(Press-News.org) https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/11/issue/3
The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association, Acta Pharmaceutica Sinica B (APSB) is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences -- including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Featured papers in this issue are:
Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression by authors Panxia Wang, Minghui Wang, Yuehuai Hu, Jianxing Chen, Yanjun Cao, Cui Liu, Zhongkai Wu, Juan Shen, Jing Lu and Peiqing Liua (https://doi.org/10.1016/j.apsb.2020.10.017). Doxorubicin (Dox) decreased the expression of Yes-associated protein 1 (YAP1). YAP1 alleviated Dox-induced cardiomyopathy in transcription factor TEA domain 1 (TEAD1)1-dependent manner. Isorhapontigenin effectively protected against Dox-induced cardiomyopathy and improved cardiac function by increasing the expression of YAP1.
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing by authors Zhiru Wang, Wenting Kang, Ouwen Li, Fengyu Qi, Junwei Wang, Yinghua You, Pengxing He, Zhenhe Suo, Yichao Zheng and Hong-Min Liu (https://doi.org/10.1016/j.apsb.2020.11.005). In addition to inhibiting cancer cells proliferation, USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously. Hence, USP7 inhibitor is an anti-proliferation agent as well as a novel therapeutic agent in a PD-L1/PD-1 blockade strategy that can promote the immune response of a tumor.
An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis by authors Xianyan Qin, Yingying Xua, Xu Zhou, Tao Gong, Zhi-Rong Zhang and Yao Fu (https://doi.org/10.1016/j.apsb.2020.10.016). Localized delivery, comparing to systemic drug administration, offers a unique alternative to enhance efficacy, lower dosage, and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests. The authors developed, a localized drug delivery platform ("plum?pudding" structure) with controlled release and long-acting features through an injectable hydrogel ("pudding") crosslinked via self-assembled triblock polymeric micelles ("plum") to help reduce renal interstitial fibrosis.
Other articles published in the issue include:
Reviews
Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder
Pei Wang, Fang Wang, Lan Ni, Pengfei Wu, Jianguo Chen
https://doi.org/10.1016/j.apsb.2020.11.012
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment
Jinghui Zhang, Jiajun Fan, Xian Zeng, Mingming Nie, Jingyun Luan, Yichen Wang, DianwenJu, KaiYin
https://doi.org/10.1016/j.apsb.2020.10.022
Natural products as LSD1 inhibitors for cancer therapy
Yuan Fang, Chao Yang, Zhiqiang Yu, Xiaochuan Li, Qingchun Mu, Guochao Liao, Bin Yu
https://doi.org/10.1016/j.apsb.2020.06.007
Original Articles
S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling
Pingping Luo, Ming Zheng, Rui Zhang, Hong Zhang, Yingxia Liu, Wei Li, Xiaoming Sun, Qian Yu, George L. Tipoe, Jia Xiao
https://doi.org/10.1016/j.apsb.2020.11.006
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/ FOXC1 axis
Tailin He, Jialin Shang, Chenglong Gao, Xin Guan, Yingyi Chen, Liwen Zhu, Luyong Zhang, Cunjin Zhang, Jian Zhang, Tao Pang
https://doi.org/10.1016/j.apsb.2020.11.002
Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation
Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Xiao Yang, Ruimin Wang, Jianing Tian, Frank J. Gonzalez, Min Huang, Huichang Bi
https://doi.org/10.1016/j.apsb.2020.11.021
Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans
Yamin Gao, H.M. Adnan Hameed, Yang Liu, Lingmin Guo, Cuiting Fang, Xirong Tian, Zhiyong Liu, Shuai Wang, Zhili Lu, Md Mahmudul Islam, Tianyu Zhang
https://doi.org/10.1016/j.apsb.2020.11.007
A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors
Yihui Song, Min Zhao, Yahong Wu, Bin Yu, Hong-Min Liu
https://doi.org/10.1016/j.apsb.2020.10.021
Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage
Di Wang, Danting Li, Yuxin Zhang, Jie Chen, Ying Zhang, Chuyao Liao, Siyuan Qin, Yuan Tian, Zunjian Zhang, Fengguo Xu
https://doi.org/10.1016/j.apsb.2020.07.017
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai Mingyue Zheng, Hong Liu
https://doi.org/10.1016/j.apsb.2020.09.002
Design, synthesis, molecular modelin and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis
Fanxun Zeng, Shiliang Li, Guantian Yang, Yating Luo, Tiantian Qi ,Yingfan Liang, Tingyuan Yang, Letian Zhang, Rui Wang, Lili Zhu, Honglin Li, Xiaoyong Xu
https://doi.org/10.1016/j.apsb.2020.10.008
Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability
Lei Wang, Mary C. Casey, Sanjeev Kumar, V. Vernekar Rajkumar, Lalji Sahani, Karen A. Kirby, Haijuan Du, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang
https://doi.org/10.1016/j.apsb.2020.07.016
A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion
Peng Liu, Xin Xie, Miao Liu, Shuo Hu, Jinsong Ding, Wenhu Zhou
https://doi.org/10.1016/j.apsb.2020.07.021
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CiteScore: 10.5
Impact Factor: 7.097
5-Year Impact Factor: 7.865
Source Normalized Impact per Paper (SNIP): 2.210
SCImago Journal Rank (SJR): 1.792
ISSN 2211-3835 END
Guangzhou, April 8, 2021: New journal BIO Integration (BIOI) publishes its fifth issue, volume 2, issue 1. BIOI is a peer-reviewed, open access, international journal, which is dedicated to spreading multidisciplinary views driving the advancement of modern medicine. Aimed at bridging the gap between the laboratory, clinic, and biotechnology industries, it will offer a cross-disciplinary platform devoted to communicating advances in the biomedical research field and offering insights into different areas of life science, to encourage cooperation and exchange among scientists, clinical researchers, and health care providers.
The issue contains an editorial, two mini review articles, two opinion articles and an interview offering ...
The inner surface of blood vessels is lined by a wafer-thin layer of cells known as the endothelium, which forms a crucial barrier between blood and the surrounding tissue. The single-layered cell structure promotes the exchange of oxygen and nutrients, while simultaneously preventing the uncontrolled leakage of blood components. Only when the metabolic needs of the surrounding tissue increase, e.g., during growth, wound healing or tumor development, do endothelial cells abandon this stable cell association in order to divide and form new blood vessels. The signals that trigger this activation have been ...
Detecting hidden genetic defects by applying an existing method to an existing datasets. Researchers at Radboud university medical center have succeeded: they showed that the 'Expansion Hunter' method can detect errors in the DNA that lead to repeat expansion diseases, such as the movement disorder ataxia. This result provides guidance to fellow researchers worldwide on how to use this method to diagnose patients with genetic disorders.
With current diagnostic technology for genetic disorders, it is possible to map all 20,000 genes in our DNA at once. Doctors are increasingly opting for this so-called exome technique: it is widely applicable and increasingly provides molecular diagnoses. ...
High intensity interval training has become increasingly popular as it's a quick and effective way to improve health. This is all the more important as countries around the world emerge from lockdowns due to coronavirus and are looking for quick and easy way to exercise again.
Recently, researchers have been studying whether shorter variations of HIIT, involving as little as 4-min of high intensity exercise per session (excluding a warm up and cool down), also improve health.
A new review paper published in the Journal of Physiology collates a decade's worth of research ...
Words categorize the semantic fields they refer to in ways that maximize communication accuracy while minimizing complexity. Recent studies have shown that human languages are optimally balanced between accuracy and complexity. For example, many languages have a word that denotes the colour red, but no language has individual words to distinguish ten different shades of the colour. These additional words would complicate the vocabulary and rarely would they be useful to achieve precise communication.
A study published on 23 March in the journal Proceedings of the ...
The corona pandemic has had a major impact on the Nordic news media. At the same time as advertising revenues have fallen drastically, interest among the audience for professional news coverage has increased, according to a new report from Nordicom at the University of Gothenburg. Several Nordic media companies have also reported record sales of digital subscriptions as a result of the pandemic.
Covid-19 swept over the Nordic region and the rest of the world with full force in the spring of 2020. A year later, the pandemic still has the world in a strong grip. However, both the health-related ...
ITHACA, N.Y. - Millions of people donate billions of dollars' worth of their time to citizen-science projects each year. While these efforts have broadened our understanding of everything from birds to bees to bracken ferns, rarely has citizen-science data informed policy at the highest levels of government. But that may be changing.
One of the world's largest citizen-science efforts, the Cornell Lab of Ornithology's eBird, is now helping the federal government streamline and refine its process for assessing eagle populations and informing eagle management.
New research out this week in the Journal of ...
The results of the first clinical trial of a new vaccine for a neglected tropical disease have demonstrated that it is safe and induces immune responses in patients with the infection.
There are currently no vaccines to prevent leishmaniasis which is spread by the bite of sand flies and existing drugs have many side effects and are difficult to administer.
The potential new vaccine was developed by researchers at the Hull York Medical School, which is the joint medical school of the Universities of Hull and York.
Professor Paul Kaye from the Hull York Medical School was the principal investigator on the Wellcome Trust Translation Award that funded the development of the vaccine.
Professor Kaye said: ...
Philadelphia, April 15, 2021--Researchers at Children's Hospital of Philadelphia (CHOP) have identified a key target that may be responsible for treatment failure in about 30% of patients with hemophilia A. The target, known as B cell activating factor (BAFF), appears to promote antibodies against and inhibitors of the missing blood clotting factor that is given to these patients to control their bleeding episodes. The findings, published in the Journal of Clinical Investigation, raise the possibility of using anti-BAFF therapies, potentially in combination with immune tolerance therapies, to tame the immune response in some patients with severe hemophilia A.
Hemophilia A is the most common inherited bleeding disorder, affecting ...
Philadelphia, April 15, 2021 - Early and accurate diagnosis leads to optimal recovery from concussion. Over the past year across a series of studies, the Minds Matter Concussion Program research team at Children's Hospital of Philadelphia (CHOP) has systematically evaluated the use of the visio-vestibular examination (VVE) and its ability to enhance concussion diagnosis and management. The latest of these studies published online today in the Clinical Journal of Sports Medicine.
The VVE involves a series of brief eye movement and balance tests intended to identify deficits in brain function involving the visual and vestibular systems. Researchers found that the VVE presents several advantages over current clinical measures, moving beyond subjective symptoms ...
