Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it's worked well. But it hasn't worked perfectly. A lab on UNLV's campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery -- one that could potentially provide a solution for patients who have run out of options. "It's starting to get to the point where we've kind of taken traditional drug discovery as far as we can, and we really need something new," said UNLV biochemist Gary Kleiger. Traditional drug discovery involves what is called the small molecule approach. To attack a protein that's causing disease in a cancer cell, for instance, ...

With COVID-19 making it vital for people to keep their distance from one another, the city of Toronto undertook the largest one-year expansion of its cycling network in 2020, adding about 25 kilometres of temporary bikeways. Yet, the benefits of helping people get around on two wheels go far beyond facilitating physical distancing, according to a recent study by three University of Toronto researchers that was published in the journal Transport Findings. University of Toronto Engineering PhD candidate Bo Lin, as well as professors Shoshanna Saxe and Timothy Chan used ...

Ithaca, NY--Famous for their uncanny ability to imitate other birds and even mechanical devices, researchers find that Australia's Superb Lyrebird also uses that skill in a totally unexpected way. Lyrebirds imitate the panicked alarm calls of a mixed-species flock of birds while males are courting and even while mating with a female. These findings are published in the journal Current Biology. "The male Superb Lyrebird creates a remarkable acoustic illusion," says Anastasia Dalziell, currently a Cornell Lab of Ornithology Associate and recent Cornell Lab Rose Postdoctoral Fellow, now at the ...

URBANA, Ill. - Food waste is a major problem in the U.S., and young adults are among the worst culprits. Many of them attend college or university and live on campus, making dining halls a prime target for waste reduction efforts. And a simple intervention can make a big difference, a University of Illinois study shows. Shifting from round to oval plates with a smaller surface area can significantly reduce food waste in dining halls, says Brenna Ellison, associate professor in the Department of Agricultural and Consumer Economics (ACE) and co-author on the study. "Americans waste about 31% of the food that is available at the retail and consumer levels," Ellison says. "All-you-can-eat ...

West Virginia University scientists used MRI scans to show what happens when ultrasound waves target a specific area of Alzheimer's patient's brains. They concluded that this treatment may induce an immunological healing response, a potential breakthrough for a disease that accounts for up to 80% of all dementia cases. Rashi Mehta, a researcher with the WVU School of Medicine and Rockefeller Neuroscience Institute, led the study that appears in the journal Radiology. "Focused ultrasound is an innovative technique and new way of approaching brain diseases, including Alzheimer's disease," said Mehta, an associate professor ...

New research in mice published today in the journal Scientific Reports strengthens the growing scientific consensus regarding the role of the gut microbiome in neurodegenerative disorders including Alzheimer's disease. The study, led by researchers at Oregon Health & Science University, found a correlation between the composition of the gut microbiome and the behavioral and cognitive performance of mice carrying genes associated with Alzheimer's. The mice carried the human amyloid precursor protein gene with dominant Alzheimer's mutations generated by scientists in Japan. The study further suggests a relationship between microbes in the digestive tract ...

A widespread field search for a rare Australian native bee not recorded for almost a century has found it's been there all along - but is probably under increasing pressure to survive. Only six individual were ever found, with the last published record of this Australian endemic bee species, Pharohylaeus lactiferus (Colletidae: Hylaeinae), from 1923 in Queensland. "This is concerning because it is the only Australian species in the Pharohylaeus genus and nothing was known of its biology," Flinders University researcher James Dorey says in a new scientific paper in the journal Journal of Hymenoptera Research. The ...

Immunologists at St. Jude Children's Research Hospital have mapped the previously unknown biological machinery by which the immune system generates T cells that kill bacteria, viruses and tumor cells. The findings have multiple implications for how the adaptive immune system responds to infections to generate such memory T cells. The experiments revealed mechanisms that inhibit development of the long-lived memory T cells that continually renew to protect the body over time. Blocking these inhibitory mechanisms with pharmacological or genetic approaches could boost protective immunity against infection and cancers. The researchers also discovered a subtype of memory T cells that they named terminal effector prime cells. Mapping the pathway that controls these cells raises the possibility ...

(Boston)--What if you could improve your heart health and brain function by changing your diet? Boston University School of Medicine researchers have found that by eating more plant-based food such as berries and green leafy vegetables while limiting consumption of foods high in saturated fat and animal products, you can slow down heart failure (HF) and ultimately lower your risk of cognitive decline and dementia. Heart failure (HF) affects over 6.5 million adults in the U.S. In addition to its detrimental effects on several organ systems, presence of HF is associated with higher risk of cognitive decline and dementia. Similarly, changes in cardiac structure ...

When building a nest, previous experience raising chicks will influence the choices birds make, according to a new study by University of Alberta scientists. The results show that birds that have successfully raised families stick with tried-and-true methods when building their nests, whereas less successful birds will try something new. "We found that when presented with a choice between a familiar material, coconut fibre, and a never-before-encountered material, white string, zebra finches who had successfully raised chicks preferred to stick with the same material they had previously used. Birds who failed to raise chicks built nests with equal amounts of familiar and novel material," explained ...

America's stark racial disparities in health care have been exposed by COVID-19, but a new study from Michigan State University suggests that Black individuals are more likely than conservative White people to adhere to public health standards due to disparities. The study, published in the Journal of Racial and Ethnic Health Disparities, used data from MSU's State of the State Survey that was captured during the initial COVID-19 outbreak from a representative group of 800 adults in Michigan. "Our findings suggest that although COVID impacts all Michiganders, ...

Fiber-optic cables run underneath nearly all city grids across the United States and provide internet and cable TV to millions, but what if those systems could also provide valuable information related to hazardous events such as earthquakes and flooding? A team of researchers at Penn State have found they can do just that. The scientists are using fiber-optic distributed acoustic sensing (DAS) technology to turn existing telecommunication infrastructure that is already installed underground into a valuable resource for monitoring ground vibrations. "We discovered the fibers could pick up a wide variety of signal vibrations, from thunderstorms to human walking steps to music concerts," said Tieyuan Zhu, assistant professor of geophysics at Penn State and principal investigator on ...

American Geophysical Union U.S. Geological Survey Joint ReleaseWASHINGTON--Southern California can now expect to see post-wildfire landslides occurring almost every year, with major events expected roughly every ten years, a new study finds. The results show Californians are now facing a double whammy of increased wildfire and landslide risk caused by climate change-induced shifts in the state's wet and dry seasons, according to researchers who mapped landslide vulnerability in the southern half of the state. "This is our attempt to get people thinking about where these hazards are going to be before there's even a fire," said Jason Kean, a hydrologist at the U.S. Geological Survey in Denver and lead author ...

HOUSTON - (Feb. 25, 2021) - A new theory by Rice University scientists could boost the growing field of spintronics, devices that depend on the state of an electron as much as the brute electrical force required to push it. Materials theorist Boris Yakobson and graduate student Sunny Gupta at Rice's Brown School of Engineering describe the mechanism behind Rashba splitting, an effect seen in crystal compounds that can influence their electrons' "up" or "down" spin states, analogous to "on" or "off" in common transistors. "Spin" is a misnomer, since quantum physics constrains electrons ...

BUFFALO, N.Y. -- Graphene is incredibly strong, lightweight, conductive ... the list of its superlative properties goes on. It is not, however, magnetic -- a shortcoming that has stunted its usefulness in spintronics, an emerging field that scientists say could eventually rewrite the rules of electronics, leading to more powerful semiconductors, computers and other devices. Now, an international research team led by the University at Buffalo is reporting an advancement that could help overcome this obstacle. In a study published today in the journal Physical Review Letters, researchers describe how they paired a magnet with graphene, and induced what they describe as "artificial magnetic texture" in the nonmagnetic wonder material. "Independent of each ...

As climate change increases the occurrence of catastrophic natural disasters around the world, international organizations are looking for ways to reduce the risk of such disasters. One approach under exploration is the humanitarian community's forecast-based early action (FbA), which seeks to enable pre-emptive actions based on forecasts of extreme events. With FbA, disaster response shifts toward anticipating disasters to ameliorate their destructive effects. However, the development of data-based triggers and metrics for action rely on timely and accurate information. A group of researchers publishing in SPIE's END ...

HOUSTON - (Feb. 25, 2021) - COVID-19 can be diagnosed in 55 minutes or less with the help of programmed magnetic nanobeads and a diagnostic tool that plugs into an off-the-shelf cell phone, according to Rice University engineers. The Rice lab of mechanical engineer Peter Lillehoj has developed a stamp-sized microfluidic chip that measures the concentration of SARS-CoV-2 nucleocapsid (N) protein in blood serum from a standard finger prick. The nanobeads bind to SARS-CoV-2 N protein, a biomarker for COVID-19, in the chip and transport it to an electrochemical sensor that detects minute amounts of the biomarker. The ...

LOS ALAMOS, N.M., February 24, 2021--The Beaufort Sea, the Arctic Ocean's largest freshwater reservoir, has increased its freshwater content by 40 percent over the last two decades, putting global climate patterns at risk. A rapid release of this freshwater into the Atlantic Ocean could wreak havoc on the delicate climate balance that dictates global climate. "A freshwater release of this size into the subpolar North Atlantic could impact a critical circulation pattern, called the Atlantic Meridional Overturning Circulation, which has a significant influence on northern-hemisphere climate," ...

After traveling several billion miles toward the Sun, a wayward young comet-like object orbiting among the giant planets has found a temporary parking place along the way. The object has settled near a family of captured ancient asteroids, called Trojans, that are orbiting the Sun alongside Jupiter. This is the first time a comet-like object has been spotted near the Trojan population. The unexpected visitor belongs to a class of icy bodies found in space between Jupiter and Neptune. Called "Centaurs," they become active for the first time when heated as they approach the Sun, and dynamically transition into becoming more comet-like. Visible-light snapshots by NASA's Hubble Space Telescope reveal that the vagabond object shows signs of comet activity, such as a tail, ...

Researchers have discovered that there may be a new pathway in the brain that provides pain relief and reduces cravings for opioids. Over a third of the U.S. population suffers from chronic pain, with little to no reported relief from medication. Transcranial magnetic brain stimulation (TMS) is a noninvasive form of brain stimulation that may offer a new treatment option for these underserved members of our community. In a recent paper in Drug and Alcohol Dependence, researchers at the Medical University of South Carolina evaluated two different strategies for relieving pain with TMS: applying TMS to the motor cortex and the ...

When birds see a predator in their midst, one defensive strategy is to call out loudly, attracting other birds of the same or different species to do the same. Sometimes individuals within this "mobbing flock" will fly over or at the predator or attack it directly. Now, researchers reporting in the journal Current Biology on February 25 have found that male superb lyrebirds do something rather unexpected: they imitate a mobbing flock in courtship and even in the act of mating with a female. "Our paper shows that male superb lyrebirds regularly create a remarkable acoustic illusion of a flock of mobbing birds ...

Researchers at the Garvan Institute of Medical Research have discovered a new type of bone cell that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The new cells, which the researchers term 'osteomorphs', are found in the blood and bone marrow, and fuse together to form osteoclasts, specialised cells that break down bone tissue. They have a unique genomic profile that reveals promising and as yet unexplored targets for therapy. "This discovery is a game-changer, which not only helps us understand bone biology but presents significant new in-roads for osteoporosis therapy," says co-senior ...

A 20% shift in beverage sales from small to medium-sized plastic bottles could reduce the production of polyethylene terephthalate (PET) waste in the USA by over 9,000 tonnes annually, a study in Scientific Reports suggests. PET is the dominant material used in plastic bottles containing non-alcoholic beverages. Rafael Becerril-Arreola and Randolph Bucklin weighed 187 differently sized PET bottles sold by the best-selling beverage brands in Minnesota, USA, to identify which bottles sizes were the most efficient at delivering the highest volume of beverage for the lowest packaging weight. To validate their findings, the researchers combined data on sales of different sized PET bottles ...

Researchers at the University of California, Berkeley, have found a new way to harness properties of light waves that can radically increase the amount of data they carry. They demonstrated the emission of discrete twisting laser beams from antennas made up of concentric rings roughly equal to the diameter of a human hair, small enough to be placed on computer chips. The new work, reported in a paper published Thursday, Feb. 25, in the journal Nature Physics, throws wide open the amount of information that can be multiplexed, or simultaneously transmitted, by a coherent light source. A common example of multiplexing is the transmission of multiple telephone calls ...

Never before in over 1000 years the Atlantic Meridional Overturning Circulation (AMOC), also known as Gulf Stream System, has been as weak as in the last decades. This is the result of a new study by scientists from Ireland, Britain and Germany. The researchers compiled so-called proxy data, taken mainly from natural archives like ocean sediments or ice cores, reaching back many hundreds of years to reconstruct the flow history of the AMOC. They found consistent evidence that its slowdown in the 20th century is unprecedented in the past millennium; it is likely linked to human-caused climate change. The giant ocean circulation is relevant for weather patterns ...