Oak Brook, IL – Volume 33 of SLAS Discovery features one review, three original research articles and one entry in the upcoming Special Issue on Biomolecular Condensates as Targets for Drug Discovery. Reviews Antimicrobial resistance: Linking molecular mechanisms to public health impact This review highlights how β-lactamases and efflux pumps, combined with mobile genetic elements, drive the rapid spread of multidrug-resistant (MDR) and extremely drug-resistant (XDR) pathogens, posing a serious threat to global health and agriculture. Original Research Advancing the development of TRIP13 inhibitors: A high-throughput screening ...

Embargoed for release: Thursday, June 26, 2025, 6:00 AM ET Boston, MA—In the midst of a multi-state measles outbreak, a new poll by Harvard T.H. Chan School of Public Health and the de Beaumont Foundation finds that most U.S. adults (79%) say parents should be required to have children vaccinated against preventable diseases like measles, mumps, and rubella to attend school. This includes a majority of adults across party lines—90% among Democrats and 68% among Republicans – as well as 66% of those who support the “Make America Great Again” (MAGA) movement. It also includes 72% of all parents. ...

Artificial intelligence is considered to be computationally and energy-intensive – a challenge for the Internet of Things (IoT), where small, embedded sensors have to make do with limited computing power, little memory and small batteries. In the E-MINDS project, a research team from the COMET K1 centre Pro2Future, Graz University of Technology (TU Graz) and the University of St. Gallen has found ways to run AI locally and efficiently on the smallest devices – without having to rely on external computing power. For example, it has been possible to run specialised AI models on an ultra-wideband localisation device ...

Patients with atrial fibrillation who have experienced a stroke would benefit greatly from earlier treatment than is currently recommended in current UK guidelines, finds a new study led by UCL (University College London) researchers. The results of the CATALYST study, published in The Lancet, included data from four randomised trials with a total of 5,441 patients across the UK, Switzerland, Sweden and the United States, who had all experienced a recent stroke (between 2017-2024) due to a blocked artery and atrial ...

A new gene therapy delivery device could let hospital pharmacies make personalized nanomedicines to order. This democratized approach to precision medicine, as published in Frontiers in Science, could revolutionize how hospitals treat rare diseases, even in low-resource settings.  Rare diseases affect millions worldwide, yet the one-size-fits-all model of drug development leaves patients with few treatment options. Now a European research project called NANOSPRESSO aims to tip the balance in patients’ favor by boosting access to low-cost bespoke gene and RNA therapies.  The prototype NANOSPRESSO device combines two proven technologies—nucleic acid ...

LMU researchers have demonstrated a possible mechanism for metabolic processes without cell membranes in water-filled pores. Looking at life today, it is difficult to imagine how complex biological processes and structures could have developed from simple building blocks. All cellular processes and reactions appear to be closely interdependent and necessarily occur within a cell membrane. There is no known organism that deviates from this pattern. But how did it come about? How does a cell membrane form without metabolism? Or conversely, how does metabolism arise without a cell ...

An interdisciplinary team of experts in green chemistry, engineering and physics at Flinders University in Australia has developed a safer and more sustainable approach to extract and recover gold from ore and electronic waste. Explained in the leading journal Nature Sustainability, the gold-extraction technique promises to reduce levels of toxic waste from mining and shows that high purity gold can be recovered from recycling valuable components in printed circuit boards in discarded computers. The project team, led by Matthew Flinders Professor Justin Chalker, applied this integrated method for high-yield gold extraction ...

Optical biosensors use light waves as a probe to detect molecules, and are essential for precise medical diagnostics, personalized medicine, and environmental monitoring. Their performance is dramatically enhanced if they can focus light waves down to the nanometer scale – small enough to detect proteins or amino acids, for example – using nanophotonic structures that ‘squeeze’ light at the surface of a tiny chip. But the generation and detection of light for these nanophotonic biosensors requires ...

Scientists at the University of Oxford have unveiled a pioneering method for capturing the full structure of ultra-intense laser pulses in a single measurement. The breakthrough, published in close collaboration with Ludwig-Maximilian University of Munich and the Max Planck Institute for Quantum Optics, could revolutionise our ability to control light-matter interactions. This would have transformative applications in many areas, including research into new forms of physics and realising the extreme ...

Biological drugs have improved the lives of many people with severe asthma. However, a new study from Karolinska Institutet in Sweden shows that some immune cells with high inflammatory potential are not completely eradicated after treatment. Biological drugs (biologics) have become an important tool in the treatment of severe asthma. “They help most patients to keep their symptoms under control, but exactly how these drugs affect the immune system has so far remained unknown,” says Valentyna Yasinska, consultant ...

A new international study drawing on 73 million nights of data reveals that our sleep patterns are seriously shaped by the day of the week, the season, and where we live. Working with sleep data from more than 116,000 adults across the globe, Flinders University sleep experts used insights from an FDA-cleared under-mattress device to track sleep duration and timing over 3.5 years. Lead author, Dr Hannah Scott from FHMRI Sleep Health says the findings give a detailed look at how geography, seasons, and our day-to-day schedules quietly disrupt the way we sleep. “Sleep patterns aren’t just about habits – they’re deeply connected to the environment around ...

Niigata, Japan— In a remarkable advancement for soil science, researchers from Japan have developed a novel method for estimating microbial biomass using water-extractable organic matter (WEOM) from air-dried soils. This innovative approach not only simplifies the estimation process but also eliminates the need for toxic solvents typically used in traditional methods, such as chloroform fumigation extraction. A research was conducted by a dedicated team from Niigata University, Kyushu University, Japan Atomic Energy Agency, and Anhui Academy of Agricultural Sciences researchers. The study analyzed 50 soil samples from ten diverse profiles across various regions in Japan, including six ...

New commentary published in the Journal of the Royal Society of Medicine warns that current risk-based regulatory approaches to Artificial Intelligence (AI) in healthcare fall short in protecting patients, potentially leading to over- and undertreatment as well as discrimination against patient groups. The authors found that while AI and machine learning systems can enhance clinical accuracy, concerns remain over their inherent inaccuracy, opacity, and potential for bias which are not adequately addressed by the current regulatory ...

Hot tubs and saunas can both soothe aching muscles and provide welcome warmth, but hot tubs might offer greater health benefits. That’s the takeaway from a new study done by researchers in the Bowerman Sports Science Center at the University of Oregon, which compared the physiological effects of soaking in a hot tub to sitting in a traditional dry heat sauna or a more modern far-infrared sauna. By raising core body temperatures, soaking in hot water can help lower blood pressure, stimulate the immune system and, over time, improve the body’s ...

Combining neck surgery with intensive speech therapy is associated with greater improvements in a person's ability to communicate after a stroke than intensive speech therapy alone, finds a clinical trial published by The BMJ today. The results show improvements immediately after surgery without any long-term severe adverse events or lasting discomfort, as well as reported improvements in quality of life and post-stoke depression over six months. Stroke is the most common cause of aphasia (problems with communication, including speaking, understanding others, reading and writing). More than 60% of patients are ...

Introducing performance related pay for UK general practices initially improved quality of care, but did not seem to provide lasting improvements beyond that expected by previous trends, finds a study published by The BMJ today. And initial gains in quality seemed to reverse when financial incentives were withdrawn, say the researchers. The UK Quality and Outcomes Framework (QOF) pay-for-performance programme was introduced across the NHS in 2004 to reward general practices for providing high quality care across a range of disease indicators ...

Focusing solely on achieving weight loss for people with a high body mass index (BMI) may do more harm than good, argue experts in The BMJ today. Dr Juan Franco and colleagues say, on average, people with high weight will not be able to sustain a clinically relevant weight loss with lifestyle interventions, while the potential harms of weight loss interventions, including the reinforcement of weight stigma, are still unclear. They stress that a healthy lifestyle has important benefits, but that weight alone might not give an adequate picture of someone’s health, and say doctors should provide high quality, evidence based care reflecting individual preferences ...

Serious quality defects were found in a significant number of cancer medications from sub-Saharan Africa, according to new research from the University of Notre Dame. For the study published in The Lancet Global Health, researchers collected different cancer medications from Cameroon, Ethiopia, Kenya and Malawi and evaluated whether each drug met regulatory standards. Researchers considered a variety of factors, including appearance, packaging, labeling and, most importantly, the assay value. The assay value is the quantity of active pharmaceutical ingredient (API) found in each drug. To meet safety standards, most products should be within a ...

More effective platforms for drug and medical device development and better cross sector engagement are urgently required to prevent the ‘unacceptably high’ newborn death rate, according to a global report. The Lancet Child & Adolescent Health Commission on the future of neonatology report found this field of medicine faced significant challenges across leadership, collaboration, regulation and funding, which were hindering better health outcomes for newborns. The Lancet Commission was created to consider these challenges and design a roadmap to accelerate research and development ...

The Multilink Consortium, a NIHR-funded partnership between the Liverpool School of Tropical Medicine, the Malawi-Liverpool-Wellcome Programme, Muhimbili University of Health and Allied Sciences and Kilimanjaro Christian Medical University College, has published the first-of-its-kind research in sub-Saharan Africa to examine the scale and impact of ‘multimorbidity’ in patients admitted acutely to hospital. Multimorbidity refers to the presence of two or more chronic diseases. Researchers discovered that of 1007 ...

A quarter of people seeking care for symptoms of chronic respiratory diseases in Kenya may incur ‘catastrophic’ health costs, new research published in The Lancet Global Health has found. A study of almost 300 adults accessing treatment for respiratory symptoms across five health facilities in Meru County, Kenya, found that over a quarter (26%) had ‘catastrophic health expenditure’ (CHE, defined as over 10% of their household’s monthly outgoings) relating to their illness and seeking care. The severe economic burden included ...

JUNE 2025 TIP SHEET Alcohol & Cancer Sobering Truth: Alcohol-Fueled Cancer Deaths Rising Across U.S. (Video Available) Sylvester researchers have become the first to look at trends in alcohol-linked cancer mortality across the U.S. Their findings, presented last month at ASCO 2025, found that alcohol-related cancer deaths nationwide nearly doubled between 1990 and 2021. Moreover, the highest burden fell on men over 55, whose alcohol-linked cancer mortality rose by more than 1% a year between 2007 and 2021. “That’s a big and concerning rise,” said Chinmay Jani, M.D., Sylvester hematology and oncology ...

The Center for Space Exploration Research at the University of California, Davis, has partnered with Proteus Space to launch a US government-sponsored satellite into space with a custom AI-enabled payload in a brand-new, first-ever rapid design-to-deployment small satellite. The team will launch the satellite and payload in October 2025 from Vanderberg, CA. From the time the project was fully approved, the design and launch will occur within an unprecedented 13 months. (The normal pace for small satellites is often measured in years.) The UC Davis-designed ...

SYDNEY, Australia - A new study involving 121 former elite rowers from Australia has revealed one in five develops atrial fibrillation (AFib). This common heart rhythm condition can lead to stroke and heart failure in some individuals, but the researchers identified new genetic and clinical tools that enable early preventive strategies.   Researchers also found the retired rowers, who include former Olympians, are almost seven times more likely to develop AFib than the general population – despite having far fewer AFib risk factors like high ...

A common medication already used for autoimmune diseases such as rheumatoid arthritis is effective for patients with giant cell arteritis, according to findings from a team at the Perelman School of Medicine at the University of Pennsylvania published in the New England Journal of Medicine. Causing the body’s immune system to attack blood vessels in the head, neck, and other areas, giant cell arteritis often leads to headaches, vision loss, and even aortic aneurysms. But nearly half of patients taking upadacitinib in a new Phase 3 clinical trial achieved sustained remission— while reducing their dependence on glucocorticoids (typically called “steroids”), ...