(Press-News.org) New York, NY (February 19, 2013) — New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer's disease.
Most current approaches to Alzheimer's disease focus on the accumulation of amyloid plaque in the brain. The researchers at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, led by Adam M. Brickman, PhD, assistant professor of neuropsychology, examined the additional contribution of small-vessel cerebrovascular disease, which they visualized as white matter hyperintensities (WMHs).
The study included 20 subjects with clinically defined Alzheimer's disease, 59 subjects with mild cognitive impairment, and 21 normal control subjects. Using data from the Alzheimer's Disease Neuroimaging Initiative public database, the researchers found that amyloid and WHMs were equally associated with an Alzheimer's diagnosis. Amyloid and WMHs were also equally predictive of which subjects with mildcognitive impairment would go on to develop Alzheimer's. Among those with significant amyloid, WMHs were more prevalent in those with Alzheimer's than in normal control subjects.
Because the risk factors for WMHs—which are mainly vascular—can be controlled, the findings suggest potential ways to prevent the development of Alzheimer's in those with amyloid deposits.
"White Matter Hyperintensities and Cerebral Amyloidosis" was published online today in JAMA Neurology.
INFORMATION:
The other authors are Frank A. Provenzano, MS (CUMC and Fu Foundation School of Engineering and Applied Sciences); Jordan Muraskin, MS (CUMC and Fu Foundation School of Engineering and Applied Sciences); Guiseppe Tosto, MD (CUMC); Atul Narkhede, MS (CUMC); Ben T. Wasserman, AB (CUMC); Erica Y Griffith, BS (CUMC); Vanessa A. Guzman, BA (CUMC); Irene B. Meier, MSc (CUMC); and Molly E. Zimmerman, PhD (Albert Einstein College of Medicine, NY, NY).
The research was supported by NIH (U01 AG024904, P30 AG010129, K01 AG030514, AG029949, and AG034189).
The authors report no financial or other conflict of interest.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center is a multidisciplinary group that has forged links between researchers and clinicians to uncover the causes of Alzheimer's, Parkinson's and other age-related brain diseases and discover ways to prevent and cure these diseases. It has partnered with the Gertrude H. Sergievsky Center at Columbia University Medical Center, which was established by an endowment in 1977 to focus on diseases of the nervous system, and with the Departments of Pathology & Cell Biology and of Neurology to allow the seamless integration of genetic analysis, molecular and cellular studies and clinical investigation to explore all phases of diseases of the nervous system. For more information visit The Taub Institute at http://www.cumc.columbia.edu/dept/taub/.
Columbia University Medical Center provides international leadership in basic, pre-clinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia's College of Physicians and Surgeons was the first institution in the country to grant the MD degree and is among the most selective medical schools in the country. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest in the United States. Its physicians treat patients at multiple locations throughout the tri-state area, including the NewYork-Presbyterian/Columbia campus in Washington Heights, the new ColumbiaDoctors Midtown location at 51 W. 51st St. in Manhattan, and the new ColumbiaDoctors Riverdale practice. For more information, visit www.cumc.columbia.edu or columbiadoctors.org.
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Philadelphia, PA, February 20, 2013 – A study published in the Journal of the Academy of Nutrition and Dietetics has determined that there is increasing evidence of a connection between diet and acne, particularly from high glycemic load diets and dairy products, and that medical nutrition therapy (MNT) can play an important role in acne treatment.
More than 17 million Americans suffer from acne, mostly during their adolescent and young adult years. Acne influences quality of life, including social withdrawal, anxiety, and depression, making treatment essential. Since ...
PULLMAN, Wash. – Viewers of primetime crime dramas, like NCIS, CSI or Law & Order, are more inclined than non-viewers to see themselves intervening on behalf of the victim of a sexual assault, according to recent research at Washington State University.
Published in the Journal of Health Communication, the study suggests prime-time television may be a successful medium for educating the public about sexual assault and encouraging positive responses, according to Stacey Hust, associate professor of communication with the Edward R. Murrow College of Communications and ...
Twin Cities' KMOJ radio personality Georgia Ellyse is celebrating her 25th birthday this Saturday in a royal way.
The soiree, dubbed "Miss Georgia's Royal 25th Birthday Experience," is presented by Team Sophisticated as part of its weekly "A Sophisticated Experience" and has gained buzz as a must-attend event for the Twin Cities' most influential tastemakers.
As host of KMOJ/89.9 FM's Midday Show, Ellyse is excited to take a moment to celebrate this milestone in her life as she continues to pursue her dreams within the entertainment and beauty ...
Faith Lutheran High School strongly believes that it can win a football championship in the Division 1A Sunset League. On Tuesday - February 19th, during a private ceremony on campus, the school will back its belief by introducing its new head coach, Vernon Fox. Fox is a native Las Vegan who competed in the NFL (National Football League) for eight seasons with formidable teams including the multiple Super Bowl Champion Denver Broncos and Washington Redskins. Since retiring a few years ago, Fox has helped hundreds of youth become better players and individuals by hosting ...
Trinity Preparatory Academy (www.trinityprepacademy.com) is a new classical Christian University-Model School opening in fall 2013 in North Austin. The school provides faculty with a unique teaching experience. At Trinity Preparatory Academy, students are engaged in a 5-day per week, rigorous classical curriculum. In the Grammar School (K-5), students attend the Trinity Preparatory Academy campus two days per week to learn from professional teachers. The remaining three days of curriculum are delivered in the satellite classroom at home with a parent teacher. All curriculum ...
JTM Food Group, a Harrison, Ohio-based company specializing in great-tasting, fully cooked, healthier menu solutions, has added four new low sodium, vegetarian soups to their product lineup. Based on popular recipes and familiar flavor-profiles, these soups provide school food service directors with convenience and versatility while helping them meet the new minimums requirements for the vegetable subgroups which include red/orange, dark green, legumes, starchy and other.
The following varieties are available:
• Vegetarian Minestrone, a hearty soup made with diced ...
Cary Family Dental is pleased to announce that Allan Acton, DDS, has been named one of the Best Dentists in Western Wake County by readers of Cary Magazine. The 2013 Maggy Awards accepts online votes from readers who vote on their favorites among a variety of categories including services, media, restaurants, sports, and shopping. This marks the fourth time that Dr. Acton has been recognized in this category.
Cary Magazine began recognizing the Best of Western Wake in 2006. Winners in each category are chosen through a two-part nomination process. Voting began in September ...
Earning the highest customer satisfaction rating of 5 stars for two straight years, Paramount Painting & Renovations has won the prestigious CMUS Talk of the Town Customer Satisfaction Award for a second time in the Contractors — Home Improvement & Remodeling category.
Paramount Painting & Renovations is a full-service, professional Kitchener-Waterloo painting company that has been in business for more than a decade, serving residential and commercial clients in the Tri-Cities. During that time, Paramount Painting & Renovations has built a large, growing ...
A new website launched this week to help Virginia Beach and surrounding area residents find a quality magician without the hassle of searching the Internet for hours. VABeachMagician.com offers free information about choosing a comedy magician/host for your next event or program.
Visitors can browse http://www.VABeachMagician.com to view the experience and history of Joseph DePaul and his comedy magic.
The website offers the reviews of Virginia Beach area clients who've experienced his performances first hand. He has been performing for over 4 years, and in varied ...
Beck's Cajun Cafe has been named a finalist for the 2013 Philadelphia City Paper Readers' Choice Awards. Beck's is one of only five restaurants to qualify for this prestigious award in the Quick Bites category. Individuals are encouraged to visit the City Paper Readers' Choice Awards and cast their votes for Beck's Cajun.
"We are thrilled to be nominated us for this prestigious award," said Bill Beck, chef and owner of Beck's Cajun Cafe. "Now the hard work begins and we are counting on everyone to vote for us in the final round."
Beck's Cajun Cafe ...
