(Press-News.org) Lab-based studies have provided lots of information on the biology of aging, but it’s unclear how lab discoveries apply to aging in the real world. Research in Aging Cell provides insights into aging based on studies in dogs.
The Dog Aging Project (DAP) is designed to identify patterns of aging and how these are shaped by the diversity of genetic and environmental variation among companion dogs.
By analyzing metabolites from blood samples of dogs in the DAP, investigators identified effects of age on more than one-third of measured metabolites. They also discovered that post-translationally modified amino acids, which are generated from protein break-down, are strongly linked with age in dogs. These molecules might be promising indicators of physiological aging. Also, the study pointed to an important role of the kidney in the relationship between age and blood metabolites.
"Because dogs age like humans, share our environment, and receive comparable healthcare, they’re an ideal model for studying aging,” said corresponding author Daniel E.L. Promislow, PhD, of Tufts University. “Our hope is that blood metabolites like those studied here have the potential to serve as powerful biomarkers for tracking the processes that drive healthy aging, not only in dogs but in humans as well.”
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1111/acel.70226
Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com.
About the Journal
Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, and cellular aspects of the aging process, as well as the links between aging and age-related disease.
About Wiley
Wiley is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning. Visit us at Wiley.com and Investors.Wiley.com. Follow us on Facebook, X, LinkedIn and Instagram.
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Can blood analyses in dogs provide insights into human aging?
2025-10-22
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