An immunotherapy drug given after surgery improved disease-free survival rates in patients with kidney cancer at high risk of relapse. Interim results of a phase 3 trial of adjuvant therapy revealed a 32% decrease in the risk of recurrence or death with pembrolizumab compared with a placebo This is the first positive study of immunotherapy in patients with kidney cancer at high risk of relapse. BOSTON -- Treatment with an immunotherapy drug following kidney cancer surgery, prolonged disease-free survival rates in patients at high risk for recurrence, according to an interim ...

Sickle cell disease (SCD) is the most common deadly genetic disorder, affecting more than 300,000 newborns worldwide each year. It leads to chronic pain, organ failure, and early death in patients. A team led by researchers at the Broad Institute of MIT and Harvard and St. Jude Children's Research Hospital has now demonstrated a base editing approach that efficiently corrects the mutation underlying SCD in patient blood stem cells and in mice. This gene editing treatment rescued the disease symptoms in animal models, enabling the long-lasting production of healthy blood cells. The root of SCD is two mutated copies of the hemoglobin gene, HBB, which cause red ...

After a 2020 Vanderbilt University Medical Center study showed women have a difficult time accessing treatment for opioid use disorder (OUD), investigators analyzed comments received from the study's participants to further shed light on barriers to care, which included everything from long on-hold times to difficult interactions with clinic receptionists during phone calls seeking appointments. A "secret shopper" study published in JAMA Network Open in 2020 used trained actors trying to get into treatment for opioid use disorder in 10 U.S. states. More than 10,000 unique "patients" were randomly assigned to be pregnant or non-pregnant and have private or Medicaid-based insurance to assess differences ...

MEMPHIS, Tenn. - Cardiovascular imaging demonstrated no evidence of myocardial injury or myocarditis in athletes after COVID-19 infection, according to a research letter published in Circulation by Le Bonheur Children's Hospital and the University of Tennessee Health Science Center cardiologists. The screening and evaluation was conducted by the Le Bonheur Children's Heart Institute Sports Cardiology team, Benjamin S. Hendrickson, MD, Ranjit R. Philip, MD, and Ryan E. Stephens, NP-C, MBA, and Le Bonheur Director of Cardiac MRI Jason N. Johnson, MD, MHS. Researchers say this study confirms existing recommendations ...

The North American mockingbird is famous for its ability to imitate the song of other birds. But it doesn't just mimic its kindred species, it actually composes its own songs based on other birds' melodies. An interdisciplinary research team has now worked out how exactly the mockingbird constructs its imitations. The scientists determined that the birds follow similar musical rules as those found in human music, from Beethoven to Kendrick Lamar. The song of the mockingbird is so complex that to investigate it required a joint effort of experts from very different fields. Neuroscientist Tina Roeske of the Max Planck Institute for Empirical Aesthetics, field biologist Dave Gammon of Elon University, ...

COVID-19 continues to claim lives across the world and is infecting millions more. Although several vaccines have recently become available, making significant strides towards preventing COVID-19, what about the treatment of those who already have the infection? Vaccines aren't 100% effective, highlighting the need--now more than ever--for effective antiviral therapeutics. Moreover, some people can't receive vaccines due to health issues, and new variants of SARS-CoV-2, the virus that causes COVID-19, that can penetrate vaccine-conferred immunity, are being reported, indicating that we need to think beyond prevention. Given this need, a team of researchers based in Japan, the US, and the UK launched a project to develop effective therapeutics. ...

Stanford University computer science graduate student Mackenzie Leake has been quilting since age 10, but she never imagined the craft would be the focus of her doctoral dissertation. Included in that work is new prototype software that can facilitate pattern-making for a form of quilting called foundation paper piecing, which involves using a backing made of foundation paper to lay out and sew a quilted design. Developing a foundation paper piece quilt pattern - which looks similar to a paint-by-numbers outline - is often non-intuitive. There are few formal guidelines for patterning and those that ...

Humans regularly exert a powerful influence on the survival and persistence of species, yet social-science information is used only sporadically in conservation decisions. Researchers at Colorado State University and The Ohio State University have created an index depicting the mix of social values among people across all 50 states, providing data that can be useful for wildlife conservation policy and management. As a specific illustration, the research team found a supportive social context for gray wolf reintroduction in Colorado. Last fall, citizens ...

NEW YORK CITY, June 2, 2021 -- New research from Memorial Sloan Kettering Cancer Center (MSK) medical oncologist Dean Bajorin, MD, and colleagues found that patients who received nivolumab (Opdivo®) after bladder cancer surgery reduced their overall risk for high-grade bladder cancer recurrence. This research was published in the New England Journal of Medicine. In this phase III randomized study, Dr. Bajorin and a team of investigators evaluated 709 patients who were at high risk for recurrence of urothelial cancer after removal of their bladder, ureter, or kidney for high-grade cancer. To evaluate for benefit, patients were randomized to receive either nivolumab or a placebo every two weeks for one year. Patients and ...

A complex zone of folding and faulting that links two faults underneath downtown Salt Lake City could deform the ground during a large earthquake, according to a new study. The findings, published in the open-access journal The Seismic Record, suggest that earthquakes magnitude 5.0 and larger could cause ground displacement and liquefaction in Salt Lake City that increase the risk of earthquake-related building damage. As part of the Wasatch Fault Zone, the region has a complex seismic history, with at least 24 large earthquakes occurring in the urbanized parts of the zone over the past 7000 years. Along with previous excavation, borehole and other geophysical studies, the new research also supports the possibility of through-going ruptures ...

At the upcoming Conference of the Parties (COP26) in November, ample discussion is likely to focus on how the world is not on track to meet the Paris Agreement's goals of stopping warming at well below 2°C. According to a new University of California San Diego article published in Nature Energy, world diplomats will, however, find encouraging signs in emerging clean energy technology "niches"--countries, states or corporations--that are pioneering decarbonization. "In certain areas, adoption rates for solar and wind turbines, as well as electric vehicles are very high and increasing every year," write the authors of the opinion piece Ryan Hanna, assistant research scientist at UC San Diego's Center ...

TAMPA, Fla. -- There are several new treatment options available for patients with advanced melanoma. While these therapies have greatly improved the prognosis for patients, each person can respond to the treatments differently. Treatment of melanomas that have spread to the central nervous system is especially challenging. In a new article published in Clinical Cancer Research, Moffitt Cancer Center researchers reveal how different therapies impact the surrounding immune environment of metastatic melanoma tumors according to location and identify a rare population of immune cells that is associated with improved overall survival. Different types of cancer tend to spread to specific sites throughout the body. Common sites of melanoma ...

The pros make it look easy, but making a movie with a drone can be anything but. First, it takes skill to fly the often expensive pieces of equipment smoothly and without crashing. And once you've mastered flying, there are camera angles, panning speeds, trajectories and flight paths to plan. With all the sensors and processing power onboard a drone and embedded in its camera, there must be a better way to capture the perfect shot. "Sometimes you just want to tell the drone to make an exciting video," said Rogerio Bonatti, a Ph.D. candidate in Carnegie Mellon University's Robotics Institute. Bonatti was part ...

North Carolina State University researchers have developed a computer simulation tool to predict when and where pests and diseases will attack crops or forests, and also test when to apply pesticides or other management strategies to contain them. "It's like having a bunch of different Earths to experiment on to test how something will work before spending the time, money and effort to do it," said the study's lead author Chris Jones, research scholar at North Carolina State University's Center for Geospatial Analytics. In the journal Frontiers in Ecology and the Environment, researchers reported on their efforts to develop and test ...

KINGSTON, R.I. - June 3, 2021 - Scientists from the University of Rhode Island have taken the first steps toward understanding the function of microbes that live on and in Eastern oysters, which may have implications for oyster health and the management of oyster reefs and aquaculture facilities. "Marine invertebrates like oysters, corals and sponges have a very active microbiome that could potentially play a role in the function of the organism itself," said Ying Zhang, URI associate professor of cell and molecular biology. "We know very little about whether there are resident microbes in oysters, and if there are, what their function may be or how they may help or bring harm to the oyster." Zhang and doctoral student Zachary Pimentel extracted the DNA of microbes living in ...

ANN ARBOR, Mich. -- A different type of surge may be on the way more than a year into the pandemic - a baby surge. The COVID-19 shutdown initially seemed to hit pause on pregnancy and birth rates, new research from one major hospital system suggests, but that trend is quickly reversing. "Birth rates declined early on in the pandemic, but we expect a dramatic rebound soon," says lead author Molly Stout, M.D., MSci, maternal fetal medicine director at Michigan Medicine Von Voigtlander Women's Hospital. "We're already seeing signs of a summer baby surge." While infectious ...

UPTON, NY--A team of researchers led by chemists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory has studied an elusive property in cathode materials, called a valence gradient, to understand its effect on battery performance. The findings, published in Nature Communications, demonstrated that the valence gradient can serve as a new approach for stabilizing the structure of high-nickel-content cathodes against degradation and safety issues. High-nickel-content cathodes have captured the attention of scientists for their high capacity, a chemical property that could power electric vehicles over much longer distances than current batteries support. Unfortunately, the high nickel content also causes these cathode materials to degrade more quickly, creating cracks ...

The South Pole and the rest of East Antarctica is cold now and was even more frigid during the most recent ice age around 20,000 years ago -- but not quite as cold as previously believed. University of Washington glaciologists are co-authors on two papers that analyzed Antarctic ice cores to understand the continent's air temperatures during the most recent glacial period. The results help understand how the region behaves during a major climate transition. In one paper, an international team of researchers, including three at the UW, analyzed seven ice cores from across West and East Antarctica. The results published June 3 in Science show warmer ice age temperatures in the eastern part of the continent. The team ...

Scientists have gained the best view yet of the brightest explosions in the universe: A specialised observatory in Namibia has recorded the most energetic radiation and longest gamma-ray afterglow of a so-called gamma-ray burst (GRB) to date. The observations with the High Energy Stereoscopic System (H.E.S.S.) challenge the established idea of how gamma-rays are produced in these colossal stellar explosions which are the birth cries of black holes, as the international team reports in the journal Science. "Gamma-ray bursts are bright X-ray and gamma-ray flashes observed in the sky, emitted by distant extragalactic sources," explains DESY scientist Sylvia Zhu, one of the authors of the ...

The biggest shark attack in history did not involve humans. A new study by Earth scientists from Yale and the College of the Atlantic has turned up a massive die-off of sharks roughly 19 million years ago. It came at a period in history when there were more than 10 times more sharks patrolling the world's oceans than there are today. For now, researchers don't know the cause of the shark die-off. "We happened upon this extinction almost by accident," said Elizabeth Sibert, a Hutchinson postdoctoral associate in Yale's Department of Earth and Planetary Sciences and ...

Scientists have developed the first cells that can construct artificial polymers from building blocks that are not found in nature, by following instructions the researchers encoded in their genes. The study, led by scientists from the Medical Research Council (MRC) Laboratory of Molecular Biology, in Cambridge, UK, also found the synthetic genome made the bacteria entirely resistant to infection by viruses. The scientists say their research could lead to the development of new polymers - large molecules made of many repeating units, such as proteins, plastics, and many drugs including antibiotics - and make it easier to ...

Hydrogels are polymer materials made mostly from water. They can be used in a wide range of medical and other applications. However, previous incarnations of the materials suffered from repeated mechanical stress and would easily become deformed. A novel crystal that can reversibly form and deform, allows hydrogels to rapidly recover from mechanical stress. This opens up the use of such biocompatible materials in the field of artificial joints and ligaments. Many of us suffer the occasional sports injury or experience some kind of pain relating to joints and ligaments at some point in our lives. ...

Researchers from University of Toronto Engineering have developed an improved electrochemical system that raises the value of captured CO2 by converting more of it into valuable products than ever before. The International Energy Agency recently cited carbon capture and storage as one of the strategies that can help keep global emissions low enough to limit global warming to 1.5 C by 2050. But captured carbon currently has little economic value, reducing the incentive for companies to invest in this technology. A University of Toronto Engineering team led by Professor Ted Sargent is addressing this challenge by designing advanced electrolyzers that use electricity to convert captured CO2 into the petrochemical building blocks of common everyday materials, ...

An engineering researcher from the University of Sydney, in collaboration with a team at the University of Toronto, has developed an electrochemical system that coverts a greater amount of CO2 into valuable products. The International Energy Agency recently cited carbon capture and storage as a strategy that can help keep global emissions low enough to limit global warming to 1.5°C by 2050. However, captured carbon currently has little economic value, reducing the incentive for companies to invest in this technology. The team of researchers has addressed this challenge by designing advanced electrolysers - machines using electricity to convert captured CO2, plus water, into the building blocks of common everyday materials, ...

Astronomers have measured very-high-energy gamma rays coming from the aftermath of a gamma ray burst - an enormously energetic explosion of a star in another galaxy. The results shine light on these immensely powerful but little-understood cosmic events, and challenge standard models of how gamma ray bursts radiate light during their afterglow phases. As a dying massive star enters its final death throes, its core begins to collapse, and then explodes as a supernova. Some types of supernovae generate jets of particles moving at close to the speed of light; if the jet is pointed directly towards Earth it can be observed as a burst of gamma ray radiation that lasts several seconds. These gamma ray bursts are sometimes ...