Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig's disease, a debilitating neurological disorder that robs people of their motor skills. Their findings appear in the March 3, 2014, online edition of the Proceedings of the National Academy of Sciences of the United States of America, the official scientific journal of the U.S. National Academy of Sciences. "We know that both people and transgenic rodents afflicted with this disease develop spontaneous breakdown of the blood-spinal cord barrier, but how these ...

PROVIDENCE, R.I. [Brown University] — In the Proceedings of the National Academy of Sciences, a team of scientists at Brown University reports a major step forward in determining the specific behavior of the ubiquitous enzyme PP1 implicated in a wide range of diseases including cancer. PP1, whose role is to enable the passage of molecular messages among cells, is found pretty much everywhere in the body. Its wide range of responsibilities means it is essential to many healthy functions and, when things go wrong, to diseases. But its very versatility has prevented it from ...

New York, NY – Prevention and reversal of chronic kidney disease is an urgent public health need. The disease affects 1 in 10 Americans, is debilitating and deadly, and existing drugs, at best, offer only mild delay in progression to end-stage kidney failure. New research led by Icahn School of Medicine at Mount Sinai investigators has uncovered abnormal molecular signaling pathways from disease initiation to irreversible kidney damage, kidney failure, and death. Results from their preclinical and human research are published online March 3 in the Journal of Clinical Investigation. "Our ...

Researchers at New York University and the University of Texas at Austin have discovered that carbohydrates serve as identifiers for cancer cells. Their findings, which appear in the journal Proceedings of the National Academy of Sciences, show how these molecules may serve as signals for cancer and explain what's going on inside these cells, pointing to new ways in which sugars function as a looking glass into the workings of their underlying structures. "Carbohydrates can tell us a lot about what's going on inside of a cell, so they are potentially good markers for ...

There have been great expectations regarding the production of a drug to block the enzyme LTA4 hydrolase, which plays a key role in the body's inflammatory response. However, in clinical trials, such molecules have proven to be only moderately effective. Now, researchers at Karolinska Institutet have successfully refined their understanding of why previous substances have been less effective – and in so doing have produced a molecule that gets around the problem. Consequently, there is once again hope of a new anti-inflammatory drug based on the principal of blocking LTA4 ...

Researchers from Denmark demonstrate in a study that the large grazers and browsers of the past created a mosaic of varied landscapes consisting of closed and semi-closed forests and parkland. The study will be published on Monday 3 March 2014 in the renowned journal PNAS (Proceedings of the National Academy of Sciences of the United States of America). Dung beetles recount the nature of the past The biologists behind the new research findings synthesized decades of studies on fossil beetles, focusing on beetles associated with the dung of large animals in the past ...

Usually, microelectronic devices are made of silicon or similar semiconductors. Recently, the electronic properties of metal oxides have become quite interesting. These materials are more complex, yet offer a broader range of possibilities to tune their properties. An important breakthrough has now been achieved at the Vienna University of Technology: a two dimensional electron gas was created in strontium titanate. In a thin layer just below the surface electrons can move freely and occupy different quantum states. Strontium titanate is not only a potential future alternative ...

It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice published in the March issue of The Journal of Experimental Medicine. Bowel cancer, also called colorectal cancer, results from a series of genetic changes (mutations) that cause healthy cells to become progressively cancerous, first forming early tumors called polyps that can eventually become malignant. Although mutations can occur anywhere in the human intestine, certain types of colorectal cancer tend ...

In academic circles at least, women tend to cooperate with same-sex individuals of higher or lower rank less often than men do. So say researchers who report evidence on March 3 in the Cell Press journal Current Biology. The findings are based on a study of the publication records of professors working at 50 North American universities. "People are often upset to hear evidence of sex differences in behavior," says Joyce Benenson of Harvard University. "But the more we know, the more easily we can promote a fair society." The findings might seem somewhat counterintuitive. ...

People with sleep apnea appear to be at higher risk of pneumonia than people without, according to a study published in CMAJ (Canadian Medical Association Journal). Sleep apnea is characterized by disrupted sleep, caused when the upper airway becomes obstructed by soft tissue, cutting off oxygen. It has been linked to several types of heart disease and cognitive impairment. People with obstructive sleep apnea are at higher risk of aspiration while sleeping. To determine whether sleep apnea is linked to the development of pneumonia, Taiwanese researchers followed 34 ...

It's long been a popular stereotype: Men are hugely competitive, meaning cooperative effort is the exception rather than the norm, while women have a tendency to nurture relationships with others, making them much more likely to cooperate with one another. A new Harvard study, however, is turning that cliché on its head. In fact, within academic departments women of different social or professional "ranks" cooperate with each other less well than men do, according to Joyce Benenson, an Associate of Harvard's Human Evolutionary Biology Department and Professor of Psychology ...

A new study by the Johns Hopkins Bloomberg School of Public Health and the University of Illinois at Chicago finds that Medicare Part D prescription coverage significantly reduced hospital admissions and program expenditures totaling $1.5 billion annually. In the largest and most rigorous impact analysis of Medicare Part D to date, researchers found that gaining prescription drug insurance through Medicare Part D reduced hospitalizations by 8%, decreased annual Medicare expenditures for hospitalization by 7% and reduced hospital charges associated with hospitalization ...

SALT LAKE CITY, Utah, March 3, 2014 – Myriad Genetics, Inc. (Nasdaq: MYGN) today announced that it has published data from the PROCEDE 500 study in the journal Current Medical Research and Opinion, demonstrating that 65 percent of physicians changed their original treatment plans for men with prostate cancer based on results from the Prolaris test. Prolaris is a 46-gene molecular diagnostic test that has been evaluated in 11 clinical studies with more than 5,000 patients. "Prolaris is an absolute game changer for urologists because it adds meaningful new prognostic ...

Whether you have a blog about fashion, photography, food, travel, business or any other topic and you want to engage your community in powerful conversations, CM Answers Plugin can help you create the proper context for those conversations to happen. CM Answers is an easy-to-use and easy to customize Wordpress plugin through which you can empower your community-builders by allowing them to post questions and answers without admin review, while newly registered users can wait for your approval, this way keeping away any spam attempts. Users can have different categories ...

Creativity fosters well-being, encourages self-development and promotes happiness. This well-researched fact was highlighted in a provocative statement made by Dr. Thomas Moore, an internationally renowned counsellor and author: "There is definitely a correlation between disease and a lack of imagination." Recognising the benefits of creativity and original thinking, a new film production business on the Gold Coast, Gothic Zen Studios, has chosen to dedicate itself to crafting productions that affirm the creative spirit. Encouraging creativity, by promoting ...

Now it's possible to wholesale properties across the country without leaving home via Private Money Blueprint's "10-Hour Wholesaler," real-estate investment training program at http://www.10hourwholesaler.com/presentation/. After discovering ways to cut down the time, costs and efforts involved in wholesaling properties, real estate investor and coach Justin Wilmot created the program to share their three-step process with others. "My old, real estate investing process of finding deals, fixing and flipping properties and taking risks was sucking the life ...

Illustrative art, which has been inspired by humanitarians, activists and leaders that shaped our lives and still continue to mold our future, has been added to 100 T-shirts & wooden frames and is to be shared across 100 cities, creating 100 inspirational stories. Filmmaker, photographer, graphic designer and acclaimed artist Emiliano Deificus, today announces his Kickstarter campaign, which is titled 100Shirts 100Cities 100Stories. This is truly an inspirational campaign which sees the art designed by Deificus printed on combed cotton T-shirts and a high quality ...

FARROW Commercial Construction has been awarded the Perspective Magazine Award as Best Service Provider for 2014. The awards are based on a combination of judges' votes and online participation. While some of the other candidates supported developers in numerous and admirable ways, the work performed by FARROW Commercial Construction creates an environment where guests, owners and members can tangibly enjoy their timeshare or club. According to John Farrow, President and CEO of FARROW Commercial Construction, the leading hospitality construction company in the country, ...

Author Inakat releases her first urban novel, Touch of Base on Amazon. This novel is set in the city of Detroit and relates to many of the crisis and personal triumphs of the urban black male. Cheer for two different kinds of champions in a world where daily survival is often a hard-fought battle. Inakat ( Author of the Synz Series) is a self-published author, poet, and blogger. She currently resides in Detroit, MI. Touch of Base is first her Urban fiction novel. She is the CEO of Inakat Publishing. About us: Inakat Publishing is located in Detroit, MI. Author Inakat ...

Local business DFC Screen Printing is proud to announce the launch of their new website, just in time for the Q1 season. The website includes features such as an online design studio, where customers can design a wide variety of custom products from start to finish, by first selecting the product and then by creating the design; letting their imagination run wild. The website also allows users to upload images and design copy straight from their computers, directly onto their design. This feature provides users with an immediate live view of what their design will look ...

The women of Zeta Phi Beta Sorority, Inc., Phi Zeta Zeta Chapter (Queens, NY) will host their Annual Finer Womanhood Scholarship Dinner Dance. The event will be held on March 21, 2014 from 8PM - 1AM at Antun's of Queens Village at 96-43 Springfield Boulevard, Queens Village, NY 11429 This year's theme "Honoring Those Who Uplift the Community Through Mind, Body and Spirit" falls in line with Zeta Phi Beta's national signature program - Z-HOPE (Zetas Helping Other People Excel). Phi Zeta Zeta Chapter has chosen honorees that have gone above and beyond the call ...

Terezia Farkas, bestselling author of 'Heart Of Love Evolution: Surviving Depression' has pledged 50% of all author royalties to the Canadian Mental Health Association Alberta. Entitled 'Action On Depression', the fundraising project will run from March 1 through March 15, 2014. Readers can participate in the fundraiser by purchasing the book from Amazon, Friesen Press or from any Chapters/Indigo or Coles bookstore. "I want to reduce the stigma surrounding depression with my fundraiser," says Ms. Farkas. "By hosting a mental health event, I am encouraging ...

Lucky Robot, a restaurant blending traditional and innovative Japanese techniques and ingredients, today announced their Tokyo Brunch Happy Hour. This special offers 30% off food from 10-11:30 a.m. on Saturdays and Sundays for a limited time. Tokyo Brunch is served from 10 a.m. - 3 p.m. every weekend. Lucky Robot, http://www.LuckyRobotRestaurant.com, is located in the heart of the South Congress district, two doors down from the famed Continental Club and next to Amy's Ice Creams. Its Asian-inspired Tokyo Brunch features breakfast banh mi, sriracha scramble, nomnomiyaki ...

Summit Precious Metals Exchange, a new precious metals investment firm out of Phoenix, AZ has just launched their website http://summitpreciousmetals.com. Having worked for over a decade at some of Phoenix's largest precious metals firms, the principal owners of Summit Precious Metals Exchange have now decided to use their wealth of knowledge and experience to help investors make educated choices within the industry. In response to growing interest from clients, Summit created their new website to be an online repository for data, information and news related to the precious ...

IndCor, a real estate company focused on the ownership and management of industrial properties, is significantly expanding its presence in six desirable real estate markets, with a 9.6 million square foot portfolio of industrial properties. This recent acquisition, which was brokered by Eastdil Secured, increased the total square footage owned and managed by IndCor to approximately 117 million square feet. "This acquisition provides IndCor with the opportunity to increase its presence in Austin, Dallas, San Antonio, Portland, Los Angeles, and Denver, with hard-to-replace, ...