Deep learning model trained with stage II colorectal cancer whole slide images identifies features associated with risk of recurrence – with higher success rate than clinical prognostic parameters

In a new study, terrestrial bacteria-infecting viruses were still able to infect their E. coli hosts in near-weightless “microgravity” conditions aboard the International Space Station, but the dynamics of virus-bacteria interactions differed from those observed on Earth. Phil Huss of the University of Wisconsin-Madison, U.S.A., and colleagues present these findings January 13th in the open-access journal PLOS Biology. Interactions between phages—viruses that infect bacteria—and their hosts play an integral role in microbial ecosystems. Often described as being in an ...

Therapies that target the utilization of fat by tumors and activate a type of cell death dependent on fat molecules may be a promising avenue to treat cancer, according to new research by UTHealth Houston. The findings were published today in Trends in Cancer and were co-led by Daniel E. Frigo, PhD, professor at  The University of Texas MD Anderson Cancer Center and a faculty member at The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences. Researchers came to the conclusion through a review of 121 outside studies that examined the relationship between ...

Glenview, Illinois –The American College of Chest Physicians® (CHEST) recently released a new clinical guideline on biologic management in severe asthma. Published in the journal CHEST®, the guideline contains seven evidence-based recommendations to provide a framework for pulmonologists, allergists, and immunologists to implement in their own practice.  Severe asthma affects 5% to 10% of patients with asthma, which is defined as patients who require high-dose ...

(Santa Barbara, Calif.) — Clouds, smoke and fog may darken the skies, but sediment, algae blooms and organic matter can turn day into night on the seafloor. That’s why an international team of scientists have created the first framework to identify and compare these marine blackouts. The study, published in Communications Earth & Environment, introduces the concept of a marine darkwave: a short-term but intense episode of underwater darkness that can severely impact kelp forests, seagrass beds and other light-dependent ...

Dopamine in the brain influences movement, learning, motivation and sleep. In humans, problems with dopamine are linked to conditions like Parkinson’s disease, depression and sleep disorders. While scientists know a great deal about how dopamine works in the brain, they know less about how the body controls dopamine levels. Understanding this could help treat diseases where dopamine is disrupted. In a new study published in iScience, researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Institute at Texas Children’s Hospital (Duncan NRI) worked with the laboratory fruit fly to find new genes involved in regulating dopamine ...

More than 14,000 physicists from around the world will convene to present groundbreaking research at the American Physical Society’s Global Physics Summit. The conference will be held in person in Denver and online everywhere March 15-20. Scientific program The scientific program includes more than 12,000 individual presentations on new research in astrophysics, particle physics, quantum information science, biological physics, energy research, and more. For more information, search the scientific program. All times are in Mountain time. Hybrid format The Global Physics Summit will have both in-person and online experiences. The in-person ...

A landmark international study that pooled brain scans and memory tests from thousands of adults has shed new light on how structural brain changes are tied to memory decline as people age. The findings — based on more than 10,000 MRI scans and over 13,000 memory assessments from 3,700 cognitively healthy adults across 13 studies — show that the connection between shrinking brain tissue and declining memory is nonlinear, stronger in older adults, and not solely driven by known Alzheimer’s-associated genes like ...

Many people are optimistic about ammonia’s potential as an energy source and carrier of hydrogen, and though large-scale adoption would require major changes to the way it is currently manufactured, ammonia does have a number of advantages. For one thing, ammonia is energy-dense and carbon-free. It is also already produced at scale and shipped around the world, primarily for use in fertilizer. Though current manufacturing processes give ammonia an enormous carbon footprint, cleaner ways to make ammonia do exist. A better understanding of how to guide the ammonia fuel industry’s continued development ...

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with sporadic early onset Alzheimer’s disease. The findings were published in Science Advances. Only about 5% to 10% of patients with Alzheimer’s disease are younger than 65. Of those patients, 10% have mutations in the APP, PSEN1, and PSEN2 genes, which are associated with Alzheimer’s disease. The other 90% of these cases are classified as sporadic early onset Alzheimer’s, a rare and aggressive form of the ...

Increases to the minimum wage may do more than bolster household income, reduce inequality and enhance worker well-being: They may also help make pregnancies safer, according to new research from Rutgers University. A study published online ahead of the Fe in the American Journal of Preventive Medicine finds that state-level increases in the minimum wage are associated with lower rates of hypertensive disorders of pregnancy, a leading cause of maternal mortality in the United States. The study, led by Slawa Rokicki, an assistant professor at the Rutgers School of Public Health, ...