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Tracking protein traffic in living cells

2023-06-29
The genetic plans within our DNA come to functional fruition through proteins, which underlie our bodies’ structure and activity. Yet, the proteome – all the proteins within a cell or given area – remains relatively mysterious because protein landscapes are incredibly complex. Humans, for example, make tens of thousands of different proteins. To help decipher this complexity, a team of Stanford University researchers has led the development of a new method, called TransitID, for tracking the complete activity of proteins in living cells. This method is detailed in a paper published June ...

Historical Redlining May Be Linked to Current Kidney Failure

2023-06-29
FOR IMMEDIATE RELEASE                            Contact: Jillian McKoy, jpmckoy@bu.edu Michael Saunders, msaunder@bu.edu ## Historical Redlining May Be Linked to Current Kidney Failure New study shows that long-term disinvestment in health and wealth resources in historically redlined neighborhoods likely contributes to a disproportionate rate of kidney failure among Black adults today. Living ...

IceCube shows Milky Way galaxy is a neutrino desert

IceCube shows Milky Way galaxy is a neutrino desert
2023-06-29
The Milky Way galaxy is an awe-inspiring feature of the night sky, dominating all wavelengths of light and viewable with the naked eye as a hazy band of stars stretching from horizon to horizon. Now, for the first time, the IceCube Neutrino Observatory has produced an image of the Milky Way using neutrinos — tiny, ghostlike astronomical messengers. In a June 30 article in the journal Science, the IceCube Collaboration — an international group of more than 350 scientists — presents this new ...

Scientists edge toward scalable quantum simulations on a photonic chip

Scientists edge toward scalable quantum simulations on a photonic chip
2023-06-29
Scientists have made an important step toward developing computers advanced enough to simulate complex natural phenomena at the quantum level. While these types of simulations are too cumbersome or outright impossible for classical computers to handle, photonics-based quantum computing systems could provide a solution. A team of researchers from the University of Rochester’s Hajim School of Engineering & Applied Sciences developed a new chip-scale optical quantum simulation system that ...

Push to green energy is not without consequences, PSU prof explores

2023-06-29
From a proposed lithium mine near the Oregon-Nevada border to a proposed pumped hydropower facility in Washington, the transition from fossil fuels to renewables is not all clean and green. The extraction, manufacturing, storage and recycling of metals and minerals needed for electric cars, wind and solar has impacts on land, water, wildlife and people — and thanks to a new grant, a Portland State professor will take a closer look at those impacts, both good and bad. Alida Cantor, associate professor of geography, ...

Honey bees more faithful to their flower patches than bumble bees

Honey bees more faithful to their flower patches than bumble bees
2023-06-29
Kim Kaplan 301-588-5314 Kim.Kaplan@usda.gov Honey Bees More Faithful to Their Flower Patches Than Bumble Bees MADISON, WI, June 29, 2023—Honey bees are more faithful to their flower patches than bumble bees when it comes to returning to collect more pollen and nectar, according to a study by U.S. Department of Agriculture Agricultural Research Service scientists. Overall, 76 percent of honey bees in the study revisited the same plot of alfalfa flowers in contrast to just 47 percent of eastern bumble bees. But size does matter, especially to bumble bees. They were more faithful to larger flower patches, while the likelihood of honey bees returning to a flower patch ...

Where there’s smoke, there’s fire – and normal numbers of national park visitors

Where there’s smoke, there’s fire – and normal numbers of national park visitors
2023-06-29
More Americans than ever are heeding the call of the outdoors – spending time recreating outside and enjoying national parks. Simultaneously, smoky skies are worsening as the size and severity of wildfires increase and adversely affect air quality across the country. Wildfire smoke threatens human health and welfare, especially if humans are exposed to smoke for long periods or while exercising – such as during a hiking trip to one of America’s beloved national parks. Matthew Clark, a doctoral student at Boise State University studying how social and environmental ...

HIV patients in DC reported intense distress during pandemic

2023-06-29
The COVID-19 pandemic had substantial psychological impacts on the nation and around the world. New research shows patients with HIV were particularly susceptible to psychosocial challenges like depression, anxiety, substance abuse, loneliness and more. The study was co-authored by HIV/AIDS expert Michael Horberg, MD, and published in AIDS Research and Therapy. Researchers analyzed the results from a 2020 survey of nearly 900 Washington, D.C.-based participants diagnosed with HIV. The survey asked patients to rate the degree to which they experienced challenges with financial stability, mental health, social connections ...

Researchers teach an AI to write better chart captions

2023-06-29
Chart captions that explain complex trends and patterns are important for improving a reader’s ability to comprehend and retain the data being presented. And for people with visual disabilities, the information in a caption often provides their only means of understanding the chart. But writing effective, detailed captions is a labor-intensive process. While autocaptioning techniques can alleviate this burden, they often struggle to describe cognitive features that provide additional context. To help people author high-quality chart captions, MIT researchers have developed a dataset to improve automatic ...

What Genetics is Telling Us About Substance Use Disorders - A Free Webinar from the Brain & Behavior Research Foundation

What Genetics is Telling Us About Substance Use Disorders - A Free Webinar from the Brain & Behavior Research Foundation
2023-06-29
The Brain & Behavior Research Foundation (BBRF) is hosting a free webinar, “What Genetics is Telling Us About Substance Use Disorders” on Tuesday, July 11, 2023, at 2:00 pm EST. The presenter will be Sandra Sanchez-Roige, Ph.D. Dr. Sanchez-Roige is an Associate Professor at the Department of Psychiatry at the University of California San Diego, and the Department of Medicine, Division of Genetic Medicine at Vanderbilt University Medical Center. She is also the recipient of a 2018 BBRF Young Investigator Grant. The webinar will be hosted by Jeffrey Borenstein, M.D., President & CEO of the Brain & ...

Tobacco smoke exposure may increase heavy metal levels in children’s saliva

2023-06-29
UNIVERSITY PARK, Pa. — Secondhand tobacco smoke continues to be a major source of indoor air pollution that causes more than 41,000 nonsmoking adults to die every year in the United States, according to the Centers for Disease Control and Prevention. The exposure is even more dire for children, who can be more affected by less smoke. It can increase frequency and severity of asthma attacks, respiratory infections, cancer, sudden infant death syndrome and behavioral problems. Now, for the first time, Penn State-led research has shown exposure to tobacco smoke increases the presence of heavy metals in children’s saliva. The ...

Staging pancreatic cancer early with minimally invasive surgery shows positive results in patient prognosis, Mayo Clinic study finds

2023-06-29
ROCHESTER, Minn. — A study published in the Journal of the American College of Surgeons reveals that performing a minor surgical procedure on patients newly diagnosed with pancreatic cancer helps to identify cancer spread early and determine the stage of cancer. The researchers add that the surgery ideally should be performed before the patient begins chemotherapy. "This is an important study because it supports that staging laparoscopy may help with determining a patient's prognosis and better inform treatment so that patients ...

Cyanotriazole compounds can rapidly cure trypanosome infections in mice

2023-06-29
Cyanotriazole compounds are fast-acting topoisomerase II poisons that can selectively and rapidly kill trypanosome parasites that cause Chagas disease and African sleeping sickness, according to a new study. Millions who live in Latin America and sub-Saharan Africa are at risk for trypanosomatid infections – pathogenic protozoan parasites that cause Chagas disease and human African trypanosomiasis (HAT), which are potentially fatal if not treated. Although treatments for HAT have improved in recent years, Chagas therapies remain limited and rely on lengthy regimens of toxic drugs. More effective, safer, and shorter-duration ...

First 'ghost particle' image of Milky Way galaxy captured by scientists

First ghost particle image of Milky Way galaxy captured by scientists
2023-06-29
From visible starlight to radio waves, the Milky Way galaxy has long been observed through the various frequencies of electromagnetic radiation it emits. Scientists have now revealed a uniquely different image of our galaxy by determining the galactic origin of thousands of neutrinos — invisible "ghost particles" which exist in great quantities but normally pass straight through Earth undetected. The neutrino-based image of the Milky Way is the first of its kind: a galactic portrait made with particles of matter rather than electromagnetic ...

How the cat nose knows what it’s smelling

2023-06-29
COLUMBUS, Ohio – Scientists have found the secret to felines’ finesse at sniffing out food, friends and foes. A complex collection of tightly coiled bony airway structures gets the credit, according to the first detailed analysis of the domestic cat’s nasal airway. The researchers created a 3D computer model of the cat nose and simulated how an inhalation of air containing common cat food odors would flow through the coiled structures. They found that the air separates into two flow streams, one that is cleansed and humidified and another delivering the odorant quickly and efficiently to the system responsible for ...

Gullies on Mars could have been formed by recent periods of liquid meltwater, study suggests

Gullies on Mars could have been formed by recent periods of liquid meltwater, study suggests
2023-06-29
PROVIDENCE, R.I. [Brown University] — A study led by Brown University researchers offers new insights into how water from melting ice could have played a recent role in the formation of ravine-like channels that cut down the sides of impact craters on Mars. The study, published in Science, focuses on Martian gullies, which look eerily similar to gullies that form on Earth in the Dry Valleys of Antarctica and are caused by water erosion from melting glaciers. The researchers, including Brown planetary scientist Jim Head, built a model that simulates a sweet spot for when conditions on Mars allow the planet to warm above freezing temperatures, ...

Chemists develop new method to create chiral structures

Chemists develop new method to create chiral structures
2023-06-29
RIVERSIDE, Calif. -- Some molecules exist in two forms such that their structures and their mirror images are not superimposable, like our left and right hands. Called chirality, it is a property these molecules have due to their asymmetry. Chiral molecules tend to be optically active because of how they interact with light. Oftentimes, only one form of a chiral molecule exists in nature, for example, DNA. Interestingly, if a chiral molecule works well as a drug, its mirror image could be ineffective for therapy. In ...

The first neutrino image of our galaxy

The first neutrino image of our galaxy
2023-06-29
For the first time, researchers have produced an image of the Milky Way using neutrinos, which were observed with the IceCube telescope in the Antarctic ice. The neutrino image suggests that cosmic ray interactions are more intense in the center of our galaxy than once thought. The results are published in an article in the journal Science. For ages, the view of our Milky Way galaxy has inspired awe, visible with the naked eye as a hazy band of stars that stretches across the sky. Now IceCube researchers are able to see the Milky Way using neutrinos – tiny, ghostlike ...

DNA organization in real-time

DNA organization in real-time
2023-06-29
Performing cutting-edge science requires thinking outside the box and bringing together different scientific disciplines. Sometimes this even means being in the right place at the right time. For David Brückner, postdoctoral researcher and NOMIS fellow at ISTA, all the above-mentioned things came into effect as he attended an on-campus lecture by Professor Thomas Gregor from Princeton University. Inspired by the talk, Brückner reached out with an idea: to physically interpret the specific data sets Gregor presented. Now, the results of their collaboration are published ...

JDR Clinical & Translational Research receives first ever Impact Factor™

2023-06-29
Alexandria, VA – The International Association for Dental, Oral, and Craniofacial Research (IADR) and the American Association for Dental, Oral, and Craniofacial Research (AADOCR) announced today the JDR Clinical & Translational Research (JDR CTR) has received its first Journal Impact Factor™. JDR CTR has earned a Journal Impact Factor of 3.0, with an Eigenfactor™ of 0.00148, an Immediacy Index of 0.5, and 786 total citations in 2022. This represents a significant achievement and a huge milestone in JDR CTR’s history, which was launched in 2016. “JDR CTR’s new Impact Factor marks the culmination of years of commitment ...

Journal of Dental Research announces New Impact Factor™

2023-06-29
Alexandria, VA – The International Association for Dental, Oral, and Craniofacial Research and American Association for Dental, Oral, and Craniofacial Research announced the Journal of Dental Research (JDR) 2-Year Journal Impact Factor™ is now 7.6, ranking it #3 of 91 journals in the “Dentistry, Oral Surgery & Medicine” category. The JDR 5-year Journal Impact Factor™ is also 7.6, with an Immediacy Index of 1.1 and an article Influence score of 1.638. The JDR once again ranked #1 of 91 journals in total citations, with a total of 25,849 in 2022, and ranked #3 in Eigenfactor with a score of 0.01345. The 2-year Journal Impact Factor™ is defined ...

NASA’s Webb identifies the earliest strands of the cosmic web

NASA’s Webb identifies the earliest strands of the cosmic web
2023-06-29
Galaxies are not scattered randomly across the universe. They gather together not only into clusters, but into vast interconnected filamentary structures with gigantic barren voids in between. This “cosmic web” started out tenuous and became more distinct over time as gravity drew matter together.   Astronomers using NASA’s James Webb Space Telescope have discovered a thread-like arrangement of 10 galaxies that existed just 830 million years after the big bang. The 3 million light-year-long structure is anchored by a luminous quasar – a galaxy with an active, supermassive black hole at ...

Improvement to CRISPR gene editing could make it more effective

2023-06-29
DURHAM, N.C. – CRISPR gene editing is a breakthrough that has been used to treat diseases such as sickle cell anemia, leukemia and genetic disorders, but it has challenges that limit its broad utility.   Identifying the root of those issues led a research team at Duke Health to find an improved approach to gene editing that expands its functionality.   In work appearing online June 29 in the journal Cell Chemical Biology, the researchers lay out a new way to identify diverse CRISPR RNA variants that can specifically home in on challenging areas of DNA to target for editing. The new approach opens up more of the genome for editing, ...

Water fasts can help you lose weight, but you might gain it back quickly

2023-06-29
Water fasts — where people consume nothing but water for several days — might help you lose weight, but it’s unclear how long you’ll keep it off, according to research from the University of Illinois Chicago. And the other metabolic benefits of water fasts, such as lower blood pressure and improved cholesterol, seem to disappear soon after the fast ends, the researchers found.  However, there do not appear to be any serious adverse effects for those who do a water fast or a similar kind of fast where people consume a very small number of calories a day, said Krista Varady, professor of kinesiology and nutrition, who led the research, ...

Energy insecurity is an underappreciated social and environmental determinant of health

2023-06-29
In light of climate change and the impending transition to clean energy, many long-standing programs to address energy insecurity need to be refreshed. A new paper published online in the journal Health Affairs provides growing documentation of the connections between energy insecurity and poor health. The paper, by Diana Hernandez, PhD, associate professor of sociomedical sciences at Columbia University Mailman School of Public Health, also offers an overview of current policy initiatives and discusses ways that current policies can be improved upon. The average U.S. household allocates 3.1 percent of its income to energy expenses but for low-income households, ...
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