Dolutegravir has been approved since January 2014 in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus (HIV) infected adults and adolescents above 12 years of age. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) now examined whether the new drug offers an added benefit over the appropriate comparator therapy. The dossier compiled by the drug manufacturer provided proof of a considerable added ...

The EORTC will present nine abstracts at the ASCO 2014 Annual Meeting which will be held 30 May – 03 June 2014 in Chicago, Illinois. Four abstracts will be presented in Oral Abstract Sessions, one in a Poster Highlights Session, and another four in General Poster Sessions. Oral Abstract Sessions Abstract # 4500 Monday, 02 June, 9:45 – 9:57, E Hall D1 Cora N. Sternberg, Iwona Skoneczna, J.M.Kerst, Sophie Fossa, Peter Albers, Mads Agerbaek, Herlinde Dumez, Maria De Santis, Christine Theodore, Michael Leahy, J.D. Chester, Antony Verbaeys, Armelle Caty, Gedske Daugaard, ...

Washington, DC (May 21, 2014) The Net Children Go Mobile project will release new data on children's mobile use at the 64th Annual Conference of the International Communication Association at the Seattle Sheraton hotel. The project found that 46% of children own a smartphone and 41% use it daily to go online, while 20% own a tablet but 23% use it on a daily basis to access the Internet. Smartphone and tablet users engage more in communication and entertainment activities. They also have a higher level of digital skills, safety skills, and communicative abilities. However, ...

NGC 3590 is a small open cluster of stars around 7500 light-years from Earth, in the constellation of Carina (The Keel). It is a gathering of dozens of stars loosely bound together by gravity and is roughly 35 million years old. This cluster is not just pretty; it is very useful to astronomers. By studying this particular cluster — and others nearby — astronomers can explore the properties of the spiral disc of our galaxy, the Milky Way. NGC 3590 is located in the largest single segment of a spiral arm that can be seen from our position in the galaxy: the Carina spiral ...

A newly-discovered source of oceanic bioavailable iron could have a major impact our understanding of marine food chains and global warming. A UK team has discovered that summer meltwaters from ice sheets are rich in iron, which will have important implications on phytoplankton growth. The findings are reported in the journal Nature Communications on 21st May, 2014*. It is well known that bioavailable iron boosts phytoplankton growth in many of the Earth's oceans. In turn phytoplankton capture carbon – thus buffering the effects of global warming. The plankton also feed ...

Maternal depression is more common at four years following childbirth than at any other time in the first 12 months after childbirth, and there needs to be a greater focus on maternal mental health, suggests a new study published today (21 May) in BJOG: An International Journal of Obstetrics and Gynaecology. The study using data from 1507 women from six public hospitals in Melbourne, Australia, examines the prevalence of maternal depression from early pregnancy to four years postpartum. The researchers identify the possible risk factors for depressive symptoms at four ...

JACKSONVILLE, Fla. — Mayo Clinic researchers have discovered an enzyme they say is tightly linked to how aggressive pancreatic cancer will be in a patient. They say the study, published in Molecular Cancer Research, provides key insights into the most aggressive form of the disease, which is one of the deadliest human cancers. It also offers a number of possible future clinical advances, such as a way to gauge outcome in individual patients, and insight into potential therapy to shut down activity of the enzyme, known as Rac1b. "The implication from our research is ...

Researchers at the University of Montreal have developed an improved chemical analysis method that is more efficient and faster in detecting counterfeit medicines, which have skyrocketed in recent years. The method was developed and tested in a study by Philippe Lebel, Alexandra Furtos and Karen Waldron of the university's Department of Chemistry. It identifies and quantifies the various compounds present in a pharmaceutical product, in a fifth of the time it takes governmental services to do the same job. "Fake drugs are a scourge for public health," says Lebel. Once a ...

ST. LOUIS -- A molecular compound developed by Saint Louis University scientists restored learning, memory and appropriate behavior in a mouse model of Alzheimer's disease, according to findings in the May issue of the Journal of Alzheimer's Disease. The molecule also reduced inflammation in the part of the brain responsible for learning and memory. The paper, authored by a team of scientists led by Susan Farr, Ph.D., research professor of geriatrics at Saint Louis University, is the second mouse study that supports the potential therapeutic value of an antisense compound ...

CHICAGO --- A large new Northwestern Medicine® study upends our understanding of vitamin E and ties the increasing consumption of supposedly healthy vitamin E-rich oils -- canola, soybean and corn – to the rising incidence of lung inflammation and, possibly, asthma. The new study shows drastically different health effects of vitamin E depending on its form. The form of Vitamin E called gamma-tocopherol in the ubiquitous soybean, corn and canola oils is associated with decreased lung function in humans, the study reports. The other form of Vitamin E, alpha-tocopherol, ...

In Lewis Carroll's 1871 classic novel Through the Looking Glass, the Red Queen tells Alice: "Now, here, you see, it takes all the running you can do, to keep in the same place." Over the years, evolutionary biologists have used the Red Queen's statement to refer to the "Red Queen" hypothesis, which describes how living organisms, including humans, manage to survive in a changing environment by adapting through sexual reproduction. According to a University of Iowa researcher, the hypothesis is supported. In a paper published in the journal Biology Letters, lead author ...

Oil and gas development from shale fields has generally helped the public finances of local communities, providing new revenues and resources that usually -- but not always -- outweigh the increased demand for public services and other costs, according to a new analysis from two Duke University researchers. Daniel Raimi and Richard Newell gathered data from communities surrounding 10 oil and gas "plays" from September 2013 through February 2014, traveling to Arkansas, Colorado, Louisiana, Montana, North Dakota, Pennsylvania, Texas and Wyoming to interview local officials ...

DALLAS – May 20, 2014 – A lean "Supermodel" mouse type has revealed the potentially critical role played by a largely unknown gene that regulates metabolism, findings that could provide new insight into diseases ranging from diabetes to obesity, a new study by UT Southwestern Medical Center researchers suggests. The Supermodel mouse's phenotype – the physical characteristics that result from its gene makeup – include being very small in size, with an unusual body form caused by abnormal distribution of fat, said Dr. Zhe Chen,  Assistant Professor of Biophysics, and ...

CORVALLIS, Ore. – A proven approach to slow the aging process is dietary restriction, but new research in the Linus Pauling Institute at Oregon State University helps explain the action of a drug that appears to mimic that process – rapamycin. Rapamycin, an antibiotic and immunosuppressant approved for use about 15 years ago, has drawn extensive interest for its apparent ability – at least in laboratory animal tests – to emulate the ability of dietary restriction in helping animals to live both longer and healthier. However, this medication has some drawbacks, including ...

Many have assumed that warmer winters as a result of climate change would increase the growth of trees and shrubs because the growing season would be longer. But shrubs achieve less yearly growth when cold winter temperatures are interrupted by temperatures warm enough to trigger growth. "When winter temperatures fluctuate between being cold and warm enough for growth, plants deplete their resources trying to photosynthesize and end the winter with fewer reserves than they initially had. In the summer they have to play catch up," said Melanie Harsch, a University of Washington ...

Boston, MA – Primary care providers who engaged in an online game to solve clinical cases about hypertension management improved blood pressure control of their patients in a shorter amount of time compared to non-gamers, according to a new study by researchers at Brigham and Women's Hospital (BWH) and the Veterans Affairs Boston Healthcare System. The study was published May 20, 2014 in Circulation: Cardiovascular Quality and Outcomes. "This study is the first to show that an online educational game among medical professionals can improve the health measures of their ...

WHAT: Clinicians treating patients suffering from Middle East respiratory syndrome (MERS) currently have no drugs specifically targeted to the MERS coronavirus (MERS-CoV), a virus first detected in humans in 2012 that has since caused 614 laboratory-confirmed infections, including 181 that were fatal, according to the World Health Organization. The case count escalated sharply in the spring of this year, and the first cases in the United States were announced in early May. To address the urgent need for therapies, researchers supported by the National Institutes of Health ...

ANN ARBOR—The Detroit Lions' new model of philanthropy and community engagement may prove to be a touchdown for the city of Detroit. A new case study of corporate social responsibility in sport by University of Michigan researchers uses the Lions as an exemplar of a professional sports team reinventing its charitable giving and community relations approach in hopes of making a bigger impact on the community. In 2012, the Lions created the "Living in the City" campaign—a new model of corporate philanthropy that emphasizes deeper relationships with a small core group ...

LOUISVILLE, Ky. – An aging population poses challenges for governments around the globe as nations grapple with how to satisfy the physical, social and economic needs of older adults. About 126 million adults 65 years and older live in China - the country with the largest population of senior citizens, while 40 million adults 65 years and older live in the United States. In an article published today in Journal of Transcultural Nursing, University of Louisville School of Nursing assistant professor Valerie Lander McCarthy, PhD, RN; Ji Hong, MSN, a visiting scholar from ...

Can plants and animals evolve to keep pace with climate change? A study published May 19 in the journal Proceedings of the National Academy of Sciences shows that for at least one widely-studied plant, the European climate is changing fast enough that strains from Southern Europe already grow better in the north than established local varieties. Small and fast-growing, Arabidopsis thaliana is widely used as the "lab mouse" of plant biology. The plant grows in Europe from Spain to Scandinavia and because Arabidopsis is so well-studied, there is a reference collection of ...

(Santa Barbara, Calif.) — As the largest purchaser of wholesale produce in Santa Barbara County, UC Santa Barbara's residential dining services provided the perfect avenue for a pilot project incorporating local pesticide-free or certified organic produce into an institutional setting. The idea was conceived almost 10 years ago, when a group of students approached environmental studies professor David Cleveland about becoming a faculty adviser for student-led sustainable living classes. The group wanted to explore how to bring more local organic food in the dining halls. ...

BERKELEY — California's winter tule fog -- hated by drivers, but needed by fruit and nut trees -- has declined dramatically over the past three decades, raising a red flag for the state's multibillion dollar agricultural industry, according to researchers at the University of California, Berkeley. Crops such as almonds, pistachios, cherries, apricots and peaches go through a necessary winter dormant period brought on and maintained by colder temperatures. Tule fog, a thick ground fog that descends upon the state's Central Valley between late fall and early spring, helps ...

A quantum particle can search for an item in an unsorted "database" by jumping from one item to another in superposition, and it does so faster than a classical computer ever could. This assertion assumes, however, that the particle can directly hop from any item to any other. Any restriction on which items the particle can directly hop to could slow down the search. "Intuition says that a symmetric database allows the particle to hop freely enough to retain the quantum speedup, but our research has shown this intuition to be false," says Tom Wong, a physicist at ...

Nearly half of all adults in the United States suffer from the gum disease periodontitis, and 8.5 percent have a severe form that can raise the risk of heart disease, diabetes, arthritis and pregnancy complications. University of Pennsylvania researchers have been searching for ways to prevent, half and reverse periodontitis. In a report published in the Journal of Immunology, they describe a promising new target: a component of the immune system called complement. Treating monkeys with a complement inhibitor successfully prevented the inflammation and bone loss that ...

Most Americans eat a diet that consists of little to no protein for breakfast, a bit of protein at lunch and an overabundance of protein at dinner. As long as they get their recommended dietary allowance of about 60 grams, it's all good, right? Not according to new research from a team of scientists led by muscle metabolism expert Doug Paddon-Jones of the University of Texas Medical Branch at Galveston. This research shows that the typical cereal or carbohydrate-dominated breakfast, a sandwich or salad at lunch and overly large serving of meat/protein for dinner may not ...