Ammonia build-up kills liver cells but can be prevented using existing drug
High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice led by researchers from UCL.
The study, published in Science Advances, is the first to observe that build-up of ammonia (hyperammonaemia) can harm liver cells and describe how this damage occurs in mouse models that are clinically relevant for humans.
Hyperammonaemia is known to cause brain dysfunction in those with liver disease, ...










