Estimated effectiveness of 2024-2025 COVID-19 vaccination against severe COVID-19

JAMA Network Open

2026-02-03

(Press-News.org) About The Study: This multicenter, case-control study found that the vaccine effectiveness of 2024-2025 COVID-19 vaccines was associated with protection against COVID-19 hospitalization and severe in-hospital outcomes and against multiple JN.1 descendants. Monitoring COVID-19 vaccine effectiveness, including stratifying by SARS-CoV-2 lineage and spike protein mutations, remains important to guide COVID-19 vaccine composition and recommendations.

Corresponding Author: To contact the corresponding author, Kevin C. Ma, PhD, email tra3@cdc.gov.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.57415)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Estimated effectiveness of 2024-2025 COVID-19 vaccination against severe COVID-19

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