Intestinal worm infections can leave women in sub-Saharan Africa more vulnerable to sexually-transmitted viral infections, a new study reveals. The rate and severity of sexually-transmitted viral infections (STI) in the region are very high, as are those of worm infections, which when caught in the intestine can change immunity in other parts of the body. Researchers at the Universities of Birmingham and Cape Town led an international team which discovered that intestinal worm infection can change vaginal immunity and increase the likelihood of Herpes simplex virus type 2 (HSV-2) infection - the main cause of genital herpes. ...

Non-alcoholic fatty liver, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients with the goal of reducing the risk of cancer. "In this study with detailed liver histology data, we were able to quantify the increased risk of cancer associated with NAFLD, particularly hepatocellular carcinoma," says first author, Tracey G. Simon, researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, and hepatologist at Massachusetts General Hospital and Harvard ...

An outbreak of vomiting among dogs has been traced back to a type of animal coronavirus by researchers. Vets across the country began reporting cases of acute onset prolific vomiting in 2019/20. The Small Animal Veterinary Surveillance Network (SAVSNet) at the University of Liverpool asked vets for help in collecting data, with 1,258 case questionnaires from vets and owners plus 95 clinical samples from 71 animals. Based on this data, a team from the universities of Liverpool, Lancaster, Manchester and Bristol identified the outbreak as most likely to ...

ITHACA, N.Y. - Women's increased agricultural labor during harvest season, in addition to domestic house care, often comes at the cost of their health, according to new research from the Tata-Cornell Institute for Agriculture and Nutrition (TCI). Programs aimed at improving nutritional outcomes in rural India should account for the tradeoffs that women experience when their agricultural work increases, according to the study, "Seasonal time trade-offs and nutrition outcomes for women in agriculture: Evidence from rural India," which published in the journal Food Policy on March ...

PHILADELPHIA-- Humans have a uniquely high density of sweat glands embedded in their skin--10 times the density of chimpanzees and macaques. Now, researchers at Penn Medicine have discovered how this distinctive, hyper-cooling trait evolved in the human genome. In a study published today in the Proceedings of the National Academy of Sciences of the USA, researchers showed that the higher density of sweat glands in humans is due, to a great extent, to accumulated changes in a regulatory region of DNA--called an enhancer region--that drives the expression of a sweat gland-building gene, explaining why humans are the sweatiest ...

PHOENIX, Ariz. -- April 13, 2021 -- Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ABCC1 could not only reduce the deposition of a hard plaque in the brain that leads to Alzheimer's disease, but might also prevent or delay this memory-robbing disease from developing. ABCC1, also known as MRP1, has previously been shown in laboratory models to remove a plaque-forming protein known as amyloid beta (Abeta) from specialized endothelial cells that surround and protect ...

Compared to newborns conceived traditionally, newborns conceived through in vitro fertilization (IVF) are more likely to have certain chemical modifications to their DNA, according to a study by researchers at the National Institutes of Health. The changes involve DNA methylation--the binding of compounds known as methyl groups to DNA--which can alter gene activity. Only one of the modifications was seen by the time the children were 9 years old. The study was conducted by Edwina Yeung, Ph.D., and colleagues in NIH's Eunice Kennedy Shriver National Institute of Child Health and Human ...

A team of UBC Okanagan researchers has determined that the type of fats a mother consumes while breastfeeding can have long-term implications on her infant's gut health. Dr. Deanna Gibson, a biochemistry researcher, along with Dr. Sanjoy Ghosh, who studies the biochemical aspects of dietary fats, teamed up with chemistry and molecular biology researcher Dr. Wesley Zandberg. The team, who conducts research in the Irving K. Barber Faculty of Science, explored the role of feeding dietary fat to gestating rodents to determine the generational effects of fat exposure on their offspring. "The goal was to investigate how maternal dietary habits can impact an offspring's gut microbial communities and their associated sugar molecule patterns ...

HANOVER, N.H. - April 14, 2021 - Scientists have searched for years to understand how cells measure their size. Cell size is critical. It's what regulates cell division in a growing organism. When the microscopic structures double in size, they divide. One cell turns into two. Two cells turn into four. The process repeats until an organism has enough cells. And then it stops. Or at least it is supposed to. The complete chain of events that causes cell division to stop at the right time is what has confounded scientists. Beyond being a textbook problem, the question relates to serious medical challenges: ...

LOS ANGELES (April 13, 2021) -- The Lundquist Institute (TLI) Investigator Dong W. Chang, MD, and his colleagues' study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study - "Evaluation of Time-Limited Trials Among Critically Ill Patients with Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments" - found that training physicians to communicate with family members of critically ill patients using a structured approach, which promotes shared decision-making, improved the quality of family meetings. This intervention was associated with reductions in invasive ICU treatments that prolonged suffering without benefit for patients and their families. "Invasive ICU treatments are frequently delivered to patients ...

In April 2019, scientists released the first image of a black hole in galaxy M87 using the Event Horizon Telescope (EHT). However, that remarkable achievement was just the beginning of the science story to be told. Data from 19 observatories released today promise to give unparalleled insight into this black hole and the system it powers, and to improve tests of Einstein's General Theory of Relativity. "We knew that the first direct image of a black hole would be groundbreaking," says Kazuhiro Hada of the National Astronomical Observatory of Japan, a co-author of a new study published in The Astrophysical Journal Letters that ...

If global warming continues unchecked, summer monsoon rainfall in India will become stronger and more erratic. This is the central finding of an analysis by a team of German researchers that compared more than 30 state-of-the-art climate models from all around the world. The study predicts more extremely wet years in the future - with potentially grave consequences for more than one billion people's well-being, economy, food systems and agriculture. "We have found robust evidence for an exponential dependence: For every degree Celsius of warming, monsoon rainfalls will likely increase by about 5%," says lead author Anja Katzenberger from the Potsdam-Institute ...

A team of scientists, led by the University of Bristol, with colleagues from Goethe University, Frankfurt, has found the first evidence for ancient honey hunting, locked inside pottery fragments from prehistoric West Africa, dating back some 3,500 years ago. Honeybees are an iconic species, being the world's most important pollinator of food crops. Honeybee hive products, including beeswax, honey and pollen, used both for food and medicinal purposes, support livelihoods and provide sources of income for local communities across much of Africa, through both beekeeping ...

A potential treatment for dementia and epilepsy could look to reduce the amounts of a toxic gas in the brain has been revealed in a new study using rat brain cells. The research published in Scientific Reports today [Wednesday 14 April] shows that treatments to reduce levels of hydrogen sulfide (H2S) in the brain may help to ward off damage caused by the gas. By testing rat brain cells, the team of scientists from the University of Reading, University of Leeds and John Hopkins University in the USA found that H2S is involved in blocking a key brain cell gateway ...

If you were to visit the Great Basin and Colorado Plateau a thousand years ago, you'd find conditions remarkably familiar to the present. The climate was warm, but drier than today. There were large populations of Indigenous people known as the Fremont, a who hunted and grew crops in the area. With similar climate and moderate human activity, you might expect to see the types of wildfires that are now common to the American West: infrequent, gigantic and devastating. But you'd be wrong. In a new study led by the University of Utah, researchers found that ...

CLEVELAND, Ohio (April 14, 2021)--Despite all the advances in medicine, some basic questions remain. For example, people cannot be told with any certainty how long they'll live. Nor can it be predicted exactly when a woman's childbearing years will end. However, a new study offers insights into factors that might predict a woman's age at natural menopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). Factors that affect age at natural menopause are one of the most frequently studied topics in menopause-related research in recent decades, and with good reason. Knowing when a woman will enter menopause could be ...

Researchers have developed a new superbug-destroying coating that could be used on wound dressings and implants to prevent and treat potentially deadly bacterial and fungal infections. The material is one of the thinnest antimicrobial coatings developed to date and is effective against a broad range of drug-resistant bacteria and fungal cells, while leaving human cells unharmed. Antibiotic resistance is a major global health threat, causing at least 700,000 deaths a year. Without the development of new antibacterial therapies, the death toll could rise to 10 million people a year by 2050, equating to $US100 trillion in health care costs. While the health burden of fungal infections is less recognised, globally they kill about ...

Researchers from University of Hawaii and Cornell University published a new paper in the Journal of Marketing that explores the challenges and opportunities with nonprofit fundraising to provide organizations with strategies they can use to increase sustainable giving and profitability. The study, forthcoming in the Journal of Marketing, is titled "Managing Members, Donors, and Member-Donors for Effective Non-profit Fundraising" and is authored by Sungjin Kim, Sachin Gupta, and Clarence Lee. Individual philanthropy is the primary funding source for many nonprofit organizations. A major challenge facing such organizations ...

While a slow resting heart rate is generally considered a good thing, investigators have some of the first evidence that if that rate decreases rapidly as children move into young adulthood, it's an indicator that cardiovascular disease may be in their future. Medical College of Georgia investigators report a significant association between a faster decrease in resting heart rate from childhood to adulthood and a larger left ventricle, the heart's major pumping chamber, over a 21-year period in hundreds of individuals who were healthy at the start. The faster decrease in heart rate also was associated with a higher level of pressure inside the blood vessels of the body, which ...

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer's disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar amyloids. Researchers injected the molecule directly into the brains of live mice with Alzheimer's disease and then used a specialized probe to shine light into their brains for 30 minutes each day for one week. Chemical analysis of the mouse brain tissue showed that the treatment significantly reduced amyloid protein. Results from additional ...

UNIVERSITY PARK, Pa. -- Two opposing evolutionary forces explain the presence of the two different colors of spotted salamander egg masses at ponds in Pennsylvania, according to a new study led by a Penn State biologist. Understanding the processes that maintain biological diversity in wild populations is a central question in biology and may allow researchers to predict how species will respond to global change. Spotted salamanders (Ambystoma maculatum) are a widespread species that occur across the eastern United States and return to temporary ponds in the spring to reproduce. Female salamanders lay their eggs in clumps called egg masses, which are either opaque white or completely clear. Females lay the same color ...

Though noise may change moment by moment for humans, it has a more lasting effect on trees and plants. A new Cal Poly study reveals that human noise pollution affects the diversity of plant life in an ecosystem even after the noise has been removed. This is the first study that explores the long-term effects of noise on plant communities. It was published in the Proceedings of the Royal Society B. In a study conducted twelve years ago near natural gas wells in New Mexico, researchers found that there were 75% fewer piñon pine seedlings in noisy sites as in quiet ones. This was most likely due to the noise driving away the Woodhouse's scrub jay, which ...

PASADENA, Calif. -- A Kaiser Permanente study of nearly 50,000 people with COVID-19 suggested that regular physical activity provided strong protection from hospitalization, intensive care unit admission, and death. Even exercising inconsistently lowered the odds for severe COVID-19 outcomes when compared to people who were not active at all. The study, led by investigators in Kaiser Permanente Southern California, was published in the British Journal of Sports Medicine. "This is a wake-up call for the importance of healthy lifestyles and especially physical activity," said Robert E. Sallis, MD, a family and sports medicine physician at the Kaiser Permanente Fontana Medical Center. "Kaiser Permanente's motivation is to keep people healthy, and this study truly shows how important ...

DALLAS - April 13, 2021 - A chemical modification of RNA that can be influenced by diet appears to play a key role in polycystic kidney disease, an inherited disorder that is the fourth leading cause of kidney failure in the U.S., UT Southwestern researchers report in a new study. The findings, published online today in Cell Metabolism, suggest new ways to treat this incurable condition. About 600,000 Americans and 12.5 million people worldwide have autosomal dominant polycystic kidney disease (PKD), a condition caused by mutations in either of two genes, PKD1 or PKD2. These mutations cause kidney tubules ...

MINNEAPOLIS - Half of the children who developed the serious condition associated with COVID-19 called multisystem inflammatory syndrome in children (MIS-C) had neurologic symptoms or signs when they entered the hospital, according to preliminary research released today, April 13, 2021, that will be presented at the American Academy of Neurology's 73rd Annual Meeting being held virtually April 17 to 22, 2021. Those symptoms included headaches, encephalopathy and hallucinations. "With this new inflammatory syndrome that develops after children are infected with ...