SGLT2 inhibitors vs GLP-1 receptor agonists for kidney outcomes in individuals with type 2 diabetes

JAMA Internal Medicine

2026-01-20

(Press-News.org) About The Study: This comparative effectiveness study found that initiation of sodium-glucose cotransporter-2 inhibitor (SGLT2i) vs glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment in individuals with type 2 diabetes was associated with a lower 5-year risk of chronic kidney disease and a lower 5-year count of acute kidney injury. These findings underscore the potential of SGLT2i treatment for primary prevention of kidney disease in individuals with type 2 diabetes.

Corresponding Author: To contact the corresponding author, Simon K. Jensen, PhD, email skj@clin.au.dk.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2025.7409)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.7409?guestAccessKey=e82fc7fb-b365-4d12-b854-29fe96923002&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=012026

END

ELSE PRESS RELEASES FROM THIS DATE:

Long-term exposure to air pollution and risk and prognosis of motor neuron disease

2026-01-20

About The Study: The findings of this case-control study suggest that air pollution, even at relatively low levels typical of Sweden, may contribute both to the risk of developing motor neuron disease and disease prognosis after motor neuron disease diagnosis. Corresponding Authors: To contact the corresponding authors, email Jing Wu, PhD, (jing.wu@ki.se) and Fang Fang, MD, PhD, (fang.fang@ki.se). To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaneurol.2025.5379) Editor’s ...

Five-year absolute risk–based and age-based breast cancer screening in the US

2026-01-20

About The Study: In this decision analytical modeling study of breast cancer screening, population risk-based screening using 5-year invasive breast cancer risk was associated with similar or greater benefits than age-based screening as well as reduced false-positive recalls. As personalized medicine advances, risk-based screening is poised to become a cornerstone of breast cancer prevention, offering a more nuanced and tailored approach to patient care. Corresponding Author: To contact the corresponding author, Oguzhan Alagoz, PhD, email alagoz@engr.wisc.edu. To ...

Study finds elevated alcohol involvement in suicides of lesbian, gay and bisexual women

2026-01-20

Lesbian, gay, and bisexual (LGB) women are significantly more likely to have alcohol involved at the time of suicide compared with heterosexual women, according to a new study from Columbia University Mailman School of Public Health. The findings are published in JAMA Network Open. The researchers found that lesbian and gay women had a 15 percent higher likelihood of detectable blood alcohol content, a 17 percent higher chance of intoxication, and a 38 percent higher probability of any alcohol involvement at the time of death. Statistical interaction tests confirmed that associations between alcohol involvement and suicide varied ...

Air pollution may increase the risk of the neurodegenerative disease ALS

2026-01-20

Prolonged exposure to air pollution can be linked to an elevated risk for serious neurodegenerative diseases like ALS and seems to speed up the pathological process, report researchers from Karolinska Institutet in Sweden. The study is published in the journal JAMA Neurology. “We can see a clear association, despite the fact that levels of air pollution in Sweden are lower than in many other countries,” says Jing Wu, researcher at the Institute of Environmental Medicine, Karolinska Institutet. “This underlines the importance of improving air quality.” Motor neuron diseases (MNDs) are serious neurological diseases in which the nerve cells ...

Chronic kidney disease poisons patients’ hearts, scientists discover

2026-01-20

Scientists have discovered an answer to the longstanding mystery of why more than half of patients with chronic kidney disease ultimately die of cardiovascular problems: Their kidneys produce a substance that poisons the heart. The researchers, at UVA Health and Mount Sinai, say the discovery could let doctors identify people at risk and develop new treatments to help prevent and treat heart failure for these patients. “Kidney and heart disease can develop silently, so they are often discovered only after damage has already been done,” ...

Hollings researchers reveal why some pancreatic tumors behave differently

2026-01-20

A new study led by Aaron Hobbs, Ph.D., and Rachel Burge, Ph.D., at MUSC Hollings Cancer Center, reveals why a specific gene mutation behaves differently from other variants. The study, published in Cancer Research, a journal of the American Association for Cancer Research, shows that the mutation drives a less aggressive form of pancreatic cancer, challenging notions about how the gene functions and identifying new opportunities for personalized treatments. Pancreatic cancer is among the toughest cancers to detect early, and it’s even harder to treat. Unlike many cancers fueled by a mix of genetic changes, most pancreatic ...

DNA ties gut motility to vitamin B1

2026-01-20

Bowel habits aren’t exactly dinner-table talk. But they reflect how quickly the gut moves things along, and when that goes wrong people can experience constipation, diarrhoea, or irritable bowel syndrome (IBS). Yet the biological mechanisms that control bowel movements are still not fully understood. A new study, published today in Gut, reports DNA clues to intestinal motility and spotlights vitamin B1 (thiamine) biology as an unexpected pathway for follow-up research. An international team coordinated by Mauro D’Amato, Professor of Medical Genetics ...

Study suggests pathway for life-sustaining conditions in Europa’s ocean

2026-01-20

PULLMAN, Wash.—A recent study by geophysicists at Washington State University offers insight into how nutrients may reach the subsurface ocean of Europa, one of Jupiter’s moons and a leading candidate for extraterrestrial life in the solar system. Scientists have long wondered how life-sustaining nutrients could make it from the surface into Europa’s ice-covered ocean, where microscopic life is believed to exist. Drawing from a process from Earth’s geology known as crustal delamination, the research team used computer modeling to show that dense, nutrient-rich ice can separate from the surrounding ...

Researchers discover potential new target to treat Parkinson’s disease

2026-01-20

CLEVELAND—About 1 million Americans suffer from Parkinson’s disease, with around 90,000 new cases diagnosed each year, according to the Parkinson’s Foundation. The chronic, degenerative brain disorder destroys dopamine-producing cells essential for smooth, coordinated movement. Current treatments provide only short-term relief for such symptoms. But a team of Case Western Reserve University researchers have discovered a particular biochemical route that plays a role in the debilitating neurological condition. Their findings, published recently in Molecular ...

Global societies unite to address environmental threats to heart health

2026-01-20

Key take-aways The European Society of Cardiology, the American College of Cardiology, the American Heart Association and the World Heart Federation have published the first joint statement calling for urgent action to address environmental stressors as major contributors to cardiovascular disease. Environmental risk factors that impact cardiovascular health include air pollution, traffic, airplane and industrial noise, artificial light exposure, chemical pollution, plastic and the various effects of climate change, such as heat extremes. Regulatory ...

SGLT2 inhibitors vs GLP-1 receptor agonists for kidney outcomes in individuals with type 2 diabetes

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: