Stanford University computer science graduate student Mackenzie Leake has been quilting since age 10, but she never imagined the craft would be the focus of her doctoral dissertation. Included in that work is new prototype software that can facilitate pattern-making for a form of quilting called foundation paper piecing, which involves using a backing made of foundation paper to lay out and sew a quilted design. Developing a foundation paper piece quilt pattern - which looks similar to a paint-by-numbers outline - is often non-intuitive. There are few formal guidelines for patterning and those that ...

Humans regularly exert a powerful influence on the survival and persistence of species, yet social-science information is used only sporadically in conservation decisions. Researchers at Colorado State University and The Ohio State University have created an index depicting the mix of social values among people across all 50 states, providing data that can be useful for wildlife conservation policy and management. As a specific illustration, the research team found a supportive social context for gray wolf reintroduction in Colorado. Last fall, citizens ...

NEW YORK CITY, June 2, 2021 -- New research from Memorial Sloan Kettering Cancer Center (MSK) medical oncologist Dean Bajorin, MD, and colleagues found that patients who received nivolumab (Opdivo®) after bladder cancer surgery reduced their overall risk for high-grade bladder cancer recurrence. This research was published in the New England Journal of Medicine. In this phase III randomized study, Dr. Bajorin and a team of investigators evaluated 709 patients who were at high risk for recurrence of urothelial cancer after removal of their bladder, ureter, or kidney for high-grade cancer. To evaluate for benefit, patients were randomized to receive either nivolumab or a placebo every two weeks for one year. Patients and ...

A complex zone of folding and faulting that links two faults underneath downtown Salt Lake City could deform the ground during a large earthquake, according to a new study. The findings, published in the open-access journal The Seismic Record, suggest that earthquakes magnitude 5.0 and larger could cause ground displacement and liquefaction in Salt Lake City that increase the risk of earthquake-related building damage. As part of the Wasatch Fault Zone, the region has a complex seismic history, with at least 24 large earthquakes occurring in the urbanized parts of the zone over the past 7000 years. Along with previous excavation, borehole and other geophysical studies, the new research also supports the possibility of through-going ruptures ...

At the upcoming Conference of the Parties (COP26) in November, ample discussion is likely to focus on how the world is not on track to meet the Paris Agreement's goals of stopping warming at well below 2°C. According to a new University of California San Diego article published in Nature Energy, world diplomats will, however, find encouraging signs in emerging clean energy technology "niches"--countries, states or corporations--that are pioneering decarbonization. "In certain areas, adoption rates for solar and wind turbines, as well as electric vehicles are very high and increasing every year," write the authors of the opinion piece Ryan Hanna, assistant research scientist at UC San Diego's Center ...

TAMPA, Fla. -- There are several new treatment options available for patients with advanced melanoma. While these therapies have greatly improved the prognosis for patients, each person can respond to the treatments differently. Treatment of melanomas that have spread to the central nervous system is especially challenging. In a new article published in Clinical Cancer Research, Moffitt Cancer Center researchers reveal how different therapies impact the surrounding immune environment of metastatic melanoma tumors according to location and identify a rare population of immune cells that is associated with improved overall survival. Different types of cancer tend to spread to specific sites throughout the body. Common sites of melanoma ...

The pros make it look easy, but making a movie with a drone can be anything but. First, it takes skill to fly the often expensive pieces of equipment smoothly and without crashing. And once you've mastered flying, there are camera angles, panning speeds, trajectories and flight paths to plan. With all the sensors and processing power onboard a drone and embedded in its camera, there must be a better way to capture the perfect shot. "Sometimes you just want to tell the drone to make an exciting video," said Rogerio Bonatti, a Ph.D. candidate in Carnegie Mellon University's Robotics Institute. Bonatti was part ...

North Carolina State University researchers have developed a computer simulation tool to predict when and where pests and diseases will attack crops or forests, and also test when to apply pesticides or other management strategies to contain them. "It's like having a bunch of different Earths to experiment on to test how something will work before spending the time, money and effort to do it," said the study's lead author Chris Jones, research scholar at North Carolina State University's Center for Geospatial Analytics. In the journal Frontiers in Ecology and the Environment, researchers reported on their efforts to develop and test ...

KINGSTON, R.I. - June 3, 2021 - Scientists from the University of Rhode Island have taken the first steps toward understanding the function of microbes that live on and in Eastern oysters, which may have implications for oyster health and the management of oyster reefs and aquaculture facilities. "Marine invertebrates like oysters, corals and sponges have a very active microbiome that could potentially play a role in the function of the organism itself," said Ying Zhang, URI associate professor of cell and molecular biology. "We know very little about whether there are resident microbes in oysters, and if there are, what their function may be or how they may help or bring harm to the oyster." Zhang and doctoral student Zachary Pimentel extracted the DNA of microbes living in ...

ANN ARBOR, Mich. -- A different type of surge may be on the way more than a year into the pandemic - a baby surge. The COVID-19 shutdown initially seemed to hit pause on pregnancy and birth rates, new research from one major hospital system suggests, but that trend is quickly reversing. "Birth rates declined early on in the pandemic, but we expect a dramatic rebound soon," says lead author Molly Stout, M.D., MSci, maternal fetal medicine director at Michigan Medicine Von Voigtlander Women's Hospital. "We're already seeing signs of a summer baby surge." While infectious ...

UPTON, NY--A team of researchers led by chemists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory has studied an elusive property in cathode materials, called a valence gradient, to understand its effect on battery performance. The findings, published in Nature Communications, demonstrated that the valence gradient can serve as a new approach for stabilizing the structure of high-nickel-content cathodes against degradation and safety issues. High-nickel-content cathodes have captured the attention of scientists for their high capacity, a chemical property that could power electric vehicles over much longer distances than current batteries support. Unfortunately, the high nickel content also causes these cathode materials to degrade more quickly, creating cracks ...

The South Pole and the rest of East Antarctica is cold now and was even more frigid during the most recent ice age around 20,000 years ago -- but not quite as cold as previously believed. University of Washington glaciologists are co-authors on two papers that analyzed Antarctic ice cores to understand the continent's air temperatures during the most recent glacial period. The results help understand how the region behaves during a major climate transition. In one paper, an international team of researchers, including three at the UW, analyzed seven ice cores from across West and East Antarctica. The results published June 3 in Science show warmer ice age temperatures in the eastern part of the continent. The team ...

Scientists have gained the best view yet of the brightest explosions in the universe: A specialised observatory in Namibia has recorded the most energetic radiation and longest gamma-ray afterglow of a so-called gamma-ray burst (GRB) to date. The observations with the High Energy Stereoscopic System (H.E.S.S.) challenge the established idea of how gamma-rays are produced in these colossal stellar explosions which are the birth cries of black holes, as the international team reports in the journal Science. "Gamma-ray bursts are bright X-ray and gamma-ray flashes observed in the sky, emitted by distant extragalactic sources," explains DESY scientist Sylvia Zhu, one of the authors of the ...

The biggest shark attack in history did not involve humans. A new study by Earth scientists from Yale and the College of the Atlantic has turned up a massive die-off of sharks roughly 19 million years ago. It came at a period in history when there were more than 10 times more sharks patrolling the world's oceans than there are today. For now, researchers don't know the cause of the shark die-off. "We happened upon this extinction almost by accident," said Elizabeth Sibert, a Hutchinson postdoctoral associate in Yale's Department of Earth and Planetary Sciences and ...

Scientists have developed the first cells that can construct artificial polymers from building blocks that are not found in nature, by following instructions the researchers encoded in their genes. The study, led by scientists from the Medical Research Council (MRC) Laboratory of Molecular Biology, in Cambridge, UK, also found the synthetic genome made the bacteria entirely resistant to infection by viruses. The scientists say their research could lead to the development of new polymers - large molecules made of many repeating units, such as proteins, plastics, and many drugs including antibiotics - and make it easier to ...

Hydrogels are polymer materials made mostly from water. They can be used in a wide range of medical and other applications. However, previous incarnations of the materials suffered from repeated mechanical stress and would easily become deformed. A novel crystal that can reversibly form and deform, allows hydrogels to rapidly recover from mechanical stress. This opens up the use of such biocompatible materials in the field of artificial joints and ligaments. Many of us suffer the occasional sports injury or experience some kind of pain relating to joints and ligaments at some point in our lives. ...

Researchers from University of Toronto Engineering have developed an improved electrochemical system that raises the value of captured CO2 by converting more of it into valuable products than ever before. The International Energy Agency recently cited carbon capture and storage as one of the strategies that can help keep global emissions low enough to limit global warming to 1.5 C by 2050. But captured carbon currently has little economic value, reducing the incentive for companies to invest in this technology. A University of Toronto Engineering team led by Professor Ted Sargent is addressing this challenge by designing advanced electrolyzers that use electricity to convert captured CO2 into the petrochemical building blocks of common everyday materials, ...

An engineering researcher from the University of Sydney, in collaboration with a team at the University of Toronto, has developed an electrochemical system that coverts a greater amount of CO2 into valuable products. The International Energy Agency recently cited carbon capture and storage as a strategy that can help keep global emissions low enough to limit global warming to 1.5°C by 2050. However, captured carbon currently has little economic value, reducing the incentive for companies to invest in this technology. The team of researchers has addressed this challenge by designing advanced electrolysers - machines using electricity to convert captured CO2, plus water, into the building blocks of common everyday materials, ...

Astronomers have measured very-high-energy gamma rays coming from the aftermath of a gamma ray burst - an enormously energetic explosion of a star in another galaxy. The results shine light on these immensely powerful but little-understood cosmic events, and challenge standard models of how gamma ray bursts radiate light during their afterglow phases. As a dying massive star enters its final death throes, its core begins to collapse, and then explodes as a supernova. Some types of supernovae generate jets of particles moving at close to the speed of light; if the jet is pointed directly towards Earth it can be observed as a burst of gamma ray radiation that lasts several seconds. These gamma ray bursts are sometimes ...

The widespread non-pharmaceutical interventions implemented to mitigate the transmission of COVID-19 have led to drastic reductions in the annual circulation patterns of other endemic respiratory viruses, including influenza and the common cold. How this will affect future transmission patterns of these pathogens remains unknown. In a Perspective, Gabriela Gomez and colleagues discuss what could be expected concerning the epidemiology of common respiratory viruses once the COVID-19 pandemic subsides and argue that expanded genomic and clinical surveillance is needed to best understand the spread of respiratory viruses in a post-COVID-19 world. "Currently, the emergency response to COVID-19 is a global priority, but preparation for future threats ...

Nineteen million years ago, sharks nearly disappeared from Earth's oceans, according to a new study, which provides evidence for a previously unknown mass ocean extinction event. Sharks as a species never recovered from this, the study's authors say; their diversity today represents only a fraction of what it once was, the data suggest. Much of what is known about ancient ocean ecosystems is derived from rock and fossil records, which are generally limited to shallow-water deposits and provide only a small glimpse into the ocean-wide history of marine ...

By engineering the genetic code of a synthetic strain of E. coli to include several nonstandard amino acids, researchers rendered the synthetic bacterium virtually invincible to viral infection. Their work is some of the first to design proteins using not one but multiple non-canonical amino acids. "The ability to generate designer proteins using multiple non-natural building blocks will unlock countless applications, from the development of new classes of biotherapeutics to biomaterials with innovative properties," write Delila Jewel and Abhishek Chatterjee in a related Perspective. In nature, biological systems use 64 codons - a unique triplet of nucleotides - to encode ...

Small-scale mixed-use agriculture that avoids synthetic fertilizers in favor of manure could eliminate agricultural greenhouse gas emissions if established across the United States' 100 million hectares of lush high quality cropland, according to a study by Gidon Eshel, publishing 3rd June 2021 in the open-access journal PLOS Biology. The minor catch: beef consumption would need to decrease, but by only 20%. Beef is the most resource-intensive food item that we regularly put into our shopping carts -- for every gram of protein, beef uses 7 times more cropland and 20 times as much water and emits 11 times the greenhouse gases. At the same time, cattle manure is a valuable source of natural fertilizer. Nitrogen-sparing agriculture avoids external inputs of nitrogen, such as synthetic ...

A collection of genetic variants influences the expression of obesity-associated genes in both the brain and fat tissue, according to a new study from researchers at the University of Chicago. The research team found that changes in the expression of the obesity-associated genes correlated with both metabolic and behavioral changes, suggesting that these variants produce combinatorial effects that increase the risk of obesity. The results, which scientists hope will lead to better understanding of the mechanisms that make some people more susceptible to obesity, were published June 4 in END ...

The immune system is the brain's best frenemy. It protects the brain from infection and helps injured tissues heal, but it also causes autoimmune diseases and creates inflammation that drives neurodegeneration. Two new studies in mice suggest that the double-edged nature of the relationship between the immune system and the brain may come down to the origins of the immune cells that patrol the meninges, the tissues that surround the brain and spinal cord. In complementary studies published June 3 in the journal Science, two teams of researchers at Washington University School of Medicine in St. Louis unexpectedly found that many of the immune cells in the meninges come from bone marrow in the skull and migrate to the brain through special channels without passing through ...