ROCHESTER, Minn. -- Mayo Clinic researchers and colleagues at the University of Minnesota showed that COVID-19 exacerbates the damaging impact of senescent cells in the body. In preclinical studies, the senolytic drugs discovered at Mayo significantly reduced inflammation, illness, and mortality from COVID infection in older mice. The findings appear in the journal Science. Senescent cells (damaged or non-functioning cells that persist in the body) contribute to many aspects of aging and illness, including inflammation and multiple chronic diseases. Based on the "Amplifier/Rheostat Hypothesis" of senescent ...

A study of the associations between drinking alcohol and the chances of becoming pregnant suggests that women who want to conceive should avoid heavy drinking. In the second half of menstrual cycle even moderate drinking is linked to reduced chances of pregnancy. The study, published today (Wednesday) in Human Reproduction [1], one of the world's leading reproductive medicine journals, investigated alcohol intake and fecundability, which is defined as the probability of conceiving during a single menstrual cycle. It is the first study to look at this according to the difference phases of women's menstrual cycles. Researchers led by Dr Kira Taylor, associate professor of epidemiology and population ...

As new research on anaesthesia trainee morale is published, an impassioned plea is today being made in an open letter from the Association of Anaesthetists to the UK's four Health Secretaries: to urgently double the number of training posts for anaesthetists this summer and for subsequent years so that the UK can safely negotiate the current COVID-19 pandemic, any future pandemics, and deal with the huge backlog of surgical procedures that has built up during lockdown. The Association has sent a separate letter to go to each Health Secretary - Matt Hancock MP in the UK Department of Health, Humza Yousaf MSP in Scotland, Baroness Eluned Morgan MS in Wales, and Robin Swann MLA in ...

According to the National Alliance on Mental Illness and the World Health Organization, depression affects 16 million Americans and 322 million people worldwide. Emerging evidence suggests that the COVID-19 pandemic is further exacerbating the prevalence of depression in the general population. With this trajectory, it is evident that more effective strategies are needed for therapeutics that address this critical public health issue. In a recent study, publishing in the June 9, 2021 online edition of Nature Translational Psychiatry, researchers at University of California San Diego School of Medicine used a combination of modalities, such as measuring brain function, cognition and lifestyle factors, to generate individualized predictions of depression. The machine learning and personalized ...

In "Atchafalaya," John McPhee's essay in the 1989 book The Control of Nature, the author chronicles efforts by the U.S. Army Corps of Engineers to prevent the Atchafalaya River from changing the course of the Mississippi River where they diverge, due to the Atchafalaya's steeper gradient and more direct route to the gulf. McPhee's classic essay proved inspirational to John Shaw, an assistant professor of geosciences who called it "a foundational text." Indeed, his latest work adds to the story. In a recent paper published in the American Geophysical Union's journal, Water ...

Everyone is familiar with tiny gas bubbles gently rising up in sparkling water. But the bubbles that were created by intense focused lasers in this experiment were ten times smaller and contained water vapour at a pressure around a hundred thousand times higher. Under these conditions, the bubble expands at supersonic speed and pushes a shockwave, consisting of a spherical shell of highly compressed water, ahead of itself. Now the research team led by the University of Göttingen, together with the Deutsches Elektronen-Synchroton (DESY) and the European X-Ray Free-Electron Laser (European XFEL), has created such an event and then, with an innovative ...

The analysis of very old plant fossils discovered in South Africa and dating from the Lower Devonian period documents the transition from barren continents to the green planet we know today. Cyrille Prestianni, a palaeobotanist at the EDDy Lab at the University of Liège (Belgium), participated in this study, the results of which have just been published in the journal Scientific Reports. The greening of continents - or terrestrialisation - is undoubtedly one of the most important processes that our planet has undergone. For most of the Earth's history, the continents were devoid of macroscopic ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--QurAlis Corporation, a biotech company developing breakthrough precision medicines for ALS and other genetically validated neurodegenerative diseases, today announced the publication of an article in Cell Reports titled Human Amyotrophic Lateral Sclerosis Excitability Phenotype Screen: Target Discovery and Validation by QurAlis founders Kasper Roet, Ph.D., Clifford Woolf, M.D., Ph.D., and Kevin Eggan, Ph.D., who pioneered a high-content, live-cell imaging screen using ALS patient-derived motor neurons in combination with a compound library generated by Pfizer to identify drug targets to treat hyperexcitability induced neurodegeneration ...

A research team from the University of Massachusetts Amherst has created an electronic microsystem that can intelligently respond to information inputs without any external energy input, much like a self-autonomous living organism. The microsystem is constructed from a novel type of electronics that can process ultralow electronic signals and incorporates a device that can generate electricity "out of thin air" from the ambient environment. The groundbreaking research was published June 7 in the journal Nature Communications. Jun Yao, an assistant professor in the electrical and computer engineering (ECE) and an adjunct professor in biomedical engineering, ...

DURHAM, N.C. - Using drones and artificial intelligence to monitor large colonies of seabirds can be as effective as traditional on-the-ground methods, while reducing costs, labor and the risk of human error, a new study finds. Scientists at Duke University and the Wildlife Conservation Society (WCS) used a deep-learning algorithm--a form of artificial intelligence--to analyze more than 10,000 drone images of mixed colonies of seabirds in the Falkland Islands off Argentina's coast. The Falklands, also known as the Malvinas, are home to the world's largest colonies of black-browed albatrosses (Thalassarche melanophris) and second-largest ...

Researchers from the University of Liège (Belgium) have recently developed a new artificial neuron inspired by the different modes of operation of human neurons. Called a Bistable Recurrent Cell (BRC), this process has enabled recurrent networks to learn temporal relationships of more than a thousand discrete time units where classical methods failed after only a hundred time units. These important results are published in the journal PLOS One. The enormous interest in artificial intelligence (AI) in recent years has led to the development of extremely powerful machine learning techniques. For example, time series - any series of data where a time component is ...

The speed of water flow is a limiting factor in many membrane-based industrial processes, including desalination, molecular separation and osmotic power generation. Researchers at The University of Manchester's National Graphene Institute (NGI) have published a study in Nature Communications showing a dramatic decrease in friction when water is passed through nanoscale capillaries made of graphene, whereas those with hexagonal boron nitride (hBN) - which has a similar surface topography and crystal structure as graphene - display high friction. The team also demonstrated that water velocity could be selectively controlled by covering the high friction hBN channels with graphene, opening ...

DURHAM, N.H.--Why did the deer cross the road? According to research from the University of New Hampshire to keep going and going and going. Researchers have discovered the longest distance ever recorded by an adult male white-tailed deer--300 kilometers, or close to 200 miles, in just over three weeks. The finding has important implications for population management and the transmission of disease, especially chronic wasting disease, a fatal neurological disease. "Deer are one of the most abundant, well-known and intensely managed species of wildlife in the United States," said Remington Moll, assistant ...

The bad odors produced by the Waste Water Treatment Plants, known as WWTPs, have become a growing concern in the cities and towns that host these facilities and are considered by citizens to be the main cause of the perception of pollution, along with the dust and noise. Now, and thanks to a collaboration between the Institute for Bioengineering of Catalonia (IBEC) and the company DAM, a new way is being opened to detect and treat these odors. According to the researchers, "the results obtained in the SNIFFDRONE project (Odor monitoring by drones for environmental purposes) are very positive and represent a significant advance ...

- Most high-value chemicals are currently produced using fossil fuels - industrial chemistry's use of petroleum accounts for 14% of all greenhouse gas emissions. - An exciting alternative is to engineer bacteria as "cell-factories" with a genetic switch that reroutes their chemistry to produce high-value chemicals, such as biofuels, polymers and pharmaceuticals. - The use of expensive chemicals to switch them on severely limits their commercial potential, researchers have used mathematical models to develop a new genetic switch that can use a cheap natural ...

JUNE 8, 2021, NEW YORK - A study conducted by researchers at the Ludwig Center at Harvard has demonstrated how a drug screening method known as dynamic BH3 profiling can be used to quickly identify potentially effective combinations of existing drugs for personalized cancer therapy. "We know that cancer cells and healthy cells have different metabolisms," said Ludwig Harvard investigator Anthony Letai who, with former postdoctoral researcher Veerle Daniels, led the study reported in the current issue of Science Signaling. "Using BH3 profiling, we found a specific metabolic dependency in triple ...

Published monthly, the journal CHEST® features peer-reviewed, cutting-edge original research in chest medicine: Pulmonary, critical care, sleep medicine and related disciplines. Journal topics include asthma, chest infections, COPD, critical care, diffuse lung disease, education and clinical practice, pulmonology and cardiology, sleep and thoracic oncology. The June issue of CHEST includes 95 articles, clinically relevant research, reviews, case series, commentary and more. Each month, the journal also offers END ...

A new Alzheimer's disease drug will hit the market soon, the first in nearly two decades. But some experts say the evidence for it isn't terribly strong and worry that it may cost a lot. Still, the announcement of its approval by the U.S. Food and Drug Administration made headlines nationwide. The attention reflects the toll dementia takes on patients, families and society, and the lack of good treatment options. Meanwhile, millions of adults could lower the chance that they'll ever need a drug like that. To do so, they will need to work with their primary care providers and use the power ...

There is a growing body of evidence supporting airborne transmission of SARS-CoV-2, the virus that causes COVID-19. Despite updates from the World Health Organization, the U.S. Centers for Disease Control and Prevention (CDC) and the Public Health Agency of Canada that the virus can be transmitted by short- and long-range aerosols, Canada's public health guidance has not been adequately updated to address this mode of transmission, argue authors of a commentary published in CMAJ (Canadian Medical Association Journal) Canadian public health guidance and practices should be updated to include more emphasis on the following airborne mitigation measures: ventilation, filtration and better masks. "Ventilation is a key element in the fight against airborne transmission. We need clear guidelines ...

Researchers at the University of Illinois Chicago have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair through treatment with microgel-coated mesenchymal stromal cells. Pulmonary fibrosis is a chronic disease caused by environmental toxins, medications or medical conditions like pneumonia and rheumatoid arthritis. It is characterized by the formation of scar tissue due to damage or an unchecked immune response, and it can cause mild to severe difficulty breathing and oxygen deprivation. Fibrosis ...

 Most cities in São Paulo state (Brazil) have low potential capacity to adapt to climate change in terms of the ability to formulate public policy that facilitates the revamping of their housing and transportation systems, for example, to account for the impact of climate change. This is the main conclusion of a study conducted by researchers at the University of São Paulo (USP) in partnership with colleagues at the University of Campinas (UNICAMP) and the Federal University of Itajubá (UNIFEI) in Brazil, and the University of Michigan in the United States.  Researchers linked to a project supported by FAPESP participated in the study. The results ...

If your idea of conspiracy theories entails aliens, UFOs, governmental cover-ups at Roswell Air Force base, and the melody of The X-Files--you're not alone. That was, indeed, the classic notion, says END ...

The spectacularly colorful aurora borealis -- or northern lights -- that fills the sky in high-latitude regions has fascinated people for thousands of years. Now, a team of scientists has resolved one of the final mysteries surrounding its origin. Scientists know that electrons and other energized particles that emanate from the sun as part of the "solar wind" speed down Earth's magnetic field lines and into the upper atmosphere, where they collide with oxygen and nitrogen molecules, kicking them into an excited state. These molecules then relax by emitting light, producing the beautiful green and red hues of the aurora. What ...

MELVILLE, N.Y., June 8, 2021 -- Many voice actors use a variety of speech vocalizations and patterns to create unique and memorable characters. How they create those amazing voices could help speech pathologists better understand the muscles involved for creating words and sounds. During the 180th Meeting of the Acoustical Society of America, which will be held virtually June 8-10, Colette Feehan, from Indiana University, will talk about how voice actor performances can lead to better understanding about the speech muscles under our control. The session, "Articulatory and acoustic phonetics of voice actors," will take place Tuesday, June 8, at 2:40 p.m. Eastern U.S. Just like any professional of any field that requires some sort of physical skill, voice actors certainly put in time and ...

New research published in the journal Psychological Science reveals a pervasive but unfounded stereotype: that women (but not men) who engage in casual sex have low self-esteem. This finding was consistent across six separate experiments with nearly 1,500 total participants. "We were surprised that this stereotype was so widely held," said Jaimie Arona Krems, an assistant professor of psychology at Oklahoma State University and first author on the paper. "This stereotype was held by both women and men, liberals and conservatives, and across the spectrum in terms of people's levels of religiosity and sexism." But across the studies, Krems also observed that the stereotype was unfounded: There was virtually no relationship ...