In a study that included data on more than 800,000 Medicare beneficiaries who died between 2000 – 2009, a lower proportion died in an acute care hospital in recent years, although both intensive care unit (ICU) use and the rate of health care transitions increased during the last month of life, according to a study appearing in the February 6 issue of JAMA. "Site of death has been proposed as a quality measure for end-of-life care because, despite general population surveys indicating the majority of respondents and those with serious illness want to die at home, in ...

Among patients with peripheral artery disease and intermittent claudication (pain in the calf that comes and goes, typically felt while walking), 24 weeks of treatment with the angiotensin-converting enzyme (ACE) inhibitor ramipril was associated with improvement in pain-free and maximum walking times and the physical health aspect of quality of life, according to a study appearing in the February 6 issue of JAMA. "Approximately 27 million individuals in Europe and North America have peripheral artery disease (PAD). Intermittent claudication occurs in approximately one-third ...

Among patients with chronic unilateral lateral epicondylalgia ("tennis elbow"), a single injection of corticosteroid medication was associated with poorer outcomes after one year and higher recurrence rates compared with placebo, while eight weeks of physiotherapy did not significantly improve long-term outcomes, according to a study appearing in the February 6 issue of JAMA. "Use of corticosteroid injections to treat lateral epicondylalgia is increasingly discouraged, partly because evidence of long-term efficacy has not been found, and due to high recurrence rates," ...

A training regimen to adjust the body's motor reflexes may help improve mobility for some people with incomplete spinal cord injuries, according to a study supported by the National Institutes of Health. During training, the participants were instructed to suppress a knee jerk-like reflex elicited by a small shock to the leg. Those who were able to calm hyperactive reflexes – a common effect of spinal cord injuries – saw improvements in their walking. The study was led by Aiko Thompson, Ph.D., and Jonathan Wolpaw, M.D., both of whom hold appointments at the New York ...

Obesity can lead to a lack of vitamin D circulating in the body, according to a study led by the UCL Institute of Child Health (ICH). Efforts to tackle obesity should thus also help to reduce levels of vitamin D deficiency in the population, says the lead investigator of the study, Dr Elina Hypponen. While previous studies have linked vitamin D deficiency with obesity, the ICH-led paper, published in the journal PLOS Medicine, sought to establish the direction of causality i.e. whether a lack of vitamin D triggers a weight gain, or whether obesity leads to the deficiency. This ...

LA, CA (05 February 2013). Tourists coming into contact with sea turtles at holiday attractions face a risk of health problems, according to research published today by JRSM Short Reports. Encountering free-living sea turtles in nature is quite safe, but contact with wild-caught and captive-housed sea turtles, typically through handling turtles in confined pools or through consuming turtle products, carries the risk of exposure to toxic contaminants and to zoonotic (animal to human) pathogens such as bacteria, viruses, fungi and parasites. Symptoms, which may take some ...

A small, two-wheeled robot has been driven by a male silkmoth to track down the sex pheromone usually given off by a female mate. The robot has been used to characterise the silkmoth's tracking behaviours and it is hoped that these can be applied to other autonomous robots so they can track down smells, and the subsequent sources, of environmental spills and leaks when fitted with highly sensitive sensors. The results have been published today, 6 February, in IOP Publishing's journal Bioinspiration and Biomimetics, and include a video of the robot in action http://www.youtube.com/watch?v=n2k1T2X7_Aw&feature=youtu.be The ...

(Embargoed) CHAPEL HILL, N.C. – New research in animals triggered by a combination of serendipity and counterintuitive thinking could point the way to treating fractures caused by rapid bone loss in people, including patients with metastatic cancers. A series of studies at the University of North Carolina School of Medicine found that steroid drugs, known for inducing bone loss with prolonged use, actually help suppress a molecule that's key to the rapid bone loss process. A report of the new findings appears online Feb. 5, 2013 in the journal PLOS ONE. Osteoporosis ...

Maternal diet and weight can impact their child's health even before birth – but so can a father's, shows a study published in BioMed Central's open access journal BMC Medicine. Hypomethylation of the gene coding for the Insulin-like growth factor 2, (IGF2),in newborns correlates to an increased risk of developing cancer later in life, and, for babies born to obese fathers, there is a decrease in the amount of DNA methylation of IGF2 in foetal cells isolated from cord blood. As part of the Newborn Epigenetics Study (NEST) at Duke University Hospital, information was collected ...

The number of congenital anomalies, or birth defects arising from multiple births has almost doubled since the 1980s, suggests a new study published today (6 February) in BJOG: An International Journal of Obstetrics and Gynaecology. The study investigates how the change in the proportion of multiple births has affected the prevalence of congenital anomalies from multiple births, and the relative risk of congenital anomaly in multiple versus singleton births. This study, led by the University of Ulster over a 24-year period (1984 – 2007) across 14 European countries ...

Dietary advice about fats and the risk of heart disease is called into question on bmj.com today as a clinical trial shows that replacing saturated animal fats with omega-6 polyunsaturated vegetable fats is linked to an increased risk of death among patients with heart disease. The researchers say their findings could have important implications for worldwide dietary recommendations. Advice to substitute vegetable oils rich in polyunsaturated fatty acids (PUFAs) for animal fats rich in saturated fats to help reduce the risk of heart disease has been a cornerstone of ...

Natural chemicals found in green tea and red wine may disrupt a key step of the Alzheimer's disease pathway, according to new research from the University of Leeds. In early-stage laboratory experiments, the researchers identified the process which allows harmful clumps of protein to latch on to brain cells, causing them to die. They were able to interrupt this pathway using the purified extracts of EGCG from green tea and resveratrol from red wine. The findings, published in the Journal of Biological Chemistry, offer potential new targets for developing drugs to treat ...

DURHAM, N.C. -- A father's obesity is one factor that may influence his children's health and potentially raise their risk for diseases like cancer, according to new research from Duke Medicine. The study, which appears Feb. 6 in the journal BMC Medicine, is the first in humans to show that paternal obesity may alter a genetic mechanism in the next generation, suggesting that a father's lifestyle factors may be transmitted to his children. "Understanding the risks of the current Western lifestyle on future generations is important," said molecular biologist Adelheid ...

CAMBRIDGE, MA -- Increased natural gas production is seen as a crucial step away from the greenhouse gas emissions of coal plants and toward U.S. energy independence. But natural gas wells have problems: Large volumes of deep water, often heavily laden with salts and minerals, flow out along with the gas. That so-called "produced water" must be disposed of, or cleaned. Now, a process developed by engineers at MIT could solve the problem and produce clean water at relatively low cost. After further development, the process could also lead to inexpensive, efficient desalination ...

(SACRAMENTO, Calif.) — Deaf and hard of hearing (DHoH) people must overcome significant professional barriers, particularly in health care professions. A number of accommodations are available for hearing-impaired physicians, such as electronic stethoscopes and closed-captioning technologies, but are these approaches making a difference? A team of researchers from the University of California, Davis, the University of Texas Health Science Center at San Antonio and the University of Michigan surveyed DHoH physicians and medical students to determine whether these and ...

ARLINGTON, Va. —The Navy's fifth Littoral Combat Ship (LCS), Milwaukee, will be the first to benefit from new high-power density waterjets aimed at staving off rudder and propeller damage experienced on high-speed ships. The product of an Office of Naval Research (ONR) Future Naval Capabilities (FNC) program, the waterjets arrived last month at the Marinette Marine shipyard in Wisconsin, where Milwaukee (LCS 5) is under construction. "We believe these waterjets are the future," said Dr. Ki-Han Kim, program manager in ONR's Ship Systems and Engineering Research Division. ...

ANN ARBOR, Mich. — When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist. Now in a new study, University of Michigan Comprehensive Cancer Center researchers assess the complete landscape of a cancer's "kinome" expression and determine which kinases are acting up in a particular tumor. They go on to show that those particular kinases can be targeted with drugs – potentially combining multiple drugs to target multiple ...

WEST LAFAYETTE, Ind. – Researchers are improving the performance of technologies ranging from medical CT scanners to digital cameras using a system of models to extract specific information from huge collections of data and then reconstructing images like a jigsaw puzzle. The new approach is called model-based iterative reconstruction, or MBIR. "It's more-or-less how humans solve problems by trial and error, assessing probability and discarding extraneous information," said Charles Bouman, Purdue University's Michael and Katherine Birck Professor of Electrical and Computer ...

EurekAlert!'s most-viewed news release from 2012 focused on a breakthrough in the treatment of obesity and related diseases using a combination of hormones, tested in mice, that resulted in weight loss and lowered blood sugar without negative side effects. The theme of obesity was prominent in three other most-viewed news releases on EurekAlert! during 2012.. Other topics were mental health, neuroscience, marine conservation, human behavioral science, and progress toward a male contraceptive pill. EurekAlert! is the global science news service operated by the American ...

A pair of commentaries to appear in an upcoming issue of the journal Antimicrobial Agents and Chemotherapy highlight a debate within the public health community surrounding Centers for Disease Control and Prevention (CDC) recommendations for treatment of exposed individuals during last year's fungal meningitis outbreak. Manuscripts of the commentaries were published ahead of print today on the journal's webpage. "I will try to offer sufficient documentation to show there are alternative approaches worthy of consideration," writes David A Stevens of Stanford University ...

Ever since Austrian scientist Erwin Schrodinger put his unfortunate cat in a box, his fellow physicists have been using something called quantum theory to explain and understand the nature of waves and particles. But a new paper by physics professor Andreas Albrecht and graduate student Dan Phillips at the University of California, Davis, makes the case that these quantum fluctuations actually are responsible for the probability of all actions, with far-reaching implications for theories of the universe. Quantum theory is a branch of theoretical physics that strives ...

LA JOLLA, CA----You might think you have nothing in common with mustard except hotdogs. Yet based on research in a plant from the mustard family, Salk scientists have discovered a possible explanation for how organisms, including humans, directly regulate chemical reactions that quickly adjust the growth of organs. These findings overturn conventional views of how different body parts coordinate their growth, shedding light on the development of more productive plants and new therapies for metabolic diseases. Metabolism refers to all the chemical reactions in the body ...

The vast edges of our solar system – the boundary at the edge of our heliosphere where material streaming out from the sun interacts with the galactic material – is essentially invisible. It emits no light and no conventional telescope can see it. However, particles from inside the solar system bounce off this boundary and neutral atoms from that collision stream inward. Those particles can be observed by instruments on NASA's Interstellar Boundary Explorer (IBEX). Since those atoms act as fingerprints for the boundary from which they came, IBEX can map that boundary in ...

HOUSTON – (February 5, 2013) – American Indians are at much greater risk of suicide after acute alcohol intoxication, according to a study led by researchers at The University of Texas Health Science Center at Houston (UTHealth). The study examined the prevalence and social demographic correlates of suicide involving acute alcohol intoxication among United States ethnic minorities. Results will be published in the May 2013 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View. "Some reviews suggest that people with alcohol ...

An allergic reaction to cockroaches is a major contributor to asthma in urban children, but new research suggests that the insects are just one part of a more complex story. Very early exposure to certain components of air pollution can increase the risk of developing a cockroach allergy by age 7 and children with a common mutation in a gene called GSTM may be especially vulnerable. Researchers at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health published the findings, the first on this interplay of risk factors, in the February ...