Clinical research requires that data be mined for insights. Machine learning, which develops algorithms to find patterns, has difficulty doing this with data related to health records because this type of information is neither static nor regularly collected. A new study developed a transparent and reproducible machine learning tool to facilitate analysis of health information. The tool can be used in clinical forecasting, which can predict trends as well as outcomes in individual patients. The study, by a researcher at Carnegie Mellon University (CMU), appears in Proceedings of Machine Learning Research. "Temporal Learning Lite, or TL-Lite, is a visualization and forecasting tool to ...

Physicists from Russia, Chile, Brazil, Spain, and the UK, have studied how the magnetic properties change in 3D nanowires, promising materials for various magnetic applications, depending on the shape of their cross-section. Particularly, they more deeply probed into the Walker breakdown phenomenon, on the understanding of which the success of the implementation of the future electronics devices depends. The research outcome appears in Scientific Reports. The cross-sectional geometry of a three-dimensional nanowire affects the domain wall dynamics and therefore is crucial for their control. In turn, managing the DW dynamics under various external conditions is necessary in order to realize the future electronics and computing devices, operating on new physical principles. ...

Born in food web ecology, the concept of trophic levels -- the hierarchy of who eats who in the natural world -- is an elegant way to understand how biomass and energy move through a natural system. It's only natural that the idea found its way into the realm of aquaculture, where marine and freshwater farmers try to maximize their product with efficient inputs. "It's often used as a measure of how sustainable it is to harvest or consume that species," said Rich Cottrell(link is external), a postdoctoral researcher at UC Santa Barbara's National Center for Ecological Analysis & Synthesis (NCEAS). As plants (level 1) become food to plant eaters (level 2), who in turn are consumed by carnivores (level 3) and so on, the amount of energy ...

Hypertrophic cardiomyopathy (HCM) is a cardiovascular disease characterized by thickening of the left ventricle, otherwise known as the main squeezing chamber of the heart. HCM is best known for causing sudden death in athletes but can occur in persons of any age, often without symptoms. While frequently discussed in the context of genetics, most patients with HCM do not have a known genetic variant. Investigators from Brigham and Women's Hospital uncovered a means to study the complexity of this disease beyond the identification of individual genes. This new approach offers a path toward treating HCM using individualized medicine. ...

While protons populate the nucleus of every atom in the universe, sometimes they can be squeezed into a smaller size and slip out of the nucleus for a romp on their own. Observing these squeezed protons may offer unique insights into the particles that build our universe. Now, researchers hunting for these squeezed protons at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility have come up empty handed, suggesting there's more to the phenomenon than first thought. The result was recently published in Physical Review Letters. "We were looking to squeeze the proton such that its quarks are in a small-size configuration. And that's a pretty tough ...

A University of Oklahoma-led study published in 2020 revealed that both area and plant growth of paddy rice is significantly related to the spatial-temporal dynamics of atmospheric methane concentration in monsoon Asia, where 87% of the world's paddy rice fields are situated. Now, the same international research team has released a follow-up discussion paper in the journal Nature Communications. In this paper, the team identifies the limits and insufficiency of the major greenhouse emission database (EDGAR) in estimating paddy rice methane emissions. "Methane emission from paddy ...

EL PASO, Texas - A study by physiology researchers at The University of Texas at El Paso found that El Paso's stay-at-home ordinance due to the COVID-19 pandemic had positive effects on the health and well-being of the region's residents. Despite a shutdown of gyms and movement restrictions on non-essential activities, residents increased their fitness activity and closely monitored their food and nutrition intake, said Cory M. Smith, Ph.D., assistant professor of kinesiology in UTEP's College of Health Sciences and the study's principal investigator. More than 1,300 El Paso and ...

Researchers at the University of Maryland School of Medicine (UMSOM) co-authored a study, published today in the journal Science, that details the sequencing of 64 full human genomes. This reference data includes individuals from around the world and better captures the genetic diversity of the human species. Among other applications, the work will enable population-specific studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation. Twenty years ago this month, the International Human Genome Sequencing Consortium announced the first draft of the human genome reference sequence. The Human Genome Project, as it was called, required 11 years of work and involved more than 1000 ...

Psychologists have long found that people behave differently than when they learn of peers' actions. A new study by computer scientists found that when individuals in an experiment about autonomous vehicles were informed that their peers were more likely to sacrifice their own safety to program their vehicle to hit a wall rather than hit pedestrians who were at risk, the percentage of individuals willing to sacrifice their own safety increased by approximately two-thirds. As computer scientists train machines to act as people's agents in all sorts of situations, the study's authors indicate that the social component of decision-making is often overlooked. This could be of great consequence, note the paper's authors who show that the trolly problem -long shown to be ...

States regularly use administrative records, such as motor-vehicle data, in determining whether people have moved to prune their voter rolls. A Yale-led study of this process in Wisconsin shows that a significant percentage of registered voters are incorrectly identified as having changed addresses, potentially endangering their right to vote. The study, published in the journal Science Advances, found that at least 4% of people listed as suspected "movers" cast ballots in 2018 elections using addresses that were wrongly flagged as out of date. Minority voters were twice as likely as white voters to cast their ...

The COVID-19 virus holds some mysteries. Scientists remain in the dark on aspects of how it fuses and enters the host cell; how it assembles itself; and how it buds off the host cell. Computational modeling combined with experimental data provides insights into these behaviors. But modeling over meaningful timescales of the pandemic-causing SARS-CoV-2 virus has so far been limited to just its pieces like the spike protein, a target for the current round of vaccines. A new multiscale coarse-grained model of the complete SARS-CoV-2 virion, its core genetic material and virion shell, has been developed for the first time using supercomputers. The model offers ...

Litter is not only a problem on Earth. According to NASA, there are currently millions of pieces of space junk in the range of altitudes from 200 to 2,000 kilometers above the Earth's surface, which is known as low Earth orbit (LEO). Most of the junk is comprised of objects created by humans, like pieces of old spacecraft or defunct satellites. This space debris can reach speeds of up to 18,000 miles per hour, posing a major danger to the 2,612 satellites that currently operate at LEO. Without effective tools for tracking space debris, parts of LEO may even become too hazardous for satellites. In a paper publishing today in the SIAM Journal on Imaging Sciences, Matan Leibovich (New York University), George Papanicolaou (Stanford University), and Chrysoula Tsogka (University of California, ...

The unprecedented cost of the 2018 Kilauea eruption in Hawai'i reflects the intersection of distinct physical and social phenomena: infrequent, highly destructive eruptions, and atypically high population growth, according to a new study published in Nature Communications and led by University of Hawai'i at Mānoa researchers. It has long been recognized that areas in Puna, Hawai'i, are at high risk from lava flows. This ensured that land values were lower in Puna--which lies within the three highest risk lava hazard zones 1, 2 and 3--which actively promoted rapid population ...

Our body consists of 100 trillion cells that communicate with each other, receive signals from the outside world and react to them. A central role in this communication network is attributed to receiver proteins, called receptors, which are anchored at the cell membrane. There, they receive and transmit signals to the inside of the cell, where a cell reaction is triggered. In humans, G protein-coupled receptors (GPC receptors) represent the largest group of these receptor molecules, with around 700 different types. The research of the Frankfurt and Leipzig scientists focused on a GPC receptor that serves as a receptor for the ...

Timothy Callaghan, PhD, and Alva Ferdinand, DrPH, JD, from the Southwest Rural Health Research Center at Texas A&M University School of Public Health, joined colleagues in the first national study of how often people in urban and rural areas in the United States follow COVID-19 guidelines. These include public health best practices like wearing masks in public, sanitizing homes and work areas, maintaining physical distancing, working from home and avoiding dining in restaurants or bars. The research team used a survey of 5,009 U.S. adults that closely matched the makeup of the country's population as a whole. The survey asked how often participants followed COVID-19 prevention recommendations and collected data on political ideology, perceived risk ...

ITHACA, N.Y. - A team from Cornell University's Environmental Systems Lab, led by recent graduate Allison Bernett, has put forth a new framework for injecting as much information as possible into the pre-design and early design phases of a project, potentially saving architects and design teams time and money down the road. "(Our framework) allows designers to understand the full environmental impact of their building," said Bernett, corresponding author of "Sustainability Evaluation for Early Design (SEED) Framework for Energy Use, Embodied Carbon, Cost, and Daylighting Assessment" which published Jan. 10 in the Journal of ...

WEST LAFAYETTE, Ind. -- Doppler radar improves lives by peeking inside air masses to predict the weather. A Purdue University team is using similar technology to look inside living cells, introducing a method to detect pathogens and treat infections in ways that scientists never have before. In a new study, the team used Doppler to sneak a peek inside cells and track their metabolic activity in real time, without having to wait for cultures to grow. Using this ability, the researchers can test microbes found in food, water, and other environments to see if they are pathogens, or help them identify the right medicine to treat antibiotic-resistant bacteria. David Nolte, Purdue's Edward ...

HOUSTON - (Feb. 25, 2021) - Low-income livestock farmers in developing countries are often faced with a difficult dilemma: protect their animals from endangered predators, or spare the threatened species at the expense of their livestock and livelihood. A new paper by Rice University economist Ted Loch-Temzelides examines such circumstances faced by farmers in Pakistan. "Conservation, risk aversion, and livestock insurance: The case of the snow leopard" outlines a plan under which farmers can protect themselves from crippling financial losses while ...

While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, research from the Children's Medical Center Research Institute at UT Southwestern (CRI) has identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver. These findings, reported today in Science, could help scientists answer important questions about liver maintenance, liver damage (such as from fatty liver or alcoholic liver disease), and liver cancer. The liver performs vital functions, including chemical detoxification, blood protein production, bile excretion, and regulation of energy metabolism. Structurally, the liver ...

Paleo-ecologists from The University of New Mexico and at the University of Nebraska-Lincoln have demonstrated that the offspring of enormous carnivorous dinosaurs, such as Tyrannosaurus rex may have fundamentally re-shaped their communities by out-competing smaller rival species. The study, released this week in the journal Science, is the first to examine community-scale dinosaur diversity while treating juveniles as their own ecological entity. "Dinosaur communities were like shopping malls on a Saturday afternoon ? jam-packed with teenagers" explained Kat Schroeder, a graduate student in the UNM Department of Biology who led the study. "They made up a significant portion of the individuals in a species and would have had a very real impact ...

An international team of scientists has developed a system that can generate random numbers over a hundred times faster than current technologies, paving the way towards faster, cheaper, and more secure data encryption in today's digitally connected world. The random generator system was jointly developed by researchers from Nanyang Technological University, Singapore (NTU Singapore), Yale University, and Trinity College Dublin, and made in NTU. Random numbers are used for a variety of purposes, such as generating data encryption keys and one-time ...

As Covid-19 impacts lives around the world- a new skeleton study is reconstructing ancient pandemics to assess human's evolutionary ability to fight off leprosy, tuberculosis and treponematoses with help from declining rates of transmission when the germs became widespread. The researchers state the germs mutated to infect ancient humans so they could replicate- hopping across to as many new hosts as possible- but the severity of the diseases reduced as a result. The analysis by Adjunct Professor in Archaeology Maciej Henneberg and Dr Teghan Lucas at Flinders ...

In 2001, the International Human Genome Sequencing Consortium announced the first draft of the human genome reference sequence. The Human Genome Project, as it was called, had taken more than eleven years of work and involved more than 1000 scientists from 40 countries. This reference, however, did not represent a single individual but instead is a composite of humans that could not accurately capture the complexity of human genetic variation. Building on this, scientists have carried out many sequencing projects over the last 20 years to identify and catalog genetic differences between an individual and the reference genome. Those differences usually ...

A chemical reaction can be understood in detail at the quantum state-resolved level, through a combined study of molecular crossed beam experiments and theoretical quantum molecular reaction dynamics simulations. At a single collision condition, the molecular crossed beam apparatus is able to detect the scattering angle-resolved product with rotational state-resolution. Whereas, with accurate global potential energy surface, quantum reactive scattering theory is able to predict the corresponding reactive scattering information. In previous studies, the chemical reaction dynamics was revealed only with the product rotational state-resolution. And the investigation of a reaction ...

Although the value of vaccines for COVID-19 may seem obvious, government action and investment in vaccines have not been commensurate with the enormous scale of benefits they offer, argue Juan Camilo Castillo and colleagues in this Policy Forum. Since even one extra month of exposure to COVID-19 kills hundreds of thousands, reduces global gross domestic product (GDP) by hundreds of billions of dollars, and generates large losses to human capital by harming education and health, expanding vaccine capacity even further would generate substantial global benefits. Castillo et al. report results of two related exercises: estimating the global benefits from vaccine capacity already in place, and estimating the benefits ...