Psoriasis is a common inflammatory skin condition. The underlying genetic factors have not yet been sufficiently researched. The skin inflammation is usually triggered by external factors such as infections or stress. A research team at the Institute of Cancer Research of the Medical University of Vienna has now managed to identify a new factor in signal transmission of the immune system that plays a major role in the development of a psoriatic episode. The scientists have shown that symptoms can be alleviated by inhibiting the "c-Jun" protein in signal transmission. The common clinical manifestation of psoriasis is a pinkish-grey thickening of the epidermis in distinct foci of infection, ...

It has been known for about a year that minks can become infected with SARS-CoV-2. The virus had been transmitted from humans to farmed mink and mutated in infected animals. Mutations were acquired in the spike protein, which is crucial for the entry of the virus into host cells and represents the central point of attack for antibodies. These SARS-CoV-2 variants from mink were transmitted back to humans, raising concerns that minks could be a continuing source of infection of humans with SARS-CoV-2 variants with altered biological properties. Researchers at the German Primate Center (DPZ) - Leibniz Institute for Primate Research in Göttingen, Germany, have now shown that an antibody used for COVID-19 ...

A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons' cellular skeletons. The supplement betaine was first isolated from sugar beets and is often associated with sweetness or umami flavor. Healthy levels of betaine come from both external food sources and internal synthesis in the body. Betaine ...

Up to 25 percent of global food production is lost annually due to insects, primarily beetles. For the past 500 million years, beetles have successfully spread and adapted to life around the globe and now account for one of every five animal species on Earth. Yet as far back as ancient Egypt, these tough little bugs have invaded granaries and vexed us humans by destroying our crops. As a result, food production and an abundant use of pesticides now go hand in hand. A large share of these pesticides damage biodiversity, the environment and human health. As various pesticides are phased out, new solutions are required to target and eradicate pests without harming humans or beneficial ...

Atlantic bluefin tuna have returned to UK waters and can once again be seen during the summer and autumn months. Their numbers appear to be increasing, following a long period of absence linked to population decline, according to research led by Cefas and the University of Exeter. Marine scientists in the UK and Ireland have analysed multiple datasets, spanning a 16-year period, to document the increase in bluefin, which arrive into the waters of the Celtic Seas and off South West England, the Scilly Isles, and North West Ireland to feed in late summer and autumn. The research is part of the Defra-funded "Thunnus UK" research project. ...

Stroke risk for patients with traumatic brain injuries is at its highest in the four months following injury and remains significant for up to five years post-injury, finds a new systematic review led by a team at the University of Birmingham. Traumatic brain injury (TBI) is a global health problem affecting over 60 million people a year worldwide. Incidences of TBI are rising due to a range of factors including increased falls in the elderly, military conflict, sports injuries and road traffic accidents. However, advances in critical care and imaging have led to a reduction in TBI-related mortality. Previous studies have associated TBI with a long-term risk of neurological diseases including dementia, ...

There are many variants of "goblet cells" in the intestines and they seem to have different functions, according to a new study from the University of Gothenburg. The study indicates that defects in goblet cells of a particular type may be a factor contributing to ulcerative colitis, an inflammatory bowel disease. The entire inside of our intestines is covered by a thin layer of mucus that protects the fragile mucous membrane (mucosa) from bacteria and other microorganisms. If the microorganisms repeatedly come into contact with the intestinal mucosa, inflammation and even cell changes may result. These increase the risk of intestinal cancer. In a healthy colon, the mucus layer is up to a millimeter ...

Genova (Italy), 16th April 2021 - A micro-sized polymeric net wrapping around brain tumors, just like a fishing net around a shoal of fish: this is the microMESH, a new nanomedicine device capable to conform around the surface of tumor masses and efficiently deliver drugs. It has been described by the researchers of the IIT - Istituto Italiano di Tecnologia (Italian Institute of Technology) in Nature Nanotechnology. The new biomedical implant has been validated in preclinical studies that demonstrate its effectiveness for the treatment of glioblastoma multiforme. This work has been carried out by the group of Prof. Paolo Decuzzi, head of the IIT Laboratory of Nanotechnology ...

The prevalence of intellectual disabilities, which means difficulties with learning and understanding new things, is roughly 1-2% in the population. People with a severe intellectual disability need help from others in daily activities throughout their lives. Such disabilities can be caused by genetic changes or external factors. According to estimates, roughly 2,500 genes underlie intellectual disability, of which approximately half remain unidentified. In recent years, the diagnostics for intellectual disabilities have improved thanks to advancements in techniques that make it possible ...

Language is one of the most notable abilities humans have. It allows us to express complex meanings and transmit knowledge from generation to generation. An important question in human biology is how this ability ended up being developed, and researchers from the universities of Barcelona, Cologne and Tokyo have treated this issue in a recent article. Published in the journal Trends in Cognitive Sciences, the article counts on the participation of the experts from the Institute of Complex Systems of the UB (UBICS) Thomas O'Rourke and Pedro Tiago Martins, led by Cedric Boeckx, ICREA research professor at the Faculty of Philology ...

In December 2019, a new viral infection was detected in Wuhan, China. On January 30, 2020, the World Health Organization declared the outbreak a public health emergency of international concern, and on March 11, the COVID-19 pandemic. In light of the danger that the infection poses to human personnel, the idea to utilize automation in hospitals is one of the natural solutions in healthcare. Among the paper's five co-authors, four are working in robotics and one is an expert in medicine. The paper presents a new concept of an infectious hospital that may become a worldwide standard in the future. The idea of this appeared while the authors ...

While studying strontium titanate with electron paramagnetic resonance, a team from KFU's Center for Quantum Technology has found that the shape of a specimen of strontium titanate influences its internal symmetry. The research was co-conducted by the Ioffe Institute of Physics and Technology (Russia) and the Institute of Physics of the Czech Academy of Sciences. At room temperature, SrTiO3 is a crystal with high cubic symmetry, that is, the lattice of strontium titanate, like bricks, is composed of unit cells, each of which is a regular cube. However, the researchers showed the picture is a bit more nuanced. In ...

The research is conducted by Kazan University's Open Lab Gene and Cell Technologies (Center for Precision and Regenerative Medicine, Institute of Fundamental Medicine and Biology) and Republic Clinical Hospital of Kazan. Lead Research Associate Yana Mukhamedshina serves as project head. Spinal cord injury mechanisms include primary and secondary injury factors. Primary injury is mechanical damage to the nervous tissue and vasculature with immediate cell death and hemorrhage. Secondary damage leads to significant destructive changes in the nervous tissue due to the development of excitotoxicity, death ...

The project was kickstarted in 2017 when a delegation of YTC America (subsidiary of Yazaki Corporation) visited Kazan Federal University. During the talks, YTC suggested that KFU participate in developing effective methods of separating single-wall carbon nanotubes (SWCNTs) into metallic and semiconducting specimens. This was to be done on Tuball tubes produced by OCSiAl, since they are the only ones currently available in industrial quantities. Carbon nanotubes (CNT) is a family of 1D nanostructures with numerous verified applications, made possible due to their ...

A recent study finds that social inequality persists, regardless of educational achievement - particularly for men. "Education is not the equalizer that many people think it is," says Anna Manzoni, author of the study and an associate professor of sociology at North Carolina State University. The study aimed to determine the extent to which a parent's social status gives an advantage to their children. The research used the educational achievements of parents as a proxy for social status, and looked at the earnings of adult children as a proxy for professional success. To ...

ADELPHI, Md. -- Spoken dialogue is the most natural way for people to interact with complex autonomous agents such as robots. Future Army operational environments will require technology that allows artificial intelligent agents to understand and carry out commands and interact with them as teammates. Researchers from the U.S. Army Combat Capabilities Development Command, known as DEVCOM, Army Research Laboratory and the University of Southern California's Institute for Creative Technologies, a Department of Defense-sponsored University Affiliated Research Center, created an approach to flexibly interpret and respond to Soldier intent derived from spoken dialogue with autonomous systems. This technology is currently the primary ...

The Andes Mountains of South America are the most species-rich biodiversity hotspot for plant and vertebrate species in the world. But the forest that climbs up this mountain range provides another important service to humanity. Andean forests are helping to protect the planet by acting as a carbon sink, absorbing carbon dioxide and keeping some of this climate-altering gas out of circulation, according to new research published in Nature Communications. The study -- which draws upon two decades of data from 119 forest-monitoring plots in Colombia, Ecuador, Peru, Bolivia and Argentina -- was produced by an international team of scientists including researchers supported by the Living Earth Collaborative at Washington University in St. Louis. The lead author was Alvaro Duque from the ...

A team of scientists from Russia studied the role of double-stranded fragments of the maturing RNA and showed that the interaction between distant parts of the RNA can regulate gene expression. The research was published in Nature Communications. At school, we learn that DNA is double-stranded and RNA is single-stranded, but that is not entirely true. Scientists have encountered many cases of RNA forming a double-stranded (a.k.a. secondary) structure that plays an important role in the functioning of RNA molecules. These structures are involved in the regulation of gene expression, where the double-stranded regions typically carry specific functions and, if lost, may cause severe disorders. A double-stranded structure is created by sticky complementary ...

New, detailed study of the Renland Ice Cap offers the possibility of modelling other smaller ice caps and glaciers with significantly greater accuracy than hitherto. The study combined airborne radar data to determine the thickness of the ice cap with on-site measurements of the thickness of the ice cap and satellite data. Researchers from the Niels Bohr Institute - University of Copenhagen gathered the data from the ice cap in 2015, and this work has now come to fruition in the form of more exact predictions of local climate conditions. The accuracy ...

A new study led by researchers at Johns Hopkins and the University of Pennsylvania uses computer modeling to suggest that eviction bans authorized during the COVID-19 pandemic reduced the infection rate and not only protected those who would have lost their housing but also entire communities from the spread of infections. With widespread job loss in the U.S. during the pandemic, many state and local governments temporarily halted evictions last spring, and just as these protections were about to expire in September, the Centers for Disease Control ...

Alzheimer's disease (AD) is a form of progressive dementia interfering with daily living. It is caused by the decline in the number of brain cells resulting in the deterioration of our mental abilities. One of the main reasons for the worsening brain cells condition and even the brain shrinkage are molecules having a specific structure called β-amyloids (Aβ). They are peptides that tend to agglomerate around the nerve cells, becoming toxic and damage them. Recent studies, presented by scientists from the Institute of Physical Chemistry, Polish Academy of Sciences, led by dr. Piotr Pieta, give hope for inhibition of the β-amyloids' toxicity by applying the K162 molecule. Researchers present a tremendous protective impact on the biological membranes ...

UPTON, NY--Scientists have identified the primary cause of failure in a state-of-the-art lithium-metal battery, of interest for long-range electric vehicles. Using high-energy x-rays, they followed the cycling-induced changes at thousands of different points across the battery and mapped the variations in performance. At each point, they used the x-ray data to calculate the amount of cathode material and its local state of charge. These findings, combined with complementary electrochemical measurements, enabled them to determine the dominant mechanism driving the loss of ...

A joint research carried out by MIPT scientists and Harvard researchers have presented retinal cells that can integrate into the retina. This is the first successful attempt to transplant ganglion cells (retinal neurons that are destroyed by glaucoma) derived from stem cells in a lab setting. Scientists tested the technology in mice and established that the cells successfully integrated and survived for a year. In the future, the researchers plan to create specialized cell banks, which will permit individual, tailored therapy for each patient. The world's first successful attempt to grow and transplant ...

COVID-19 patients who are overweight or obese are more likely to develop a more severe infection than patients of healthy weight, and they require oxygen and invasive mechanical ventilation more often. There is no increased risk of death . These conclusions, for which more than 7,000 patients were studied, appear from international research in eleven countries, including the Netherlands (Radboud university medical center). The study, led by Australian researchers, examined over 7000 patients from eleven different countries who were admitted to 18 hospitals. Of this group, over a third (34.8%) were overweight and almost a third (30.8%) were obese. COVID-19 patients with obesity required ...

Coral reefs are one of the most biologically diverse ecosystems on earth. In the northern Red Sea and Gulf of Aqaba corals also have exceptionally high tolerance to increasing seawater temperatures, now occurring as a consequence of global warming. This characteristic led coral reef scientists to designate this region as a potential coral reef refuge in the face of climate change - a reef where corals may survive longer than others that are being lost at an alarming rate due to human pressures. However, global climate change will also result in more variable weather patterns, including extreme cold periods. Some researchers predict that the Red Sea region is entering a cooling phase. Therefore, researchers from Bar-Ilan University and ...