Subscribe to UCSF News A UCSF analysis has found that the newer generation of much more effective diabetes medications are reaching only a fraction of the patients who are recommended to take them based on new guidelines.   Type 2 diabetes (T2D), a condition in which the body can’t use insulin to clear sugar from the bloodstream, affects 1 in 10 Americans. It comes with grave health risks, including cardiovascular and kidney disease.   The study assessed medications that patients received within a year of T2D diagnosis. During the period under review — ...

Scientists at the National Institutes of Health (NIH) have found that two common types of hormone therapy may alter breast cancer risk in women before age 55. Researchers discovered that women treated with unopposed estrogen hormone therapy (E-HT) were less likely to develop the disease than those who did not use hormone therapy. They also found that women treated with estrogen plus progestin hormone therapy (EP-HT) were more likely to develop breast cancer than women who did not use hormone therapy. Together, these results could help to guide clinical recommendations for hormone therapy use among younger women.   The two hormone therapies analyzed in the study are ...

For people recovering from substance use disorders, quitting smoking remains one of the most difficult—but most crucial—steps toward long-term health. New research from Flinders University reveals that providing consistent support and access to a range of nicotine replacement therapies (NRTs) can help people in recovery take that vital step. A first-of-its-kind trial to compare vapes with combination nicotine replacement therapy (cNRT) - patches, gum, and lozenges - in people leaving smoke-free ...

(Boston)—While severe maternal hypothyroidism (low thyroid hormone levels) in pregnancy is known to increase risks of adverse pregnancy outcomes, it is unclear whether mild (subclinical) hypothyroidism causes similarly adverse pregnancy complications. It is also not clear whether maternal hypothyroidism in pregnancy increases risks of gestational diabetes.   A new study in the journal Lancet Diabetes and Endocrinology (Osinga et al “Association of gestational thyroid function and thyroid ...

A new study published in The Lancet has raised urgent concerns about the global health consequences of recent cuts to U.S. foreign aid. The study, coordinated by researchers from the Barcelona Institute for Global Health (ISGlobal), together with the Institute of Collective Health of the Federal University of Bahia (ISC-UFBA), the University of California Los Angeles (UCLA), and the Manhiça Centre for Health Research (CISM), among others, estimates that 91 million deaths were prevented between 2001 and 2021 in low- and middle-income countries (LMICs) thanks to programs supported by the United States ...

(Tuesday 1 July 2025, London, United Kingdom) New research, presented at the ESOT Congress 2025, reveals persistent inequalities in children’s access to life-saving kidney transplants across the UK. The study highlights how ethnicity, socioeconomic status, and gender significantly influence a child's likelihood of receiving a transplant.1 Researchers from the University of Bristol analysed national data from the UK Renal Registry and NHS Blood & Transplant, focusing on patients under 18 years who started kidney replacement therapy between 1996 and 2020.2 Their findings reveal concerning disparities ...

(Paris, France, Tuesday, 1 July 2025) Novel research presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has found that embryos from women with polycystic ovary syndrome (PCOS) carry a distinctive ‘epigenetic memory’ that could explain why the condition often runs in families.[1] PCOS is a common hormonal disorder affecting an estimated 1 in 10 women of reproductive age worldwide.[2] It is characterised by irregular menstrual cycles, excess levels of androgens (male hormones) and the presence of multiple cysts on the ovaries.[3] While it is recognised as a leading ...

(Paris, France, Tuesday, 1 July 2025) Fewer in vitro fertilisation (IVF) and intrauterine insemination (IUI) cycles were reported in Europe in 20202, but clinical pregnancy rates remained stable, according to data presented at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) [1].   Preliminary data from the ESHRE European IVF Monitoring (EIM) Consortium [2] reveals a steady and progressive rise in the use of Assisted Reproductive Technology (ART). In 2022, a total of 960,347 ART treatment cycles were reported by 1,371 clinics across 39 European countries, a 15.6% reduction from the 1,137,177 cycles reported in 2021 [3]. Of ...

DURHAM, N.C. — In chimpanzee communities, strong social ties can be a matter of life and death not just for the adults who form them, but for their kids, too. A new federally-funded study of wild eastern chimpanzees (Pan troglodytes schweinfurthii) from Gombe National Park shows that female chimpanzees who were more socially integrated with other females in the year before giving birth were more likely to raise surviving offspring. The findings, published online on June 18 in iScience, show that these survival benefits hold for females ...

In recent years, scientists have been exploring the use of renewable polymers derived from natural sources. Materials such as vegetable cellulose, bacterial cellulose, chitosan, and starch offer attractive properties for biomedical applications, especially in controlled drug release systems and regenerative medicine. However, despite their potential, many of these polymers still face significant challenges in reaching commercialization. The study conducted by Lopes et al. points out that despite advances, only a few natural polymers have become available on the market. The research emphasizes the importance ...

Embargoed for release until 5:00 p.m. ET on Monday 30 June 2025    Follow @Annalsofim on X, Facebook, Instagram, threads, and Linkedin         Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, ...

Study from Mass General Brigham and Karolinska Institutet researchers suggests that patients with the condition do not need to stop taking important medications  Microscopic colitis (MC) is a chronic inflammatory bowel disease that severely reduces quality of life. MC is responsible for over 30% of all chronic diarrhea cases in people over 65 years of age, and its prevalence is rising worldwide. Although little is known about what causes MC, previous studies have suggested that a range of common medications could trigger ...

Abu Dhabi, UAE, June 30, 2025: A team of researchers at NYU Abu Dhabi has uncovered a key mechanism that helps shape how our brains are wired, and what can happen when that process is disrupted. In a new study published in Cell Reports, the RNA-MIND Lab at NYU Abu Dhabi, led by Professor of Biology Dan Ohtan Wang, with Research Associate Belal Shohayeb, reveals how a small molecular mark on messenger RNA, called m6A methylation, regulates the production of essential proteins inside growing neurons. This process plays a critical role in the development of axons, the long extensions that neurons use to connect and communicate with each other. The study ...

June 30, 2025 -- Inflammation, long considered a hallmark of aging, may not be a universal human experience, according to a new study from Columbia University Mailman School of Public Health. The research suggests that "inflammaging"—chronic, low-grade inflammation associated with aging—appears to be a byproduct of industrialized lifestyles and varies significantly across global populations. The findings are published in Nature Aging. Researchers analyzed data from four populations: two industrialized ...

With a new $11 million federal grant, the University of Oregon will create a national center for children’s mental health, putting the university at the forefront of national prevention efforts to improve the mental health and well-being of adolescents. The center will be housed in the UO’s Prevention Science Institute. It will be funded over the next five years by the National Institute of Mental Health. “This center will build on the strong work the UO’s Prevention Science Institute has done over decades in the area of school-based mental health prevention, bringing ...

Caroline King didn’t expect to get involved in research when she arrived at The University of Texas at Arlington. But after joining the Honors College and taking a job with the Center for Rural Health and Nursing, she found herself diving into a literature review on midwifery in rural Texas. Two and a half years later, King is a published author in the Online Journal of Rural Nursing and Health Care. While publication is a milestone for any academic, it’s a rare achievement for an undergraduate. “It’s ...

TikTok is one of the fastest-growing and most popular social media platforms in the world – especially among college-age individuals. In the United States alone, there are over 136 million TikTok users aged 18 and older, with approximately 45 million falling within the college-age demographic. And college students aren’t just using the platform to watch viral videos. They’re also turning to it as a source of information, with around 40% of Americans using TikTok as a search engine. While the ...

PITTSBURGH, June 30, 2025—For the first time, the extreme variability in dengue fever has been linked to a biological mechanism, potentially opening doors to new treatments and vaccines for the most common mosquito-borne disease worldwide. The study was published today in Proceedings of the National Academy of Sciences (PNAS) by researchers from the University of Pittsburgh, UPMC and Instituto Aggeu Magalhães in Brazil.   Cases of dengue fever, commonly known as “breakbone fever” for the excruciating joint pain that is the hallmark of the disease, have ...

Using whole genome sequencing and cutting-edge analyses researchers at Stockholm University have uncovered the surprising evolutionary history of the Norwegian lemming (Lemmus lemmus), revealing it to be one of the most recently evolved mammal species. The results published in Proceedings of the National Academy of Sciences (PNAS), reveal that the Norwegian lemming is a distinct species that split from its closest relative, the Western Siberian lemming, approximately 35,000 years ago — just before the peak of the last Ice Age. “The ...

Going to bed earlier than usual may help to optimise physical activity the following day, Monash University-led research has found. Published in Proceedings of the National Academy of Sciences (PNAS), the study examined whether sleep duration and sleep timing were associated with the duration of moderate-to-vigorous and overall physical activity the following day. In the primary study, almost 20,000 participants wore a validated biometric device (WHOOP) for one year, resulting in almost six million nights of data. Objective sleep and physical activity metrics were derived from the wrist-worn device. The study examined how both typical ...

27 June 2025 UNDER EMBARGO UNTIL 20:00 UK TIME (15:00 U.S. EASTERN TIME) ON MONDAY JUNE 30, 2025 Groundbreaking analysis provides day-by-day insight into prehistoric plankton’s capacity for change Scientists at the University of Southampton have developed a new way of analysing fossils allowing them to see how creatures from millions of years ago were shaped by their environment on a day-to-day basis for the first time. The research published today [30 June] in Proceedings of the National Academy ...

UNDER EMBARGO UNTIL 20:00 UK TIME (15:00 U.S. EASTERN TIME) ON MONDAY JUNE 30, 2025 Southern Ocean saltier, hotter and losing ice fast as decades-long trend unexpectedly reverses Researchers have discovered a dramatic and unexpected shift in the Southern Ocean, with surface water salinity rising and sea ice in steep decline. Since 2015, Antarctica has lost sea ice equal to the size of Greenland — the largest environmental shift seen anywhere on Earth in the last decades. The Southern Ocean is also getting saltier, and this unexpected change is making the problem worse. For decades, the ocean’s surface freshened (becoming less salty), helping sea ice grow. Now, scientists ...

When we think of fossils, giant prehistoric creatures like dinosaurs may come to mind. But the fossil record also holds the remains of smaller organisms, such as fish and corals, that tell us about our oceans’ past. Scientists at the Smithsonian Tropical Research Institute (STRI) recently studied exposed fossilized coral reefs from Panama's Bocas del Toro Province and the Dominican Republic, comparing them with nearby modern reefs. These exceptionally well-preserved reefs date back 7,000 ...

  In the study, researchers from Canada, New Zealand and Mexico reported on 34 interactions spanning two decades in which orcas in the wild attempted to offer food to humans. The incidents took place in oceans around the world, from California to New Zealand to Norway to Patagonia. “Orcas often share food with each other – it’s a prosocial activity and a way that they build relationships with each other,” said study lead author Jared Towers, of Bay Cetology in British Columbia, Canada. “That they also share with humans may show their interest ...

A recently published article in the journal BioScience reveals that endangered longleaf pine ecosystems—among North America's most biodiverse habitats—face mounting threats from intensifying hurricane regimes driven by climate change. An interdisciplinary team of authors headed by Nicole Zampieri (Tall Timbers and The Jones Center at Ichauway) describe the urgent situation: The North American Coastal Plain was once characterized by extensive longleaf pine savannas covering approximately 36 million hectares. Today, these ecosystems "now occupy ...