Taming the Huntington's disease proteome: Mass spectrometry may provide answers

YorkU pain research finds what you say in the first minute after a vaccine can be key in reducing a child's future distress New study finds it's not just what say, but when you say it that can keep preschoolers calmer during vaccinations TORONTO, July 13, 2021 - As we look forward to a fall with hopefully one of the most important vaccination uptakes of children in a generation, a new study provides insights to help parents with reducing post-vaccination distress in younger kids. The study, published in END ...

WASHINGTON--In cities and towns across the United States, neighborhoods with more Black, Hispanic and Asian residents experience hotter temperatures during summer heatwaves than nearby white residents, a new study finds. It is the first to show that the trend, documented in some major cities, is widespread, even in small towns, nationwide.   According to the new nationwide study, these racial disparities exist because non-white neighborhoods tend to be more densely built up with buildings and pavement that trap heat and have fewer trees to cool the landscape.    "Urban climate is different from temperatures outside the city," said co-author Susanne Benz, an ...

Antimicrobials are used to kill or slow the growth of bacteria, viruses and other microorganisms. They can be in the form of antibiotics, used to treat bodily infections, or as an additive or coating on commercial products used to keep germs at bay. These life-saving tools are essential to preventing and treating infections in humans, animals and plants, but they also pose a global threat to public health when microorganisms develop resistance to them, a concept known as antimicrobial resistance. One of the main drivers of antimicrobial resistance is the misuse and overuse of antimicrobial agents, which includes silver nanoparticles, ...

The COVID-19 pandemic caused an unprecedented disruption to health care delivery, with resources shifted toward telehealth services and mass viral testing. While early studies in the pandemic highlighted differences in health care utilization among patients with commercial insurance, data from publicly insured or uninsured "safety-net" patient populations continue to emerge. A recent study from researchers at the University of Minnesota and Hennepin Healthcare Research Institute (HHRI) is among the first to examine how different socio-demographic groups used telehealth, outpatient (i.e., clinic), emergency department and inpatient (i.e., hospital) care to test for SARS-CoV-2, the virus that causes COVID-19. ...

In particle physics, a Majorana Fermion is charge neutral and its antiparticle is just itself. In condensed matter physics, a Majorana zero mode (MZM) is a quasi-particle excitation, which appears in the surfaces or edges of topological superconductors. Unlike the ordinary particles or quasi-particles that obey boson or fermion statistics, MZM obeys non-abelian statistics, a key property that makes MZM the building block for realizing topological quantum computation. Currently major experimental efforts focus on heterostructures made of superconductors and spin-orbit coupled systems (such as semiconducting nano-wires and topological insulators), where evidences of MZMs have been found. Unambiguous detection and manipulation of MZMs in these heterostructures, ...

North Carolina State University researchers have created insecticide-free, mosquito-resistant clothing using textile materials they confirmed to be bite-proof in experiments with live mosquitoes. They developed the materials using a computational model of their own design, which describes the biting behavior of Aedes aegypti, the mosquito that carries viruses that cause human diseases like Zika, Dengue fever and yellow fever. Ultimately, the researchers reported in the journal Insects that they were able to prevent 100 percent of bites when a volunteer wore their clothing - a base layer undergarment and a combat shirt initially designed for the military - in a cage with 200 live, disease-free mosquitoes. Vector Textiles, an NC State startup company, ...

Contractile injection systems (CISs) are widely distributed in bacteria and archaea that can form a nanomachine resembling the contractile tails of bacteriophage (T4, P2, etc.) to translocate proteins and nucleic acids . The P. asymbiotica was shown to be involved in the human infection with severe skin lesions. The PVC loci within P. asymbiotica genome produce molecular needle complexes and encode several putative effector genes. It would be a candidate P. asymbiotica weapon that participates in the attack of mammalian cells, but substantial evidences will be needed to verify this hypothesis. In this study, researchers have characterized the PAU_RS16575 as a potent PVC effector, which is widely present in bacteria. ...

To extract the polarization information of incident light, polarization-sensitive photodetectors (PSPDs) exhibit significant practical application in both military and civil areas, like bio-imaging, remote sensing, night vision, and helmet-mounted sight for fighter plane. Optical filters combined with polarizers are usually needed for traditional photodetectors to realize polarized light detection. But it will increase the size and complexity of devices. To obtain a small-size PSPD, one-dimensional (1D) nanomaterials with geometrical anisotropy, such as nanowires, nanoribbons, and nanotubes, have been used as the sensitive materials for PSPDs, which can directly identify the polarization information of incident light without any optical filters and polarizers. However, it is not ...

Google searches related to infertility and coronavirus (COVID-19) vaccines increased by 34,900% after a pair of physicians submitted a petition questioning the safety and efficacy data of the COVID-19 Pfizer vaccine. Referencing the petition, anti-vaccine activists circulated claims that misconstrued the information regarding the possibility that the vaccine could impact fertility in women. The inaccurately represented information spread rapidly on social media channels, potentially influencing public perception and decision-making among pregnant patients or those ...

The human brain has extreme ability in thinking and computation, but it only requires a very low energy power of about 20W, which is much lower than that of electronic computers. The neuronal connections in the brain network have a globally sparse but locally compact modular topological characteristics, which greatly reduces the total resource consumption for establishing the connections. The spikes of each neuron in the brain are sparse and irregular, and the clustered firing of the neuronal populations has a certain degree of synchronization, forming neural avalanches with scale-free characteristics, and the network can sensitively respond to external stimuli. However, it is still not clear how the ...