Philadelphia, June 3, 2021 - Researchers at Children's Hospital of Philadelphia (CHOP) have demonstrated how to use standardized reporting of clinical data for seizures caused by a variety of neurological disorders, providing fundamental baseline information that can determine what methods work best for keeping seizures under control. The findings were published today in the journal Epilepsia. In order to make improvements in epilepsy care, clinicians need a reliable and efficient method to measure outcomes. While Electronic Medical Records (EMR) are being used more frequently for research and quality improvement, important epilepsy outcome measures such ...

MUSC Hollings Cancer Center researchers are finding solutions to the aging-related changes that reduce anti-cancer immunity. Besim Ogretmen, Ph.D., and colleagues found a novel link between aging, metabolism and anti-cancer T-cell function. Their work, published in Cell Reports, sheds light on an important pathway that cannot be ignored during cancer treatment. Two broad questions in cancer research are: How can cancer treatments be improved, and what is the link between cancer and aging? "We know that the protective T-cell response deteriorates with age. Mitochondrial function is now thought to be one of the central regulators of the aging process. Our experiments connected the dots with what was previously shown and highlighted some ...

Thursday, June 3, 2021, CLEVELAND: A Cleveland Clinic study shows that survivors of COVID-19 who have moderate or severe obesity may have a greater risk of experiencing long-term consequences of the disease, compared with patients who do not have obesity. The study was recently published online in the journal of Diabetes, Obesity and Metabolism. Multiple studies have identified obesity as a risk factor for developing a severe form of COVID-19 that may require hospital admission, intensive care, and ventilator support in the early phase of the disease. Obesity, which is a complex disease caused by multiple factors, is associated with an increased risk for cardiovascular ...

DURHAM, N.H.-- Bears are known for being devoted and protective of their baby cubs, but research from the University of New Hampshire shows that they may also play a significant role in shielding gray fox from predators like coyotes, who compete with the fox for food and space. The research is one of the first studies to show how black bears provide a buffer to allow other, smaller carnivores to safely co-exist. "Even though black bears and coyotes are the two most common carnivores in North America, we're still learning how they affect the ecosystems around them," said Rem Moll, assistant professor of wildlife ecology and lead author ...

The fabrication device for the battery revolution looks quite unconspicuous: It is a modified, commercially available 3D printer, located in a room in the Empa laboratory building. But the real innovation lies within the recipe for the gelatinous inks this printer can dispense onto a surface. The mixture in question consists of cellulose nanofibers and cellulose nanocrystallites, plus carbon in the form of carbon black, graphite and activated carbon. To liquefy all this, the researchers use glycerin, water and two different types of alcohol. Plus a pinch of table salt for ionic conductivity. A sandwich of four layers To build a functioning supercapacitor from these ingredients, four layers are needed, all flowing out of the 3D printer one after the ...

Left- or right-handedness is a symmetry property that many macroscopic objects also exhibit and which is of immense importance, particularly for the bioactivity of organic molecules. Chirality is also relevant for physical or chemical properties such as optical activity or enantioselectivity of crystalline solids or their surfaces. In the case of chiral metallic phases, unconventional superconductivity and unusual magnetic ordered states are linked to the chirality of the underly-ing crystal structure. Despite this connection between chirality and the properties of a material, detection is often difficult because left-handed and righthanded ...

The expansion of wind energy in the German Bight and the Baltic Sea has accelerated enormously in recent years. The first systems went into operation in 2008. Today, wind turbines with an output of around 8,000 megawatts rotate in German waters, which corresponds to around eight nuclear power plants. But space is limited. For this reason, wind farms are sometimes built very close to one another. A team led by Dr. Naveed Akhtar from Helmholtz Zentrum Hereon has found that wind speeds at the downstream windfarm are significantly slowed down. As the researchers now write in the journal Nature Scientific Reports, this braking effect results in astonishingly large-scale low wind pattern noticeable in mean ...

Neurodegenerative disorders that cause dementia increase the risk of contracting severe COVID-19 and dying from the disease. For people with Alzheimer's the risk is three times greater. It can be six times greater if they are over 80, according to a study conducted in Brazil by researchers at the University of São Paulo (USP) and Butantan Institute in partnership with colleagues at the Federal University of Rio de Janeiro (UFRJ). An article on the study, which was supported by FAPESP, is published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. "We found that all causes of dementia are risk factors for severity and death in COVID-19 and that these ...

ITHACA, N.Y. - Water regulation in leaves is vital to a plant's health, affecting its growth and yield, disease susceptibility and drought resistance. A breakthrough technology developed by Cornell University researchers uses nanoscale sensors and fiber optics to measure water status just inside a leaf's surface, where water in plants is most actively managed. The engineering feat provides a minimally invasive research tool that will greatly advance the understanding of basic plant biology, and opens the door for breeding more drought-resistant crops. The technology could eventually be adapted for use as an agronomic tool for measuring water status in crops in real time. The study in maize plants, "A Minimally Disruptive Method for Measuring Water Potential In-Planta ...

Sickle Cell Disease (SCD) is a genetically inherited group of red blood cell disorders. END ...

DURHAM, N.C. - A group of researchers have discovered the detailed inner workings of the molecular motor that packages genetic material into double-stranded DNA viruses. The advance provides insight into a critical step in the reproduction cycle of viruses such as pox- herpes- and adeno-viruses. It could also give inspiration to researchers creating microscopic machines based on naturally occurring biomotors. The research was conducted by scientists from Duke University, the University of Minnesota, the University of Massachusetts and the University of Texas Medical Branch (UTMB). The results appear online in a trilogy of papers published in Science Advances, ...

WHO: JoAnn Manson, MD, DrPH, Physician and Epidemiologist, Division of Preventive Medicine, Brigham and Women's Hospital; co-author of a new Perspective piece published in The New England Journal of Medicine (pdf attached) WHAT: Less than 50 years ago, a U.S. Supreme Court decision paved the way for women's use of contraception irrespective of marital status, and a year later, in 1973, the Court ruled in Roe v. Wade that women have a right to legalized abortion. In recent decades, clinical researchers and policymakers alike have made important strides ...

You would not be surprised to see an elephant in the savanna or a plate in your kitchen. Based on your prior experiences and knowledge, you know that is where elephants and plates are often to be found. If you saw a mysterious object in your kitchen, how would you figure out what it was? You would rely on your expectations or prior knowledge. Should a computer approach the problem in the same way? The answer may surprise you. Cold Spring Harbor Laboratory Professor Partha Mitra described how he views problems like these in a "Perspective" in Nature Machine Intelligence. He hopes his insights will help researchers teach computers how to analyze complex systems more effectively. Mitra thinks it helps to understand the nature of knowledge. Mathematically speaking, many data scientists ...

The surface of the sun churns with energy and frequently ejects masses of highly-magnetized plasma towards Earth. Sometimes these ejections are strong enough to crash through the magnetosphere -- the natural magnetic shield that protects the Earth -- damaging satellites or electrical grids. Such space weather events can be catastrophic. Astronomers have studied the sun's activity for centuries with greater and greater understanding. Today, computers are central to the quest to understand the sun's behavior and its role in space weather events. The ...

MADISON, Wis. -- For birds and other wildlife, winter is a time of resource scarcity. Extreme winter weather events such as a polar vortex can push some species to the edge of survival. Yet winter tends to get short shrift in climate change research, according to UW-Madison forest and wildlife ecology Professor Ben Zuckerberg. "When we think about the impact of climate change, winter tends to be overlooked as a time of year that could have significant ecological and biological implications," says Zuckerberg. "It makes me, and my colleagues, think quite deeply about the impacts of these extreme events during this time when species are particularly vulnerable." Zuckerberg, ...

Using a piece of magnet, researchers have designed a simple system that can control the movement of a small puddle of water, even when it's upside down. The new liquid manipulation strategy, described in the journal Cell Reports Physical Science on June 3, can have a wide range of applications including cleaning hard-to-reach environments or delivering small objects. Previous attempts to control the movement of fluids often relied on special platforms. For example, on a surface that has one section more hydrophobic than another, water will spontaneously ...

Anyone that's ever interacted with a dog knows that they often have an amazing capacity to interact with people. Now researchers reporting in the journal Current Biology on June 3 have found that this ability is present in dogs from a very young age and doesn't require much, if any, prior experience or training. But, some of them start off better at it than others based on their genetics. "We show that puppies will reciprocate human social gaze and successfully use information given by a human in a social context from a very young age and prior to extensive experience with humans," said Emily E. Bray of the University of Arizona, Tucson. "For example, even before puppies have left their littermates to live ...

Whales are largely protected from direct catch, but many populations' numbers still remain far below what they once were. A study published in the journal Current Biology on June 3 suggests that, in addition to smaller population sizes, those whales that survive are struggling. As evidence, they find that right whales living in the North Atlantic today are significantly shorter than those born 30 to 40 years ago. "On average, a whale born today is expected to reach a total length about a meter shorter than a whale born in 1980," said Joshua Stewart of the National Oceanic and Atmospheric Administration (NOAA) in La Jolla, CA. That represents an average decline in length of about 7%. "But that's just the average--there are also some extreme cases where young whales are several ...

Patients who, perhaps unbeknownst to their health care providers, are in need of genetic testing for rare undiagnosed diseases can be identified en masse based on routine information in electronic health records (EHRs), a research team reported today in the journal Nature Medicine. Findings from the Vanderbilt University Medical Center study suggest that, among the patients of any sizeable health care system, there are hundreds or thousands with undiagnosed rare diseases of the sort where a genetic test could lead to a diagnosis. "Patients with rare genetic diseases often face ...

What The Study Did: Changes in pregnancy and birth rates before and after COVID-19 lockdown measures were estimated using electronic medical records. Authors: Molly J. Stout, M.D., of the University of Michigan in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.11621) Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study is linked to this news release. Embed this link to provide your readers free access ...

Quantum computers with their promises of creating new materials and solving intractable mathematical problems are a dream of many physicists. Now, they are slowly approaching viable realizations in many laboratories all over the world. But there are still enormous challenges to master. A central one is the construction of stable quantum bits - the fundamental unit of quantum computation called qubit for short - that can be networked together. In a study published in Nature Materials and led by Daniel Jirovec from the Katsaros group at IST Austria in close collaboration with researchers from the L-NESS Inter-university Centre in Como, Italy, scientists now have created a new and promising candidate system for reliable qubits. Spinning Absence The researchers created the qubit using the ...

Dogs may have earned the title "man's best friend" because of how good they are at interacting with people. Those social skills may be present shortly after birth rather than learned, a new study by University of Arizona researchers suggests. Published today in the journal Current Biology, the study also finds that genetics may help explain why some dogs perform better than others on social tasks such as following pointing gestures. "There was evidence that these sorts of social skills were present in adulthood, but here we find evidence that puppies - sort of like humans - are biologically prepared to interact in these social ways," said lead study author Emily Bray, a postdoctoral research associate in the UArizona School of Anthropology in the College of Social and Behavioral ...

(Toronto, June 3, 2021) -- The impact of deploying Artificial Intelligence (AI) for radiation cancer therapy in a real-world clinical setting has been tested by Princess Margaret researchers in a unique study involving physicians and their patients. A team of researchers directly compared physician evaluations of radiation treatments generated by an AI machine learning (ML) algorithm to conventional radiation treatments generated by humans. They found that in the majority of the 100 patients studied, treatments generated using ML were deemed to be clinically acceptable for patient treatments by physicians. Overall, 89% of ML-generated treatments were considered clinically acceptable for treatments, ...

For reasons unknown, Earth's solid-iron inner core is growing faster on one side than the other, and it has been ever since it started to freeze out from molten iron more than half a billion years ago, according to a new study by seismologists at the University of California, Berkeley. The faster growth under Indonesia's Banda Sea hasn't left the core lopsided. Gravity evenly distributes the new growth -- iron crystals that form as the molten iron cools -- to maintain a spherical inner core that grows in radius by an average of 1 millimeter per year. But the enhanced growth on one side suggests that something in Earth's outer core or mantle under Indonesia is removing heat from the inner core at a faster rate than on the opposite side, under Brazil. Quicker cooling on one side would ...

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in partnership with researchers at the Institut de Recherches Cliniques de Montréal (IRCM) in Canada, have identified Meis transcription factors as essential biomolecules for the formation and antero-posterior patterning of the limbs during embryonic development. In the study, published in Nature Communications, the research team carried out an in-depth characterization of the Meis family of transcription factors. Genetic deletion of all four family members showed that these proteins are essential for the formation of the limbs during embryonic development. "An embryo that develops in the absence of Meis does not ...