In the treatment of aggressive lymphomas and blood cancer (leukaemia), so-called chimeric antigen receptor T cells (CAR T cells) are increasingly being used. For this therapy, immune cells are taken from patients and programmed by means of genetic engineering to detect proteins on the malignant tumour cells. Back in the body, the CAR T cells then fight the cancer cells. Due to some heavy side effects, this therapy requires extreme caution and long hospital stays. Scientists at University Hospital Cologne are therefore researching ...

Acting on a proposal from the Institut Pasteur President Yasmine Belkaid, the Institut Pasteur Board of Governors appointed Mariana Mesel-Lemoine as Director of Diversity, Equity and Inclusion on Wednesday February 7, 2024. This appointment marks a significant milestone in the history of the Institut Pasteur, and it is the first French research institute to establish a position of this kind at such a senior and strategic level. Mariana Mesel-Lemoine will report directly to the President. Her mission will be to propose policy and strategy priorities related to diversity, equity and inclusion for the "Pasteur 2030" Strategic Plan, to oversee ...

About The Study: In hospitals participating in Get With The Guidelines–Stroke, earlier anticoagulation reversal was associated with improved survival for patients with intracerebral hemorrhage. These findings support intensive efforts to accelerate evaluation and treatment for patients with this devastating form of stroke. Authors: Kevin N. Sheth, M.D., of the Yale University School of Medicine in New Haven, Connecticut, is the corresponding author. To access the embargoed study: Visit our For The Media website at this ...

Sleep apnea is prevalent among cardio-oncology patients who are at higher risk for congestive heart failure from cancer therapy, according to a new study being presented at the American College of Cardiology (ACC) Advancing the Cardiovascular Care of the Oncology Patient course. Sleep apnea is a disorder of altered breathing while asleep with two types, obstructive (OSA) or central (CSA). Both can be treated to alleviate symptoms and improve cardiovascular outcomes. This study pertains to obstructive sleep apnea. A well-established screening tool for detecting sleep apnea is the STOP-BANG questionnaire utilizing eight questions using ...

Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a worldwide threat. The emergence of the BA.2.86 variant, a subvariant of Omicron, has raised significant concerns due to its substantial number of mutations. Discovered in August 2023, this variant differs markedly from other existing types such as Omicron XBB (including EG.5.1 and HK.3).  Compared with XBB and BA.2, BA.2.86 exhibits more than 30 mutations in its spike protein, contributing to its ability to effectively evade the immune system’s defenses. Over ...

Sensory feedback is important for amputees to be able to explore and interact with their environment. Now, researchers have developed a device that allows amputees to sense and respond to temperature by delivering thermal information from the prosthesis’ fingertip to the amputee’s residual limb. The “MiniTouch” device, presented February 9 in the journal Med, uses off-the-shelf electronics, can be integrated into commercially available prosthetic limbs, and does not require surgery. Using the thermally sensitive prosthetic hand, ...

Pisa, 9 February 2024. “When one of the researchers placed the sensor on his own body, I could feel the warmth of another person with my phantom hand. it was a very strong emotion for me, it was like reactivating a connection with someone”.   Thanks to a sensorised prosthetic hand that provides realistic and real-time thermal feedback, Fabrizio, a 57-year-old man from Pistoia with a transradial (wrist) amputation, was able to discriminate between and manually sort objects of different temperatures or materials and ...

The past year has seen major advances in Large Language Models (LLMs) such as ChatGPT. The ability of these models to interpret and produce human text sources (and other sequence data) has implications for people in many areas of human activity. A new perspective paper in the journal Neuron argues that like many professionals, neuroscientists can either benefit from partnering with these powerful tools or risk being left behind.   In their previous studies, the authors showed that important preconditions are met to develop LLMs that can interpret and analyze neuroscientific data like ChatGPT interprets language. These AI models can be built for many different types ...

About The Study: This study including 202,000 veterans with COVID-19 and 202,000 matched uninfected veterans found that outpatient use increased significantly in the month after infection, then attenuated but remained greater than the uninfected cohorts’ use through 12 months, which suggests that there are sustained impacts of COVID-19 infection. Authors: Matthew L. Maciejewski, Ph.D., of the Durham Veterans Affairs Health Care System in Durham, North Carolina, is the corresponding author.  To access the embargoed study: Visit our For The Media ...

About The Study: The findings of this study including 133 adults with severe obesity suggest that bariatric surgery was associated with health benefits two years after surgery. Bariatric surgery was associated with improved cognition and general health and changed blood vessel efficiency and cortical thickness of the temporal cortex. These results may improve treatment options for patients with obesity and dementia. Authors: Amanda J. Kiliaan, Ph.D., of the Radboud University Medical Center, Donders Institute for Brain, Cognition, ...

A technique can determine for the first time how frequently, and exactly where, a molecular event called “backtracking” occurs throughout the genetic material (genome) of any species, a new study shows. Published online February 9 in Molecular Cell, the study results support the theory that backtracking represents a widespread form of gene regulation, which influences thousands of human genes, including many involved in basic life processes like cell division and development in the womb. Led by researchers from NYU Grossman School of Medicine, the work revolves around genes, the stretches ...

BOSTON, MA — A new study led by researchers at the Harvard Pilgrim Health Care Institute has found that reducing out-of-pocket costs for patients with diabetes, especially those considered low income, can be one step toward improving health outcomes. The study, “Acute Diabetes Complications After Transition to a Value-Based Medication Benefit,” was published in the February 9 edition of JAMA Health Forum. Treatment with antidiabetic agents, antihypertensives, and lipid-lowering ...

An international research project led by the Martin Luther University Halle-Wittenberg (MLU) delves into the next generation of seasonal thermal energy storage systems. The "INTERSTORES" project is investigating optimal ways to construct new types of storage systems and integrate them into energy systems. The collaboration between science and industry will receive nearly eleven million euros as part of "Horizon Europe", with around 1.5 million euros going to MLU. The aim is to improve the ...

L'Hospitalet de Llobregat, February 8th, 2024. Once they enter the body, drugs, apart from carrying out their therapeutic function, are biochemically transformed by the action of the metabolic machinery, a process that facilitates their expulsion. This biotransformation results in a gradual disappearance of the drug, which is converted into its metabolites. These, in turn, can reach high concentrations in the body and also show a biological activity that may be different from that of the original drug. That is, the metabolites and the drug coexist ...

Hot water tanks, washing machines, kettles: limescale forms in every domestic appliance that comes into contact with (hot) water – especially in areas where the water is hard, meaning high in calcium. Often the only thing that helps is to use vinegar or a special descaler to dissolve the rock-​hard deposits and restore the appliance’s functionality. This is a nuisance in households – and an expensive problem in thermal power stations, for example those that generate electricity, where the formation of limescale is known as fouling. Heat exchangers are particularly prone to limescale, which greatly reduces the efficiency of the systems: ...

OAK BROOK, Ill. – An innovative breast imaging technique provides high sensitivity for detecting cancer while significantly reducing the likelihood of false positive results, according to a study published today in Radiology: Imaging Cancer, a journal of the Radiological Society of North America (RSNA). Researchers said the technique has the potential to offer more reliable breast cancer screening for a broader range of patients. Mammography is an effective screening tool for early detection of breast cancer, but its sensitivity ...

Children’s Hospital Colorado (Children’s Colorado) is announcing its recent acceptance into the Pediatric Heart Network (PHN), a collective of leading hospitals working to improve outcomes and quality of life for children – and more recently adults – with heart disease. The hospital’s Heart Institute will become one of nine clinical research centers across North America selected to be a part of this national network.  “We are thrilled to be accepted as a new core site for the Pediatric Heart Network,” said Shelley Miyamoto, MD, professor and Jack Cooper Millisor Chair of Pediatric Cardiology ...

Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumour, enabling clinicians to decide how to target treatment in a more precise way. In cancers such as clear cell renal cell carcinoma (ccRCC), responses to existing treatments are different for each patient, making it difficult to identify the right drug treatment regime for each patient. For example, cancer therapeutic Belzutifan has recently been approved to treat ccRCC, but only has a response rate of 49% in patients with the most common form of the condition. To understand better why some patients respond better than others, researchers from the Universities of Bath and Nottingham studied ...

Asian Americans are less likely than their white peers to participate in health research involving MRIs and addressing this hesitancy could improve research, according to a Rutgers Health-led study. Findings by the researchers, published in Alzheimer's & Dementia: Translational Research & Clinical Interventions, a journal of the Alzheimer’s Association, surveyed older adults about their experiences and perceptions of MRI brain imaging scans, their desire to learn results of scans and their attitudes related to dementia and overall research participation. According to the study, South Asian older adults – those 65 and older – are less likely than older white adults ...

Ordinarily, planets in evolved planetary systems, such as the Solar System, follow stable orbits around their central star. However, many indications suggest that some planets might depart from their birthplaces during their early evolution by migrating inward or outward. This planetary migration might also explain an observation that has puzzled researchers for several years: the relatively low number of exoplanets with sizes about twice as large as Earth, known as the radius valley or gap. Conversely, there are many exoplanets smaller and larger than this size. “Six years ago, a reanalysis of data from the Kepler space telescope revealed a shortage of exoplanets with sizes around ...

Fukuoka, Japan – Materials just atoms in thickness, known as two-dimensional (2D) materials, are set to revolutionize future technology, including in the electronics industry. However, commercialization of devices that contain 2D materials has faced challenges due to the difficulty in transferring these extremely thin materials from where they are made onto the device. Now, a research team from Kyushu University, in collaboration with Japanese company Nitto Denko, have developed a tape that can be used to stick 2D materials to many different surfaces, in an ...

Cosmic dust—like dust on Earth—comprises groupings of molecules that have condensed and stuck together in a grain. But the exact nature of dust creation in the universe has long been a mystery. Now, however, an international team of astronomers from China, the United States, Chile, the United Kingdom, Spain, etc., has made a significant discovery by identifying a previously unknown source of dust in the universe: a Type Ia supernova interacting with gas from its surroundings.   The study was published in Nature Astronomy on Feb. 9, and was led by Prof. WANG Lingzhi from the South America Center for Astronomy of the Chinese Academy ...

Nearly 400 exceptionally well-preserved fossils dating back 470 million years have been discovered in the south of France by two amateur paleontologists. This new fossil site of worldwide importance has been analyzed by scientists from the University of Lausanne, in collaboration with the CNRS and international teams. This discovery provides unprecedented information on the polar ecosystems of the Ordovician period. Paleontology enthusiasts have unearthed one of the world's richest and most diverse fossil sites from the Lower Ordovician period (around 470 million ...

For millions of years, a variety of large herbivores, or megafauna, influenced terrestrial ecosystems. Among many others, these included elephants in Europe, giant wombats in Australia, and ground sloths in South America. However, these animals experienced a wave of extinctions coinciding with the worldwide expansion of humans, leading to dramatic but still not fully understood changes in ecosystems. Even the survivors of these extinctions strongly declined, and many are currently threatened with extinction.   While there are many case studies as well as theories about the effects of large animals, formal attempts to quantitatively synthesize their effects and establish ...

The looming threat of climate change has motivated scientists worldwide to look for cleaner alternatives to fossil fuels, and many believe hydrogen is our best bet. As an environmentally friendly energy resource, hydrogen (H2) can be used in vehicles and electric power plants without releasing carbon dioxide into the atmosphere. However, storing and transporting H2 safely and efficiently remains a challenge. Compressed gaseous hydrogen poses a significant risk of explosion and leakage, whereas liquid hydrogen must be maintained at extremely low temperatures, ...