Nonregistration, discontinuation, and nonpublication of randomized trials

JAMA Network Open

2025-09-03

(Press-News.org) About The Study: Findings from this systematic review indicated that nonregistration, premature discontinuation due to poor recruitment, and nonpublication of randomized clinical trial (RCT) results remained major challenges, especially for non–industry-sponsored trials. To mitigate these challenges, requirements enforced by funders and ethics committees also taking into account legal obligations should be considered and empirically evaluated.

Corresponding Author: To contact the corresponding author, Matthias Briel, MD, PhD, email matthias.briel@usb.ch.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.24440?guestAccessKey=d272dd36-3307-4ccd-88be-0d8095689054&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=090325

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Editor’s Note: Please see article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Media advisory: This study is being presented at the 10th International Congress on Peer Review and Biomedical Publication. For more information on the Congress, go to peerreviewcongress.org.

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