Scientists believe a stomach-specific protein plays a major role in the progression of obesity, according to new research in Scientific Reports. The study co-authored by an Indiana University School of Medicine researcher, could help with development of therapeutics that would help individuals struggling with achieving and maintaining weight loss. Researchers focused on Gastrokine-1 (GKN1) -- a protein produced exclusively and abundantly in the stomach. Previous research has suggested GKN1 is resistant to digestion, allowing it to pass into the intestine and interact with microbes in the gut. In the Scientific Reports study, researchers show that inhibiting GKN1 produced significant differences in weight and levels of body fat in comparison to when the protein was expressed. "While ...

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions. Johns Hopkins Kimmel Cancer Center researchers developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application. To correct for these sequencing errors, the research team from the Ludwig Center and Lustgarten Laboratory at the Johns Hopkins ...

ROCHESTER, Minn. -- A pair of Mayo Clinic studies shed light on something that is typically difficult to see with the eye: respiratory aerosols. Such aerosol particles of varying sizes are a common component of breath, and they are a typical mode of transmission for respiratory viruses like COVID-19 to spread to other people and surfaces. Researchers who conduct exercise stress tests for heart patients at Mayo Clinic found that exercising at increasing levels of exertion increased the aerosol concentration in the surrounding room. Then also found that a high-efficiency particulate air (HEPA) device effectively filtered out the aerosols and decreased the time needed to ...

Reston, VA--For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable information about the effectiveness of state-of-the-art treatments. When treatment monitoring with contrast-enhanced magnetic resonance imaging (MRI) is unclear, adding 18F-FET PET can help to accurately diagnose recurring brain metastases and reliably assess patient response. This research was published in The Journal of Nuclear Medicine. Newer treatment options for patients with brain metastases--such as immune checkpoint inhibitors and targeted therapies--are effective, but can cause a variety of side effects. ...

The human immune system doesn't just protect our health, it reflects it. Each encounter with a potential disease-causing agent causes the body to produce specific immune agents -- proteins known as antibodies and T-cell receptors -- tailor-made to recognize and destroy the invader. Tasked with preventing re-infection, antibodies and T-cell receptors (TCR) from your previous encounters circulate throughout the body indefinitely, like a record of your personal medical history that you carry inside of you. Clinical pathologist Ramy Arnaout, MD, DPhil, ...

WASHINGTON, DC -- A new case report, detailed in Annals of Emergency Medicine, is the first known case of a patient with VITT (vaccine-induced thrombotic thrombocytopenia) treated with a heparin alternative following the Centers for Disease Control and Prevention (CDC) guidance. An otherwise healthy female patient in her 40s came to the emergency department at UCHealth University of Colorado Hospital twelve days after receiving the Johnson & Johnson vaccine with a headache, dizziness, and vision changes. The patient was treated on April 13, 2021, the same day that the Centers for Disease Control and Prevention (CDC) announced a pause in the administration of the Johnson & Johnson vaccine. CDC guidance recommended ...

You know that raw overwhelm people have been reporting after months of a pandemic, compounded by economic issues and social unrest? Does fatigue and compulsive social media scrolling strike a familiar chord? Those brittle feelings offer us a glimpse into what regular life can be like for individuals with sensory processing sensitivity (SPS), a biological trait possessed by roughly a third of the population. In a world of constant information overload and stress, it's a characteristic that can result in a variety of behaviors, from emotional outbursts to withdrawal, overwhelm and procrastination. "Behaviorally, we observe it as being more careful and cautious when approaching new things," said Bianca Acevedo, a researcher ...

Boulder, Colo., USA: The Geological Society of America regularly publishes articles online ahead of print. For April, GSA Bulletin topics include multiple articles about the dynamics of China and Tibet; the Bell River hypothesis that proposes that an ancestral, transcontinental river occupied much of northern North America during the Cenozoic Era; new findings in the climatic history during one of the Earth's coldest periods: The Late Paleozoic Ice Age; and the age an nature of the Chicxulub impact crater. You can find these articles at END ...

PHILADELPHIA - Lung cancer is the third most common cancer in the U.S. and the leading cause of cancer death, with about 80% of the total 154,000 deaths recorded each year caused by cigarette smoking. Black men are more likely to develop and die from lung cancer than persons of any other racial or ethnic group, pointing to severe racial disparities. For example, research has shown that Black patients are less likely to receive early diagnosis and life-saving treatments like surgery. Now researchers at Jefferson have found that a commonly used risk prediction model does not accurately identify high-risk Black patients who could gain life-saving benefit from early screening, and paves the way for improving screenings and guidelines. The research was published in JAMA Network ...

A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for obesity and insulin resistance. Approximately one-third of the adults and one in five children in the U.S. have obesity problems. Unfortunately, the condition is also associated with the development of other diseases including diabetes, cardiovascular disorders, and cancer. "One of the biggest challenges we face is trying to understand how people develop obesity. If we can understand that, we can develop solutions for treating or preventing these diseases," said Lin-Feng Chen (MME), a professor of biochemistry. The researchers investigated the role of the ...

The soybean cyst nematode (SCN) is the most damaging pathogen of soybean in the United States and Canada and it is spreading rapidly, according to information compiled by Gregory Tylka and Christopher Marett, nematologists at Iowa State University. SCN was first found in the United States in 1954 and most recent estimates show that SCN results in $1.5 billion in annual yield losses. "The continuing spread of SCN is alarming, but not surprising," said Tylka. "Anything that moves soil can move the nematode, including wind, water, and farm machinery." ...

Educating athletes, parents and coaches about concussion treatment and prevention has been a priority during the last decade, but are the intended audiences hearing the message? New research from the University of Michigan found that 1 in 4 adolescents self-reported at least one concussion in 2020, up from about 20% in 2016. During that same time period, youth who reported one concussion rose from roughly 14% to 18%, and those who reported at least two concussions increased from about 6% to 7%. "Self-reported concussions could be increasing given that both children and parents have greater ...

Researchers at AMBER, the SFI Centre for Advanced Materials and BioEngineering Research, and from Trinity's School of Physics, have developed next-generation, graphene-based sensing technology using their innovative G-Putty material. The team's printed sensors are 50 times more sensitive than the industry standard and outperform other comparable nano-enabled sensors in an important metric seen as a game-changer in the industry: flexibility. Maximising sensitivity and flexibility without reducing performance makes the teams' technology an ideal candidate for the emerging areas ...

A hot topic symposia session during the Pediatric Academic Societies (PAS) 2021 Virtual Meeting will address the persistent controversies and questions in preterm infant nutrition. After six years of interdisciplinary expert discussion and critical evidence review, the 2014 vision to develop evidence-informed guidance for the nutritional care of preterm infants has come to fruition. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the Academy of Nutrition and Dietetics (AND) initiated this multiphase process involving expert physician, dietitian, and pharmacology scientists. The first phase, Pre-B, addressed the existing evidence and research ...

WASHINGTON, May 4, 2021 -- How body clocks work could lead to science that can turn an early bird into a night owl or vice versa as well as other advances, like helping crops grow all year long. In Applied Physics Reviews, by AIP Publishing, scientists at Penn State report on their work advancing knowledge about circadian rhythms, the natural process that governs sleep and waking patterns in humans, animals, and plants. Researchers have identified a set of genes, called clock genes, that control these rhythms. But a more complicated network of genes than previously known appears related to circadian rhythms. More fully ...

WASHINGTON, May 4, 2021 -- If a respiratory droplet from a person infected with COVID-19 lands on a surface, it becomes a possible source of disease spread. This is known as the fomite route of disease spread, in which the aqueous phase of the respiratory droplet serves as a medium for virus survival. The lifespan of the respiratory droplet dictates how likely a surface is to spread a virus. While 99.9% of the droplet's liquid content evaporates within a few minutes, a residual thin film that allows the virus to survive can be left behind. This begs ...

What The Study Did: This survey study estimated change in the percentage of adolescents in the United States who reported at least one diagnosed concussion during their lifetime. Authors: Phil Veliz, Ph.D., of the University of Michigan in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.1538) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, ...

During our waking hours, the brain is receiving a near-constant influx of sensory signals of various strengths. For decades, scientists have wondered why some signals rise to the light of conscious awareness while other signals of a similar strength remain in the dark shadows of unconsciousness. What controls the gate that separates the shadows and the light? In a new study from the Department of Anesthesiology and Center for Consciousness Science at Michigan Medicine, researchers identify a key area in the cortex that appears to be the gate of conscious awareness. "Information processing in the brain ...

WASHINGTON, May 4, 2021 -- Spinal fusion is frequently performed to restore spinal stability in patients with spinal diseases, such as spinal stenosis, vertebral fractures, progressive deformities, and instability. In the past two decades, there has been marked increase in the number of people over 65 years in age who have needed spinal fusion surgery. While autogenous bone grafts have long been considered the reference standard for spinal fusion, painful pseudoarthrosis remains a leading cause of poor clinical outcomes. Many researchers have consequently focused on ...

WASHINGTON, May 4, 2021 -- Scientists from Texas A&M have developed an extension to an ordinary cellphone that turns it into an instrument capable of detecting chemicals, drugs, biological molecules, and pathogens. The advance is reported in Reviews of Scientific Instruments, by AIP Publishing. Modern cellphones include high-quality cameras capable of detecting low levels of light and eliminating digital noise through software processing of the captured images. Recent work has taken advantage of this sensitivity to produce cellphone cameras that ...

SAN ANTONIO (May 4, 2021) - Risk-reducing mastectomy saves lives of women who, because of hereditary or other risk factors, may have a very high lifetime risk of developing breast cancer, according to two new journal articles written to guide physicians and patients. All of these women should also discuss with their physicians nonsurgical options such as screening and medications to reach the best, customized treatment strategy, the essays mention. Both articles, published May 4 in the Journal of the American Medical Association (JAMA), are by END ...

WHO Benjamin Rome, MD, Instructor of Medicine at Harvard Medical School and researcher in the Program On Regulation, Therapeutics, And Law (PORTAL) in the Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital; corresponding author of a paper published in JAMA Network Open. WHAT When drug manufacturers raise the list price for brand-name prescription drugs, do patients' out-of-pocket costs rise too? A new study published in JAMA Network Open by Dr. Benjamin Rome and colleagues in the Brigham's Division of Pharmacoepidemiology and Pharmacoeconomics finds that more than half of patients may experience increases in out-of-pocket spending when drug ...

BOSTON - Researchers from Massachusetts General Hospital (MGH) appear to have solved the 120-year-old mystery surrounding the failing health of famed Antarctic explorer Sir Ernest Shackleton over the course of his daring expeditions to Antarctica in the early part of the twentieth century. In a paper published online in the END ...

Researchers have found that people who live beyond 105 years tend to have a unique genetic background that makes their bodies more efficient at repairing DNA, according to a study published today in eLife. This is the first time that people with 'extreme longevity' have had their genomes decoded in such detail, providing clues as to why they live so long and manage to avoid age-related diseases. "Aging is a common risk factor for several chronic diseases and conditions," explains Paolo Garagnani, Associate Professor at the Department of Experimental, Diagnostic ...

Studying protein changes in the kidneys as we age, as well as the transcription of genes into proteins, helps provide a full picture of the age-related processes that take place in these organs, says a study in mice published today in eLife. Aging causes many changes in the body and in essential organs such as the kidneys, which function less efficiently later in life. Age-related changes in the kidneys have mostly been reported by looking at the transcription of genes - the process by which a segment of DNA is copied into RNA. The current study suggests that this approach, combined with studying changes in proteins, gives us a better understanding of age-related changes in the kidney and may point to new approaches for treating ...