Cell velocity, or how fast a cell moves, is known to depend on how sticky the surface is beneath it, but the precise mechanisms of this relationship have remained elusive for decades. Now, researchers from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and Ludwig Maximilians Universität München (LMU) have figured out the precise mechanics and developed a mathematical model capturing the forces involved in cell movement. The findings, reported in the journal Proceedings of the National Academy of Sciences (PNAS), provide new insight for developmental biology and potential cancer treatment. Cell ...

Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own. There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D scaffold in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue. In a major step toward transforming this hope into reality, researchers at the University of Washington have developed a technique to ...

A brain region involved in processing information about ourselves biases our ability to remember, according to new research published in JNeurosci. People are good at noticing information about themselves, like when your eye jumps to your name in a long list or you manage to hear someone address you in a noisy crowd. This self-bias extends to working memory, the ability to actively think about and manipulate bits of information: people are also better at remembering things about themselves. To pinpoint the source of this bias, Yin et al. measured participants' brain activity in an fMRI scanner while they tried to remember the location of different colored dots representing themselves, a friend, or a stranger. The participants' fastest response ...

The core mass of the giant exoplanet WASP-107b is much lower than what was thought necessary to build up the immense gas envelope surrounding giant planets like Jupiter and Saturn, astronomers at Université de Montréal have found. This intriguing discovery by Ph.D. student Caroline Piaulet of UdeM's Institute for Research on Exoplanets (iREx) suggests that gas-giant planets form a lot more easily than previously believed. Piaulet is part of the groundbreaking research team of UdeM astrophysics professor Björn Benneke that in 2019 announced the first detection of water on an exoplanet located in its star's habitable zone. Published today in the Astronomical Journal with colleagues ...

Indiana Jones and Lara Croft have a lot to answer for. Public perceptions of archaeology are often thoroughly outdated, and these characterisations do little to help. Yet archaeology as practiced today bears virtually no resemblance to the tomb raiding portrayed in movies and video games. Indeed, it bears little resemblance to even more scholarly depictions of the discipline in the entertainment sphere. A paper published today in Nature Ecology and Evolution aims to give pause to an audience that has been largely prepared to take such out-of-touch depictions at face value. It reveals an archaeology practiced by scientists in white lab coats, using multi-million-euro instrumentation and state of the art computers. It also reveals an archaeology poised to ...

Irvine, Calif. -- Future climate change will cause a regionally uneven shifting of the tropical rain belt - a narrow band of heavy precipitation near the equator - according to researchers at the University of California, Irvine and other institutions. This development may threaten food security for billions of people. In a study published today in Nature Climate Change, the interdisciplinary team of environmental engineers, Earth system scientists and data science experts stressed that not all parts of the tropics will be affected equally. For instance, the rain belt ...

Range anxiety, the fear of running out of power before being able to recharge an electric vehicle, may be a thing of the past, according to a team of Penn State engineers who are looking at lithium iron phosphate batteries that have a range of 250 miles with the ability to charge in 10 minutes. "We developed a pretty clever battery for mass-market electric vehicles with cost parity with combustion engine vehicles," said Chao-Yang Wang, William E. Diefenderfer Chair of mechanical engineering, professor of chemical engineering and professor of materials science and engineering, and director of the Electrochemical Engine Center at Penn State. "There ...

Targeted neuromodulation tailored to individual patients' distinctive symptoms is an increasingly common way of correcting misfiring brain circuits in people with epilepsy or Parkinson's disease. Now, scientists at UC San Francisco's Dolby Family Center for Mood Disorders have demonstrated a novel personalized neuromodulation approach that -- at least in one patient -- was able to provide relief from symptoms of severe treatment-resistant depression within minutes. The approach is being developed specifically as a potential treatment for the significant fraction of people with debilitating depression ...

More than 3,000 animal species in the world today are considered endangered, with hundreds more categorized as vulnerable. Currently, ecologists don't have reliable tools to predict when a species may become at risk. A new paper published in Nature Ecology and Evolution, "Management implications of long transients in ecological systems," focuses on the transient nature of species' and ecosystem stability and illustrates how management practices can be adjusted to better prepare for possible system flips. Some helpful modeling approaches are also offered, including one tool that may help identify potentially ...

Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Published today in Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the role of androgens - commonly thought of as male sex hormones but also found at lower levels in women - as a potential treatment for estrogen receptor positive breast cancer. Watch a video explainer about the new ...

Some of the low-carbon policy options currently used by governments may be detrimental to the households and small businesses less able to manage added short-term costs from energy price hikes, according to a new study. However, it also suggests that this menu of decarbonising policies, from quotas to feed-in tariffs, can be designed and balanced to benefit local firms and lower-income families - vital for achieving 'Net Zero' carbon and a green recovery. University of Cambridge researchers combed through thousands of studies to create the most comprehensive analysis to date of widely used types of low-carbon policy, and compared how they perform in areas such as cost and competitiveness. ...

Some of the low-carbon policy options currently used by governments may be detrimental to the households and small businesses less able to manage added short-term costs from energy price hikes, according to a new study. However, it also suggests that this menu of decarbonising policies, from quotas to feed-in tariffs, can be designed and balanced to benefit local firms and lower-income families - vital for achieving 'Net Zero' carbon and a green recovery. University of Cambridge researchers combed through thousands of studies to create the most comprehensive analysis to date of widely used types of low-carbon policy, and compared how they perform in areas such ...

Researchers from the National Institutes of Health have discovered Jekyll and Hyde immune cells in the brain that ultimately help with brain repair but early after injury can lead to fatal swelling, suggesting that timing may be critical when administering treatment. These dual-purpose cells, which are called myelomonocytic cells and which are carried to the brain by the blood, are just one type of brain immune cell that NIH researchers tracked, watching in real-time as the brain repaired itself after injury. The study, published in Nature Neuroscience, ...

UNIVERSITY PARK, Pa. -- Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine. "The antibiotic thiostrepton is very potent against Gram-positive pathogens and can even target certain breast cancer cells in culture," said Squire Booker, a biochemist at Penn State and investigator with the Howard Hughes Medical Institute. "While it has been used ...

HOUSTON — In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples. The work was published today in Nature Biotechnology. The new tool, dubbed CopyKAT (copy number karyotyping of aneuploid tumors), allows researchers to more easily examine the complex data obtained from large single-cell RNA-sequencing experiments, which deliver gene expression data from ...

Mount Sinai researchers have published one of the first studies using a machine learning technique called "federated learning" to examine electronic health records to better predict how COVID-19 patients will progress. The study was published in the Journal of Medical Internet Research - Medical Informatics on January 18. The researchers said the emerging technique holds promise to create more robust machine learning models that extend beyond a single health system without compromising patient privacy. These models, in turn, can help triage patients and improve the quality of their care. Federated ...

A research team from the Institut national de la recherche scientifique (INRS) has developed a process for the electrolytic treatment of wastewater that degrades microplastics at the source. The results of this research have been published in the Environmental Pollution journal. Wastewater can carry high concentrations of microplastics into the environment. These small particles of less than 5 mm can come from our clothes, usually as microfibers. Professor Patrick Drogui, who led the study, points out there are currently no established degradation methods to handle this contaminant during wastewater ...

Philadelphia, January 18, 2021 - A new study comparing the incidence of sudden deaths occurring outside the hospital across New York City's highly diverse neighborhoods with the percentage of positive SARS-CoV-19 tests found that increased sudden deaths during the pandemic correlate to the extent of virus infection in a neighborhood. The analysis appears in Heart Rhythm, the official journal of the Heart Rhythm Society, the Cardiac Electrophysiology Society, and the Pediatric & Congenital Electrophysiology Society, published by Elsevier. "Our research shows the highly diverse regional distribution of out-of-hospital sudden death during ...

ANN ARBOR, Mich. -- An estimated one in five teenagers has symptoms of a mental health disorder such as depression or anxiety, and suicide is the second leading cause of death among teens. But the first person a teen confides in may not always be an adult - they may prefer to talk to another teen. And three-quarters of parents in a new national poll think peers better understand teen challenges, compared to teachers or counselors in the school. The majority also agree that peer support leaders at school would encourage more teens to talk with someone about their mental health problems, according to the C.S. Mott Children's Hospital National Poll on Children's Health at Michigan Medicine. "Peers may provide valuable support for ...

New research examining more than 800,000 traffic stops in Vermont over the course of five years substantiates the term "driving while Black and Brown." Compared to white drivers, Black and Latinx drivers in Vermont are more likely to be stopped, ticketed, arrested, and searched. But they are less likely to be found with contraband than white drivers. The report finds evidence not only of racial disparities but also racial bias in policing. What's more, a number of these gaps widened over the years examined in the report. With such comprehensive data encompassing the state of Vermont, the authors also found that Vermont police stop cars at a rate ...

A student infected with COVID-19 returning home from university for Christmas would, on average, have infected just less than one other household member with the virus, according to a new model devised by mathematicians at Cardiff University and published in END ...

Variation in consumption of market-acquired foods outside of the traditional diet -- but not in total calories burned daily -- is reliably related to indigenous Amazonian children's body fat, according to a Baylor University study that offers insight into the global obesity epidemic. "The importance of a poor diet versus low energy expenditure on the development of childhood obesity remains unclear," said Samuel Urlacher, Ph.D., assistant professor of anthropology at Baylor University, CIFAR Azrieli Global Scholar and lead author of the study. "Using gold-standard measures of energy expenditure, we show that relatively lean, rural forager-horticulturalist children in the Amazon spend approximately the same total number of calories each day as their much ...

Spiritualist mediums might be more prone to immersive mental activities and unusual auditory experiences early in life, according to new research. This might explain why some people and not others eventually adopt spiritualist beliefs and engage in the practice of 'hearing the dead', the study led by Durham University found. Mediums who "hear" spirits are said to be experiencing clairaudient communications, rather than clairvoyant ("seeing") or clairsentient ("feeling" or "sensing") communications. The researchers conducted a survey of 65 clairaudient spiritualist mediums from the Spiritualists' National Union and 143 members of the general population in the ...

Tokyo, Japan - Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans. Looking at the brain cells of aging flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans. The brain is a particularly power-hungry part of our bodies, consuming 20% of the oxygen we take in and 25% of the glucose. That's why it's so important that it can stay powered, ...

The spread of COVID-19 in Brazil overwhelmed the health systems in all the country's regions, particularly in areas where they were already fragile, according to a collaborative effort involving the Barcelona Institute for Global Health (ISGlobal), an institution supported by the "la Caixa" Foundation, the University of Sao Paulo, the Catholic University of Rio de Janeiro, the D'Or Institute of Research and Education and the Oswaldo Cruz Foundation. The findings, published in The Lancet Respiratory Medicine, reveal that a large percentage of COVID-19 patients that were hospitalised in Brazil required intensive care and respiratory support, and many did not survive. The COVID-19 pandemic has put an enormous strain on healthcare ...