The tuberculosis (TB) burden in the WHO European Region as a whole is decreasing, and is down 19% overall for 2015-2019, according to the latest WHO/European Centre for Disease Prevention and Control (ECDC) report Tuberculosis surveillance and monitoring in Europe 2021 (2019 data). Regional TB mortality has gone down, declining by 9.4% between 2018 and 2019. This is notably higher than the average global decline in TB mortality (3.7%) and enough to have reached the End TB Strategy milestone of a 35% reduction by 2020 compared to 2015. However, TB is second only to COVID-19 as an infectious disease that kills, and drug resistance is a major concern. There are also worrying indications that the COVID-19 pandemic may stall progress or cause significant setbacks in the fight against TB. The ...

Developing a standardized drying protocol for goldenseal could lead to more predictable health applications and outcomes by preserving the alkaloids found in the plant, which is native to Appalachia, according to Penn State researchers, who conducted a new study of the medicinal forest herb. The roots and rhizomes of goldenseal -- Hydrastis canadensis -- have been used for hundreds of years as a source of antimicrobials and compounds to treat intestinal ailments, noted study co-author Eric Burkhart, associate teaching professor, ecosystem science ...

Antibody injections are a highly desirable treatment for people with chronic diseases such as cancer, psoriasis, Crohn's disease and arthritis. And recently, antibodies have been in the news as a promising treatment for severe cases of COVID-19. But the costly, time-consuming manufacturing process to produce antibodies prevents these treatments from being accessible to most patients. Andrew Zydney, Bayard D. Kunkle Chair and professor of chemical engineering at Penn State, has identified a new method to manufacture antibodies, which could drive down the production cost. His research results were recently published in Biotechnology Progress. "If you look at the top 10 best-selling medications, by annual sales, eight ...

A new type of rock created during large and exceptionally hot volcanic eruptions has been discovered beneath the Pacific Ocean. An international team of researchers including the University of Leeds unearthed the previously unknown form of basalt after drilling through the Pacific ocean floor. The discovery suggests that ocean floor eruptions sourced in the Earth's mantle were even hotter and more voluminous than previously thought. Report co-author is Dr Ivan Savov, of Leeds' Institute of Geophysics and Tectonics, in the university's School of Earth and Environment. He said: "In an era when we rightly admire discoveries made through space exploration, our findings show there are still many discoveries still to make on our ...

The increasing frequency and severity of extreme weather events like droughts and floods have taken a toll on the midwestern U.S. in recent years, putting a major strain on the region's farmers. From 2001 to 2010, the Federal Crop Insurance Program, a government program created to protect farmers from crop loss, covered $4.1 billion in damages; in 2011 alone, the program paid out $10.8 billion. With the largest U.S. crop -- corn -- conservatively estimated to drop in yield anywhere from 20 to 80 percent due to extreme weather exacerbated by climate change, insurance claims may skyrocket to levels that may not be sustainable. But researchers from the Yale School of the Environment (YSE) found that by considering soil properties when determining insurance premiums ...

Less than a decade after unveiling the "Map of Life," a global database that marks the distribution of known species across the planet, Yale researchers have launched an even more ambitious and perhaps important project -- creating a map of where life has yet to be discovered. For Walter Jetz, a professor of ecology and evolutionary biology at Yale who spearheaded the Map of Life project, the new effort is a moral imperative that can help support biodiversity discovery and preservation around the world. "At the current pace of global environmental change, there is no doubt that many species will go extinct before we have ever learned ...

Efficient conversion of CO2 is strategically significant for alleviating the energy crisis and achieving the goal of carbon neutrality. One promising conversion route is the hydrogenation of CO2 to methanol using a renewable energy-based "green hydrogen" source. Traditional metal oxide catalysts for this reaction typically require a high temperature (>300 oC), which tends to promote undesired reverse water-gas shift (RWGS) side reactions, thus producing a large amount of CO as the by-product. Introduction of transition metal components onto metal oxides can promote the activation of H2, thereby reducing the reaction temperature, but this also facilitates excessive hydrogenation of CO2 to CH4, leading to lowered methanol selectivity. Further improvement of the performance ...

Physicians across the country have analyzed the emerging scientific data about the long-term effects of COVID-19, creating an initial knowledge base about the clinical experiences of so-called "long-haulers" - patients with COVID-19 who experience prolonged symptoms and/or the emergence of new ones well after the initial viral infection has resolved. A comprehensive review published today in Nature Medicine offers an initial glimpse of the multi-organ effects of long-term COVID-19 and suggests a framework for the care of COVID-19 long-haulers through dedicated, multidisciplinary clinics. "It was important to respond to our patients' concerns and pay close attention to the symptoms they were experiencing beyond the acute phase of COVID-19," said Kartik Sehgal, MD, a lead ...

Oncotarget published "Predictors of immunotherapy benefit in Merkel cell carcinoma" which reported that the authors retrospectively analyzed electronic health records and next-generation sequencing data of 45 patients treated at our institution from 2013 to 2020 to understand clinical and genomic correlates of benefit from immunotherapy. They reported that their cohort predominantly included individuals with stage III disease at primary disease diagnosis and individuals with stage IV disease at recurrent/metastatic disease diagnosis. Less advanced stages at primary disease diagnosis and shorter disease-free interval between completion of initial treatment and recurrence were each associated with greater odds of response. Single-nucleotide ...

Oncotarget published "Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico" which reported that one hundred and eleven Hispanic CMML patients from Puerto Rico were diagnosed in our institute from 2009 to 2018. Karyotypes were available in one hundred and seven patients. Compared to previously published data, Hispanic CMML patients in this study had significantly lower rates of overall cytogenetic abnormalities and trisomy 8. Among one hundred and eleven Hispanic CMML patients, 40-gene myeloid molecular profile tests were performed in fifty-six CMML patients. Previous studies indicated that mutated ASXL1, DNMT3A, NRAS, RUNX1, and SETBP1 may associate with an unfavorable prognosis ...

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects. One example is its ability to inhibit the alternative splicing event generating RAC1B, which is overexpressed in a specific subset ...

Aging-US published "Aging and rejuvenation - a modular epigenome model" which reported that the view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock (also published in Aging-US here). It was at this point ...

Having the right tool for the job makes the job a lot easier, less expensive and faster. Chemical engineering researchers have now developed a virtual laboratory that can be used to determine the artificial intelligence (AI) tools best suited for addressing various chemical synthesis challenges in flow chemistry systems. "Autonomous systems have tremendous potential for accelerating chemical R&D and manufacturing, but they are not in widespread use yet," says Milad Abolhasani, corresponding author of a paper on the work and an assistant professor of chemical engineering at North Carolina State University. "These systems face two kinds of ...

Scientists from MIPT and ITMO University and their colleagues have studied the formation and growth of crystals from simple organic molecules into large associations. These experiments will help create capsules for targeted drug delivery to specific tissues in the human body. The scientific paper was published in the journal Crystal Growth & Design. Melamine cyanurate consists of melamine, colourless crystals, and cyanuric acid, whose molecules associate in a similar way to DNA formation. The various studies associated with it could be useful ...

COLUMBUS, Ohio - As psychedelics gain ground as a potential therapy for mental health disorders, there remains a pressing concern that patients in clinical trials may have adverse effects to the drugs. New research identifies personality traits that have been associated with positive and negative experiences on psychedelics in previous studies, information that could help predict how future clinical trial participants will respond to the drugs. The findings suggest that people more open to new experiences and willing to surrender to the unknown may be best positioned to have a positive experience on psychedelics, and individuals who tend to be preoccupied or apprehensive could be more likely to have a ...

ITHACA, N.Y. - As the COVID-19 pandemic took hold in 2020, the list of things people could not do grew increasingly long. But while going to the office, attending live events and gathering with large groups of friends became difficult or impossible, other activities grew in popularity - including online learning. Drawing on records from DataCamp, an online platform tailored toward programming skills, a research team at Cornell University and Arizona State University used U.S. states' staggered adoption of nonessential business closures (NBC) to estimate their effects on the demand for online learning. The gradual closure of businesses across the U.S. gave the researchers a way to make a case for the cause and effect of NBC on increased engagement with the DataCamp ...

Aging-US published "Impact of adiposity on muscle function and clinical events among elders with dynapenia, presarcopenia and sarcopenia: a community-based cross-sectional study" which reported that low muscle function determined unfavorable clinical outcome than low muscle mass; nevertheless, comparison of detrimental parameters among dynapenia, presarcopenia and sarcopenia was sparse. The authors hypothesized that adiposity is implicated in low muscle function related adverse events. Associations of different obesity parameters, metabolic syndrome and fall among the groups were analyzed. Among 765 participants, ...

The COVID-19 and Cancer Consortium (CCC19) published new findings in the Annals of Oncology, showing heightened mortality and racial disparities for patients with cancer diagnosed with SARS-CoV-2 infection. After reviewing detailed information from almost 5,000 patients with active or past cancer and laboratory-confirmed COVID-19 diagnosis, CCC19 study authors found associations among laboratory measures, clinical factors -- including older age, hematological malignancy and recent chemotherapy - and poor clinical outcomes. Of the patients in the study with COVID-19 ...

Aging-US published "Functional analysis of POLD1 p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity" which reported that Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy define a rare systemic disorder, named MDPL Syndrome, due to almost always a de novo variant in POLD1 gene, encoding the DNA polymerase δ. A decline of cell growth, cellular senescence and a blockage of proliferation in G0/G1 phase complete the aged cellular picture. Moreover, the rate of telomere shortening was greater in pathological ...

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies. It leverages zinc finger proteins, which specifically bind to the DNA that codes for the protein Tau without altering it, thereby reducing Tau production in the brain and preventing nerve damage. The preclinical results, published in the journal Science Advances, could lay the foundation for new therapies. The Tau ...

The efficacy of biosensors used in clinical tests depends critically on the surface of the device on which the biorecognition molecules are immobilized. This surface can be adjusted and sometimes controlled using self-assembled molecular monolayers as matrices. The monolayers are films made up of organic molecules that under the right conditions assemble spontaneously on metal surfaces via chemical bonds between the sulfur atoms and the metal. A study conducted at the University of São Paulo's São Carlos Physics Institute (IFSC-USP) in Brazil compared the performances of two types of self-assembled ...

Myelodysplastic syndrome (MDS) is a disease of the stem cells in the bone marrow, which disturbs the maturing and differentiation of blood cells. Annually, some 200 Finns are diagnosed with MDS, which can develop into acute leukaemia. Globally, the incidence of MDS is 4 cases per 100,000 person years. To diagnose MDS, a bone marrow sample is needed to also investigate genetic changes in bone marrow cells. The syndrome is classified into groups to determine the nature of the disorder in more detail. In the study conducted at the University of Helsinki, microscopic images of MDS patients' bone marrow samples were examined utilising an image analysis technique based ...

Greenwood, SC (March 22, 2021) - A research team at the Greenwood Genetic Center (GGC) has identified the mechanism that causes movement disorders in patients with mutations in the NUS1 gene. Using both cellular and model organism studies, cholesterol accumulation was found to contribute to the symptoms of seizures, ataxia, and movement abnormalities. This breakthrough study on NUS1, a gene that has also been potentially linked to Parkinson's Disease, is reported in the current issue of Genetics in Medicine, the Journal of the American College of Medical Genetics and Genomics. Chloe Murphy, 15, of Bluffton, SC began experiencing tremors at age three. Through the years she has also experienced seizures, atypical eye movements, learning delays, ...

Reston, VA--A new treatment for late-stage neuroendocrine tumors (NETs) has been found to be more effective and have fewer side effects than the current standard of care, according to research published in the March issue of The Journal of Nuclear Medicine. The novel peptide receptor radionuclide therapy holds promise to reduce mortality among NET patients and decrease the financial burden of their continual treatment. NETs are a diverse group of tumors that originate from the neuroendocrine system, which is responsible for regulating hormones throughout the body. The number of people who are diagnosed with NETs is growing; the incidence of NETs increased 6.4-fold from 1973 to 2012. However, because they are rare, varied, ...

HOUSTON - (March 22, 2021) - There are many ways to test municipal wastewater for signs of the virus that causes COVID-19, but scientists in Houston have determined theirs is the best yet. A study led by environmental engineer Lauren Stadler of Rice University's Brown School of Engineering with the aid of the City of Houston Health Department and Baylor College of Medicine compared five processes used by labs around the country to concentrate samples and find the virus in wastewater from six Houston plants. The process employed at Rice and now Baylor, called "electronegative filtration with bead beating," proved the most sensitive to signs of the virus as well as the most cost-effective. The study appears in the Elsevier journal Water Research. There ...