“This study uncovered important roles for USP1 in Ewing sarcoma.” BUFFALO, NY- February 14, 2024 – A new research paper was published in Genes & Cancer on February 5, 2024, entitled, “Roles of USP1 in Ewing sarcoma.” Ewing sarcoma is a cancer of bone and soft tissue in children and young adults that is driven by the EWS-ETS fusion transcription factor, most commonly EWS-FLI1. Researchers Panneerselvam Jayabal, Xiuye Ma and Yuzuru Shiio from The University of Texas Health Science Center previously reported that Ewing sarcoma harbors two populations of cells, ...

Maryam Shanechi, Dean’s Professor of Electrical and Computer Engineering and founding director of the USC Center for Neurotechnology, and her team have developed a new machine learning method that reveals surprisingly consistent intrinsic brain patterns across different subjects by disentangling these patterns from the effect of visual inputs.The work has been published in the Proceedings of the National Academy of Sciences (PNAS). When performing various everyday movement behaviors, such as reaching for a book, our brain has to take in information, often in the form of visual input — for example, seeing where the book is. Our brain then has to process ...

Every year, around 50,000 people in the United States experience cardiogenic shock — a life-threatening condition, usually caused by a severe heart attack, in which the heart can’t pump enough blood for the body’s needs. Many of these patients end up receiving help from a mechanical pump that can temporarily help the heart pump blood until it recovers enough to function on its own. However, in nearly half of these patients, the extra help leads to an imbalance between the left and right ventricles, which can pose danger to the patient. In a ...

Chronic exposure of human skin to ultraviolet light causes premature aging, or photoaging. As the skin undergoes photoaging, type I collagen bundles, which are found in the dermis beneath the top layer of the skin and provide strength and support to skin, become fragmented. This leads to wrinkles, fragility and loss of support and elasticity.   “The best way to prevent damage to type I collagen by sunlight is to wear sunscreen consistently, daily if possible and particularly when spending time outdoors,” said Frank Wang, MD,  the William B. Taylor Endowed Professor of Clinical Dermatology at U-M Medical School.  Experts ...

LOS ANGELES — City of Hope®, one of the largest cancer research and treatment organizations in the United States, treated the oldest person to be cured of a blood cancer and then achieve remission for HIV after receiving a blood stem cell transplant from a donor with a rare genetic mutation. Research published in NEJM today demonstrates that older adults with blood cancers who receive reduced intensity chemotherapy before a stem cell transplant with donor cells that are resistant to HIV may be cured of HIV infection. Paul Edmonds, 68, of Desert Springs, California, is the fifth person in the world to achieve remission for acute myelogenous leukemia ...

Los Angeles, CA (February 14, 2024) — A new study published in the journal PLOS ONE explores the weight great fossil sites have on our understanding of evolutionary relationships between fossil groups—the lagerstätten effect—and for the first time, quantified the power these sites have on our understanding of evolutionary history. Surprisingly, the authors discovered that the wind-swept sand deposits of the Late Cretaceous Gobi Desert’s extraordinarily diverse and well-preserved ...

Le Bonheur’s risk-based innovation program Changing High-Risk Asthma in Memphis through Partnership (CHAMP) significantly decreased health care use related to asthma by targeting barriers to asthma care, according to research published in the Annals of Allergy, Asthma & Immunology. After one year of enrollment in the program, results analyzing 945 children included a 48% reduction in Emergency Department (ED) visits, 68% reduction in inpatient and observation visits, 42% reduction in urgent care visits and 53% reduction in asthma exacerbations. Asthma exacerbations per patient significantly decreased from 2.97 to 1.4. “Children ...

Published in the Journal of Infectious Diseases Oxford Academic, research led by the University of Minnesota Medical School offers a new avenue of hope in the fight against chronic human immunodeficiency virus (HIV) infection.  The researchers explored the use of Natural Killer (NK) cells aiming to restore their function for better infection control — an approach that could be used in a broader HIV cure strategy as multiple companies are working on mass production of healthy NK cells. “HIV has really excellent therapies thanks to the unprecedented progress in developing antiretroviral therapy, ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, FEBRUARY 14, 2024 MINNEAPOLIS – Indigenous people may be more likely to have a stroke than non-Indigenous people, according to a systematic review that looked at populations around the world. The review is published in the February 14, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers looked at countries with a very high Human Development Index, which measures average achievements in three areas: health, knowledge ...

Irvine, Calif., Feb. 14, 2024 — A research team led by the University of California, Irvine has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer’s disease brain neurons.   The study published today online in the journal Molecular Psychiatry, introduced proof-of-concept data demonstrating the power of these new vectors, which express a range of improved ...

The Broad Institute of MIT and Harvard is now accepting applications for its 2024 Media Boot Camp. This annual program connects health/science journalists and editors with faculty from the Broad Institute, Massachusetts Institute of Technology, Harvard University, and Harvard’s teaching hospitals for a two-day event exploring the latest advances in genomics and biomedicine. Journalists will explore possible future storylines, gain fundamental background knowledge, and build relationships with researchers. The program format ...

(New York, NY – February 9, 2024) – High-risk pregnancy specialists from the Mount Sinai Health System are presenting research at the Annual Pregnancy Meeting of the Society for Maternal-Fetal Medicine (SMFM) in Fort Washington, MD from February 10-14. Mount Sinai experts are available for interview about their research findings, and can also provide commentary on other women’s health topics, breaking news, and studies. PRESENTATIONS and POSTER SESSIONS (*All abstracts are under embargo until the below listed times*) Sunday, February 11, 2024 FGR prevention: Is there a role for aspirin, heparin, ...

Significantly more babies were born on a weekday instead of weekend day or holiday, reveals a large-scale analysis of 21 million births in Japan over almost four decades published February 14, 2024 in the open-access journal PLOS ONE by Miho Sassa from the University of Tokyo, Japan, and colleagues. Medical resources are generally stretched during holidays (including weekends) due to factors like staffing and hospital policies. This may amplify holiday effects: disparities and variations of health outcomes between holidays and weekdays. Dr. Sassa and colleagues studied this holiday effect with a focus on birth, especially high-risk births as measured by babies born preterm ...

Vittrup Man was born along the Scandinavian coast before moving to Denmark, where he was later sacrificed, according to a study published February 14, 2024 in the open-access journal PLOS ONE by Anders Fischer of the University of Gothenburg, Sweden and colleagues. Vittrup Man is the nickname of a Stone Age skeleton recovered from a peat bog in Northwest Denmark, dating to between 3300-3100 BC. The fragmented nature of the remains, including a smashed skull, indicate that he was killed in a ritualistic sacrifice, a common practice in this region at this time. After a DNA study found Vittrup Man’s genetic ...

Some people from an ancient community in what is now northern Italy were interred with animals and animal parts from species such as dogs, horses and pigs. The reasons remain mysterious, but might indicate an enduring companion relationship between these humans and animals, or religious sacrificial practices, according to a study published February 14, 2023 in the open-access journal PLOS ONE by Zita Laffranchi from the University of Bern, Stefania Zingale from the Institute for Mummy Studies, Eurac Research Bozen, ...

Australian adults who report a good relationship that meets their original expectations tend to score higher in mental health, while adults who report loving their spouse but wished they had never entered the relationship and note relationship problems tend to score significantly lower in mental health, according to a survey of almost 7000 Australian adults published February 14, 2024 in the open-access journal PLOS ONE by Bernard Kwadwo Yeboah Asiamah-Asare and colleagues. Many recent studies have examined the possible social determinants of mental health. In this study, Yeboah Asiamah-Asare and colleagues looked specifically at how one’s ...

Just a few sites of exceptional fossil preservation may significantly distort the phylogenetic record for birds, scaly reptiles and dinosaurs ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0297637 Article Title: Quantifying the effects of exceptional fossil preservation on the global availability of phylogenetic data in deep time Author Countries: USA Funding: CHW: Richard Estes Memorial Award (No grant number); Society of Vertebrate Paleontology; www.vertpaleo.org; NO - CHW: Theodore Roosevelt Memorial Grant (No grant number); American Museum of Natural History; www.amnh.org; NO - CHW: EAR-PF 2305564; ...

Gender, culture, and age all appear to play a role in how emojis are interpreted, according to a study published February 14, 2024 in the open-access journal PLOS ONE by Yihua Chen, Xingchen Yang and colleagues from the University of Nottingham, UK. Stylized images of faces expressing different emotions, emojis can add both emotional nuance as well as potential ambiguity to electronic messages.   To understand how gender, age, and culture may influence emoji interpretation, Chen, Yang and colleagues recruited a group of 253 Chinese and 270 UK adults (51 percent women and 49 percent ...

Global health photography is often caught between photojournalistic intentions of accurately reflect local communities, and marketing directives to create attention-grabbing imagery, according to a study published February 14, 2024 in the open-access journal PLOS Global Public Health by Arsenii Alenichev from Oxford Population Health, the University of Oxford, United Kingdom, and colleagues. Standing at such representational crossroads, photographers are forced to engage with numerous—and often unresolvable — ethical and practical dilemmas. Photographers ...

Researchers at the Spanish National Cancer Research Center (CNIO) and the 12 de Octubre University Hospital have developed a new cell-based immunotherapy to treat multiple myeloma   The new immunotherapy is based on STAb cells and has yet to pass clinical trials.   The study is published in Science Translational Medicine, with head of the H12O-CNIO Cancer Immunotherapy Clinical Research Unit Luis Álvarez-Vallina as senior author.   Immunotherapy is already improving treatment options for many cancer types, but research groups keep exploring ...

Laval, February 14, 2024 – A research team of Canadian and French scientists, led by INRS professor Maya Saleh, has been investigating immunotherapy resistance in certain patients with hepatocellular carcinoma (HCC) associated with steatotic liver disease. The findings are published in the journal Cell Reports. Hepatocellular carcinoma is associated with known risk factors such as chronic hepatitis B or C infection, alcohol abuse, and metabolic dysfunction. It is the most common type of liver cancer. ...

The 17th World Congress on Polyphenols Applications 2024, scheduled for September 19-20, 2024, at Università degli Studi di Milano Statale in Italy, has revealed its program. This congress aims to bridge the latest scientific research on polyphenols with their potential to promote health. Goals The Polyphenols Applications 2024 Congress aims to share novel insights into polyphenols and their impact on human health, with the goal of finding practical ways to enhance well-being. Highlighted Program Polyphenols in Health & Diseases: Understanding the effects of polyphenols on health. Polyphenols, Microbiota & ...

The 15th World Congress on Targeting Mitochondria is set to take place in Berlin from October 28-30, 2024, promising a platform for front-line discussions and major insights into mitochondrial research. Prof. Volkmar Weissig, president of the World Mitochondria Society stated: "In this 15th edition, we'll explore the fundamental and mechanistic research of mitochondria. But what really sets this year apart is our special focus on how mitochondria can be applied in real-world medical settings. We'll be ...

FOR IMMEDIATE RELEASE A novel three-drug combination achieved notable responses in patients with advanced HER2-negative breast cancer, according to new research directed by investigators from the Johns Hopkins Kimmel Cancer Center. The treatment included a histone deacetylase (HDAC) inhibitor — a drug that causes a chemical change to stop tumor cells from dividing — with two types of immunotherapy known as checkpoint inhibitors, which unharness the power of the immune response against cancer.  The multicenter ...

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature. The work provides insights into cancer progression and neurodegenerative diseases as well as a potential therapeutic avenue in the form of a protein inhibitor. The genome contains all the genes and genetic material within an organism's cells. When the genome is stable, cells can accurately replicate and divide, passing on correct genetic ...