Durham, NC - The standard of treatment for bone tumors is often two-fold: surgery to remove the cancerous section followed by radiation therapy to ensure all the cancerous cells have been killed off. This is an effective way to defeat bone tumors; however, it often results in large bone defects and hampers wound healing because of extensive tissue cutoff and irradiation-induced tissue damage. A new study published in STEM CELLS Translational Medicine demonstrates how stem cells primed with ferulic acid can repair such bone damage and how this occurs. The information this study provides could aid in the development of new treatments for irradiated bone injuries. Heng Zhu, M.D., Ph.D., of the Beijing Institute of ...

As World Water Day is observed around the globe, new research from UBC Okanagan suggests a systematic approach to forest and water supply research may yield an improved assessment and understanding of connections between the two. Healthy forests play a vital role in providing a clean, stable water supply, says eco-hydrologist Dr. Adam Wei. Acting as natural reservoirs, forests in watersheds release and purify water by slowing erosion and delaying its release into streams. But forests are changing--in part because of human activity--and that's having an impact on forests' interaction with hydrological ...

Latino undergraduate male college students are involved in many leadership roles, yet how this leadership evolves in higher education has been understudied. Researchers from Florida Atlantic University in collaboration with San Diego State University and Texas A&M University explored how Latino male college students make meaning of their masculinity and how this meaning shapes their understanding and performance of leadership. The study published in the International Journal of Leadership Education, utilized a qualitative method to delve deep into the understandings of the masculinities, gender socialization, leadership and transfer experiences of 34 Latino undergraduate male students. Using a philosophical approach, the researchers ...

Researchers from Chalmers University of Technology have produced a structural battery that performs ten times better than all previous versions. It contains carbon fibre that serves simultaneously as an electrode, conductor, and load-bearing material. Their latest research breakthrough paves the way for essentially 'massless' energy storage in vehicles and other technology. The batteries in today's electric cars constitute a large part of the vehicles' weight, without fulfilling any load-bearing function. A structural battery, on the other hand, is one that works as both a power source and as part of the structure - for example, in a car body. This is termed 'massless' energy storage, because in essence the battery's weight vanishes when it becomes part of ...

Announcing a new article publication for BIO Integration journal. In this review article the authors Oliver K. Semisch-Dieter, Andy H. Choi and Martin P. Stewart from the University of Technology Sydney, Ultimo, NSW, Australia discuss the use of biomaterials in dental implants. Biomaterials have become essential for modern implants. A suitable implant biomaterial integrates into the body to perform a key function, whilst minimizing negative immune response. Focusing on dentistry, the use of dental implants for tooth replacement requires a balance between bodily response, mechanical structure and performance, and aesthetics. ...

A team of researchers from Tübingen and Israel uncovers how brain structures can maintain function and stable dynamics even in unusual conditions. Their results might lay the foundations for better understanding and treating conditions like epilepsy and autism. The neurons in our brains are connected with each other, forming small functional units called neural circuits. A neuron that is connected to another one via a synapsis can transmit information to the second neuron by sending a signal. This, in turn, might prompt the second neuron to transmit a signal to ...

Tsukuba, Japan - An earthquake is generally viewed to be caused by a rupture along a fault that is transmitted outward from its point of origin in a uniform, predictable pattern. Of course, given the complexity of the environments where these ruptures typically occur, the reality is often much more complicated. In a new study published in Scientific Reports, a research team led by the University of Tsukuba developed a new method to model the details of complex earthquake rupture processes affecting systems of multiple faults. They then applied this method to the magnitude ...

An international team of interdisciplinary researchers has identified mathematical metrics to characterize the fragility of financial markets. Their paper "Network geometry and market instability" sheds light on the higher-order architecture of financial systems and allows analysts to identify systemic risks like market bubbles or crashes. With the recent rush of small investors into so-called meme stocks and reemerging interest in cryptocurrencies talk of market instability, rising volatility, and bursting bubbles is surging. However, "traditional economic theories cannot foresee events like the US subprime mortgage collapse of 2007" according ...

Point Epithelial cell rests of Malassez derived from the periodontal ligament were transformed into progenitor stem-like cells by stimulation with epigenetic agents. Subsequently, the progenitor stem-like cells were directly differentiated into endothelial, mesenchymal stem, and osteogenic cells that constitute the periodontal ligament. Background Stem cells derived from the dental pulp or periodontal ligament have been used for regenerative dentistry. Although it is relatively easy to collect the dental pulp stem cells, it is difficult to obtain adequate numbers of good quality cells; a ...

Using an improved version of the gene editing tool CRISPR/Cas9, researchers knocked out up to twelve genes in plants in a single blow. Until now, this had only been possible for single or small groups of genes. The approach was developed by researchers at Martin Luther University Halle-Wittenberg (MLU) and the Leibniz Institute of Plant Biochemistry (IPB). The method makes it easier to investigate the interaction of various genes. The study appeared in The Plant Journal. The inheritance of traits in plants is rarely as simple and straightforward as Gregor Mendel described. The monk, whose experiments in the 19th century on trait inheritance in peas laid the foundation of genetics, in fact got lucky. "In the traits that ...

Patricia Bernal, a Ramón y Cajal researcher at the Department of Microbiology of the University of Seville's Faculty of Biology, is working with the bacterium Pseudomonas putida, a biological control agent found in the soil and in plant roots and which, as such, has the ability to protect plants from pathogen attacks (organisms that cause diseases) also known as phytopathogens. Specifically, the US researcher is studying a molecular weapon that bacteria use (Type VI Secretion System or T6SS) to eliminate their competitors. The T6SS could be compared to a harpoon with a poisonous tip that bacteria throw at their enemies to annihilate them. In a recent paper, which has just been published in the scientific journal PNAS and for ...

Igor Stagljar made his career building molecular tools to combat cancer. But when the pandemic hit last March, he aimed his expertise at a new adversary, SARS-CoV-2. Stagljar is a professor of biochemistry and molecular genetics in the Donnelly Centre for Cellular and Biomolecular Research at U of T's Temerty Faculty of Medicine. Last spring, with support from U of T's Toronto COVID-19 Action Fund, his team began developing a new method for measuring immunity to coronavirus in those who recovered from COVID-19. They are now ready to reveal their creation -- a pinprick test that accurately measures ...

"You have to win the battle against depression", "what counts is not surrendering" and "this is not a short road" are examples of conceptual metaphors typically used to describe experiences and issues associated with disorders like depression. Such expressions allude to abstract concepts but do so using familiar terms that enable better understanding of the experience. This kind of metaphor is often used unconsciously, going unnoticed by both speaker and listener. However, the study of metaphors can help access and understand the thinking, beliefs and feelings of individuals with mental disorders. The conceptual metaphors of depression found in 23 blogs written by people with major depressive disorders were analysed by a multidisciplinary UOC team composed of Marta Coll-Florit and Salvador ...

The results argue for a comprehensive approach to disease prevention. The scientists have now published their findings in the journal Nature Medicine. Many elderly people suffer simultaneously from several, frequently very different diseases, a condition also known as multimorbidity. Their quality of life is severely restricted, and they receive medication from different doctors, a process which is difficult and often insufficiently coordinated. Observations indicate that certain diseases commonly occur together, but the causes of this are largely ...

It's well known that mentoring opportunities are critical for development and career advancement, and are associated with greater job satisfaction and increased earnings and promotions. Yet a recent study co-authored by RMIT University's Professor Andrew R. Timming found women may be missing out on these opportunities due to fears by male managers of potential misconduct allegations. "Workplace relations between males and females have changed over the past two years. Male managers are significantly less likely than female managers to mentor or interact one-on-one with female employees," Timming said. "We found that male managers were less likely to work one-on-one in an office with the door closed and less likely to have ...

WASHINGTON, March 22, 2021 -- What's better at finding a hidden bomb -- a dog or an electronic chemical detector? In this episode, the Reactions team travels to the U.S. Naval Research Laboratory to find out: https://youtu.be/TRwqOFHOjac. INFORMATION: Reactions is a video series produced by the American Chemical Society and PBS Digital Studios. Subscribe to Reactions at http://bit.ly/ACSReactions and follow us on Twitter @ACSReactions. The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS' mission is to advance the broader ...

March 22, 2021 (BRONX, NY)-- Most people with cancer who are infected by the novel coronavirus produce antibodies at a rate comparable to the rest of the population--but their ability to do so depends on their type of cancer and the treatments they've received, according to a new study by researchers at Montefiore Health System and Albert Einstein College of Medicine. The findings, published online today in Nature Cancer, may lead to better care for cancer patients, who face a heightened risk of dying from COVID-19, and suggests that cancer patients should ...

PHILADELPHIA--Hormone drugs that reduce androgen levels may help disarm the coronavirus spike protein used to infect cells and stop the progression of severe COVID-19 disease, suggests a new preclinical study from researchers in the Abramson Cancer Center at the University of Pennsylvania and published online in Cell Press's iScience. Researchers show how two receptors--known as ACE2 and TMPRSS2--are regulated by the androgen hormone and used by SARS-CoV-2 to gain entry into host cells. Blocking the receptors with the clinically proven inhibitor Camostat and other anti-androgen therapies prevented viral entry and replication, they also showed in lab studies. The findings provide more insight into the molecular mechanisms of the virus but also support ...

There are some tasks that traditional robots -- the rigid and metallic kind -- simply aren't cut out for. Soft-bodied robots, on the other hand, may be able to interact with people more safely or slip into tight spaces with ease. But for robots to reliably complete their programmed duties, they need to know the whereabouts of all their body parts. That's a tall task for a soft robot that can deform in a virtually infinite number of ways. MIT researchers have developed an algorithm to help engineers design soft robots that collect more useful information about their surroundings. The deep-learning algorithm suggests an optimized placement of sensors within the robot's body, allowing it to better interact with ...

Tsukuba, Japan - Researchers from the Department of Applied Physics at the University of Tsukuba demonstrated second-order nonlinear optical effects in diamonds by taking advantage of internal color center defects that break inversion symmetry of diamond crystal. This research may lead to faster internet communications, all-optical computers, and even open a route to next generation quantum sensing technologies. Current fiber optical technology uses light pulses to transfer broad-bandwidth data that let you check your email, watch videos, and everything else on the Internet. The main drawback is that light pulses hardly interact with each other, so the information must be converted into electrical signals to allow your computer ...

In a recent study testing the effects of exercise on overall metabolism, researchers at Oregon State University found that even a single session of moderate aerobic exercise makes a difference in the cells of otherwise sedentary people. Mitochondria are the part of the cell responsible for the biological process of respiration, which turns fuels such as sugars and fats into energy, so the researchers focused only on mitochondria function. "What we found is that, regardless of what fuel the mitochondria were using, there were mild increases in the ability to burn off the fuels," said Matt Robinson, lead author on the study and an assistant professor ...

Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease. Using genomics, the team tracked DNA changes occurring in melanoma samples donated by patients as their disease progressed, right through to the time the patient died. This revealed dramatic and chaotic genetic changes that accumulated in the melanoma cells as the cancers progressed, providing clues to potential new approaches to treating this disease. The research, published in Nature Communications, was led by Professor Mark Shackleton, Professor Director of Oncology at Alfred Health and Monash University; Professor ...

Clinically, multiple lines of evidence show that chronic pain and depressive symptoms are frequently encountered. Patients suffered from both pain and depression are likely to become insensitive to drug treatment, indicating a refractory disease. The neural mechanism under this comorbidity remains unclear. In a study published in Nature Neuroscience, the research team led by Prof. ZHANG Zhi and Dr. LI Juan from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), reported the discrete thalamocortical circuits underlying the pain symptom caused by tissue injury and depression-like states. Being the gateway towards cerebral cortex and considered as the major source of 'nociceptive ...

The research team led by Prof. ZHANG Jie from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences made progress on real-time determination of earthquake focal mechanism through deep learning. The work was published in Nature Communications. Since there are connections between characteristics of the rupture surface of the source fault and seismic wave radiated by the source, it's vital to monitor the earthquake by immediate determination of the source focal mechanism which inferred from multiple ground seismic records. However, it's hard to calculate the mechanism from the simple ...

A combination of an array of atomic-level techniques has allowed researchers to show how changes in an environment-sensing protein enable bacteria to survive in different habitats, from the human gut to deep-sea hydrothermal vents. "The study gives us unprecedented atomic-level insight into how bacteria adapt to changing conditions," says Stefan Arold, professor of bioscience at KAUST. "To obtain these insights, we pushed the limits of three different methods of investigation and combined their results into a unified picture." The histone-like nucleoid-structuring (H-NS) protein allows bacteria to sense changes in their environment, such as changes in temperature and salinity. Previously, the team had shown how the intestinal pathogen Salmonella typhimurium ...