Breast cancer prognosis associated with oncometabolite accumulation

2013-12-09

(Press-News.org) Contact information: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Breast cancer prognosis associated with oncometabolite accumulation The metabolic profile of cancer cells can be used to develop therapies and identify biomarkers associated with cancer outcome. In this issue of the Journal of Clinical Investigation Stefan Ambs and colleagues at the National Cancer Institute discovered an association between the oncometabolite 2-hydroxyglutarate (2-HG) levels, DNA methylation patterns, and breast cancer prognosis. The authors identified a breast cancer subtype with high levels of 2-HG, and a district DNA methylation pattern that was associated with reduced survival. This breast cancer subtype was common in African-American breast cancer patients, who as a group have a high prevalence of aggressive breast cancers. This study indicates that evaluation of 2-HG along with DNA methylation may be a useful biomarker for breast cancer diagnosis and prognosis ### TITLE: MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis AUTHOR CONTACT: Stefan Ambs
National Cancer Institute, Bethesda, MD, USA
Phone: 301-496-4668; E-mail: ambss@mail.nih.gov View this article at: http://www.jci.org/articles/view/71180?key=e428ff2ab0218ea590e1 END

ELSE PRESS RELEASES FROM THIS DATE:

Choloroquine reduces formation of bone resorbing cells in murine osteoporosis

2013-12-09

Choloroquine reduces formation of bone resorbing cells in murine osteoporosis Bone homeostasis requires precise balance between deposition of new bone by osteoblasts and resorption of old bone by osteoclasts. Bone diseases, including osteoporosis and ...

Ancient fresh water lake on Mars could have sustained life

2013-12-09

Ancient fresh water lake on Mars could have sustained life Scientists have found evidence that there was once an ancient lake on Mars that may have been able to support life Scientists have found evidence that there was once an ancient lake on Mars that ...

Gene 'driver' of Waldenstrom's Macroglobulinemia in up to one-third of patients identified

2013-12-09

Gene 'driver' of Waldenstrom's Macroglobulinemia in up to one-third of patients identified Drug that targets the driver mutation proves effective in animal studies NEW ORLEANS— In nearly one-third of patients with Waldenstrom's Macroglobulinemia, ...

EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus

2013-12-09

EASL publishes revised clinical practice guidelines to optimise the management of hepatitis C virus The European Association for the Study of the Liver (EASL) today publishes their revised Clinical Practice Guidelines (CPGs) ...

Breakthrough in treating leukemia, lymphoma with umbilical cord blood stem cells

2013-12-09

Breakthrough in treating leukemia, lymphoma with umbilical cord blood stem cells Study finds that growing stem cells in lab before transplant boosts survival MAYWOOD, Il. - Donated umbilical cord blood contains stem cells that can save the lives of patients with ...

Pioneering path to electrical conductivity in 'tinker toy' materials to appear in Science

2013-12-09

Pioneering path to electrical conductivity in 'tinker toy' materials to appear in Science LIVERMORE, Calif.— Sandia National Laboratories researchers have devised a novel way to realize electrical conductivity in metal-organic framework (MOF) materials, a development ...

Study shows first link between altitude and concussion

2013-12-09

Study shows first link between altitude and concussion Athletes experience fewer concussions at higher elevations AURORA, Colo. (Dec. 9, 2013) – A new study shows that high school athletes playing at higher altitudes suffer fewer concussions than those closer ...

Inflammation in prostate may reduce cancer risk

2013-12-09

Inflammation in prostate may reduce cancer risk MANHASSET, NY – Doctors at the North Shore-LIJ Health System have discovered that increased inflammation in the prostate may predict reduced risk for prostate cancer. The findings are published online ...

Ovarian cancer discovery deepens knowledge of survival outcomes

2013-12-09

Ovarian cancer discovery deepens knowledge of survival outcomes 10-gene biomarker identified as a tool in evaluating diagnosis, potential response to treatment and overall prognosis LOS ANGELES (Dec. 9, 2013) – Researchers in the Women's Cancer Program at ...

REiNS collaboration seeks common outcome measures for neurofibromatosis clinical trials

2013-12-09

REiNS collaboration seeks common outcome measures for neurofibromatosis clinical trials Initial consensus recommendations for studies of NF appear in special supplement to Neurology Philadelphia, Pa. (December 9, 2013) - As potentially effective new treatments ...