. From TVs to toasters, soap to sugar -- much of it moves over the waves. Yet for ships plying the open ocean and for offshore industries, waves present an enormous challenge --because they can increase operational risks, reduce operating efficiency, and be dangerous if large enough and not handled well -- and they can be difficult to predict. Ships can access information about wave heights, directions and frequency, but those data may be expensive to obtain or delayed because of satellite communication limitations, says Zhengru ...

Undocumented women in Finland access pregnancy care later than others. Yet, screening of infectious diseases at the early stages of pregnancy would be particularly important to these women, a new study carried out in Helsinki, Finland, shows. Conducted by the University of Eastern Finland and the University of Helsinki, the study on undocumented women's pregnancy care and childbirth was published in BMC Pregnancy and Childbirth. Undocumented pregnant women constitute a vulnerable group of people who lack equal access to pregnancy care. Previous ...

Study finds that children who experienced housing loss in the 2011 Great East Japan Earthquake are more inclined to opt for short-term gratification Tokyo - Living through a tragic event might make us more inclined to live for the moment, but not always in a good way. Research is looking into the psychological after-effects among children who survived the 2011 Great East Japan Earthquake, and a recent study may have made a connection: the children may forgo greater long-term reward for short-term pleasure. Among the traumatic experiences in the quake and subsequent tsunami that killed almost 16,000 people, some survivors witnessed people washed ...

In their pursuit of maximum reward, people suffering from gambling disorder rely less on exploring new but potentially better strategies, and more on proven courses of action that have already led to success in the past. The neurotransmitter dopamine in the brain may play an important role in this, a study in biological psychology conducted at the University of Cologne's Faculty of Human Sciences by Professor Dr Jan Peters und Dr Antonius Wiehler suspects. The article 'Attenuated directed exploration during reinforcement learning in gambling disorder' has appeared in the latest edition of the Journal of Neuroscience, published ...

In cancer immunotherapy, cells in the patient's own immune system are activated to attack cancer cells. CAR T cell therapy has been one of the most significant recent advances in immunotherapies targeted at cancer. In CAR T cell therapy, T cells are extracted from the patient for genetic modification: a chimeric antigen receptor (CAR) is transported into the cells using a viral vector, helping the T cells better identify and kill cancer cells. When the antigen receptor cells identify the desired surface structure in the patient's cells, they start multiplying and killing the target cells. CAR T cell therapy was introduced to Finland in 2018, and the treatment form has been used in support of patients suffering from leukaemia and lymphomas. So ...

A Delphi survey carried out by Dr Lyn Robinson, Head of Department and Reader in Library and Information Science at City, University of London, and Dr David Haynes, former Visiting Lecturer and Post-Doctoral Fellow in City's Department of Library and Information Science, has revealed priorities for protecting personal privacy online. Their research study, "Delphi study of risk to individuals who disclose personal information online", published in the Journal of Information Science, was conducted at City in 2019, and is based on the views of a panel of privacy and information security experts. A literature review, published between 2014 and ...

For years, in the vastness of our galaxy, astrophysicists have been tracking down pevatrons - natural accelerators of particles with monstrous energies. Thanks to the HAWC Observatory for Cosmic Radiation, another probable trace of their existence has just been found: photons with some of the highest energies. However, what is particularly important is that this time the high-energy photons have not only been recorded, but also their probable place of origin has been determined. We know they exist, we just don't know where exactly they are or what they look like. Pevatrons - because this is what we are talking ...

Marine heatwaves are dramatically affecting the marine ecosystems of the world and the Mediterranean is no exception. In the Mediterranean, these extreme climate episodes and its resulting massive mortality of species are getting more and more intense and frequent. To date, most of the studies analysed the effects of these perturbations on specific species and populations, although researchers still do not know how this affects the functioning of the involved ecosystems. A new study led by the University of Barcelona (UB) and the Institute of Marine Sciences (ICM-CSIC) has stated that marine heatwaves are having a strong impact on the functioning of coraligen, one of the most emblematic ...

A new study comparing decades of environmental monitoring records has confirmed that Canada's caribou are not faring as well as other animals like moose and wolves in the same areas--and also teased out why. The study used 16 years of data to examine changes in vegetation, moose, wolves and caribou. "Caribou are declining across Canada and have been recently lost in the Lower 48 States," says Melanie Dickie, a doctoral student with UBC Okanagan's Irving K. Barber Faculty of Science. "Understanding why caribou are declining is the first step to effectively managing the species--it tells ...