Any building project requires the formulation of a series of initial plans prior to starting construction to serve as a basis and guide for the whole process. A similar procedure is followed in software development, with the inclusion of a specific step known as modelling. "The process is equivalent to the production of a set of plans for a building before its construction," explained Universitat Oberta de Catalunya (UOC) Faculty of Computer Science, Multimedia and Telecommunications professor and member of the SOM Research Lab research group -from the Internet Interdisciplinary Institute (IN3)-, Robert Clarisó. Engineers use modelling to describe ...

In the last decades, Artificial Intelligence has shown to be very good at achieving exceptional goals in several fields. Chess is one of them: in 1996, for the first time, the computer Deep Blue beat a human player, chess champion Garry Kasparov. A new piece of research shows now that the brain strategy for storing memories may lead to imperfect memories, but in turn, allows it to store more memories, and with less hassle than AI. The new study, carried out by SISSA scientists in collaboration with Kavli Institute for Systems Neuroscience & Centre for Neural Computation, Trondheim, Norway, has just been published in Physical Review Letters. Neural networks, real or artificial, learn by tweaking the connections ...

An innovative new study is set to examine if changing our mealtimes to earlier or later in the day could reduce the risk of developing Type 2 diabetes. Led by Dr Denise Robertson, Professor Jonathan Johnston and post graduate researcher Shantel Lynch from the University of Surrey, the study, outlined in the journal Nutrition Bulletin, will investigate if changing the time we eat during the day could reduce risk factors such as obesity and cholesterol levels that are typically associated with the development of Type 2 diabetes. The team of researchers will also for the first time investigate, via a series of interviews with participants and their friends and family, the impact of such changes on home life, work/social commitments and whether co-habitants of those who make such ...

Having genitals of a certain shape and size gives male flies a major reproductive advantage, new research shows. University of Exeter scientists examined the reproductive success of male Drosophila simulans flies both alone with a female and in various states of competition with other males. Certain genital shapes were consistently better in terms of number of offspring sired. However - surprisingly, given how fast genital form evolves - the selection documented was rather weak. "Male genitals generally, and in Drosophila specifically, evolve very quickly, so we were really surprised to find this weak selection," said Professor David Hosken, of the University of Exeter. "Selection is the major mechanism of evolution and hence where we see rapid evolution, ...

Mitochondria are vital for the human body as cellular powerhouses: They possess more than 1,000 different proteins, required for many central metabolic pathways. Disfunction of these lead to severe diseases, especially of the nervous system and the heart. In order to transport proteins and metabolites, mitochondria contain a special group of so-called beta-barrel membrane proteins, which form transport pores in the outer mitochondrial membrane. So far, scientists have not been able to explain the operating mode of the sorting and assembly machinery (SAM) for the biogenesis of these beta-barrel proteins. A team led by Prof. Dr. Toshiya Endo from Kyoto University/Japan, Prof. Dr. Nils Wiedemann and ...

Guangzhou, January 15, 2021: New journal BIO Integration (BIOI) publishes its fourth issue, volume 1, issue 4. BIOI is a peer-reviewed, open access, international journal, which is dedicated to spreading multidisciplinary views driving the advancement of modern medicine. Aimed at bridging the gap between the laboratory, clinic, and biotechnology industries, it will offer a cross-disciplinary platform devoted to communicating advances in the biomedical research field and offering insights into different areas of life science, in order to encourage cooperation and exchange among scientists, clinical researchers, and health care providers. The issue contains an original article, three review ...

A clinical trial involving COVID-19 patients hospitalized at UT Health San Antonio and University Health, among roughly 100 sites globally, found that a combination of the drugs baricitinib and remdesivir reduced time to recovery, according to results published Dec. 11 in the New England Journal of Medicine. Six researchers from UT Health San Antonio and University Health are coauthors of the publication because of the San Antonio site's sizable patient enrollment in the trial. The Adaptive COVID-19 Treatment Trial 2 (ACTT-2), which compared the combination therapy versus remdesivir paired with an inactive placebo in hospitalized COVID-19 patients, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), ...

Certain snakes have evolved a unique genetic trick to avoid being eaten by venomous snakes, according to University of Queensland research. Associate Professor Bryan Fry from UQ's Toxin Evolution Lab said the technique worked in a manner similar to the way two sides of a magnet repel each other. "The target of snake venom neurotoxins is a strongly negatively charged nerve receptor," Dr Fry said. "This has caused neurotoxins to evolve with positively charged surfaces, thereby guiding them to the neurological target to produce paralysis. "But some snakes have evolved to replace a negatively charged amino acid on their receptor with a positively charged one, meaning the neurotoxin is repelled. "It's an inventive genetic mutation and it's been completely missed until now. "We've ...

PHILADELPHIA - Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It's no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S. With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer - ...

Oxygen levels in the ancient oceans were surprisingly resilient to climate change, new research suggests. Scientists used geological samples to estimate ocean oxygen during a period of global warming 56 million years ago - and found "limited expansion" of seafloor anoxia (absence of oxygen). Global warming - both past and present - depletes ocean oxygen, but the new study suggests warming of 5°C in the Paleocene Eocene Thermal Maximum (PETM) led to anoxia covering no more than 2% of the global seafloor. However, conditions are different today to the PETM - today's rate of carbon emissions is much faster, and we are adding nutrient pollution to the oceans - both of which could drive more rapid and expansive oxygen loss. The study was carried out by an international ...

Champaign, IL, January 15, 2021 - American dairy consumers are often influenced by a variety of factors that can affect their buying habits. These factors include taste, preference, government information, cultural background, social media, and the news. In an article appearing in JDS Communications, researchers found that households that frequently bought food for children are interested in dairy as part of their diet and purchased larger quantities of fluid milk and more fluid milk with a higher fat content. To assess the purchasing habits of households that purchase food for children versus those ...

Families are complicated. For members of the Alligatoridae family, which includes living caimans and alligators - this is especially true. They are closely related, but because of their similarity, their identification can even stump paleontologists. But after the recent discovery of a partial skull, the caimans of years past may provide some clarity into the complex, and incomplete, history of its relatives and their movements across time and space. Michelle Stocker, an assistant professor of vertebrate paleontology in Virginia Tech's Department of Geosciences in the College of Science; Chris Kirk, of the University of Texas at Austin; and Christopher Brochu, of the University of Iowa, have ...

Researchers from University of Stavanger, University of Melbourne, and University of Wisconsin-Madison published a new paper in the Journal of Marketing that examines how major projects undertaken by temporary organizations can be better managed so that cost overruns are minimized. The study forthcoming in the Journal of Marketing is titled "Mobilizing the Temporary Organization: The Governance Roles of Selection and Pricing" and is authored by Elham Ghazimatin, Erik Mooi, and Jan Heide. When consumers return to the skies again, they may do so in Boeing's 787 Dreamliner. But the project, or "temporary organization," created to make this plane ...

Just like humans trying to stick to New Year's resolutions, guppies have varying levels of self-control, a new study shows. Researchers from the University of Exeter and Ghent University studying the behaviours of Trinidadian guppies tested "inhibitory control" (suppressing unhelpful impulses or urges). The tiny fish first learned how to swim into a cylinder to get food - then a cover was removed to make the cylinder transparent. Inhibitory control was measured by whether a guppy resisted the urge to swim directly towards the food - bumping into the cylinder - or still swam around, ...

Researchers have developed a DNA test to quickly identify secondary infections in COVID-19 patients, who have double the risk of developing pneumonia while on ventilation than non-COVID-19 patients. For patients with the most severe forms of COVID-19, mechanical ventilation is often the only way to keep them alive, as doctors use anti-inflammatory therapies to treat their inflamed lungs. However, these patients are susceptible to further infections from bacteria and fungi that they may acquire while in hospital - so called 'ventilator-associated pneumonia'. Now, a team of scientists ...

Former director of public health Professor John Ashton has said that scientific scepticism may be reinforced by the UK's rush to approve COVID vaccines for public use and the apparent political desire to be the first out of the blocks in contrast to our European neighbours. Writing in the Journal of the Royal Society of Medicine, Prof Ashton says that to risk the trust of the public for the sake of a couple of weeks propaganda advantage could prove to be unforgivable should vaccine uptake fall below that required for the ubiquitous 'herd immunity' as a result of giving oxygen to the sceptics. "In this age of scientific rationality, superstition and anti-science still run deep," he writes. "When an overwhelming majority of the public welcomes the arrival of ...

BOSTON - Studies with a popular laboratory model, the nematode Caenorhabditis elegans, have revealed a possible therapeutic avenue for a rare but deadly condition in which children are born without the ability to make molybdenum cofactor (Moco) on their own. Though little known, Moco is essential for life and so far it has proven extremely difficult to stably isolate this compound in the laboratory, preventing its use as a therapeutic supplement. This new work, which appears in Genes & Development, reveals that nematodes genetically engineered to be Moco-deficient can take up Moco that is attached to several types of proteins. This suggests that such protein-Moco complexes could be used as a treatment ...

In a normal year, biologists Daniel Janzen and Winnie Hallwachs spend about six months in Costa Rica, where they conduct research and pursue conservation efforts in Área de Conservación Guanacaste (ACG), a World Heritage Site in the northwest that encompasses, a network of parks and preserves they helped establish in the 1980s and that has grown to more than 400,000 acres, including marine, dry forest, cloud forest, and rain forest environments. In 2020 that is where the married couple was when the COVID-19 pandemic took hold of the world, and compelled them to extend their stay in the virus-free forest until the fall, when they felt safe enough to travel back to their other home in Philadelphia. "With modern laptops and internet, we could watch the world go ...

Anthropologist Caleb Everett and former student Sihan Chen used a novel data analysis of thousands of languages, in addition to studying a unique subset of celebrities, to reveal how a soft food diet--contrasted with the diet of hunter-gatherers--is restructuring dentition and changing how people speak. Their findings, published in Scientific Reports, counter the longstanding belief within the field that maintains that languages are susceptible to the same pressures and so are essentially immune to external factors. "Our results represent the most compelling evidence to date that languages are very much affected by external ...

When the Thomas Fire raged through Ventura and Santa Barbara counties in December 2017, Danielle Touma, at the time an earth science researcher at Stanford, was stunned by its severity. Burning for more than a month and scorching 440 square miles, the fire was then considered the worst in California's history. Six months later the Mendocino Complex Fire upended that record and took out 717 square miles over three months. Record-setting California wildfires have since been the norm, with five of the top 10 occurring in 2020 alone. The disturbing trend sparked some questions for Touma, who is now a postdoctoral researcher at UC Santa Barbara's Bren School for Environmental ...

DARIEN, IL - Editors of the Journal of Clinical Sleep Medicine have identified some of the most significant articles in the publication's history, publishing new commentaries on them in a special 15th anniversary collection. The 15 commentaries from associate editors and members of the journal's editorial board describe the impact of the selected articles both at the time of their publication and today. "The collection highlights some of the most influential publications in clinical sleep research over the past 15 years," JCSM Editor-in-Chief Dr. Nany Collop said. "These studies underscore the remarkable ...

By feeding arctic ground squirrels special diets, researchers have found that omega-3 fatty acids, common in flax seed and fish oil, help keep the animals warmer in deep hibernation. A University of Alaska Fairbanks-led study fed ground squirrels either a diet high in omega-3s or a normal laboratory diet, and measured how the animals hibernated afterward. Researchers found that the omega-3 diet helped the animals hibernate a little warmer than normal without negatively affecting hibernation. The omega-3 diets also increased the amount of a heat-producing fat, called brown adipose tissue, the animals pack on. The discovery could add more understanding ...

DURHAM, N.H.-- Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that were effective in reducing the growth of the cancer cells and when combined with a third drug were even more successful in killing the WM cancer cells which could lead to more treatment options. "This is the first study to report the promising results ...

Astronomers are winding back the clock on the expanding remains of a nearby, exploded star. By using NASA's Hubble Space Telescope, they retraced the speedy shrapnel from the blast to calculate a more accurate estimate of the location and time of the stellar detonation. The victim is a star that exploded long ago in the Small Magellanic Cloud, a satellite galaxy to our Milky Way. The doomed star left behind an expanding, gaseous corpse, a supernova remnant named 1E 0102.2-7219, which NASA's Einstein Observatory first discovered in X-rays. Like detectives, researchers sifted through archival images taken by Hubble, analyzing visible-light observations made 10 years apart. The research team, led by John Banovetz and Danny Milisavljevic ...

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines -- the standard treatment for itching and allergy -- often don't help. New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn't respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don't target. The new findings, published ...