inGenious Targeting Laboratory Launches a New FLP Embryonic Stem Cell Line for Faster Mouse Models Generation

RONKONKOMA, NY, April 10, 2014 (Press-News.org) Company officials describe the new FLP ES cell line as one in which the FLP transgene is silent in the ES cells but is expressed in the resulting mice. This allows iTL to produce Neo negative mice in the first generation while maintaining the integrity of the ES cells. Hence, FLP matings are no longer needed and germline transmission remains robust. This saves iTL clients 3 months in the mouse production process, allowing researchers to begin their studies faster using these genetically modified mice.

Over the last couple of years, the field of model generation has seen an unprecedented increase in its ability to produce genetically modified mice. Researchers are now looking for more sophisticated models utilizing advanced gene targeting approaches. In an effort to obtain these models, academic institutions and the biopharma industry are seeking out companies as a source of breakthrough technologies to produce these models.

"There are immediate benefits to this new cell line," Paul Sheiffele, President of iTL, points out. "Our business model aligns us with the implementation of new technologies. Saving significant time and money on the generation of mouse models is essential in today's funding environment. By using a synergistic combination of technologies with proven success, iTL continues to set the tone as an innovator in model generation."

Established in 1998, inGenious Targeting Laboratory (iTL) exclusively creates mice whose genetic make-up is tailored to the client's research needs. Clients retain all intellectual property rights to their projects. A full range of project capabilities are available including; conventional and conditional knockouts, knockin models (humanized, inducible, reporter gene/cassette insertion, point mutations), as well as novel approaches for customized mouse models. Projects are initiated immediately upon completion of design parameters and progress to completion on-site in the USA, under the supervision of a dedicated scientific Project Manager. iTL is located in Ronkonkoma, New York.